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Journal of Biomedical Optics

Gabriela Apiou-Sbirlea, Regine Choe, Markus Kleemann, Bruce J Tromberg
This guest editorial introduces the special section on Translational Biophotonics.
February 2019: Journal of Biomedical Optics
Callum D Little, Radhika K Poduval, Richard Caulfield, Sacha Noimark, Richard J Colchester, Chris D Loder, Manish K Tiwari, Roby D Rakhit, Ioannis Papakonstantinou, Adrien E Desjardins
Microscopic and mesoscale optical imaging techniques allow for three-dimensional (3-D) imaging of biological tissue across millimeter-scale regions, and imaging phantom models are invaluable for system characterization and clinical training. Phantom models that replicate complex 3-D geometries with both structural and molecular contrast, with resolution and lateral dimensions equivalent to those of imaging techniques (<20  μm), have proven elusive. We present a method for fabricating phantom models using a combination of two-photon polymerization (2PP) to print scaffolds, and microinjection of tailored tissue-mimicking materials to simulate healthy and diseased tissue...
February 2019: Journal of Biomedical Optics
Nico J J Arezza, Marjan Razani, Michael C Kolios
Optical coherence tomography (OCT) is used to provide anatomical information of biological systems but can also provide functional information by characterizing the motion of intracellular structures. Dynamic light scattering OCT was performed on intact, control MCF-7 breast cancer cells and cells either treated with paclitaxel to induce apoptosis or deprived of nutrients to induce oncosis. Autocorrelations (ACs) of the temporal fluctuations of OCT intensity signals demonstrate a significant decrease in decorrelation time after 24 h in both the paclitaxel-treated and nutrient-deprived cell groups but no significant differences between the two groups...
February 2019: Journal of Biomedical Optics
Michael Pinto, Kevin C Zorn, Jean-Philippe Tremblay, Joannie Desroches, Frédérick Dallaire, Kelly Aubertin, Eric Marple, Chris Kent, Frederic Leblond, Dominique Trudel, Frederic Lesage
Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requirement of adjuvant treatment. Margin assessment is currently only performed by pathologists hours to days following surgery and the integration of a real-time surgical readout would benefit current prostatectomy procedures...
February 2019: Journal of Biomedical Optics
Zongxi Li, Haley Marks, Conor L Evans, Gabriela Apiou-Sbirlea
This erratum corrects an error in "Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages," by Z. Li et al.
February 2019: Journal of Biomedical Optics
Toyohiko Yatagai, Osamu Matoba, Yoshihisa Aizu, Yasuhiro Awatsuji, Yuan Luo
This guest editorial introduces the special section on Biomedical Imaging and Sensing.
February 2019: Journal of Biomedical Optics
Judith Lindert, Kianusch Tafazzoli-Lari, Ludger Tüshaus, Beke Larsen, Anna Bacia, Marie Bouteleux, Tina Adler, Valerie Dalicho, Vasileios Vasileiadis, Tobias Kisch, Felix Stang, Julia Welzel, Lutz Wünsch
This erratum corrects a misspelling of an author's name.
February 2019: Journal of Biomedical Optics
Weisi Xie, Ye Chen, Yu Wang, Linpeng Wei, Chengbo Yin, Adam K Glaser, Mark E Fauver, Eric J Seibel, Suzanne M Dintzis, Joshua C Vaughan, Nicholas P Reder, Jonathan T C Liu
Intraoperative assessment of breast surgical margins will be of value for reducing the rate of re-excision surgeries for lumpectomy patients. While frozen-section histology is used for intraoperative guidance of certain cancers, it provides limited sampling of the margin surface (typically <1  %   of the margin) and is inferior to gold-standard histology, especially for fatty tissues that do not freeze well, such as breast specimens. Microscopy with ultraviolet surface excitation (MUSE) is a nondestructive superficial optical-sectioning technique that has the potential to enable rapid, high-resolution examination of excised margin surfaces...
February 2019: Journal of Biomedical Optics
Jasmin M Schaefer, Connor W Barth, Scott C Davis, Summer L Gibbs
Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in >25  %   of cases due to positive or closely involved margins. Clinical translation of margin assessment modalities that must directly contact the patient or required administered contrast agents are time consuming and costly to move from bench to bedside...
February 2019: Journal of Biomedical Optics
Parikshat Sirpal, Ali Kassab, Philippe Pouliot, Dang Khoa Nguyen, Frédéric Lesage
In the context of epilepsy monitoring, electroencephalography (EEG) remains the modality of choice. Functional near-infrared spectroscopy (fNIRS) is a relatively innovative modality that cannot only characterize hemodynamic profiles of seizures but also allow for long-term recordings. We employ deep learning methods to investigate the benefits of integrating fNIRS measures for seizure detection. We designed a deep recurrent neural network with long short-term memory units and subsequently validated it using the CHBMIT scalp EEG database-a compendium of 896 h of surface EEG seizure recordings...
February 2019: Journal of Biomedical Optics
Arseniy A Gavdush, Nikita V Chernomyrdin, Kirill M Malakhov, Sheyh-Islyam T Beshplav, Irina N Dolganova, Alexandra V Kosyrkova, Pavel V Nikitin, Guzel R Musina, Gleb M Katyba, Igor V Reshetov, Olga P Cherkasova, Gennady A Komandin, Valery E Karasik, Alexander A Potapov, Valery V Tuchin, Kirill I Zaytsev
We applied terahertz (THz)-pulsed spectroscopy to study ex vivo the refractive index and absorption coefficient of human brain gliomas featuring different grades, as well as perifocal regions containing both intact and edematous tissues. Glioma samples from 26 patients were considered and analyzed according to further histological examination. In order to fix tissues for the THz measurements, we applied gelatin embedding, which allows for sustaining their THz response unaltered, as compared to that of the freshly excised tissues...
February 2019: Journal of Biomedical Optics
Sergey Komarov, Yongjian Liu, Yuan-Chuan Tai
We experimentally investigated the Cherenkov luminescence imaging (CLI) of the isotopes with different beta particles energies (Cu64, F18, Au198, P32, and Br76) in semitransparent biological equivalent media. The main focus of this work is to characterize the CLI when the sources are at the depth comparable with the range of beta particles. The experimental results were compared with Monte Carlo (MC) simulation results to fine tune the simulation parameters to better model the phantom materials. This approach can be applied to estimate the CLI performance for different phantom materials and isotopes...
February 2019: Journal of Biomedical Optics
Rolf B Saager, Rebecca A Rowland, Melissa L Baldado, Gordon T Kennedy, Nicole P Bernal, Adrien Ponticorvo, Robert J Christy, Anthony J Durkin
Burn wounds and wound healing invoke several biological processes that may complicate the interpretation of spectral imaging data. Through analysis of spatial frequency domain spectroscopy data (450 to 1000 nm) obtained from longitudinal investigations using a graded porcine burn wound healing model, we have identified features in the absorption spectrum that appear to suggest the presence of hemoglobin breakdown products, e.g., methemoglobin. Our results show that the calculated concentrations of methemoglobin directly correlate with burn severity, 24 h after the injury...
February 2019: Journal of Biomedical Optics
Hasan Ayaz, Meltem Izzetoglu, Kurtulus Izzetoglu, Banu Onaral, Baruch Ben Dor
Timing of the intervention for intracranial hematomas is critical for its success, specifically since expansion of the hemorrhage can result in debilitating and sometimes fatal outcomes. Led by Britton Chance, we and an extended team from University of Pennsylvania, Baylor and Drexel universities developed a handheld brain hematoma detector for early triage and diagnosis of head trauma victims. After obtaining de novo Food and Drug Administration clearance, over 200 systems are deployed in all Marine battalion aid stations around the world...
February 2019: Journal of Biomedical Optics
Elisabeth J M Baltussen, Esther N D Kok, Susan G Brouwer de Koning, Joyce Sanders, Arend G J Aalbers, Niels F M Kok, Geerard L Beets, Claudie C Flohil, Sjoerd C Bruin, Koert F D Kuhlmann, Henricus J C M Sterenborg, Theo J M Ruers
In the last decades, laparoscopic surgery has become the gold standard in patients with colorectal cancer. To overcome the drawback of reduced tactile feedback, real-time tissue classification could be of great benefit. In this ex vivo study, hyperspectral imaging (HSI) was used to distinguish tumor tissue from healthy surrounding tissue. A sample of fat, healthy colorectal wall, and tumor tissue was collected per patient and imaged using two hyperspectral cameras, covering the wavelength range from 400 to 1700 nm...
January 2019: Journal of Biomedical Optics
Daniel A Gil, Joe T Sharick, Sophie Mancha, Ute A Gamm, Michael A Choma, Melissa C Skala
Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary information to OCT for airway and lung imaging...
January 2019: Journal of Biomedical Optics
Shaohua Pi, Acner Camino, Xiang Wei, Tristan T Hormel, William Cepurna, John C Morrison, Yali Jia
Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow velocity in vessels. Instead of inspecting the phase shift manually, the algorithm calculates the gradient magnitude of the phase shift on the cross-sectional image and automatically detects the presence of phase wrapping...
January 2019: Journal of Biomedical Optics
Tianmeng Li, Hui Hui, Chaoen Hu, He Ma, Xin Yang, Jie Tian
The objective of our study is to develop a multimodality approach by combining magnetic resonance imaging (MRI) and optical imaging methods to assess acute murine colitis at the macro- and microscopic level. In vivo MRI is used to measure the cross-sectional areas of colons at the macroscopic level. Dual-color confocal laser endomicroscopy (CLE) allows in vivo examination of the fluorescently labeled epithelial cells and microvessels in the mucosa with a spatial resolution of ∼1.4  μm during ongoing endoscopy...
January 2019: Journal of Biomedical Optics
Akash Swamy, Gustav Burström, Jarich W Spliethoff, Drazenko Babic, Christian Reich, Joanneke Groen, Erik Edström, Adrian Elmi Terander, John M Racadio, Jenny Dankelman, Benno H W Hendriks
Safe and accurate placement of screws remains a critical issue in open and minimally invasive spine surgery. We propose to use diffuse reflectance (DR) spectroscopy as a sensing technology at the tip of a surgical instrument to ensure a safe path of the instrument through the cancellous bone of the vertebrae. This approach could potentially reduce the rate of cortical bone breaches, thereby resulting in fewer neural and vascular injuries during spinal fusion surgery. In our study, DR spectra in the wavelength ranges of 400 to 1600 nm were acquired from cancellous and cortical bone from three human cadavers...
January 2019: Journal of Biomedical Optics
Christian Zoller, Alwin Kienle
A software for fast rendering the visual appearance of a blood vessel located in human skin was developed based on a numerical solution of the radiative transfer equation. The user can specify geometrical properties, such as the depth and the diameter of the vessel, and physiological properties, such as the oxygen saturation of the vessel or the blood concentration in the skin. From these data, the spatially and spectrally resolved reflectance from the skin containing the blood vessel is calculated via Monte Carlo simulations, by which a two-dimensional image is generated...
January 2019: Journal of Biomedical Optics
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