Menaouar Touimer, Hana Charfi, Antonio Sa Cunha, Alfred Penfornis, Coralie Amadou
Pancreatic diabetes is associated with glycemic variability, poor metabolic control, and reduced quality of life. Though hybrid closed-loop (HCL) insulin delivery systems were not originally developed for these types of diabetes, they could address the therapeutic challenge. We aimed to evaluate long-term metabolic control in ten adult patients (mean ± SD age: 59 ± 12) treated with HCL insulin delivery systems for pancreatitis or pancreatectomy-induced diabetes. After a median of 346 days (range 64 - 631) with HCL insulin delivery, continuous glucose monitoring showed 59±19 % time-in-range [70-180 mg/dl] (versus 49±24 % before HCL insulin delivery, P = 0...
May 23, 2024: Diabetes & Metabolism
Yu-Chi Su, Pei-Chun Hsieh, Edward Chia-Cheng Lai, Yun-Cian Lin, Yu-Ching Lin
AIM: Preclinical studies have shown that sodium-glucose cotransporter 2 inhibitors (SGLT2is) have a neuroprotective effect. This study compared the risks of carpal tunnel syndrome and carpal tunnel release surgery between new users of SGLT2is and new users of glucagon-like peptide-1 receptor agonists (GLP-1RAs). METHODS: A retrospective new-user active comparator cohort study with a target trial design was conducted by using the TriNetX platform. Patients with type 2 diabetes mellitus prescribed SGLT2is or GLP-1RAs were identified...
May 20, 2024: Diabetes & Metabolism
Wenyu Shao, Yichun Su, Jiayin Liu, Yu Long Liu, Jinghui Zhao, Xiaotang Fan
Autism spectrum disorders (ASD) encompass a collection of neurodevelopmental disorders that exhibit impaired social interactions and repetitive stereotypic behaviors. Although the exact cause of these disorders remains unknown, it is widely accepted that both genetic and environmental factors contribute to their onset and progression. Recent studies have highlighted the potential negative impact of maternal diabetes on embryonic neurodevelopment, suggesting that intrauterine hyperglycemia could pose an additional risk to early brain development and contribute to the development of ASD...
May 16, 2024: Diabetes & Metabolism
Damien Denimal, Laurence Duvillard, Sarah Béland-Bonenfant, Béatrice Terriat, Jean-Paul Pais-de-Barros, Isabelle Simoneau, Alexia Rouland, Lina Houbachi, Benjamin Bouillet, Bruno Vergès, Jean-Michel Petit
AIM: - New tools are required to better assess cardiovascular risk in individuals with type 2 diabetes mellitus (T2DM). Plasma ceramides emerge as promising candidates, given their substantial influence on the pathogenesis of both T2DM and atherosclerosis. The current study aimed to investigate whether plasma ceramides in patients with T2DM are a predictive factor for carotid intima-media thickness (CIMT), a well-established noninvasive marker for atherosclerosis that predicts adverse cardiovascular outcomes...
May 4, 2024: Diabetes & Metabolism
Fadi Alkhami, Sébastien Rubin, Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Marie-Amélie Barbet-Massin, Frédéric Domenge, Kamel Mohammedi, Vincent Rigalleau
OBJECTIVE: Diabetic kidney disease favors diabetic foot ulcers, however we do not know whether the reverse relation exists. We investigated whether diabetic foot disease (DFD) related to an increased risk of developing renal events. RESEARCH DESIGN AND METHODS: We conducted a retrospective analysis of a cohort of patients hospitalized for type 2 diabetes mellitus (T2DM) between 2009 and 2017, stratified for the risk of diabetic foot ulcer grades 0 (no risk), 1 and 2 (at risk), and 3 (DFD) according to the International Work Group on Diabetic Foot (IWGDF) classification...
May 1, 2024: Diabetes & Metabolism
Laurence Duvillard, Jean-Paul Pais de Barros, Alexia Rouland, Isabelle Simoneau, Damien Denimal, Benjamin Bouillet, Jean-Michel Petit, Bruno Vergès
AIM: The catabolism of high density lipoprotein (HDL) apolipoprotein AI (apoAI) is accelerated in patients with type 2 diabetes (T2D), related to hypertriglyceridemia, insulin resistance and low plasma adiponectin levels. Since liraglutide is likely to partly correct these abnormalities, we hypothesized that it might have a beneficial effect on HDL apoAI kinetics in patients with T2D. METHODS: An in vivo kinetic study of HDL apoAI was performed in 10 patients with T2D before and after 6 months of treatment with 1...
April 21, 2024: Diabetes & Metabolism
Gyuri Kim, Tae Yang Yu, Jae Hwan Jee, Ji Cheol Bae, Mira Kang, Jae Hyeon Kim
AIM: Left ventricular diastolic dysfunction (LVDD) has been observed in people with nonalcoholic fatty liver disease (NAFLD) in cross-sectional studies but the causal relationship is unclear. This study aimed to investigate the impact of NAFLD and the fibrotic progression of the disease on the development of LVDD, assessed by serial echocardiography, in a large population over a 7-year longitudinal setting. METHODS: This retrospective cohort study included the data of 3,496 subjects from a medical health check-up program...
April 10, 2024: Diabetes & Metabolism
Adrien Henry, Tiffany Boigelot, Thomas Ferreira DE Moura, Isabelle Leclercq, Coralie Barbe, Aurore Thiery, Zoubir Djerada, Pierre Nazeyrollas, Christine Clavel, Pascale Cornillet-Lefebvre, Jean-Paul Berrod, Catherine Creuzot-Garcher, Laurent Meyer, David Gaucher, Bruno Guerci, Patrick Lenoble, Solange Milazzo, Jean-Marc Perone, Carl Arndt, Vincent DURLACHd
No abstract text is available yet for this article.
April 1, 2024: Diabetes & Metabolism
Yilin Chen, Huachen Xue, Sizhi Ai, Yaping Liu, Yu Nie, Qi-Yong H Ai, Jihui Zhang, Yannis Yan Liang
AIM: - This study aimed to investigate the association of social isolation, loneliness, and their trajectory with the risk of developing type 2 diabetes mellitus (T2DM) across genetic risk. METHODS: - We included 439,337 participants (mean age 56.3 ± 8.1 years) enrolled in the UK Biobank study who were followed up until May 31, 2021. Social isolation and loneliness were self-reported and were further categorized into never, transient, incident, and persistent patterns...
March 6, 2024: Diabetes & Metabolism
Chan-Young Jung, Hee Byung Koh, Ga Young Heo, Byounghwi Ko, Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
AIMS: Although cellular and animal models have suggested a protective effect of ketone bodies (KBs), clinical data are still lacking to support these findings. This study aimed to investigate the association of KB levels with incident chronic kidney disease (CKD) and death. METHODS: This was a prospective cohort study of 87,899 UK Biobank participants without baseline CKD who had plasma levels of β-hydroxybutyrate, acetoacetate, and acetone levels measured at the time of enrollment...
March 4, 2024: Diabetes & Metabolism
Nolan Hassold, Hélène Bihan, Yolène Pambo Moumba, Isabelle Poilane, Frédéric Méchaï, Nabil Assad, Véronique Labbe-Gentils, Meriem Sal, Omar Nouhou Koutcha, Antoine Martin, Dana Radu, Emmanuel Martinod, Hugues Cordel, Nicolas Vignier, Sopio Tatulashvili, Narimane Berkane, Etienne Carbonnelle, Olivier Bouchaud, Emmanuel Cosson
OBJECTIVE: We aimed to assess the feasibility and diagnostic performance of ultrasound-guided bone biopsies at the bedside of diabetic patients admitted for suspected foot osteitis not requiring surgery. RESEARCH DESIGN AND METHODS: In this retrospective monocentric study, we compared the performance of ultrasound-guided (n = 29 consecutive patients, Dec.2020-Oct.2022) versus surgical (n = 24 consecutive patients, Jan.2018-Nov.2020) bone biopsies at confirming or ruling out diabetic foot osteitis (primary outcome)...
March 3, 2024: Diabetes & Metabolism
Philippe Oriot, Michel P Hermans, Antoine Vandelaer, Jean Christophe Philips, Gaëtan Prévost
No abstract text is available yet for this article.
March 2024: Diabetes & Metabolism
Charles Thivolet
No abstract text is available yet for this article.
March 2024: Diabetes & Metabolism
André J Scheen
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is), while developed as antihyperglycaemic medications for the treatment of type 2 diabetes, have proven to reduce major cardiovascular adverse events (MACEs) and hospitalization for heart failure (especially for SGLT2is) in dedicated cardiovascular outcome trials. The contribution of the glucose-lowering effect in the cardiovascular protection is uncertain and may differ between the two drug classes...
March 2024: Diabetes & Metabolism
Fadi Alkhami, Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Marie-Amélie Barbet-Massin, Amandine Ferriere, Claire Ducos, Kamel Mohammedi, Sami Fawaz, Thierry Couffinhal, Vincent Rigalleau
BACKGROUND: Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM. RESEARCH DESIGN AND METHODS: We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death)...
February 10, 2024: Diabetes & Metabolism
JaeHyuck Lee, In Cheol Hwang, Hong Yup Ahn
No abstract text is available yet for this article.
February 8, 2024: Diabetes & Metabolism
Yan Zhao, Wenyu Zhu, Miao Wang, Luyi Cai, Xueying Zheng, Liping Jin
AIMS: Identifying physiological factors that could reduce pregnant women's risk for developing gestational diabetes mellitus (GDM) is crucial for early prevention and intervention. We aimed to examine whether higher serum levels of total bilirubin (TBIL) were associated with a decreased risk of GDM. METHODS: We conducted a retrospective cohort study in a tertiary care hospital in Shanghai, China. A total of 92,885 pregnant women were included. Serum TBIL levels were determined during the first antenatal visit before 24 weeks of gestation and GDM was diagnosed with a 75-g oral glucose tolerance test (OGTT) at 24-28 weeks of gestation...
February 8, 2024: Diabetes & Metabolism
Yu-Chi Su, Pei-Chun Hsieh, Edward Chia-Cheng Lai, Yu-Ching Lin
AIM: Theoretically, sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce the risk of rotator cuff tear through an anti-inflammatory mechanism. To clarify this association, in this study, we compared SGLT2is users and glucagon-like peptide-1 receptor agonists (GLP-1RAs) users in terms of the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery. METHODS: A retrospective cohort analysis was conducted using data from the TriNetX platform...
February 8, 2024: Diabetes & Metabolism
Jielong Wu, Jie Fang, Xiaodong Yuan, Lingshan Ma, Liangcheng Zheng, Qing Lin, Xingkai An, Zhanxiang Wang, Qilin Ma
AIM: We aimed to explore the relationship between type 2 diabetes mellitus (T2DM) and the incidence rate of migraine in a Chinese population, and analyze the clinical characteristics of migraine patients with T2DM. METHODS: Data on the study cohort of 9873 individuals were obtained from the China Health and Retirement Longitudinal Study (CHARLS). The incidence rate of migraine from 2015 to 2018 was assessed. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs) for the relationship between T2DM and the incidence of migraine...
January 23, 2024: Diabetes & Metabolism
Yanjun Zhang, Mengyi Liu, Chun Zhou, Ziliang Ye, Yuanyuan Zhang, Sisi Yang, Panpan He, Xiaoqin Gan, Xianhui Qin
AIM: The modifying effect of prediabetic status on the association of social isolation and loneliness with the risk of type 2 diabetes mellitus (T2DM) remains uncertain. We aimed to explore whether prediabetic status modifies the association of social isolation and loneliness with incident T2DM. METHODS: 358,951 participants with random blood glucose < 11.1mmol/l, hemoglobin A1c < 6.5% and without diagnosis of diabetes from the UK Biobank were included. Prediabetes was defined by hemoglobin A1c level at 5...
January 20, 2024: Diabetes & Metabolism
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