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Journals Biomarkers : Biochemical Indic...

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

https://read.qxmd.com/read/38506499/exocyclic-dna-adducts-and-oxidative-stress-parameters-useful-tools-for-biomonitoring-exposure-to-aldehydes-in-smokers
#1
JOURNAL ARTICLE
Héléna Alamil, Marie-Lise Colsoul, Natacha Heutte, Marie Van Der Schueren, Laurence Galanti, Mathilde Lechevrel
Exocyclic DNA adducts have been shown to be potential biomarkers of cancer risk related to oxidative stress and exposure to aldehydes in smokers. In fact, aldehydes potentially arise from tobacco combustion directly and endogenously through lipid peroxidation. This study aims to investigate the relationship between a profile of nine aldehydes-induced DNA adducts and antioxidant activities, in order to evaluate new biomarkers of systemic exposure to aldehydes. Using our previously published UPLC-MS/MS method, adducts levels were quantified in the blood DNA of 34 active smokers...
March 20, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38483941/date-phoenix-dactylifera-l-mill-fruit-enhances-sexual-performance-via-modulation-of-oxido-inflammatory-mediators-and-purinergic-signaling-in-hypertensive-male-rats
#2
JOURNAL ARTICLE
Adeniyi A Adebayo, Ayokunle O Ademosun, Ganiyu Oboh
Introduction: The present study aimed at investigating the effect of dietary supplementation of Phoenix dactylifera , an important component of aphrodisiac supplements, on sexual performance, oxido-inflammatory mediators and purinergic signaling system in hypertensive rats. Material and methods: Hypertension was induced via oral administration of 40 mg/kg L-NAME. Thereafter, the sexual performance of the experimental animals was determined and the hypertensive rats with impaired sexual activities were placed on P...
March 14, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38444305/interpreting-quantitative-rna-expression-prognostic-and-predictive-results-generated-from-synchronous-rather-than-solitary-breast-cancers
#3
JOURNAL ARTICLE
Steven Sorscher, Priya Gor
No abstract text is available yet for this article.
March 5, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38428950/-ile105val-polymorphism-in-the-gstp1-gene-is-associated-with-susceptibility-to-acute-myeloid-leukemia-an-updated-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Raphael Enrique Tiongco, Neil David Cayanan, Miljun Catacata, Michael John Dominguez
Background and Objective: Several genetic variations are associated with acute myeloid leukemia (AML) susceptibility, including the GSTP1 Ile105Val polymorphism. Even with the existing meta-analysis conducted on the topic, no consensus has been reached since none of the studies available performed in-depth data analysis. Hence, we performed an updated systematic review and meta-analysis in this paper to obtain more precise estimates. Materials and Methods: We searched various databases and calculated the odds ratio (OR) and 95% confidence interval (CI) to examine whether the GSTP1 Ile105Val polymorphism is associated with AML susceptibility...
March 1, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38385211/high-tissue-frmd6-expression-predicts-better-outcome-among-colorectal-cancer-patients
#5
JOURNAL ARTICLE
Arthur vonKoskull, Jaana Hagström, Caj Haglund, Tuomas Kaprio, Camilla Böckelman
INTRODUCTION: Colorectal cancer (CRC) is the second most common cause of cancer-related deaths. The hippo pathway works as a regulator of organ growth and is often a target for mutations in cancer. Ferm domain containing protein 6 (FRMD6) is an activator of the hippo pathway. This study aimed to explore the role of FRMD6 in CRC and to determine how well it works as a prognostic factor among CRC patients. METHODS: The tumor expression of FRMD6 was evaluated using immunohistochemistry in 538 colorectal patients operated on at Helsinki University Hospital...
February 22, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38376506/prognostic-and-clinicopathological-value-of-osteopontin-expression-in-non-small-cell-lung-cancer-a-meta-analysis-and-systematic-review
#6
REVIEW
Yu Song, Haibo Li, Qing Jiang, Lianghong Wu
BACKGROUND: Although Osteopontin (OPN) has been reported to be associated with many different human cancers, the data on non-small cell lung cancer (NSCLC) are not definitive. This study aimed to explore the prognostic effect of OPN expression and clinicopathological characteristics in patients with NSCLC. METHODS: This study followed all aspects of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) report. PubMed, Embase and the Cochrane Library were searched to identify the relative studies...
February 20, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38362802/circulating-trna-derived-fragments-are-decreased-in-patients-with-rheumatoid-arthritis-and-increased-in-patients-with-psoriatic-arthritis
#7
JOURNAL ARTICLE
Marina Dunaeva, Jan Blom, Rogier Thurlings, Margot van Weijsten, Fons A J van de Loo, Ger J M Pruijn
Introduction - tRNA-derived fragments (tRFs) play an important role in immune responses. To clarify the role of tRFs in autoimmunity we studied circulating tRF-levels in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), and in a murine model for arthritis. Material and Methods - Circulating tRF-levels were quantified by miR-Q RT-qPCR. tRNA processing and modification enzyme expression was analyzed by RT-qPCR and public transcriptomics data. Results - Significant reduction (up to 3-fold on average) of tRF-levels derived from tRNA-Gly-GCC,CCC, tRNA-Glu-CTC, and tRNA-Val-CAC,AAC was observed in RA patients, whereas tRNA-Glu-CTC and tRNA-Val-CAC,AAC tRFs were found at significantly higher levels (up to 3-fold on average) in PsA patients, compared to healthy controls...
February 16, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38361436/protein-kinase-c-delta-enhances-the-diagnostic-performance-of-hepatocellular%C3%A2-carcinoma
#8
JOURNAL ARTICLE
Chika Nakagawa, Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Kuniko Katagiri, Naoko Tago, Hiroshi Kamioka, Kaoru Ueda, Koichiro Haruki, Kenei Furukawa, Masanori Nakano, Yuichi Torisu, Toru Ikegami, Kiyotsugu Yoshida, Masayuki Saruta
BACKGROUND: The conventional markers for hepatocellular carcinoma (HCC), α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), have several limitations; both have low sensitivity in patients with early-stage HCC; low sensitivity for AFP with HCC after eliminating hepatitis C virus (HCV); low specificity for DCP in patients with non-viral HCC, which is increasing worldwide; low specificity for AFP in patients with liver injury; and low specificity for DCP in patients treated with warfarin...
February 15, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38354024/investigation-of-exosomal-tetraspanin-profile-in-sepsis-patients-as-a-promising-diagnostic-biomarker
#9
JOURNAL ARTICLE
Roushka Bhagwan Valjee, Irene Mackraj, Roshila Moodley, Usri H Ibrahim
INTRODUCTION: Sepsis, a leading cause of mortality globally, has a complex and multifaceted pathophysiology which still requires elucidation. Therefore, this study aimed to analyse and quantify the number of exosomes in sepsis patients from a South African cohort using the ExoView (NanoView Biosciences, Boston, MA) platform. METHODS: Blood samples were collected from black South African patients attending the local Intensive Care Unit (ICU) hospital. Exosomes were isolated and characterise via TEM and CD63 ELISA kits...
February 14, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38353603/serum-free-light-chains-among-twin-siblings-is-the-kappa-lambda-ratio-genetically-determined
#10
JOURNAL ARTICLE
Alan H B Wu, Chia-Ching Wang
BACKGROUND: Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed that free light chains have a low within and high between-individual variation. We determined if this variation were genetically linked. METHODS: We obtained a single serum sample from 16 pairs of identical twins, neonate twins, and 19 presumed directly-related siblings children, measured Κ and λ light chains and computed the Κ/λ ratio...
February 14, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38344835/investigating-the-diagnostic-potential-of-il-1%C3%AE-il-10-and-il-36%C3%AE-in-gingival-crevicular-fluid-in-patients-with-different-periodontal-conditions
#11
JOURNAL ARTICLE
Mihtikar Gürsel, Tuba Bayat, Niyazi Dü Ndar, Ayşegül Yabaci Tak, Burcu Karaduman
No abstract text is available yet for this article.
February 12, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38314578/-ph%C3%A5-nix-dactylifera-l-seed-oil-alleviates-bleomycin-induced-pulmonary-fibrosis-and-oxidative-stress-in-wistar-rats
#12
JOURNAL ARTICLE
Sana Bahri, Raed Abdennabi, Asma Chaker, Afef Nahdi, Amine Elgheryeni, Mona Mlika, Saloua Jameleddine
OBJECTIVE: Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of Phœnix dactylifera, L. seed oil (DSO) on a murine model of IPF induced by bleomycin (BLM). METHODS: Male Wistar rats were treated with a single intra-tracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of DSO (75, 150 and 300 mg/kg) for 4 weeks. RESULTS: Our phytochemical results showed that DSO has an important antioxidant activity with a high content of polyphenols and flavonoids...
February 5, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38299991/subchronic-exposure-to-fenpyroximate-causes-multiorgan-toxicity-in-wistar-rats-by-disrupting-lipid-profile-inducing-oxidative-stress-and-dna-damage
#13
JOURNAL ARTICLE
Imen Ayed-Boussema, Karima Rjiba, Asma M'nassri, Hiba Hamdi, Salwa Abid
Background Fenpyroximate (FEN) is an acaricide that inhibits the complex I of the mitochondrial respiratory chain in mites. Data concerning mammalian toxicity of this acaricide are limited; thus the aim of this work was to explore FEN toxicity on Wistar rats, particularly on cardiac, pulmonary, and splenic tissues and in bone marrow cells. Methods rats were treated orally with FEN at 1, 2, 4, and 8 mg/Kg bw for 28 days. <u>After treatment, we analyzed lipid profile, oxidative stress and DNA damage in rat tissues...
February 1, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38261718/a-cross-talk-on-the-role-of-contemporary-biomarkers-in-depression
#14
REVIEW
Aditi Vyas, Gaurav Doshi
Biomarkers can be used to identify determinants of response to various treatments of mental disorders. Evidence to date demonstrates that markers of inflammatory, neurotransmitter, neurotrophic, neuroendocrine, and metabolic function can predict the psychological and physical consequences of depression in individuals, allowing for the development of new therapeutic targets with fewer side effects. Extensive research has included hundreds of potential biomarkers of depression, but their roles in depression, abnormal patients, and how bioinformatics can be used to improve diagnosis, treatment, and prognosis have not been determined or defined...
January 23, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38258494/nucleosome-assembly-protein-1-like-1-nap1l1-in-gastric-cancer-patients-a-potential-biomarker-with-diagnostic-and-prognostic-utility
#15
JOURNAL ARTICLE
Gungor Gul, Mehmet Akif Aydin, Sermin Algul, Remzi Kiziltan, Ozgur Kemik
BACKGROUND: The nucleosome assembly protein 1-like 1 (NAP1L1) is suggested to have an oncogenic role in several tumors based on its overexpression. However, its diagnostic and prognostic role in gastric cancer remains unclarified. This study aimed to evaluate the diagnostic and prognostic utility of NAP1L1 in gastric cancer patients. METHODS: A total of 85 patients (mean(SD) age: 60.9(1.6) years, 49.4% were males) with newly-diagnosed gastric cancer and 40 healthy individuals (mean(SD) age: 60...
January 23, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38252065/deciphering-the-potential-of-proteomic-based-biomarkers-in-women-s-reproductive-diseases-empowering-precision-medicine-in-gynecology
#16
REVIEW
Ishwerpreet KaurJawanda, Thomson Soni, Seema Kumari, Vijay Prabha
Context: Gynecological disorders represent a complex set of malignancies that result from a diverse array of molecular changes affecting the lives of over a million women worldwide. Ovarian, Endometrial, and Cervical cancers, Endometriosis, PCOS are the most prevalent ones that pose a grave threat to women's health. Proteomics has emerged as an invaluable tool for developing novel biomarkers, screening methods, and targeted therapeutic agents for gynecological disorders. Some of these biomarkers have been approved by the FDA, but regrettably, they have a constrained diagnostic accuracy in early-stage diagnosis as all of these biomarkers lack sensitivity and specificity...
January 22, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38251636/assessing-angiogenesis-factors-as-prognostic-biomarkers-in-breast-cancer-patients-and-their-association-with-clinicopathological-factors
#17
JOURNAL ARTICLE
Tannaz Abbasi-Dokht, Farhad Malek, Nahid Nafissi, Maryam Mohammadlou, Maryam Sheikh, Sedigheh Akbari, Mohammad Zargaran, Rasoul Baharlou
INTRODUCTION: Angiogenesis is fundamental for tumor growth and metastasis across many solid malignancies. Considerable interest has focused on the molecular regulation of tumor angiogenesis as a means to predict disease outcomes and guide therapeutic decisions. METHODS: In the present study, we investigated the prognostic value of transforming growth factor beta (TGF-β), epidermal growth factor (EGF), fibroblast growth factor (FGF), delta-like ligand 4 (DLL4), and vascular endothelial growth factor (VEGF) in the serum of 120 women diagnosed with breast cancer using ELISA as well as examined their associations with clinical parameters and the outcome of the disease...
January 22, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38193494/-the-role-of-asxl1-mutations-and-asxl1-circrnas-in-cancer
#18
REVIEW
Narges Jafarbeik-Iravani, Sara Kolahdozan, Rezvan Esmaeili
Background: The Mutations in the additional sex combs like the 1 ( ASXL1 ) gene were first reported in Myelodys plastic syndromes. Recent studies have clarified the relationship between ASXL1 mutation and the development of cancers. Moreover, ASXL1 has role in poor overall survival and metastasis. ASXL1 encodes conserved and abundant Circular RNAs (circRNAs) as post-transcriptional regulators and regulates tumorogenesis and progression in cancer. ASXL1 circRNA was mentioned as the top 10% of differentially expressed circRNAs in hierarchical clustering in clinically relevant tissues...
January 9, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38133614/relationships-between-charlson-comorbidity-index-associated-biomarkers-and-outcomes-among-participants-in-the-malm%C3%A3-diet-and-cancer-study
#19
JOURNAL ARTICLE
Torgny Wessman, Toralph Ruge, Axel Carl Carlsson, Per Wändell, Ardavan Khoshnood, Olle Melander
IntroductionThe aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.MethodsCardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC). Individuals with CCI diagnoses and other major comorbidities were excluded. Another score of 11 biomarkers associated with comorbidity burden from a previous study of acute dyspnea was also created (BSADYS)...
December 22, 2023: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38131287/comet-assay-as-a-suitable-biomarker-for-in-vivo-oral-carcinogenesis-a-systematic-review
#20
REVIEW
Thiago GuedesPinto, Daniel Vitor deSouza, Glenda Nicioli da Silva, Daisy Maria Favero Salvadori, Manoela Domingues Martins, Daniel Araki Ribeiro
Background and Objectives: In order to detect genetic damage, different methods have been developed, such as micronuclei, and comet assay. The comet assay presents some advantages when compared to the other aforementioned methods, including wide versatility, as any eukaryotic cell can be evaluated at an individual cellular level. In this context, the aim of this systematic review was designed to help further elucidate the following question: is the comet assay a suitable biomarker of in vivo oral carcinogenesis? Material and Methods: The present systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines...
December 22, 2023: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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