journal
https://read.qxmd.com/read/38609585/dentate-gyrus-is-needed-for-memory-retrieval
#1
JOURNAL ARTICLE
Alejandro Carretero-Guillén, Mario Treviño, María Ángeles Gómez-Climent, Godwin K Dogbevia, Ilaria Bertocchi, Rolf Sprengel, Matthew E Larkum, Andreas Vlachos, Agnès Gruart, José M Delgado-García, Mazahir T Hasan
The hippocampus is crucial for acquiring and retrieving episodic and contextual memories. In previous studies, the inactivation of dentate gyrus (DG) neurons by chemogenetic- and optogenetic-mediated hyperpolarization led to opposing conclusions about DG's role in memory retrieval. One study used Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-mediated clozapine N-oxide (CNO)-induced hyperpolarization and reported that the previously formed memory was erased, thus concluding that denate gyrus is needed for memory maintenance...
April 12, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38605171/robust-and-replicable-functional-brain-signatures-of-22q11-2-deletion-syndrome-and-associated-psychosis-a-deep-neural-network-based-multi-cohort-study
#2
JOURNAL ARTICLE
Kaustubh Supekar, Carlo de Los Angeles, Srikanth Ryali, Leila Kushan, Charlie Schleifer, Gabriela Repetto, Nicolas A Crossley, Tony Simon, Carrie E Bearden, Vinod Menon
A major genetic risk factor for psychosis is 22q11.2 deletion (22q11.2DS). However, robust and replicable functional brain signatures of 22q11.2DS and 22q11.2DS-associated psychosis remain elusive due to small sample sizes and a focus on small single-site cohorts. Here, we identify functional brain signatures of 22q11.2DS and 22q11.2DS-associated psychosis, and their links with idiopathic early psychosis, using one of the largest multi-cohort data to date. We obtained multi-cohort clinical phenotypic and task-free fMRI data from 856 participants (101 22q11...
April 12, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38605172/longitudinal-inference-of-multiscale-markers-in-psychosis-from-hippocampal-centrality-to-functional-outcome
#3
JOURNAL ARTICLE
Jana F Totzek, M Mallar Chakravarty, Ridha Joober, Ashok Malla, Jai L Shah, Delphine Raucher-Chéné, Alexandra L Young, Dennis Hernaus, Martin Lepage, Katie M Lavigne
Multiscale neuroscience conceptualizes mental illness as arising from aberrant interactions across and within multiple biopsychosocial scales. We leverage this framework to propose a multiscale disease progression model of psychosis, in which hippocampal-cortical dysconnectivity precedes impairments in episodic memory and social cognition, which lead to more severe negative symptoms and lower functional outcome. As psychosis represents a heterogeneous collection of biological and behavioral alterations that evolve over time, we further predict this disease progression for a subtype of the patient sample, with other patients showing normal-range performance on all variables...
April 11, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38600227/exploring-the-genetic-etiology-across-the-continuum-of-the-general-psychopathology-factor-a-swedish-population-based-family-and-twin-study
#4
JOURNAL ARTICLE
Yangjun Liu, Paul Lichtenstein, Roman Kotov, Henrik Larsson, Brian M D'Onofrio, Erik Pettersson
Psychiatric comorbidity can be accounted for by a latent general psychopathology factor (p factor), which quantifies the variance that is shared to varying degrees by every dimension of psychopathology. It is unclear whether the entire continuum of the p factor shares the same genetic origin. We investigated whether mild, moderate, and extreme elevations on the p factor shared the same genetic etiology by, first, examining the linearity of the association between p factors across siblings (N = 580,891 pairs)...
April 10, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38589563/tau-pathology-is-associated-with-synaptic-density-and-longitudinal-synaptic-loss-in-alzheimer-s-disease
#5
JOURNAL ARTICLE
Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Yiyun Huang, Yang Yang, Zengping Lin, Tengfei Guo, Jun Zhao, Yihui Guan, Binyin Li, Fang Xie
The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography (PET) and plasma analysis in Alzheimer's disease (AD) patients are unknown. Seventy-five participants, including 26 AD patients, 19 mild cognitive impairment (MCI) patients, and 30 normal controls (NCs), underwent [18 F]SynVesT-1 PET/MR scans to assess synaptic density and [18 F]florbetapir and [18 F]MK6240 PET/CT scans to evaluate Aβ plaques and tau tangles. Among them, 19 AD patients, 12 MCI patients, and 29 NCs had plasma Aβ42/40 and p-tau181 levels measured by the Simoa platform...
April 8, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38580810/social-experience-in-adolescence-shapes-prefrontal-cortex-structure-and-function-in-adulthood
#6
JOURNAL ARTICLE
Dan C Li, Elizabeth A Hinton, Jidong Guo, Kristopher A Knight, Michelle K Sequeira, Meghan E Wynne, Niharika M Dighe, Shannon L Gourley
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC development is profoundly influenced by the social environment, disruptions to which may prime the emergence of psychopathology across the lifespan. We investigated the neurobehavioral consequences of isolation experienced in adolescence in mice, and in particular, the long-term consequences that were detectable even despite normalization of the social milieu. Isolation produced biases toward habit-like behavior at the expense of flexible goal seeking, plus anhedonic-like reward deficits...
April 5, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38580809/genetic-influences-and-causal-pathways-shared-between-cannabis-use-disorder-and-other-substance-use-traits
#7
JOURNAL ARTICLE
Marco Galimberti, Daniel F Levey, Joseph D Deak, Hang Zhou, Murray B Stein, Joel Gelernter
Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using cannabis develop CanUD, and the number of users has grown with increasing ease of access. CanUD and other substance use disorders (SUDs) are associated phenotypically and genetically. We leveraged new CanUD genomics data to undertake genetically-informed analyses with unprecedented power, to investigate the genetic architecture and causal relationships between CanUD and lifetime cannabis use with risk for developing SUDs and substance use traits...
April 5, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38575807/loss-of-mglu-5-receptors-in-somatostatin-expressing-neurons-alters-negative-emotional-states
#8
JOURNAL ARTICLE
Arnau Ramos-Prats, Pawel Matulewicz, Marie-Luise Edenhofer, Kai-Yi Wang, Chia-Wei Yeh, Ana Fajardo-Serrano, Michaela Kress, Kai Kummer, Cheng-Chang Lien, Francesco Ferraguti
Subtype 5 metabotropic glutamate receptors (mGlu5 ) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu5 act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu5 has been proposed to contribute to the exacerbation of neuropsychiatric disorders. Here, we examined how these receptors regulate the activity of somatostatin-expressing (SST+) neurons, as well as their influence on behavior and brain rhythmic activity...
April 4, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38575806/ketamine-s-mechanism-of-action-with-an-emphasis-on-neuroimmune-regulation-can-the-complement-system-complement-ketamine-s-antidepressant-effects
#9
REVIEW
Brandi Quintanilla, Carlos A Zarate, Anilkumar Pillai
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30-40% of patients with MDD achieve complete remission after conventional monoamine antidepressant therapy. In recent years, ketamine has revolutionized the treatment of MDD, with its rapid antidepressant effects manifesting within a few hours as opposed to weeks with conventional antidepressants. Many research endeavors have sought to identify ketamine's mechanism of action in mood disorders; while many studies have focused on ketamine's role in glutamatergic modulation, several studies have implicated its role in regulating neuroinflammation...
April 4, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38575805/patterns-of-stressful-life-events-and-polygenic-scores-for-five-mental-disorders-and-neuroticism-among-adults-with-depression
#10
JOURNAL ARTICLE
Jacob J Crouse, Shin Ho Park, Enda M Byrne, Brittany L Mitchell, Jan Scott, Sarah E Medland, Tian Lin, Naomi R Wray, Nicholas G Martin, Ian B Hickie
The dominant ('general') version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, and accumulated stressful life events (SLEs). In false discovery rate-corrected models, the clearest PGS-SLE relationships were for the ADHD- and depression-PGSs, and to a lesser extent, the anxiety- and schizophrenia-PGSs...
April 4, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38561468/substance-use-and-spine-density-a-systematic-review-and-meta-analysis-of-preclinical-studies
#11
Henrique Nunes Pereira Oliva, Tiago Paiva Prudente, Eric J Nunes, Kelly P Cosgrove, Rajiv Radhakrishnan, Marc N Potenza, Gustavo A Angarita
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies, synaptic density markers, like spine density, are altered by substances of abuse (e.g., alcohol, amphetamine, cannabis, cocaine, opioids, nicotine). These changes could be linked to phenomena including behavioral sensitization and drug self-administration in rodents. However, studies have produced heterogeneous results for spine density across substances and brain regions...
April 2, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38561467/pharmacological-fingerprint-of-antipsychotic-drugs-at-the-serotonin-5-ht-2a-receptor
#12
JOURNAL ARTICLE
Supriya A Gaitonde, Charlotte Avet, Mario de la Fuente Revenga, Elodie Blondel-Tepaz, Aida Shahraki, Adrian Morales Pastor, Valerij Talagayev, Patricia Robledo, Peter Kolb, Jana Selent, Javier González-Maeso, Michel Bouvier
The intricate involvement of the serotonin 5-HT2A receptor (5-HT2A R) both in schizophrenia and in the activity of antipsychotic drugs is widely acknowledged. The currently marketed antipsychotic drugs, although effective in managing the symptoms of schizophrenia to a certain extent, are not without their repertoire of serious side effects. There is a need for better therapeutics to treat schizophrenia for which understanding the mechanism of action of the current antipsychotic drugs is imperative. With bioluminescence resonance energy transfer (BRET) assays, we trace the signaling signature of six antipsychotic drugs belonging to three generations at the 5-HT2A R for the entire spectrum of signaling pathways activated by serotonin (5-HT)...
April 2, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38561466/gestational-epigenetic-age-and-adhd-symptoms-in-childhood-a-prospective-multi-cohort-study
#13
Kristina Salontaji, Kristine L Haftorn, Faye Sanders, Christian M Page, Esther Walton, Janine F Felix, Mona Bekkhus, Jon Bohlin, Henning Tiemeier, Charlotte A M Cecil
Epigenetic age acceleration (EAA), defined as the difference between chronological age and epigenetically predicted age, was calculated from multiple gestational epigenetic clocks (Bohlin, EPIC overlap, and Knight) using DNA methylation levels from cord blood in three large population-based birth cohorts: the Generation R Study (The Netherlands), the Avon Longitudinal Study of Parents and Children (United Kingdom), and the Norwegian Mother, Father and Child Cohort Study (Norway). We hypothesized that a lower EAA associates prospectively with increased ADHD symptoms...
April 2, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38561465/differential-dna-methylation-in-ipsc-derived-dopaminergic-neurons-a-step-forward-on-the-role-of-snord116-microdeletion-in-the-pathophysiology-of-addictive-behavior-in-prader-willi-syndrome
#14
JOURNAL ARTICLE
Juliette Salles, Sanaa Eddiry, Saber Amri, Mélissa Galindo, Emmanuelle Lacassagne, Simon George, Xavier Mialhe, Émeline Lhuillier, Nicolas Franchitto, Freddy Jeanneteau, Isabelle Gennero, Jean-Pierre Salles, Maithé Tauber
INTRODUCTION: A microdeletion including the SNORD116 gene (SNORD116 MD) has been shown to drive the Prader-Willi syndrome (PWS) features. PWS is a neurodevelopmental disorder clinically characterized by endocrine impairment, intellectual disability and psychiatric symptoms such as a lack of emotional regulation, impulsivity, and intense temper tantrums with outbursts. In addition, this syndrome is associated with a nutritional trajectory characterized by addiction-like behavior around food in adulthood...
April 2, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38556557/genetic-contribution-to-disease-course-severity-and-progression-in-the-super-finland-study-a-cohort-of-10-403-individuals-with-psychotic-disorders
#15
JOURNAL ARTICLE
Anders Kämpe, Jaana Suvisaari, Markku Lähteenvuo, Tarjinder Singh, Ari Ahola-Olli, Lea Urpa, Willehard Haaki, Jarmo Hietala, Erkki Isometsä, Tuomas Jukuri, Olli Kampman, Tuula Kieseppä, Kaisla Lahdensuo, Jouko Lönnqvist, Teemu Männynsalo, Tiina Paunio, Jussi Niemi-Pynttäri, Kimmo Suokas, Annamari Tuulio-Henriksson, Juha Veijola, Asko Wegelius, Mark Daly, Jacob Taylor, Kenneth S Kendler, Aarno Palotie, Olli Pietiläinen
Genetic factors contribute to the susceptibility of psychotic disorders, but less is known how they affect psychotic disease-course development. Utilizing polygenic scores (PGSs) in combination with longitudinal healthcare data with decades of follow-up we investigated the contributing genetics to psychotic disease-course severity and diagnostic shifts in the SUPER-Finland study, encompassing 10 403 genotyped individuals with a psychotic disorder. To longitudinally track the study participants' past disease-course severity, we created a psychiatric hospitalization burden metric using the full-coverage and nation-wide Finnish in-hospital registry (data from 1969 and onwards)...
April 1, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38553540/brain-stars-take-the-lead-during-critical-periods-of-early-postnatal-brain-development-relevance-of-astrocytes-in-health-and-mental-disorders
#16
REVIEW
Eugenia Vivi, Barbara Di Benedetto
In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and membrane-bound proteins. An imbalanced astrocyte activity can therefore have drastic negative impacts on brain development, leading to the onset of severe pathologies. Clinical and pre-clinical studies show alterations in astrocyte cell number, morphology, molecular makeup and astrocyte-dependent processes in different affected brain regions in neurodevelopmental (ND) and neuropsychiatric (NP) disorders...
March 29, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38553539/neural-foundation-of-the-diathesis-stress-model-longitudinal-gray-matter-volume-changes-in-response-to-stressful-life-events-in-major-depressive-disorder-and-healthy-controls
#17
JOURNAL ARTICLE
Florian Thomas-Odenthal, Kai Ringwald, Lea Teutenberg, Frederike Stein, Nina Alexander, Linda M Bonnekoh, Katharina Brosch, Katharina Dohm, Kira Flinkenflügel, Dominik Grotegerd, Tim Hahn, Andreas Jansen, Elisabeth J Leehr, Susanne Meinert, Julia-Katharina Pfarr, Harald Renz, Navid Schürmeyer, Thomas Stief, Benjamin Straube, Katharina Thiel, Paula Usemann, Alexandra Winter, Axel Krug, Igor Nenadić, Udo Dannlowski, Tilo Kircher
Recurrences of depressive episodes in major depressive disorder (MDD) can be explained by the diathesis-stress model, suggesting that stressful life events (SLEs) can trigger MDD episodes in individuals with pre-existing vulnerabilities. However, the longitudinal neurobiological impact of SLEs on gray matter volume (GMV) in MDD and its interaction with early-life adversity remains unresolved. In 754 participants aged 18-65 years (362 MDD patients; 392 healthy controls; HCs), we assessed longitudinal associations between SLEs (Life Events Questionnaire) and whole-brain GMV changes (3 Tesla MRI) during a 2-year interval, using voxel-based morphometry in SPM12/CAT12...
March 29, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38548985/correction-neuron-type-specific-proteomics-reveals-distinct-shank3-proteoforms-in-ispns-and-dspns-lead-to-striatal-synaptopathy-in-shank3b-mice
#18
Yi-Zhi Wang, Tamara Perez-Rosello, Samuel N Smukowski, D James Surmeier, Jeffrey N Savas
No abstract text is available yet for this article.
March 28, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38548984/the-relationship-between-prefrontal-cortex-gray-matter-volume-and-subcortical-dopamine-release-an-addendum
#19
LETTER
Matthäus Willeit, Ulrich Sauerzopf, Nicole Praschak-Rieder, Ana Weidenauer
No abstract text is available yet for this article.
March 28, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38548983/genome-wide-association-study-of-obsessive-compulsive-symptoms-including-33-943-individuals-from-the-general-population
#20
JOURNAL ARTICLE
Nora I Strom, Christie L Burton, Conrad Iyegbe, Talisa Silzer, Lilit Antonyan, René Pool, Mathieu Lemire, James J Crowley, Jouke-Jan Hottenga, Volen Z Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell Schachar, Hei Man Wu, Danielle Cath, Jennifer Crosbie, David Mataix-Cols, Dorret I Boomsma, Manuel Mattheisen, Sandra M Meier, Dirk J A Smit, Paul D Arnold
While 1-2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13-38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (GWAS) meta-analysis of parent- or self-reported OCS to date (N = 33,943 with complete phenotypic and genome-wide data), combining the results from seven large-scale population-based cohorts from Sweden, the Netherlands, England, and Canada (including six twin cohorts and one cohort of unrelated individuals)...
March 28, 2024: Molecular Psychiatry
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