journal
https://read.qxmd.com/read/38307456/safety-and-efficacy-of-insulins-in-critically-ill-patients-receiving-continuous-enteral-nutrition
#21
JOURNAL ARTICLE
Kevin Ni, R Matthew Hawkins, Heather L Smyth, Stacey A Seggelke, Joanna Gibbs, Mark C Lindsay, Laura K Kaizer, Cecilia C Low Wang
OBJECTIVE: There is a relative lack of consensus regarding the optimal management of hyperglycemia in patients receiving continuous enteral nutrition (EN), with or without a diagnosis of diabetes. METHODS: This retrospective study examined 475 patients (303 with known diabetes) hospitalized in critical-care setting units in 2019 in a single center who received continuous EN. Rates of hypoglycemia, hyperglycemia, and glucoses within target range (70-180 mg/dL) were compared in those with or without diabetes, and treated with intermediate acting (IA) biphasic neutral protamine Hagedorn (NPH) 70/30 or long-acting (LA) or rapid-acting (RA) only insulin...
January 31, 2024: Endocrine Practice
https://read.qxmd.com/read/38307455/clinical-characteristics-and-management-of-cosecreting-tsh-or-prl-pituitary-gh-adenomas-a-case-control-study
#22
JOURNAL ARTICLE
Caiyan Mo, Han Chen, Jian Xu, Ying Guo, Yao Wang, Zheng Li, Tao Tong, Songbai Gui, Liyong Zhong
OBJECTIVE: Cosecreting thyroid stimulating hormone (TSH) or prolactin (PRL) in patients with pituitary growth hormone (GH) adenomas has been rarely reported. Our study aimed to elucidate their clinical characteristics. METHODS: We retrospectively collected 22 cases of cosecreting GH and TSH pituitary adenomas [(GH+TSH)oma] and 10 cases of cosecreting GH and PRL pituitary adenomas [(GH+PRL)oma] of Beijing Tiantan Hospital, Capital Medical University between January 2009 and January 2023...
January 31, 2024: Endocrine Practice
https://read.qxmd.com/read/38244859/discriminatory-value-of-steroid-hormones-on-pcos-and-clustering-of-hyperandrogenism-and-metabolic-factors
#23
JOURNAL ARTICLE
Zheng Wang, Martijn Van Faassen, Henk Groen, Astrid E P Cantineau, Anne Van Oers, Anna Van der Veen, James M Hawley, Brian G Keevil, Ido P Kema, Annemieke Hoek
OBJECTIVE: We determined 1) If 11-oxygenated androgens better identify PCOS diagnosis in women with obesity compared to total or free testosterone (T) and free androgen index (FAI); 2) How biochemical hyperandrogenism and metabolic factors cluster in a cohort of women with infertility and obesity. METHODS: Women with obesity and PCOS comprised the study group (N=132). Ovulatory women with obesity and idiopathic, tubal or male factor infertility were the control group (N=83)...
January 18, 2024: Endocrine Practice
https://read.qxmd.com/read/38242354/pubertal-status-at-time-of-fertility-preservation-in-transgender-girls
#24
JOURNAL ARTICLE
Mabel Yau, Neha R Malhotra, John Steever, Eva Baldisserotto, Cathy Lin, Ralph Fader, Matthew Oransky, Joshua D Safer
BACKGROUND: Puberty blockade and gender affirming hormone therapy can impair fertility. Counseling on fertility preservation is important prior to initiation of therapy. The aim of our study was to assess tanner staging and the presence of virilizing secondary sex characteristics at the time of sperm collection and to correlate the viability of sperm with the tanner staging and degree of virilization. METHODS: A retrospective chart review of 23 transgender girls referred to pediatric urology at our academic pediatric transgender clinic for fertility preservation counseling was performed...
January 17, 2024: Endocrine Practice
https://read.qxmd.com/read/38185329/endocrine-disruptors-and-metabolic-changes-impact-on-puberty-control
#25
REVIEW
Marcela Peralta, Fernando Lizcano
OBJECTIVE: This study aims to explore the significant impact of environmental chemicals on disease development, focusing on their role in developing metabolic and endocrine diseases. The objective is to understand how these chemicals contribute to the increasing prevalence of precocious puberty, considering various factors, including epigenetic changes, lifestyle, and emotional disturbances. METHODS: The study employs a comprehensive review of descriptive observational studies in both human and animal models to identify a degree of causality between exposure to environmental chemicals and disease development, specifically focusing on endocrine disruption...
January 6, 2024: Endocrine Practice
https://read.qxmd.com/read/38185330/predicting-osteoporotic-fracture-in-patients-with-early-stage-diabetic-kidney-disease-using-a-radiomic-model-a-longitudinal-cohort-study
#26
JOURNAL ARTICLE
Youyuan Gao, Jianya Gao, Yunting Wang, Hua Gan
OBJECTIVE: There is an urgent need for effective predictive strategies to accurately evaluate the risk of fragility fractures in elderly patients in the early stages of diabetic kidney disease (DKD). METHODS: This longitudinal cohort study included 715 older patients in the early stages of DKD diagnosed between January 2015 and August 2019. Patients were randomly allocated to a training cohort (n = 499) and a validation cohort (n = 216). The least absolute shrinkage and selection operator method was used to select key features for dual-energy X-ray absorptiometry (DXA)-based radiomic analysis...
January 5, 2024: Endocrine Practice
https://read.qxmd.com/read/38184241/molecular-profiling-for-bethesda-iii-vi-nodules-results-of-a-multicenter-international-retrospective-study
#27
JOURNAL ARTICLE
Grégoire B Morand, Idit Tessler, Maxine Noik, Josh Krasner, Tzahi Yamin, Marc P Pusztaszeri, Galit Avior, Richard J Payne
BACKGROUND: Molecular testing is a well-established tool that assists in the management of thyroid nodules. We describe our experience using molecular testing of thyroid nodules with Bethesda III-VI cytology. METHODS: Retrospective multicenter multinational study of thyroid nodules that underwent preoperative molecular profiling with ThyGenX/ThyGeNEXT or ThyroSeq V3 between 2015-2022. The clinical characteristics and mutational profiles of tumors were compared. Collected data included demographics, cytology results, surgical pathology, and molecular alterations...
January 4, 2024: Endocrine Practice
https://read.qxmd.com/read/38184240/ablation-rates-and-long-term-outcome-following-low-dose-radioiodine-for-differentiated-thyroid-cancer-in-the-west-of-scotland-a-retrospective-analysis
#28
JOURNAL ARTICLE
Kathryn Graham, Fay Tough, Helena Belikova, Irene Wotherspoon, David Colville, Nicholas Reed
OBJECTIVE: Low dose radioiodine is an accepted means of remnant ablation in patients with low to intermediate risk differentiated thyroid cancer (DTC) based on the results of several Phase III trials. We evaluated the rate of ablation success and long term recurrence outcomes in the first three years of implementing this practice at our institution. METHODS: Patients who received 1.1-1.2GBq (30mCi) were identified retrospectively from the radionuclide database, 1st January 2012 - 31st December 2014 inclusive...
January 4, 2024: Endocrine Practice
https://read.qxmd.com/read/38184239/safety-net-primary-care-and-endocrinology-clinicians-knowledge-and-perspectives-on-screening-for-nonalcoholic-fatty-liver-disease-a-mixed-methods-evaluation
#29
JOURNAL ARTICLE
Kathryn L Fantasia, Kirsten Austad, Arpan Mohanty, Michelle T Long, Allan Walkey, Mari-Lynn Drainoni
OBJECTIVE: Clinical guidelines have expanded indications for nonalcoholic fatty liver disease (NAFLD) screening to type 2 diabetes mellitus and obesity, conditions common in populations that receive care in urban, safety-net settings. This study sought to evaluate safety-net primary care and endocrine clinician knowledge of NAFLD, identify barriers and facilitators to screening, and examine perspectives on use of electronic health record tools for risk assessment. METHODS: Sequential explanatory mixed methods using survey and qualitative interviews with primary care, primary care subspecialty, and endocrine clinicians in an urban, safety-net healthcare system...
January 4, 2024: Endocrine Practice
https://read.qxmd.com/read/38184238/primary-hyperparathyroidism-assessment-of-the-effects-of-parathyroidectomy-using-dual-x-ray-absorptiometry-dxa-trabecular-bone-score-and-dxa-based-three-dimensional-modeling
#30
JOURNAL ARTICLE
Rosa Arboiro-Pinel, Ignacio Mahillo-Fernández, Manuel Díaz-Curiel
OBJECTIVE: The aim of this study was to evaluate bone microstructure to determine whether curative surgery of PHPT produces changes in BMD, TBS and 3D-DXA parameters, and whether these changes are comparable. METHODS: We retrospectively studied 85 patients (60 women and 25 men, 60.4 ± 12.5 years) diagnosed with PHPT and undergoing parathyroidectomy. Mean percent changes in BMD (lumbar spine (LS), femoral neck (FN), total hip (TH) and 1/3 radius), TBS and 3D-DXA parameters (trabecular volumetric BMD (vBMD), cortical vBMD, integral vBMD, cortical surface density (sBMD) and cortical thickness at TH) after surgery (12, 24 and/or 36 months) were calculated and compared, and we sought the determinants of these changes...
January 4, 2024: Endocrine Practice
https://read.qxmd.com/read/38184237/survival-outcomes-of-medullary-thyroid-cancer-with-and-without-amyloid-deposition
#31
JOURNAL ARTICLE
Eman Toraih, Mohammad Hussein, Allison Anker, Solomon Baah, Dylan Pinion, Jessan Jishu, Salmanfaizee Sadakkadulla, Madeline Case, Alexandra LaForteza, Krzysztof Moroz, Emad Kandil
OBJECTIVE: Amyloid deposition within tumor stroma is a distinctive histologic feature of medullary thyroid cancer (MTC). However, its prognostic significance remains uncertain. We aimed to elucidate the impact of amyloid status on survival outcomes in a large cohort. METHODS: The Surveillance, Epidemiology, and End Results registry was queried to identify patients diagnosed with MTC from 2000-2019. Patients with amyloid positive (ICD-O-3 code 8345/3) and amyloid negative (ICD-O-3 code 8510/3) tumors were analyzed...
January 4, 2024: Endocrine Practice
https://read.qxmd.com/read/38029929/efficacy-and-safety-of-glucagon-like-peptide-1-receptor-agonists-on-body-weight-and-cardiometabolic-parameters-in-individuals-with-obesity-and-without-diabetes-a-systematic-review-and-meta-analysis
#32
REVIEW
Huzaifa Ul Haq Ansari, Shurjeel Uddin Qazi, Faiza Sajid, Zahabia Altaf, Shamas Ghazanfar, Naveen Naveed, Amna Shakil Ashfaq, Abdul Hannan Siddiqui, Hamza Iqbal, Sana Qazi
OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially for type 2 diabetes mellitus, show promise in promoting weight loss and improving heart health in obese individuals without diabetes. Our goal was to examine existing research for conclusive evidence on various types of GLP-1 RAs for weight loss and cardiometabolic benefits in obesity without diabetes. METHODS: We conducted an electronic search on PubMed, Scopus, and Cochrane Central using keywords, such as "GLP-1 RA," "obesity," and "weight loss...
February 2024: Endocrine Practice
https://read.qxmd.com/read/38007181/effect-of-thyroid-stimulating-hormone-suppression-therapy-on-cardiac-structure-and-function-in-patients-with-differentiated-thyroid-cancer-after-thyroidectomy-a-systematic-review-and-meta-analysis
#33
REVIEW
Hongling Zhang, Yanlong Yang, Cuixia Gao, Limin Tian
OBJECTIVE: We aimed to evaluate the effects of thyroid-stimulating hormone (TSH) suppression therapy on cardiac structure and function in patients with differentiated thyroid cancer (DTC) following thyroidectomy. METHODS: Two investigators independently searched the PubMed, Embase, Cochrane Library, and Web of Science databases for relevant studies published from inception to January 6, 2023, without any restrictions on language. Standard mean differences and 95% confidence intervals were calculated using fixed or random effects models...
February 2024: Endocrine Practice
https://read.qxmd.com/read/37913925/real-practice-assessment-of-persistent-symptoms-after-initiation-of-levothyroxine
#34
JOURNAL ARTICLE
Jessica Hidalgo, Bryan A Vallejo, Cristian Soto Jacome, Ivan N Ayala, Sandra Cordova, Mayra Duran, Elizabeth Golembiewski, David Toro-Tobon, Juan P Brito
OBJECTIVE: Levothyroxine (LT4) is the standard treatment for hypothyroidism. However, certain patients experience persistent symptoms even after achieving euthyroid status with LT4 therapy. We aimed to determine the frequency of persistent or new symptoms in patients with hypothyroidism after initiating LT4. METHODS: This retrospective study included patients with hypothyroidism who started on LT4 between January 2017 and December 2019 at Mayo Clinic in Rochester, Minnesota, USA...
February 2024: Endocrine Practice
https://read.qxmd.com/read/38178585/hormonal-contraceptive-use-is-associated-with-a-decreased-incidence-of-hypothyroidism
#35
JOURNAL ARTICLE
Shawna Gloe, Ty B Carroll
OBJECTIVE: Hypothyroidism is one of the most common endocrine disorders affecting 5 to 10 times more women than men. Given this higher incidence in women, it is possible that hormonal differences or medications more commonly used by women may play a role in the risk of developing hypothyroidism. We hypothesized that hormonal contraception affects the risk of developing hypothyroidism. METHODS: Using the TriNetX database, we developed a case-control study and identified women aged 18 to 45 years in 4 distinct groups: (1) estrogen-progestin contraceptive (EPC) use, (2) progestin-only contraceptive (POC) use, (3) progestin-containing intrauterine device (IUD) use, and (4) controls...
January 2024: Endocrine Practice
https://read.qxmd.com/read/37918624/gestational-diabetes-mellitus-and-metabolic-syndrome-a-review-of-the-associations-and-recommendations
#36
REVIEW
Bong Nguyen, Tatiana Tselovalnikova, Betty M Drees
OBJECTIVE: Gestational diabetes mellitus (GDM) and metabolic syndrome (MetS) share common characteristics and risk factors. Both conditions increase the risk of chronic diseases and, thus, may share a common pathogenesis. This review begins with a clinical vignette, followed by evidence supporting the risk of MetS after GDM among women and their offspring and the risk of having GDM among pregnant women who have MetS before pregnancy. METHODS: Research studies published between 2010 and 2023 were identified via several databases, including PubMed, the Web of Science, MEDLINE, Science Direct, ERIC, and EBSCOhost...
January 2024: Endocrine Practice
https://read.qxmd.com/read/37805100/relacorilant-a-selective-glucocorticoid-receptor-modulator-in-development-for-the-treatment-of-patients-with-cushing-syndrome-does-not-cause-prolongation-of-the-cardiac-qt-interval
#37
JOURNAL ARTICLE
Diane M Donegan, Rosario Pivonello, Antonio Stigliano, Pina Lardo, Tara Kearney, Emese Mezősi, Ezio Ghigo, Roberta Giordano, Cary N Mariash, Richard A Feelders, Kirsteen Donaldson, Borje Darpo, Hongqi Xue, Joseph M Custodio, Austin L Hand, Andreas G Moraitis
OBJECTIVE: To assess the effect of relacorilant, a selective glucocorticoid receptor modulator under investigation for the treatment of patients with endogenous hypercortisolism (Cushing syndrome [CS]), on the heart rate-corrected QT interval (QTc). METHODS: Three clinical studies of relacorilant were included: (1) a first-in-human, randomized, placebo-controlled, ascending-dose (up to 500 mg of relacorilant) study in healthy volunteers; (2) a phase 1 placebo- and positive-controlled thorough QTc (TQT) study of 400 and 800 mg of relacorilant in healthy volunteers; and (3) a phase 2, open-label study of up to 400 mg of relacorilant administered daily for up to 16 weeks in patients with CS...
January 2024: Endocrine Practice
https://read.qxmd.com/read/38160940/surveillance-imaging-strategies-for-pituitary-adenomas-when-how-frequent-and-when-to-stop
#38
REVIEW
Kevin C J Yuen, Luma Ghalib, Michael Buchfelder, Jeremy Hughes, Fabienne Langlois, Mark E Molitch
Magnetic resonance imaging is the mainstay imaging modality of choice in the assessment, treatment planning and follow-up of pituitary adenomas (PAs). Pituitary adenomas are discovered incidentally during imaging for a variety of unrelated conditions, because of clinical symptoms related to mass effects on the adjacent structures, or during work up for functional alterations of the adenoma. Imaging is also utilized in the preoperative and postoperative phases of assessment of PAs, for surgical and radiotherapy planning, for postoperative surveillance to assess for adenoma stability and detection of adenoma recurrence, and for surveillance to monitor for adenoma growth in unoperated PAs...
December 29, 2023: Endocrine Practice
https://read.qxmd.com/read/38160939/assessing-the-frequency-of-deferrable-thyroid-nodule-biopsies-to-de-escalate-low-value-care
#39
JOURNAL ARTICLE
Maya Alexis, Sara P Ginzberg, Jacqueline M Soegaard Ballester, Susan J Mandel, Jill E Langer, Rachel R Kelz, Heather Wachtel
OBJECTIVE: Thyroid nodules are common, yet fewer than 1 in 10 harbors malignancy. When present, thyroid cancer is typically indolent with excellent survival. Therefore, patients who are not candidates for thyroid cancer treatment due to comorbid disease may not require further thyroid nodule evaluation. The goal of this study was to determine the rate of deferrable thyroid nodule biopsies in patients with limited life expectancy. METHODS: We identified patients who underwent thyroid fine-needle aspiration (FNA) between 2015-2018 at our institution...
December 29, 2023: Endocrine Practice
https://read.qxmd.com/read/38142371/corrigendum-to-clinical-characteristics-of-28-patients-with-diabetes-and-covid-19-in-wuhan-china-endocrine-practice-2020-668-674
#40
Fen Wang, Yan Yang, Kun Dong, Yongli Yan, Shujun Zhang, Huihui Ren, Xuefeng Yu, Xiaoli Shi
No abstract text is available yet for this article.
December 22, 2023: Endocrine Practice
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