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Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

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https://read.qxmd.com/read/30995126/tumour-expressions-of-hypoxic-markers-predict-the-response-to-neo-adjuvant-chemotherapy-in-children-with-inoperable-rhabdomyosarcoma
#1
Malgorzata Anna Krawczyk, Malgorzata Styczewska, Ewa M Sokolewicz, Michal Kunc, Anna Gabrych, Aleksandra Fatyga, Ewa Izycka-Swieszewska, Bernarda Kazanowska, Elzbieta Adamkiewicz-Drozynska, Ewa Bien
Objective The study was to assess whether tumour expressions of hypoxia-inducible factor (HIF)-1α, glucose transporter (GLUT)-1, carbonic anhydrase (CA)IX and vascular endothelial growth factor (VEGF) predict response to neo-adjuvant chemotherapy (naCHT) in children with inoperable rhabdomyosarcoma (RMS). Methods Immunohistochemical expressions of hypoxia markers were determined semi-quantitatively in tumour tissue microarray of 46 patients with embryonal RMS (RME) and 20 with alveolar (RMA), treated with CWS protocols (1992-2013)...
April 17, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30990364/circulating-micrornas-in-human-obesity-a-systematic-review
#2
Alejandra Ortiz-Dosal, Patricia Rodil-García, Luis A Salazar-Olivo
CONTEXT: Differential expression profiles of microRNAs have been reported in human obesity suggesting a miRNAs role in the development of obesity and associated disorders. OBJECTIVE: To review circulating microRNAs (c-miRNAs) dysregulated in human obesity and to predict their possible target genes. METHODS: We performed a systematic review on PubMed database (PROSPERO, CRD42017077742) for original works on c-miRNAs and human obesity and recorded c-miRNAs with differential expression profiles...
April 16, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30979347/phytochemicals-antioxidant-activity-and-hepatoprotective-effect-of-ginger-zingiber-officinale-on-diethylnitrosamine-toxicity-in-rats
#3
Abdelgawad Fahmi, Naglaa Hassanen, Mariam Abdur-Rahman, Engy Shams-Eldin
CONTEXT: Chronic liver damage has serious medical consequences. OBJECTIVE: To investigate the hepatoprotective effect of dry Zingiber officinale (ginger) and its essential (volatile) oil against diethylnitrosamine (DEN) toxicity in rats. MATERIALS AND METHODS: Phenols and flavonoids components were characterized in dry ginger using HPLC-UV instrument while ginger essential oil (E.O) was investigated via GC-MS technique. Antioxidant activity was determined in vitro...
April 12, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30978115/association-between-high-sensitivity-cardiac-troponin-t-and-future-cardiovascular-incidence-in-a-general-japanese-population-results-from-the-tohoku-medical-megabank-project
#4
Yuji Takahashi, Mamoru Satoh, Hideki Ohmomo, Fumitaka Tanaka, Takuya Osaki, Kozo Tanno, Takahito Nasu, Kiyomi Sakata, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki
PURPOSE: Elevation of high-sensitivity cardiac troponin T (hs-cTnT) is associated with an increased risk of cardiovascular disease (CVD). This study determined whether hs-cTnT was detectable with N-terminal pro-b-type natriuretic peptide (NT-proBNP) and related to CV risk factors in a general Japanese population. MATERIALS AND METHODS: The Tohoku Medical Megabank Organization pooled individual participant data for a population-based cohort study in the Iwate prefecture (n = 30,193, age =60...
April 12, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30974974/cardiac-troponins-predict-adverse-clinical-outcomes-in-stable-coronary-artery-disease-a-dose-response-meta-analysis-of-prospective-studies
#5
Yuehua Li, Hanjun Pei, Chenghui Zhou
BACKGROUND: Predictive value of cardiac tropnins (cTns) in stable coronary artery disease (SCAD) has not been fully investigated. METHODS: We performed a meta-analysis to evaluate the dose-response relationship between serum detectable/rising cTns and adverse clinical outcomes, including all-cause mortality, cardiovascular (CV) mortality, myocardial infarction (MI), heart failure (HF) or major adverse cardiovascular events (MACEs) in SCAD. RESULTS: 16 studies involved 34 854 subjects were included...
April 11, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30924686/associations-of-rs1883832-and-rs4810485-polymorphisms-of-cd40-gene-with-myocardial-infarction-in-the-tunisian-population
#6
Meriem Soussi, Amani Kallel, Safa Ben Wafi, Meriam Ben Halima, Haifa Sanhaji, Mohamed Sami Mourali, Riadh Jemaa, Moncef Feki
CONTEXT: Cluster of differentiation 40 (CD40), and its ligand CD40L, are major co-stimulatory molecules whose interactions are important in both cellular and humoral immunity, and has been suggested to play a role in the pathogenesis of acute coronary syndrome. OBJECTIVE: The aim of this study was to examine the association of CD40 polymorphisms (-1 C > T (rs1883832) and 945G > T (rs4810485)) and myocardial infarction (MI), and to test the association of CD40 gene haplotypes with MI in Tunisians...
March 29, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30908096/evaluation-of-oxidative-stress-biomarkers-of-rabbits-liver-exposed-to-thermooxidized-virgin-olive-oil-obtained-from-blanquette-olive-cultivars
#7
Djamila Ayari, Fouad Boukazoula, Boudjema Soumati, Lynda Souiki
OBJECTIVE: This work aimed to study the effect of temperature in variation of fatty acid profiles of virgin olive oil (VOO) and to evaluate the impact of the consumption of this thermo oxidized VOO on metabolic oxidative stress Materials and methods: effect of consumption of fresh or thermo-oxidized VOO on rabbits was studied. The animals were distributed in groups of 6 rabbits each and were fed for four weeks with the incorporation of 15% VOO either fresh or heated during one, two, three, or four hours...
March 25, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30908094/is-c-reactive-protein-elevated-in-obstructive-sleep-apnoea-a-systematic-review-and-meta-analysis
#8
Tom Van der Touw, Nicholas Matthew Andronicos, Neil Smart
PURPOSE: This study examined whether circulating C-reactive protein (CRP) is elevated in obstructive sleep apnoea (OSA) independent of the confounding effects of comorbidities, smoking, body mass index (BMI), age and gender. METHODS: A systematic review of the literature was performed using PubMed, Embase and Cochrane databases from 1st January 1997 to 1st November 2017 using the key words obstructive sleep apnoea and C-Reactive protein to identify full text English language studies that compared CRP in adult non-smoking OSA participants without comorbidities and adult healthy non-smoking control participants matched for BMI, age and gender...
March 25, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30907677/the-association-between-metabolic-syndrome-severity-and-oxidative-stress-induced-by-maximal-exercise-testing-a-cross-sectional-study
#9
Alistair R Mallard, Joyce S Ramos, Llion A Roberts, Christoph M Centner, Robert G Fassett, Jeff S Coombes
PURPOSE: Oxidative stress (OS) has been implicated in the pathogenesis of metabolic syndrome (MetS). The acute change in OS biomarkers due to exercise, known as Exercise-Induced OS (EIOS), is postulated to be a more appropriate marker of OS compared to spot OS measures. This studies objectives were to investigate EIOS in participants with MetS and compare the associations between EIOS, spot OS measures and MetS severity. METHODS: Sixty-three participants with MetS had MetS severity assessed using the MetS Z-score...
March 25, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30907674/combination-of-sepsis-biomarkers-may-indicate-an-invasive-fungal-infection-in-hematological-patients
#10
Igor Stoma, Igor Karpov, Anatoly Uss, Svetlana Krivenko, Igor Iskrov, Natalia Milanovich, Svetlana Vlasenkova, Irina Lendina, Kristina Belyavskaya, Veronika Cherniak
BACKGROUND: Invasive fungal infections are a major threat to a large cohort of immunocompromised patients, including patients with chemotherapy-associated neutropenia. Early differential diagnosis with bacterial infections is often complicated, what leads to a delay in empiric antifungal therapy and increases risk for adverse outcome. Accessibility and performance of specific fungal antigen and PCR-tests is still limited, while sepsis biomarkers are more broadly used in most settings currently...
March 25, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30907672/thrombin-generation-is-increased-in-patients-with-clostridium-difficile-colitis-a-pilot-study
#11
Romeo G Mihăilă, Crina Cătană, Ariela L Olteanu, Victoria Bîrluţiu, Cosmin Sălcudean, Marius D Mihăilă
BACKGROUND: There is only limited data in the literature on the thrombotic risk of patients with Clostridium difficile colitis, although this disease is widespread throughout the world. OBJECTIVE: The aim of this study was to explore thrombin generation in these patients - the best way to evaluate their coagulation. METHODS: A prospective observational study was conducted during 15 months on hospitalized patients with Clostridium difficile colitis...
March 25, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30821522/elevated-homocysteine-level-and-prognosis-in-patients-with-acute-coronary-syndrome-a-meta-analysis
#12
Mingjin Zhu, Meng Mao, Xusheng Lou
OBJECTIVE: Controversial results exist with respect to the association between elevated homocysteine level and adverse prognosis in acute coronary syndrome (ACS) patients. We performed a meta-analysis to evaluate the prognostic value of homocysteine level on ACS patients. MATERIALS AND METHODS: A comprehensive literature search of PubMed and Embase databases was conducted prior to August 2018. Prospective observational studies reporting the association of baseline homocysteine level with major adverse cardiovascular events (MACE), cardiovascular or all-cause mortality in ACS patients were selected...
March 1, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30821519/association-of-metabolites-reflecting-type-iii-and-vi-collagen-formation-with-modified-rodnan-skin-score-in-systemic-sclerosis-a-cross-sectional-study
#13
Pernille Juhl, Line Vinderslev Iversen, Tonny Karlsmark, Morten Asser Karsdal, Anne-Christine Bay-Jensen, Mette Mogensen, Anne Sofie Siebuhr
OBJECTIVE: The objective was to investigate blood-based biomarkers of type I (PRO-C1), III (PRO-C3), and VI (PRO-C6) collagen formation in systemic sclerosis (SSc) patients and examine their correlation to modified Rodnan skin score (mRSS). METHODS: Limited (lSSc, n = 76) and diffuse SSc (dSSc, n = 41) fulfilling the ACR/EULAR 1980 and 2013 classification criteria for SSc and asymptomatic controls (n = 9) were included. PRO-C1, PRO-C3, and PRO-C6 were measured in serum...
March 1, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30821509/validation-of-urinary-sphingolipid-metabolites-as-biomarker-of-effect-for-fumonisins-exposure-in-kenyan-children
#14
Ruth Nabwire Wangia, David Peter Githanga, Kathy Siyu Xue, Lili Tang, Omu Aggrey Anzala, Jia-Sheng Wang
CONTEXT: Fumonisins [FNs], a group of mycotoxins produced mainly by Fusarium species, are ubiquitous food contaminants, especially for maize. Fumonisin B1 [FB1 ] caused severe toxicities in farm animals, induced kidney and liver tumors in rodents and is associated with many human adverse health effects, including esophageal cancer. International Agency for Research on Cancer [IARC] categorizes FB1 as possible human carcinogen [Group 2B]. Inhibition of ceramide synthesis and disruption of sphingolipids metabolism are well studied as the major mechanisms of FB1 -induced toxicity...
March 1, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30773031/circulating-fatty-acids-as-biomarkers-of-dairy-fat-intake-data-from-the-lifelines-biobank-and-cohort-study
#15
Ilse G Pranger, Eva Corpeleijn, Frits A J Muskiet, Ido P Kema, Cécile Singh-Povel, Stephan J L Bakker
BACKGROUND: C14:0, C15:0, C17:0 and trans-C16:1(n-7) are often used as biomarkers for dairy fat intake. Trans-C18:1(n-7) and CLA, two fatty acids which are also present in dairy, have hardly been explored. We investigated whether trans-C18:1(n-7) and CLA can enrich the existing biomarker portfolio. METHODS: Data were obtained from Lifelines (n = 769). Dairy fat intake was determined by FFQ. Fatty acids were measured in fasting plasma triglycerides (TG), phospholipids (PL) and cholesterol esters (CE)...
February 18, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30764677/prognostic-value-of-rassf1a-methylation-status-in-non-small-cell-lung-cancer-nsclc-patients-a-meta-analysis-of-prospective-studies
#16
Hao Hu, Yuefei Zhou, Min Zhang, Rui Ding
Objective Ras association domain family 1A (RASSF1A) has been regarded as a biomarker predicting the prognosis of non-small cell lung cancer (NSCLC), but previous findings are inconsistent. This meta-analysis of prospective studies aimed to assess the value of RASSF1A methylation in predicting the prognosis of NSCLC patients. Methods Studies were searched in PubMed and Web of Science. The estimates of the effects and the corresponding 95% confidence intervals (95% CIs) were used for the analyses. The overall effects of RASSF1A methylation on overall survival (OS) were estimated, after which subgroup analysis based on regions was conducted...
February 15, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30744430/bronchoalveolar-fluid-and-plasma-inflammatory-biomarkers-in-contemporary-ards-patients
#17
Renee D Stapleton, Benjamin T Suratt, Margaret J Neff, Mark M Wurfel, Lorraine B Ware, John T Ruzinski, Ellen Caldwell, Teal S Hallstrand, Polly E Parsons
PURPOSE: Bronchoalveolar fluid (BALF) and plasma biomarkers are often endpoints in early phase randomized trials (RCTs) in acute respiratory distress syndrome (ARDS). With ARDS mortality decreasing, we analyzed baseline biomarkers in samples from contemporary ARDS patients participating in a prior RCT and compared these to historical controls. MATERIALS AND METHODS: Ninety ARDS adult patients enrolled in the parent trial. BALF and blood were collected at baseline, day 4 ± 1, and day 8 ± 1...
February 12, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30734586/insights-into-cardiovascular-risk-and-nutritional-status-in-subjects-with-wheat-related-disorders
#18
Thushani Siriwardhane, Karthik Krishna, Koushik Devarajan, Vinodh Ranganathan, Vasanth Jayaraman, Tianhao Wang, Kang Bei, John J Rajasekaran, Hari Krishnamurthy
OBJECTIVE: Wheat-related disorders are a spectrum of disorders associated with different autoimmune and non-autoimmune diseases. However, it is unclear whether these wheat-related disorders lead to adverse health effects such as cardiovascular risk, nutritional deficiencies etc. The objective of the study was to explore the lipid profiles and the nutritional status of subjects with wheat-related disorders to understand the potential threat by wheat on cardiovascular risk and nutritional deficiency...
February 8, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30663433/prediction-of-alzheimer-s-disease-with-serum-lipid-levels-in-asian-individuals-a-meta-analysis
#19
Yufei Wu, Zhibin Wang, Xueping Jia, Huan Zhang, Hong Zhang, Junlin Li, Kejin Zhang
BACKGROUND: The serum lipid profile has become a routine clinical test and used as an important predictor for Alzheimer's disease (AD), although its predictive value remains undetermined. OBJECTIVE: To evaluate the role of serum lipid levels in predicting the risk of AD. METHODS: Meta-analyses were conducted using Comprehensive Meta-analyses (CMA) software to investigate the association between four conventional serum lipid profile parameters and the risk of AD, focused on samples from Asian...
January 21, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/30632403/high-sensitivity-troponin-t-in-asymptomatic-severe-aortic-stenosis
#20
Elena Ferrer-Sistach, Josep Lupón, Germán Cediel, Albert Teis, Francisco Gual, Sílvia Serrano, Nuria Vallejo, Gladys Juncà, Jorge López-Ayerbe, Antoni Bayés-Genís
Background-In asymptomatic severe aortic stenosis (ASAS), treatment decisions are made on an individual basis, and case management presents a clinical conundrum Methods-We prospectively phenotyped consecutive patients with ASAS using echocardiography, exercise echocardiography, cardiac MRI, and biomarkers (NT-proBNP, high-sensitivity troponin T (hs-TnT), and ST2) (n = 58). The primary endpoint was a composite of cardiovascular death, new-onset symptoms, cardiac hospitalization, guideline-driven indication for valve replacement, and cardiovascular death at 12 months...
January 11, 2019: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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