Kaizhong Xue, Bo Gao, Feng Chen, Meiyun Wang, Jingliang Cheng, Bing Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Xiaochu Zhang, Guangbin Cui, Yongqiang Yu, Quan Zhang, Weihua Liao, Hui Zhang, Xiaojun Xu, Tong Han, Wen Qin, Feng Liu, Meng Liang, Lining Guo, Qiang Xu, Jiayuan Xu, Jilian Fu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Su Lui, Zhihan Yan, Jing Zhang, Jiance Li, Dawei Wang, Junfang Xian, Kai Xu, Xi-Nian Zuo, Longjiang Zhang, Zhaoxiang Ye, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Luise Poustka, Sarah Hohmann, Nathalie Holz, Juliane H Fröhner, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Wen Shen, Yanwei Miao, Chunshui Yu
Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18-30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity...
September 22, 2023: Molecular Psychiatry