journal
https://read.qxmd.com/read/38458351/trajectories-of-social-isolation-and-loneliness-and-the-risk-of-incident-type-2-diabetes-mellitus-across-genetic-risk-score
#1
JOURNAL ARTICLE
Yilin Chen, Huachen Xue, Sizhi Ai, Yaping Liu, Yu Nie, Qi-Yong H Ai, Jihui Zhang, Yannis Yan Liang
AIM: - This study aimed to investigate the association of social isolation, loneliness, and their trajectory with the risk of developing type 2 diabetes mellitus (T2DM) across genetic risk. METHODS: - We included 439,337 participants (mean age 56.3 ± 8.1 years) enrolled in the UK Biobank study who were followed up until May 31, 2021. Social isolation and loneliness were self-reported and were further categorized into never, transient, incident, and persistent patterns...
March 6, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38447817/association-of-ketone-bodies-with-incident-ckd-and-death-a-uk-biobank-study
#2
JOURNAL ARTICLE
Chan-Young Jung, Hee Byung Koh, Ga Young Heo, Byounghwi Ko, Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
AIMS: Although cellular and animal models have suggested a protective effect of ketone bodies (KBs), clinical data are still lacking to support these findings. This study aimed to investigate the association of KB levels with incident chronic kidney disease (CKD) and death. METHODS: This was a prospective cohort study of 87,899 UK Biobank participants without baseline CKD who had plasma levels of β-hydroxybutyrate, acetoacetate, and acetone levels measured at the time of enrollment...
March 4, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38442769/bedbiopsy-diagnostic-performance-of-bedside-ultrasound-guided-bone-biopsies-for-the-management-of-diabetic-foot-infection
#3
JOURNAL ARTICLE
Nolan Hassold, Hélène Bihan, Yolène Pambo Moumba, Isabelle Poilane, Frédéric Méchaï, Nabil Assad, Véronique Labbe-Gentils, Meriem Sal, Omar Nouhou Koutcha, Antoine Martin, Dana Radu, Emmanuel Martinod, Hugues Cordel, Nicolas Vignier, Sopio Tatulashvili, Narimane Berkane, Etienne Carbonnelle, Olivier Bouchaud, Emmanuel Cosson
OBJECTIVE: - We aimed to assess the feasibility and diagnostic performance of ultrasound-guided bone biopsies at the bedside of diabetic patients admitted for suspected foot osteitis not requiring surgery. RESEARCH DESIGN AND METHODS: - In this retrospective monocentric study, we compared the performance of ultrasound-guided (n=29 consecutive patients, Dec.2020-Oct.2022) versus surgical (n=24 consecutive patients, Jan.2018-Nov.2020) bone biopsies at confirming or ruling out diabetic foot osteitis (primary outcome)...
March 3, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38346471/skin-autofluorescence-of-advanced-glycation-end-products-relates-to-new-cardiovascular-events-in-type-2-diabetes-a-longitudinal-observational-study
#4
JOURNAL ARTICLE
Fadi Alkhami, Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Marie-Amélie Barbet-Massin, Amandine Ferriere, Claire Ducos, Kamel Mohammedi, Sami Fawaz, Thierry Couffinhal, Vincent Rigalleau
BACKGROUND: Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM. RESEARCH DESIGN AND METHODS: We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death)...
February 10, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38341133/association-between-blood-urea-nitrogen-to-creatinine-ratio-and-insulin-sensitivity
#5
LETTER
JaeHyuck Lee, In Cheol Hwang, Hong Yup Ahn
No abstract text is available yet for this article.
February 8, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38341132/high-serum-total-bilirubin-as-a-potential-protective-factor-for-gestational-diabetes-mellitus-a-retrospective-cohort-study-of-92-885-chinese-pregnant-women
#6
JOURNAL ARTICLE
Yan Zhao, Wenyu Zhu, Miao Wang, Luyi Cai, Xueying Zheng, Liping Jin
AIMS: Identifying physiological factors that could reduce pregnant women's risk for developing gestational diabetes mellitus (GDM) is crucial for early prevention and intervention. We aimed to examine whether higher serum levels of total bilirubin (TBIL) were associated with a decreased risk of GDM. METHODS: We conducted a retrospective cohort study in a tertiary care hospital in Shanghai, China. A total of 92,885 pregnant women were included. Serum TBIL levels were determined during the first antenatal visit before 24 weeks of gestation and GDM was diagnosed with a 75-g oral glucose tolerance test (OGTT) at 24-28 weeks of gestation...
February 8, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38341131/risk-of-rotator-cuff-tear-and-rotator-cuff-repair-surgery-comparison-between-sodium-glucose-cotransporter-2-inhibitors-and-glucagon-like-peptide-1-receptor-agonists-a-real-world-study
#7
JOURNAL ARTICLE
Yu-Chi Su, Pei-Chun Hsieh, Edward Chia-Cheng Lai, Yu-Ching Lin
AIM: Theoretically, sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce the risk of rotator cuff tear through an anti-inflammatory mechanism. To clarify this association, in this study, we compared SGLT2is users and glucagon-like peptide-1 receptor agonists (GLP-1RAs) users in terms of the risk of rotator cuff tear and the risk of receiving rotator cuff repair surgery. METHODS: A retrospective cohort analysis was conducted using data from the TriNetX platform...
February 8, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38309693/glycemic-risk-index-gri-variability-in-type-1-diabetes-adults-with-hba1c-%C3%A2-7-insights-for-clinical-evaluation-and-intervention
#8
LETTER
Philippe Oriot, Michel P Hermans, Antoine Vandelaer, Jean Christophe Philips, Gaëtan Prévost
No abstract text is available yet for this article.
February 1, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38272255/associations-of-type-2-diabetes-and-the-risk-of-migraine-in-chinese-populations
#9
JOURNAL ARTICLE
Jielong Wu, Jie Fang, Xiaodong Yuan, Lingshan Ma, Liangcheng Zheng, Qing Lin, Xingkai An, Zhanxiang Wang, Qilin Ma
AIM: We aimed to explore the relationship between type 2 diabetes mellitus (T2DM) and the incidence rate of migraine in a Chinese population, and analyze the clinical characteristics of migraine patients with T2DM. METHODS: Data on the study cohort of 9873 individuals were obtained from the China Health and Retirement Longitudinal Study (CHARLS). The incidence rate of migraine from 2015 to 2018 was assessed. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs) for the relationship between T2DM and the incidence of migraine...
January 23, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38253174/social-isolation-loneliness-and-the-risk-of-incident-type-2-diabetes-mellitus-by-glycemic-status
#10
JOURNAL ARTICLE
Yanjun Zhang, Mengyi Liu, Chun Zhou, Ziliang Ye, Yuanyuan Zhang, Sisi Yang, Panpan He, Xiaoqin Gan, Xianhui Qin
AIM: The modifying effect of prediabetic status on the association of social isolation and loneliness with the risk of type 2 diabetes mellitus (T2DM) remains uncertain. We aimed to explore whether prediabetic status modifies the association of social isolation and loneliness with incident T2DM. METHODS: 358,951 participants with random blood glucose < 11.1mmol/l, hemoglobin A1c < 6.5% and without diagnosis of diabetes from the UK Biobank were included. Prediabetes was defined by hemoglobin A1c level at 5...
January 20, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38232814/hope-hype-and-present-limitations-of-hybrid-closed-loop-systems-for-persons-with-type-1-diabetes
#11
EDITORIAL
Charles Thivolet
No abstract text is available yet for this article.
January 15, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38216030/eleven-year-trends-in-socioeconomic-inequalities-in-the-prevalence-and-incidence-of-pharmacologically-treated-type-2-diabetes-in-france-2010-2020
#12
JOURNAL ARTICLE
Marie Guion, Laurence Mandereau-Bruno, Sarah Goria, Emmanuel Cosson, Sandrine Fosse-Edorh
AIM: This study aimed to describe the association between socioeconomic inequalities and the prevalence and incidence of pharmacologically-treated type 2 diabetes in European France over the 2010-2020 period. METHODS: Diabetes cases were identified using a validated algorithm from the French National Health Data System. Analysis was restricted to adults aged 45 years and older to focus on type 2 diabetes. Socioeconomic inequalities were measured for all years in European France using the French deprivation index (FDep, 2015 version), which is an area-based deprivation indicator using population-weighted quintiles (Q1 corresponds to the least deprived municipalities)...
January 10, 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38158077/cardiovascular-protection-significantly-depends-on-hba1c-improvement-with-glp-1ras-but-not-with-sglt2-is-in-type-2-diabetes-a-narrative-review
#13
REVIEW
André J Scheen
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is), while developed as antihyperglycaemic medications for the treatment of type 2 diabetes, have proven to reduce major cardiovascular adverse events (MACEs) and hospitalization for heart failure (especially for SGLT2is) in dedicated cardiovascular outcome trials. The contribution of the glucose-lowering effect in the cardiovascular protection is uncertain and may differ between the two drug classes...
March 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38141808/steatotic-liver-disease-masld-and-risk-of-chronic-kidney-disease
#14
REVIEW
Josh Bilson, Alessandro Mantovani, Christopher D Byrne, Giovanni Targher
With the rising tide of fatty liver disease related to metabolic dysfunction worldwide, the association of this common liver disease with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the old term non-alcoholic fatty liver disease (NAFLD). In 2023, a modified Delphi process was led by three large pan-national liver associations. There was consensus to change the fatty liver disease nomenclature and definition to include the presence of at least one of five common cardiometabolic risk factors as diagnostic criteria...
January 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38103865/increased-risk-of-incident-mental-disorders-in-adults-with-new-onset-type-1-diabetes-diagnosed-after-the-age-of-19-a-nationwide-cohort-study
#15
JOURNAL ARTICLE
Seohyun Kim, Gyuri Kim, So Hyun Cho, Rosa Oh, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
AIM: This population-based study aimed to investigate the risk of mental disorders in adults with new-onset type 1 diabetes mellitus compared to the general population without diabetes. METHODS: We selected 10,391 adults with new-onset type 1 diabetes and 51,995 adults in the general population without diabetes with a median follow-up of 7.94 years using the National Health Insurance Database in South Korea between January 2009 and December 2020. The adjusted hazard ratios (aHRs) were estimated for the occurrence of mental disorders...
January 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38061425/real-world-safety-and-effectiveness-of-dapagliflozin-in-people-living-with-type-1-diabetes-in-spain-the-dapa-on-multicenter-retrospective-study
#16
MULTICENTER STUDY
María Durán-Martínez, Sharona Azriel, Viyey Kishore Doulatram-Gamgaram, Óscar Moreno-Pérez, Pedro J Pinés-Corrales, Cristina Tejera-Pérez, Juan Francisco Merino-Torres, Miguel Brito-Sanfiel, Ana Chico, Amparo Marco, Elena García-Fernández, José Ignacio Martínez-Montoro
OBJECTIVE: To assess real-world safety and effectiveness of dapagliflozin in people living with type 1 diabetes mellitus (T1DM). METHODS: We conducted a multicenter retrospective study in Spain including data from 250 people living with T1DM receiving dapagliflozin as add-on therapy to insulin (80.8 % on-label use). The number of diabetic ketoacidosis (DKA) events was calculated over a 12-month follow-up (primary outcome). Changes in body weight, HbA1c, total daily insulin dose, and continuous glucose monitoring (CGM) metrics from baseline (at dapagliflozin prescription) to 12 months were also evaluated...
January 2024: Diabetes & Metabolism
https://read.qxmd.com/read/38141807/dominant-pdx1-deficiency-causes-highly-penetrant-diabetes-at-different-ages-associated-with-obesity-and-exocrine-pancreatic-deficiency-lessons-for-precision-medicine
#17
JOURNAL ARTICLE
Youssef Kouidrat, Lauriane Le Collen, Martine Vaxillaire, Aurélie Dechaume, Bénédicte Toussaint, Emmanuel Vaillant, Souhila Amanzougarene, Mehdi Derhourhi, Brigitte Delemer, Mustapha Azahaf, Philippe Froguel, Amélie Bonnefond
OBJECTIVE: Heterozygous pathogenic or likely pathogenic (P/LP) PDX1 variants cause monogenic diabetes. We comprehensively examined the phenotypes of carriers of P/LP PDX1 variants, and delineated potential treatments that could be efficient in an objective of precision medicine. METHODS: The study primarily involved a family harboring a novel P/LP PDX1 variant. We then conducted an analysis of documented carriers of P/LP PDX1 variants, from the Human Gene Mutation Database (HGMD), RaDiO study, and Type 2 Diabetes Knowledge Portal (T2DKP) including 87K participants...
December 21, 2023: Diabetes & Metabolism
https://read.qxmd.com/read/38097011/reduction-of-circulating-methylglyoxal-levels-by-a-mediterranean-diet-is-associated-with-preserved-kidney-function-in-patients-with-type-2-diabetes-and-coronary-heart-disease-from-the-cordioprev-randomized-controlled-trial
#18
JOURNAL ARTICLE
Francisco M Gutierrez-Mariscal, Alicia Podadera-Herreros, Juan F Alcalá-Diaz, Magdalena P Cardelo, Antonio P Arenas-de Larriva, Silvia de la Cruz-Ares, Jose D Torres-Peña, Raul M Luque, Pablo Perez-Martinez, Javier Delgado-Lista, Jose Lopez-Miranda, Elena M Yubero-Serrano
AIM: - Advanced glycation end products (AGEs) play a role in kidney disease in type 2 diabetes mellitus (T2DM). However, there have been no prior controlled clinical trials examining the effects of specific diets on AGE metabolism and their impact on kidney function. Our aim was to assess whether modulating AGE metabolism resulting in reduced AGEs levels, after consumption of two healthy diets, could delay kidney function decline in patients with T2DM and coronary heart disease (CHD)...
December 12, 2023: Diabetes & Metabolism
https://read.qxmd.com/read/38097010/metformin-treatment-is-associated-with-improved-survival-in-diabetic-patients-hospitalized-with-acute-heart-failure-a-prospective-observational-study-using-the-korean-acute-heart-failure-registry-data
#19
JOURNAL ARTICLE
Kyeong-Hyeon Chun, Jaewon Oh, Chan Joo Lee, Jin Joo Park, Sang Eun Lee, Min-Seok Kim, Hyun-Jai Cho, Jin-Oh Choi, Hae-Young Lee, Kyung-Kuk Hwang, Kye Hun Kim, Byung-Su Yoo, Dong-Ju Choi, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Seok-Min Kang
AIMS: Although the hypothesis that metformin is beneficial for patients with diabetes and heart failure (HF) has been steadily raised, there is limited data on metformin use in patients with acute HF. We analyzed the association of metformin on all-cause mortality in hospitalized patients with type 2 diabetes and acute HF. METHODS: The Korean Acute Heart Failure registry prospectively enrolled patients hospitalized for acute HF from 2011 to 2014. Among this cohort, we analyzed patients with diabetes with baseline estimated glomerular filtration rate (eGFR) of 30 ml/min/1...
December 12, 2023: Diabetes & Metabolism
https://read.qxmd.com/read/38065522/monitoring-gestational-diabetes-mellitus-patients-with-mydiabby-healthcare%C3%A2-smartphone-application-vs-classical-diary-results-from-the-non-inferiority-telesur-gdm-study
#20
JOURNAL ARTICLE
Poncelet C, Bouamoud L, Michel P, Campinos C
OBJECTIVE: The aim of the TELESUR-GDM study was to demonstrate the non-inferiority of the onset of maternal, fœtal, and neonatal complications for patients with gestational diabetes mellitus (GDM) monitored by myDiabby Healthcareࣨ (app group) compared to patients with a classical glycaemic blood monitoring by diary (control group). MATERIALS AND METHODS: TELESUR-GDM was a retrospective, monocentric, and non-inferiority study including 349 patients in the app group and 295 patients in the control group...
December 6, 2023: Diabetes & Metabolism
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