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Audiology & Neuro-otology

Francka J J Kloostra, Julia Verbist, Rutger Hofman, Rolien H Free, Rosemarie Arnold, Pim van Dijk
Previous studies have shown diverse and sometimes even contrary results concerning the effect of cochlear implantation on tinnitus and the factors that can influence this effect. The aim of this prospective questionnaire study was to determine the effects of cochlear implantation on tinnitus and explore which factors can influence the effect of cochlear implantation on tinnitus. Forty-four of the patients implanted in our hospital returned 2 questionnaire packages, i.e., one before the cochlear implantation and one 6 months after implantation...
February 8, 2019: Audiology & Neuro-otology
Miryam Calvino, Isabel Sánchez-Cuadrado, Javier Gavilán, Luis Lassaletta
BACKGROUND: The otosclerotic process may influence the performance of the cochlear implant (CI). Difficulty in inserting the electrode array due to potential ossification of the cochlea, facial nerve stimulation, and instability of the results are potential challenges for the CI team. OBJECTIVES: To evaluate hearing results and subjective outcomes of CI users with otosclerosis and to compare them with those of CI users without otosclerosis. METHOD: Retrospective review of 239 adults with bilateral profound postlingual deafness who underwent unilateral cochlear implantation between 1992 and 2017...
February 8, 2019: Audiology & Neuro-otology
Kimberley S Noij, Barbara S Herrmann, John J Guinan, Steven D Rauch
BACKGROUND: The cervical vestibular evoked myogenic potential (cVEMP) test measures saccular and inferior vestibular nerve function. The cVEMP can be elicited with different frequency stimuli and interpreted using a variety of metrics. Patients with superior semicircular canal dehiscence (SCD) syndrome generally have lower cVEMP thresholds and larger amplitudes, although there is overlap with healthy subjects. The aim of this study was to evaluate which metric and frequency best differentiate healthy ears from SCD ears using cVEMP...
January 24, 2019: Audiology & Neuro-otology
Joseph B Nadol, E Tessa Hedley-Whyte, Sami Samir Amr, Jennifer T O Apos Malley, Takefumi Kamakura
Charcot-Marie-Tooth (CMT) syndrome is a clinically and genetically heterogeneous group of neuropathies affecting both peripheral motor and sensory nerves. Progressive sensorineural hearing loss, vestibular abnormalities, and dysfunction of other cranial nerves have been described. This is the second case report of otopathology in a patient with CMT syndrome. Molecular genetic testing of DNA obtained at autopsy revealed a missense variant in the MPZ gene (p.Thr65Ala), pathogenic for an autosomal-dominant form of CMT1B...
January 24, 2019: Audiology & Neuro-otology
Thomas Zahnert, Robert Mlynski, Hubert Löwenheim, Dirk Beutner, Rudolf Hagen, Arneborg Ernst, Thorsten Zehlicke, Hilke Kühne, Natascha Friese, Anke Tropitzsch, Jan Christoffer Luers, Ingo Todt, Karl-Bernd Hüttenbrink
OBJECTIVE: To evaluate the long-term safety and performance of four different vibroplasty couplers (round window, oval window, CliP and Bell coupler) in combination with an active middle ear implant. METHODS: This was a multicentre, prospective, long-term study including 5 German hospitals. Thirty adult subjects suffering from conductive or mixed hearing loss were initially enrolled for the study, 24 of these were included in the final analysis with up to 36 months of postsurgical follow-up data...
January 16, 2019: Audiology & Neuro-otology
Yu Si, Huai Li Jiang, Yu Bin Chen, Yu Guo Chu, Sui Jun Chen, Xi Ming Chen, Wu Hui He, Yi Qing Zheng, Zhi Gang Zhang
OBJECTIVE: To explore the effectiveness and safety of round window niche drilling combined with intratympanic methylprednisolone injection for the salvage treatment of sudden sensorineural hearing loss (SSNHL) and its associated tinnitus after failed primary treatment. METHOD: SSNHL patients who showed a less than 10-dB improvement of pure-tone average after receiving standard systemic treatment and intratympanic steroid injection were enrolled. All included patients were randomly divided into two groups (control and study)...
January 10, 2019: Audiology & Neuro-otology
Dominique Vibert, John H J Allum, Martin Kompis, Simona Wiedmer, Christof Stieger, Rudolf Häusler, Marco Caversaccio
The aim of this study was to investigate changes in balance control for stance and gait tasks in patients 2 years before and after vestibular neurectomy (VN) performed to alleviate intractable Meniere's disease. Amplitudes of trunk sway in roll and pitch directions were measured for stance and gait tasks in 19 patients using gyroscopes mounted at the lower-back. Measurements before VN and 2 years later were compared to those of healthy age-matched controls (HC). We also examined if changes in trunk sway amplitudes were correlated with patients' subjective assessment of disability using the AAO-HNS scale...
December 12, 2018: Audiology & Neuro-otology
Michael F Dorman, Sarah Cook Natale, Smita Agrawal
OBJECTIVE: Our primary aim was to determine, in a simulation of a crowded restaurant, the value to speech understanding of (i) a unilateral cochlear implant (CI), (ii) a CI plus CROS (contralateral routing of signals) aid system and (iii) bilateral CIs when tested with and without beamforming microphones. DESIGN: The listeners were 7 CI listeners who had used bilateral CIs for an average of 9 years. The listeners were tested with three device configurations (bilateral CI, unilateral CI + CROS, and unilateral CI), two signal processing conditions (without and with beamformers) and with speech either from +90°, -90°, or from the front...
December 11, 2018: Audiology & Neuro-otology
Da-An Huh, Yun-Hee Choi, Myung Sun Ji, Kyong Whan Moon, Seok J Yoon, Jong-Ryeul Sohn
Previous studies have reported that exposure to lead and cadmium can damage the inner ear receptor, which perceives high-frequency sounds. However, few studies have used the pure-tone average (PTA), including high-frequency ranges, for the estimation of hearing loss caused by lead and cadmium exposure. We estimated hearing loss using the PTA test, in low-frequency, speech frequency, and high-frequency ranges and compared the differences in the results using 3 PTA calculation methods. We analyzed the data of 2,387 participants, between the ages of 19 and 85 years, that were obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) of 2010-2012...
December 11, 2018: Audiology & Neuro-otology
Stephanie C Rigters, Marc P van der Schroeff, Grigorios Papageorgiou, Robert J Baatenburg de Jong, André Goedegebure
We quantified changes in the auditory acuity of 675 aging adults (mean age 71.1 years, 52.0% female, mean follow-up 4.4 years ± 0.2) of an ongoing cohort study with a pure-tone audiogram and a speech-in-noise test. Generalized estimating equation models were used to study the association between hearing loss and the progression with age, sex, education, cognition, BMI, blood pressure, having type 2 diabetes mellitus, cholesterol ratio, smoking and alcohol consumption. The mean progression of hearing loss was 0...
December 11, 2018: Audiology & Neuro-otology
Alec N Salt, Jared J Hartsock, Fabrice Piu, Jennifer Hou
Dexamethasone phosphate is widely used for intratympanic therapy in humans. We assessed the pharmacokinetics of dexamethasone entry into perilymph when administered as a dexamethasone phosphate solution or as a micronized dexamethasone suspension, with and without inclusion of poloxamer gel in the medium. After a 1-h application to guinea pigs, 10 independent samples of perilymph were collected from the lateral semicircular canal of each animal, allowing entry at the round window and stapes to be independently assessed...
November 29, 2018: Audiology & Neuro-otology
Danuta Raj-Koziak, Elzbieta Gos, Weronika Swierniak, Joanna J Rajchel, Lucyna Karpiesz, Iwona Niedzialek, Elzbieta Wlodarczyk, Henryk Skarzynski, Piotr H Skarzynski
The aim of this study was to evaluate the psychometric properties of patient-reported visual analogue scale (VAS) ratings. All of the participants (100 Polish-speaking adults) completed a Tinnitus Functional Index (TFI) once and a 4-component VAS twice over a period of 3 days. Spearman's correlation coefficients between the VAS score and global TFI ranged from ρ = 0.52 for VAS-coping (VAS-C) to ρ = 0.81 for VAS-annoyance (VAS-A). Using the Bland-Altman method, the agreement ranged from 93% for VAS-A to 96% for VAS-distress (VAS-D)...
November 15, 2018: Audiology & Neuro-otology
Arianna Di Stadio, Laura Dipietro, Roberta Toffano, Francesca Burgio, Antonietta De Lucia, Valentina Ippolito, Sabina Garofalo, Giampietro Ricci, Francesco Martines, Franco Trabalzini, Antonio Della Volpe
The importance of a good hearing function to preserve memory and cognitive abilities has been shown in the adult population, but studies on the pediatric population are currently lacking. This study aims at evaluating the effects of a bone-anchored hearing implant (BAHI) on speech perception, speech processing, and memory abilities in children with single side deafness (SSD). We enrolled n = 25 children with SSD and assessed them prior to BAHI implantation, and at 1-month and 3-month follow-ups after BAHI implantation using tests of perception in silence and perception in phonemic confusion, dictation in silence and noise, and working memory and short-term memory function in conditions of silence and noise...
November 15, 2018: Audiology & Neuro-otology
David R Friedmann, Leena Asfour, William H Shapiro, J Thomas Roland, Susan B Waltzman
OBJECTIVE: To assess bimodal auditory performance in children with a cochlear implant (CI) and contralateral auditory brainstem implant (ABI). METHODS: This is a retrospective case review performed at a tertiary referral center. Four patients with cochlear nerve deficiency initially underwent cochlear implantation but were not benefiting from their devices and underwent ABI in the contralateral ear. The main outcome measures included age-appropriate speech perception and production assessments...
November 2, 2018: Audiology & Neuro-otology
Chia-Huei Chu, Shiau-Ru Chiou, Mao-Che Wang, An-Suey Shiao, Tzong-Yang Tu, Liang-Yu Lin, Chii-Yuan Huang, Wen-Huei Liao
OBJECTIVE: The purpose of this retrospective study was to investigate the difference in treatment outcomes for patients with idiopathic sudden sensorineural hearing loss (SSNHL) undergoing concurrent or sequential intravenous (IV) and intratympanic (IT) steroid therapies. METHODS: Patients with idiopathic SSNHL admitted to Taipei Veterans Hospital from August 2011 to August 2012 were enrolled. Patients were treated with both IV dexamethasone 5 mg b.i.d. for 5 days, then tapered over 6 days, and IT injections of dexamethasone 5 mg daily...
2018: Audiology & Neuro-otology
Patricia Castro, Sara Sena Esteves, Florencia Lerchundi, David Buckwell, Michael A Gresty, Adolfo M Bronstein, Qadeer Arshad
Gaze stabilization during head movements is provided by the vestibulo-ocular reflex (VOR). Clinical assessment of this reflex is performed using the video Head Impulse Test (vHIT). To date, the influence of different fixation distances on VOR gain using the vHIT has not been explored. We assessed the effect of target proximity on the horizontal VOR using the vHIT. Firstly, we assessed the VOR gain in 18 healthy subjects with 5 viewing target distances (150, 40, 30, 20, and 10 cm). The gain increased significantly as the viewing target distance decreased...
2018: Audiology & Neuro-otology
Christof Buhl, Dmitri Artemiev, Flurin Pfiffner, Jaap Swanenburg, Dorothe Veraguth, Christof Roosli, Alexander Huber, Adrian Dalbert
OBJECTIVES: (1) To assess dynamic postural stability before and after cochlear implantation using a functional gait assessment (FGA). (2) To evaluate the correlation between loss of residual hearing and changes in dynamic postural stability after cochlear implantation. METHODS: Candidates for first-sided cochlear implantation were prospectively included. The FGAs and pure-tone audiograms were performed before and 4-6 weeks after cochlear implantation. RESULTS: Twenty-three subjects were included...
2018: Audiology & Neuro-otology
Ilyoung Cho, Hyun-Min Lee, Sung-Won Choi, Soo-Keun Kong, Il-Woo Lee, Eui-Kyung Goh, Se-Joon Oh
OBJECTIVES: This study aimed to investigate the efficacy of simultaneous steroid and hyperbaric oxygen therapy (HBOT) in patients with severe to profound idiopathic sudden sensorineural hearing loss (ISSNHL), which has a poor prognosis. METHODS: Sixty patients diagnosed with severe to profound ISSNHL (≥70 dB HL) were randomly divided into two groups in a prospective controlled trial: an oral steroid + intratympanic steroid injection (ITSI) group (control group) and an oral steroid + ITSI + HBOT group (study group)...
2018: Audiology & Neuro-otology
Mohammad-Reza Mahmoudian-Sani, Mohammad-Saeid Jami, Ali Mahdavinezhad, Razieh Amini, Gholamreza Farnoosh, Massoud Saidijam
Hearing loss is considered the most common sensory disorder across the world. Nowadays, a cochlear implant can be an effective treatment for patients. Moreover, it is often believed that sensorineural hearing loss in humans is caused by loss or disruption of the function of hair cells in the cochlea. In this respect, mesenchymal cells can be a good candidate for cell-based therapeutic approaches. To this end, the potential of human bone marrow-derived mesenchymal stem cells to differentiate into hair cells with the help of transfection of microRNA in vitro was investigated...
2018: Audiology & Neuro-otology
Camille Dorbeau, John Galvin, Qian-Jie Fu, Elsa Legris, Mathieu Marx, David Bakhos
Cochlear implantation (CI) can benefit patients with single-sided deafness (SSD) in terms of sound localization, speech understanding in noise, tinnitus severity, and quality of life (QoL). In previous studies, CI outcomes have been largely reported for SSD patients with normal "unrestricted" hearing in the contralateral ear. However, SSD patients may often have some degree of hearing loss in the contralateral ear ("restricted" acoustic hearing). In this study, we report results from a French clinical trial for CI in in SSD patients (NCT02204618)...
2018: Audiology & Neuro-otology
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