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Bingyun Lu, Jiamin Wang, Jing Li, Le Liu, Ye Chen
BACKGROUND: Clarithromycin-containing bismuth quadruple therapy has been recommended as the first-line therapy for H pylori infection in China. However, its expensive cost and high antibiotic-related adverse reactions are always haunting us. To find a safer, more cost-effective, and high eradicative strategy for Helicobacter treatment, we investigated the efficacy of 14-day bismuth quadruple therapy and different doses of clarithromycin in the first-line treatment. METHOD: A total of 210 patients with H pylori infection were recruited and randomly assigned to half-dose clarithromycin group (esomeprazole 20 mg bid, amoxicillin 1 g bid, clarithromycin 250 mg bid, and bismuth potassium citrate 0...
February 19, 2019: Helicobacter
Massimo Rugge, Kentaro Sugano, Carmelo Scarpignato, Diana Sacchi, Walker Jove Oblitas, Antonio Giuseppe Naccarato
Gastric cancer (GC) ranks among the most lethal epithelial malignancies, and its striking mortality rate prompts a global prevention strategy. Helicobacter pylori (H. pylori) gastritis is the main GC promoter, and the 2014 Global Kyoto conference recognized H. pylori gastritis as a (treatable) infectious disease. It is therefore plausible that any large-scale intervention for H. pylori eradication would result in cleansing the world of the fifth cause of cancer-related death. Atrophic gastritis is the cancerization field in which GCs (both intestinal and diffuse histotypes) mainly develop...
February 17, 2019: Helicobacter
Olga P Nyssen, Adrian G McNicholl, Javier P Gisbert
BACKGROUND: Bismuth-containing quadruple therapy has been suggested as first-line and rescue alternative for Helicobacter pylori eradication. Our objective was to perform a meta-analysis evaluating the efficacy and safety of single capsule Pylera® (bismuth, metronidazole, and tetracycline) plus a proton-pump inhibitor (PPI) in any line of treatment. METHODS: Studies were selected up to October 2018. Outcomes were eradication and adverse events (AEs) rates pooled using the generic inverse variance method...
February 14, 2019: Helicobacter
Yubin Zhao, Xuefeng Gao, Jiaxuan Guo, Dongbao Yu, Ying Xiao, Huijie Wang, Yuchan Li
OBJECTIVE: Infection with Helicobacter pylori (H pylori), especially cytotoxin-associated gene A-positive (CagA+) strains, has been associated with various gastrointestinal and extragastric diseases. The aim of this study was to characterize H pylori-induced alterations in the gastric and tongue coating microbiota and evaluate their potential impacts on human health. DESIGN: The gastric mucosa and tongue coating specimens were collected from 80 patients with chronic gastritis, and microbiota profiles were generated by 16S rRNA gene sequencing...
February 7, 2019: Helicobacter
Sung Woo Ko, Yeon-Ji Kim, Woo Chul Chung, Seung Jae Lee
BACKGROUND AND AIMS: An increase in the use of antibiotics leads to increased antibiotic resistance of Helicobacter pylori (H pylori). Consequently, it has been considered that the first-line standard regimen should be changed. The main purpose of this study was to evaluate the efficacy of nonantibiotic (bismuth) supplements as a first-line regimen for H pylori eradication. METHODS: We searched PubMed, EMBASE, CINAHL, and the Cochrane Library databases for randomized controlled trials (RCTs) reported in English and undertaken up until August 2018...
January 30, 2019: Helicobacter
Qi Chen, Xiao Liang, Xiaohua Long, Lou Yu, Wenzhong Liu, Hong Lu
BACKGROUND: The high prevalence of Helicobacter pylori (H pylori) infection in China results in a substantial public health burden. Medical experts have not agreed on the best solution of population intervention for this problem. We presented a health economic evaluation of a population-based H pylori screen-and-treat strategy for preventing gastric cancer, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD). MATERIALS AND METHODS: Decision trees and Markov models were developed to evaluate the cost-effectiveness of H pylori screening followed by eradication treatment in asymptomatic Chinese...
January 22, 2019: Helicobacter
Yongle Zhan, Mingyu Si, Mingshuang Li, Yu Jiang
OBJECTIVE: To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes. MATERIALS AND METHODS: A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size...
January 22, 2019: Helicobacter
Jung W Lee, Nayoung Kim, Ryoung H Nam, Sun M Lee, Yong H Kwon, So D Sohn, Jung M Kim, Dong H Lee, Hyun C Jung
BACKGROUND: The eradication rate of Helicobacter pylori has declined, mainly due to antimicrobial resistance. To overcome resistance-associated treatment failure, the efficacy of culture-based, susceptibility-guided therapy was demonstrated as the first-line eradication therapy for H pylori infection. AIMS: To evaluate the efficacy of culture-based therapy as the first-line eradication therapy in regions with high levels of antimicrobial resistance. METHODS: Helicobacter pylori-positive patients without previous eradication treatment history were recommended to undergo culture to determine the minimal inhibitory concentration (MIC)...
January 10, 2019: Helicobacter
Constantin Hays, Thibault Delerue, Dominique Lamarque, Christophe Burucoa, Ghislaine Collobert, Annick Billöet, Nicolas Kalach, Josette Raymond
BACKGROUND: Adapted treatments for Helicobacter pylori infection, guided by determining antimicrobial resistance, are associated with high eradication rates. We evaluated the performance of the Amplidiag® H. pylori + ClariR PCR assay (Amplidiag® ) for detecting H. pylori and its clarithromycin resistance from gastric biopsies taken during endoscopy in comparison to culture and our "in-house" PCR. MATERIALS AND METHODS: A total of 127 gastric biopsies were analyzed (98 adults; 29 children)...
December 12, 2018: Helicobacter
Hitoshi Honma, Yoshiko Nakayama, Sawako Kato, Nao Hidaka, Mai Kusakari, Tomomitsu Sado, Ayako Suda, Yingsong Lin
BACKGROUND: Previously, we conducted an epidemiological study screening for Helicobacter pylori antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of H pylori antibody-positive junior high school students. MATERIALS AND METHODS: We assessed H pylori antibody-positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan...
December 4, 2018: Helicobacter
Michael G Bruce, Karen Miernyk, Frank Sacco, Timothy Thomas, Brian McMahon, Tom Hennessy
No abstract text is available yet for this article.
December 3, 2018: Helicobacter
Takuji Gotoda, Chika Takano, Chika Kusano, Sho Suzuki, Hisatomo Ikehara, Satoshi Hayakawa, Akira Andoh
OBJECTIVES: The effect of Helicobacter pylori eradication on the gut microbiota of teenagers is unknown; hence, this study aimed to assess changes in the gut microbiome after H. pylori eradication therapy in teenagers. MATERIALS AND METHODS: Changes in gut microbiota before and after H. pylori eradication were prospectively investigated in eight students without any underlying diseases, via next-generation sequencing of 16S rDNA. Twenty-four stool samples were collected, and operational taxonomic unit analysis was performed...
December 2018: Helicobacter
Ahmed Abdel-Razik, Nasser Mousa, Walaa Shabana, Mohamed Refaey, Rania Elhelaly, Rasha Elzehery, Mostafa Abdelsalam, Ayman Elgamal, Mervat R Nassar, Atef Abu El-Soud, Ahmed S Seif, Ahmed M Tawfik, Niveen El-Wakeel, Waleed Eldars
BACKGROUND AND AIM: The relationship between Helicobacter pylori (H. pylori) and nonalcoholic fatty liver disease (NAFLD) is a matter of debate. We achieved this prospective work to study whether H. pylori infection is a risk factor for NAFLD. METHODS: A cohort multicenter pilot study of 369 adults without NAFLD at baseline was followed up for 2 years. Serum leptin, insulin, tumor necrosis factor-α, adiponectin, and interleukin-6 were measured using an enzyme-linked immunosorbent assay (ELISA)...
December 2018: Helicobacter
Rachel Feder, Shai Posner, Yi Qin, Jiayin Zheng, Shein-Chung Chow, Katherine S Garman
BACKGROUND & AIMS: Guidelines recommend that patients with Helicobacter pylori (H. pylori)-associated peptic ulcer disease (PUD) receive H. pylori eradication therapy followed by post-treatment testing to prove eradication; however, post-treatment testing rates are suboptimal and barriers to testing are poorly understood. Our aim was to identify factors that predicted receipt of post-treatment testing. METHODS: We performed a retrospective cohort study of 152 patients with H...
December 2018: Helicobacter
Angel Cosme, Silvia Torrente Iranzo, Milagrosa Montes Ros, María Fernández-Reyes Silvestre, Horacio Alonso Galán, Jacobo Lizasoain, Luis Bujanda
BACKGROUND: Antibiotic resistance is the main cause for Helicobacter pylori therapy failure. Frequently, empirical regimens have been recommended in patients with various H. pylori eradication failures. In patients with H. pylori-resistant to various families of antibiotics, the treatment guided by antimicrobial susceptibility testing allows the achievement of good eradication rates. AIM: To evaluate the effectiveness of susceptibility-guided antimicrobial treatment for H...
November 20, 2018: Helicobacter
Alireza Neshani, Hosna Zare, Mohammad Reza Akbari Eidgahi, Amin Hooshyar Chichaklu, Aref Movaqar, Kiarash Ghazvini
BACKGROUND: The emergence of antibiotic-resistant Helicobacter pylori strains in recent years has increased the need for finding an alternative in the post-antibiotic era. One of the fields being considered for this purpose is antimicrobial peptides. The aim of this review was to provide an obvious scheme from the studied anti-H. pylori peptides and to investigate their common features. METHOD: First, all of the antimicrobial peptides with their anti-H. pylori effects have been proved up to September 2018 were selected and their information including structure, mechanism of action, and function was reviewed...
November 15, 2018: Helicobacter
Fahimeh Anbari, Anahita Ashouri Moghaddam, Elham Sabeti, Azin Khodabakhshi
INTRODUCTION: Halitosis is a common complaint among people which has various socioeconomic effects. The prevalence of halitosis includes a variety of 22% up to 50% in different societies. According to studies, there have been reports of remarkable improvements in halitosis after Helicobacter pylori eradication treatment. In studies on the relationship between H. Pylori and halitosis, the role of oral factors as the most important cause of halitosis has been neglected. This study was conducted with the aim of investigating the effect of oral factors on halitosis in patients with H...
November 15, 2018: Helicobacter
David Y Graham, Hong Lu, Maria Pina Dore
BACKGROUND: Helicobacter pylori treatment recommendations often recommend use of double-dose PPI or greater. This is confusing because PPIs very markedly in relative potency such that a double dose of one may not even be equivalent to the single dose of another. OBJECTIVE: To relate the concept of double-dose to specific amounts of the different PPIs METHODS: We used data standardizing PPI potency in terms of the duration of intragastric pH >4/24 hours (pH4-time) to rank PPIs...
November 15, 2018: Helicobacter
Chan Hyuk Park, A-Reum Lee, Yu-Ra Lee, Chang Soo Eun, Sang Kil Lee, Dong Soo Han
BACKGROUND: Despite recent advances in studies on the gastric microbiome, the role of the non-Helicobacter pylori gastric microbiome in gastric carcinogenesis remains unclear. We evaluated the characteristics of the gastric microbiome and metagenomic functions in patients with IM. METHODS: Participants were classified into six groups according to disease status (chronic superficial gastritis [CSG], intestinal metaplasia [IM], and cancer) and H. pylori- infection status (H...
November 15, 2018: Helicobacter
Anna Szaflarska-Popławska, Anetta Soroczyńska-Wrzyszcz
BACKGROUND: The purpose of the study was to assess the prevalence of Helicobacter pylori infection among the junior high school students in city Grudziądz, Poland. MATERIALS AND METHODS: A prospective cross-sectional study among second junior high school students was conducted from September 2008 to June 2015 during seven consecutive school years. The studied group was 3241 students 13-17 years old. The 13 C-urea breath test (UBT) was administered to all participants for current H...
November 15, 2018: Helicobacter
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