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JOURNAL ARTICLE
Matthew R Bruce, Amalie C M Couch, Simone Grant, Janna McLellan, Katherine Ku, Christina Chang, Angelica Bachman, Matthew Matson, Robert F Berman, Richard J Maddock, Douglas Rowland, Eugene Kim, Matthew D Ponzini, Danielle Harvey, Sandra L Taylor, Anthony C Vernon, Melissa D Bauman, Judy Van de Water
Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD). Importantly, a clinically relevant connection exists between inflammation and metabolic stress that can result in aberrant cytokine signaling and autoimmunity. In this study we examined the potential for maternal autoantibodies (aAbs) to disrupt metabolic signaling and induce neuroanatomical changes in the brains of exposed offspring. To accomplish this, we developed a model of maternal aAb exposure in rats based on the clinical phenomenon of maternal autoantibody-related ASD (MAR-ASD)...
March 27, 2023: Molecular Psychiatry
#2
Kristine E Zengeler, John R Lukens
No abstract text is available yet for this article.
March 27, 2023: Molecular Psychiatry
#3
REVIEW
Steven F Grieco, Todd C Holmes, Xiangmin Xu
The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological mechanisms that has guided therapies that attenuate neuropathological features. A new direction is emerging in AD research that focuses on the progressive loss of cognitive function due to disrupted neural circuit mechanisms. Evidence from humans and animal models of AD show that dysregulated circuits initiate a cascade of pathological events that culminate in functional loss of learning, memory, and other aspects of cognition...
March 23, 2023: Molecular Psychiatry
#4
JOURNAL ARTICLE
Prashant Tibrewal, Pramod C Nair, Karen J Gregory, Christopher J Langmead, Sherry Kit Wa Chan, Tarun Bastiampillai
No abstract text is available yet for this article.
March 17, 2023: Molecular Psychiatry
#5
JOURNAL ARTICLE
Samantha A Wong, Lauren A M Lebois, Timothy D Ely, Sanne J H van Rooij, Steven E Bruce, Vishnu P Murty, Tanja Jovanovic, Stacey L House, Francesca L Beaudoin, Xinming An, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Michael C Kurz, Robert A Swor, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Claire Pearson, David A Peak, Roland C Merchant, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Mark W Miller, Robert H Pietrzak, Jutta Joormann, Deanna M Barch, Diego A Pizzagalli, Steven E Harte, James M Elliott, Ronald C Kessler, Karestan C Koenen, Samuel A McLean, Kerry J Ressler, Jennifer S Stevens, Nathaniel G Harnett
Childhood trauma is a known risk factor for trauma and stress-related disorders in adulthood. However, limited research has investigated the impact of childhood trauma on brain structure linked to later posttraumatic dysfunction. We investigated the effect of childhood trauma on white matter microstructure after recent trauma and its relationship with future posttraumatic dysfunction among trauma-exposed adult participants (n = 202) recruited from emergency departments as part of the AURORA Study...
March 17, 2023: Molecular Psychiatry
#6
REVIEW
Yating Cheng, Hongjun Song, Guo-Li Ming, Yi-Lan Weng
Effective axonal regeneration in the adult mammalian nervous system requires coordination of elevated intrinsic growth capacity and decreased responses to the inhibitory environment. Intrinsic regenerative capacity largely depends on the gene regulatory network and protein translation machinery. A failure to activate these pathways upon injury is underlying a lack of robust axon regeneration in the mature mammalian central nervous system. Epigenetics and epitranscriptomics are key regulatory mechanisms that shape gene expression and protein translation...
March 15, 2023: Molecular Psychiatry
#7
REVIEW
Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.
Guanya Li, Yang Hu, Wenchao Zhang, Jia Wang, Weibin Ji, Peter Manza, Nora D Volkow, Yi Zhang, Gene-Jack Wang
Obesity has tripled over the past 40 years to become a major public health issue, as it is linked with increased mortality and elevated risk for various physical and neuropsychiatric illnesses. Accumulating evidence from neuroimaging studies suggests that obesity negatively affects brain function and structure, especially within fronto-mesolimbic circuitry. Obese individuals show abnormal neural responses to food cues, taste and smell, resting-state activity and functional connectivity, and cognitive tasks including decision-making, inhibitory-control, learning/memory, and attention...
March 14, 2023: Molecular Psychiatry
#8
REVIEW
Moxin Wu, Zhiying Chen, Min Jiang, Bing Bao, Dongling Li, Xiaoping Yin, Xueren Wang, Dan Liu, Ling-Qiang Zhu
Neuronal death is one of the most common pathological hallmarks of diverse neurological diseases, which manifest varying degrees of cognitive or motor dysfunction. Neuronal death can be classified into multiple forms with complicated and unique regulatory signaling pathways. Tau is a key microtubule-associated protein that is predominantly expressed in neurons to stabilize microtubules under physiological conditions. In contrast, pathological tau always detaches from microtubules and is implicated in a series of neurological disorders that are characterized by irreversible neuronal death, such as necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy-dependent neuronal death and phagocytosis by microglia...
March 14, 2023: Molecular Psychiatry
#9
JOURNAL ARTICLE
Yu Huang, Jing Wu, Hanping Zhang, Yifan Li, Lu Wen, Xunmin Tan, Ke Cheng, Yiyun Liu, Juncai Pu, Lanxiang Liu, Haiyang Wang, Wenxia Li, Seth W Perry, Ma-Li Wong, Julio Licinio, Peng Zheng, Peng Xie
Clinical and animal studies have shown that gut microbiome disturbances can affect neural function and behaviors via the microbiota-gut-brain axis, and may be implicated in the pathogenesis of several brain diseases. However, exactly how the gut microbiome modulates nervous system activity remains obscure. Here, using a single-cell nucleus sequencing approach, we sought to characterize the cell type-specific transcriptomic changes in the prefrontal cortex and hippocampus derived from germ-free (GF), specific pathogen free, and colonized-GF mice...
March 13, 2023: Molecular Psychiatry
#10
JOURNAL ARTICLE
Alexandros Rammos, George Kirov, Leon Hubbard, James T R Walters, Peter Holmans, Michael J Owen, Michael C O'Donovan, Elliott Rees
Impaired cognition in schizophrenia is associated with worse functional outcomes. While genetic factors are known to contribute to variation in cognition in schizophrenia, few rare coding variants with strong effects have been identified, and the relative effects from de novo, inherited and non-transmitted alleles are unknown. We used array and exome sequencing data from 656 proband-parent trios to examine the contribution of common and rare variants to school performance, and by implication cognitive function, in schizophrenia...
March 13, 2023: Molecular Psychiatry
#11
JOURNAL ARTICLE
Jia-Jing Lu, Peng-Fei Wu, Jin-Gang He, Yu-Ke Li, Li-Hong Long, Xia-Ping Yao, Jia-Hao Yang, Hong-Sheng Chen, Xiang-Nan Zhang, Zhuang-Li Hu, Zhong Chen, Fang Wang, Jian-Guo Chen
Recent studies based on animal models of various neurological disorders have indicated that mitophagy, a selective autophagy that eliminates damaged and superfluous mitochondria through autophagic degradation, may be involved in various neurological diseases. As an important mechanism of cellular stress response, much less is known about the role of mitophagy in stress-related mood disorders. Here, we found that tumor necrosis factor-α (TNF-α), an inflammation cytokine that plays a particular role in stress responses, impaired the mitophagy in the medial prefrontal cortex (mPFC) via triggering degradation of an outer mitochondrial membrane protein, NIP3-like protein X (NIX)...
March 13, 2023: Molecular Psychiatry
#12
JOURNAL ARTICLE
Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation.
Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P Cortés Hidalgo, Kelly M Bakulski, Elisabeth B Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A M Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F Felix, Josef Frank, Siri E Håberg, Gunda Herberth, Thanh T Hoang, Lotte C Houtepen, Anke Hüls, Nastassja Koen, Stephanie J London, Maria C Magnus, Giulia Mancano, Rosa H Mulder, Christian M Page, Katri Räikkönen, Stefan Röder, Rebecca J Schmidt, Tabea S Send, Gemma Sharp, Dan J Stein, Fabian Streit, Johanna Tuhkanen, Stephanie H Witt, Heather J Zar, Ana C Zenclussen, Yining Zhang, Lea Zillich, Rosalind Wright, Jari Lahti, Kelly J Brunst
Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve non-overlapping cohorts from ten independent longitudinal studies (N = 5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine maternal stressful life events during pregnancy and DNA methylation in cord blood...
March 10, 2023: Molecular Psychiatry
#13
Mona-Lisa Malarte, Per-Göran Gillberg, Amit Kumar, Nenad Bogdanovic, Laëtitia Lemoine, Agneta Nordberg
No abstract text is available yet for this article.
March 8, 2023: Molecular Psychiatry
#14
Guillaume Fond, Martin Vidal, Morgane Joseph, Damien Etchecopar-Etchart, Marco Solmi, Dong Keon Yon, Christoph U Correll, Laurent Boyer
In schizophrenia, it is currently thought that stigma experience is increased by psychotic and depressive symptomatology, exposure to stigma at the workplace, and that self-stigma levels vary across countries without knowing the factors explaining these variations. The aim of the present meta-analysis was to synthetize the data of observational studies comprehensively exploring multiple self-stigma dimensions and associated factors. A systematic literature search without language or time restrictions was conducted in Medline, Google Scholar, and Web of Science for studies, last 09/2021...
March 8, 2023: Molecular Psychiatry
#15
LETTER
Masaki Kato, Hikaru Hori, Aran Tajika
No abstract text is available yet for this article.
March 7, 2023: Molecular Psychiatry
#16
JOURNAL ARTICLE
Elizabeth M Humphries, Kwangmi Ahn, Rachel L Kember, Fabiana L Lopes, Evelina Mocci, Juan M Peralta, John Blangero, David C Glahn, Fernando S Goes, Peter P Zandi, Peter Kochunov, Cristopher Van Hout, Alan R Shuldiner, Toni I Pollin, Braxton D Mitchell, Maja Bucan, L Elliot Hong, Francis J McMahon, Seth A Ament
Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts have identified numerous risk loci, yet pathophysiological mechanisms remain elusive, primarily due to the very small effects of common variants. We sought to discover risk variants with larger effects by conducting a genome-wide association study of mood disorders in a founder population, the Old Order Amish (OOA, n = 1,672). Our analysis revealed four genome-wide significant risk loci, all of which were associated with >2-fold relative risk...
March 7, 2023: Molecular Psychiatry
#17
JOURNAL ARTICLE
Chia-Wen Lin, Jacob Ellegood, Kota Tamada, Ikuo Miura, Mikiko Konda, Kozue Takeshita, Koji Atarashi, Jason P Lerch, Shigeharu Wakana, Thomas J McHugh, Toru Takumi
The BTBR T+ Itpr3tf /J (BTBR/J) strain is one of the most valid models of idiopathic autism, serving as a potent forward genetics tool to dissect the complexity of autism. We found that a sister strain with an intact corpus callosum, BTBR TF/ArtRbrc (BTBR/R), showed more prominent autism core symptoms but moderate ultrasonic communication/normal hippocampus-dependent memory, which may mimic autism in the high functioning spectrum. Intriguingly, disturbed epigenetic silencing mechanism leads to hyperactive endogenous retrovirus (ERV), a mobile genetic element of ancient retroviral infection, which increases de novo copy number variation (CNV) formation in the two BTBR strains...
March 7, 2023: Molecular Psychiatry
#18
JOURNAL ARTICLE
K Roseberry, H Le-Niculescu, D F Levey, R Bhagar, K Soe, J Rogers, S Palkowitz, N Pina, W A Anastasiadis, S S Gill, S M Kurian, A Shekhar, A B Niculescu
Anxiety disorders are increasingly prevalent, affect people's ability to do things, and decrease quality of life. Due to lack of objective tests, they are underdiagnosed and sub-optimally treated, resulting in adverse life events and/or addictions. We endeavored to discover blood biomarkers for anxiety, using a four-step approach. First, we used a longitudinal within-subject design in individuals with psychiatric disorders to discover blood gene expression changes between self-reported low anxiety and high anxiety states...
March 7, 2023: Molecular Psychiatry
#19
JOURNAL ARTICLE
Kseniia Sarieva, Theresa Kagermeier, Shokoufeh Khakipoor, Ezgi Atay, Zeynep Yentür, Katharina Becker, Simone Mayer
Maternal immune activation (MIA) during critical windows of gestation is correlated with long-term neurodevelopmental deficits in the offspring, including increased risk for autism spectrum disorder (ASD) in humans. Interleukin 6 (IL-6) derived from the gestational parent is one of the major molecular mediators by which MIA alters the developing brain. In this study, we establish a human three-dimensional (3D) in vitro model of MIA by treating induced pluripotent stem cell-derived dorsal forebrain organoids with a constitutively active form of IL-6, Hyper-IL-6...
March 6, 2023: Molecular Psychiatry
#20
JOURNAL ARTICLE
Hailun Cui, Yingying Zhang, Yijie Zhao, Ying Zhao, Qiong Ding, Ruiqin Chen, Luis Manssuer, Chencheng Zhang, Wenjuan Liu, Dianyou Li, Bomin Sun, Valerie Voon
Ablative procedures such as anterior capsulotomy are potentially effective in refractory obsessive-compulsive disorder (OCD). Converging evidence suggests the ventral internal capsule white matter tracts traversing the rostral cingulate and ventrolateral prefrontal cortex and thalamus is the optimal target for clinical efficacy across multiple deep brain stimulation targets for OCD. Here we ask which prefrontal regions and underlying cognitive processes might be implicated in the effects of capsulotomy by using both task fMRI and neuropsychological tests assessing OCD-relevant cognitive mechanisms known to map across prefrontal regions connected to the tracts targeted in capsulotomy...
March 6, 2023: Molecular Psychiatry
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