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Cancer Biotherapy & Radiopharmaceuticals

Jyoti Roy, Frank Kuo, Falguni Basuli, Mark R Williams, Karen Wong, Michael V Green, Jurgen Seidel, Stephen S Adler, Biying Xu, Peter L Choyke, Elaine M Jagoda
OBJECTIVE: 18 F-albumin, a vascular imaging agent, may have potential to assess tumor responses to anti-angiogenic therapies. In these studies tumor distribution volume of 18 F-albumin were first determined in various human tumor xenografts from biodistribtuion measurments and then one of the tumor type was used to evaluate changes in 18 F-albumin uptake in anti-angiognic tumor model. METHOD: 18 F-albumin was synthesized via conjugation of 6-[18 F]fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester, [18 F]F-Py-TFP, with rat albumin...
February 15, 2019: Cancer Biotherapy & Radiopharmaceuticals
Luca Filippi, Giovan Giuseppe Di Costanzo, Raffaella Tortora, Giuseppe Pelle, Roberto Cianni, Orazio Schillaci, Oreste Bagni
BACKGROUND: The aim of this study was to evaluate the safety and efficacy of repeated administration of 90 Y-microspheres in intrahepatic cholangiocarcinoma (ICC) relapsed after the first radioembolization (RE). METHODS: Nine patients with ICC relapsed after the first 90 Y-RE were enrolled. Six patients presented recurrence in the right hepatic lobe, 3 in the left lobe. All subjects underwent a second administration of 90 Y-resin microspheres. Toxicity was assessed according to Common Terminology Criteria for Adverse Events (CTCAE, version 4...
February 13, 2019: Cancer Biotherapy & Radiopharmaceuticals
Abdulhameed Al-Ghabkari, Aru Narendran
BACKGROUND: Neuroblastoma (NB) is one of the most aggressive and common solid tumors in pediatrics. Development of effective new therapeutics for NB is in progress to help reduce mortality and morbidity of the disease, particularly in relapsed patients. The tumor suppressor protein p53 plays a critical role in multiple signaling pathways to maintain cellular hemostasis. Dysregulation of p53 protein and/or molecular aberrations have been associated with multiple human malignancies. p53 stability and protein activity is negatively regulated by the E3 ubiquitin ligase (MDM2)...
February 6, 2019: Cancer Biotherapy & Radiopharmaceuticals
Lianshu Piao, Fei Wang, Yanyan Wang, Zirong Yang, Qianwei Li, Lifeng Cui, Qinggong Yu
OBJECTIVE: Yes-associated protein (Yes-associated protein 1 [YAP1]) is an important oncogene that is related to the pathogenesis and progression of liver cancer. It was found that miR-424-5p expression was significantly decreased in liver cancer tissues, revealing its anticancer effect. Bioinformatic analysis demonstrated the targeted relationship between miR-424-5p and the 3' untranslated region of YAP1. This study investigated the role of miR-424-5p in regulating YAP1 expression and affecting hepatoma cell proliferation and apoptosis...
January 24, 2019: Cancer Biotherapy & Radiopharmaceuticals
Adriana V F Massicano, Supum Lee, Bryant K Crenshaw, Tolulope A Aweda, Retta El Sayed, Ian Super, Ron Bose, Bernadette V Marquez-Nostra, Suzanne E Lapi
BACKGROUND: The success of human epidermal growth factor receptor 2 (HER2)-targeted therapy depends on accurate characterization of HER2 expression, but current methods available have several limitations. This study aims to investigate the feasibility of [89 Zr]pertuzumab imaging to monitor early response to Ado-trastuzumab emtansine (T-DM1) therapy in mice bearing xenografts of HER2-positive breast cancer (BCa). MATERIALS AND METHODS: Pertuzumab was conjugated to DFO-Bz-NCS and labeled with 89 Zr...
January 24, 2019: Cancer Biotherapy & Radiopharmaceuticals
Hong Guo, Zhaosheng Sun, Jianhui Wei, Yi Xiang, Lei Qiu, Lianfeng Guo, Wangmiao Zhao, Zhanyi Xu, Jianhui Mao
OBJECTIVE: To investigate the expression levels of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in pituitary adenomas (PAs), and to analyze the relationship of the expressions of the two with the prognosis of patients. METHODS: A total of 108 patients with PAs diagnosed in our hospital from May 2010 to May 2012 were selected and divided into the invasive PA (IPA) group (n = 58) and the non-IPA group (n = 50) according to the invasiveness of PAs...
January 24, 2019: Cancer Biotherapy & Radiopharmaceuticals
Dalma Scheffer, Gyula Kulcsár, Tamás Czömpöly
BACKGROUND: Earlier we assumed that small molecules selectively accumulated in cancer cells might have a role in a defense system capable of killing cancer cells. We reported earlier that an experimentally selected mixture of substances present in the serum ("active mixture," AM) shows a selective toxic effect in vitro and in vivo on various cancer cells. In this study we investigated additional compounds found in the serum to further expand our knowledge of this defense system...
January 16, 2019: Cancer Biotherapy & Radiopharmaceuticals
Caijin Jin, Tao Lin, Liqun Shan
BACKGROUND: Calbindin 1 (CALB1), a constituent Ca2+ -binding protein, has been reported to prevent apoptotic death in tumor cells. However, the microRNA-mediated regulatory mechanism of CALB1 expression in nonsmall cell lung cancer (NSCLC) has not been reported so far. METHODS AND RESULTS: In this study, CALB1 was found to be overexpressed in NSCLC tissues through the immunohistochemistry assay. Higher CALB1 expression levels were significantly associated with the tumor-node-metastasis (TNM) stage...
January 14, 2019: Cancer Biotherapy & Radiopharmaceuticals
Hualong Qiang, Xiaodong Zhan, Wei Wang, Zhongqiang Cheng, Shiyin Ma, Chengyi Jiang
OBJECTIVE: To investigate the correlations of miR-31 expression with cell proliferation, invasion, and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). METHODS: The expression of miR-31 in human laryngeal cancer TU686 cells, human nasopharyngeal carcinoma CNE-2 cells, and normal human oral keratinocyte (NHOK) epithelial cells was detected via quantitative real-time polymerase chain reaction (qRT-PCR). The effects of miR-31 on the proliferation and invasion of HNSCC cells were explored through transfecting miR-31 analogs (miR-31 mimics) and miR-31 inhibitors (anti-miR-31)...
January 10, 2019: Cancer Biotherapy & Radiopharmaceuticals
Zhujun Ao, Wei Chen, Jun Tan, Yuling Cheng, Yanlan Xu, Lijun Wang, Xiaojian Yao
OBJECTIVE: Apoptosis plays an important role in both carcinogenesis and cancer treatment. Drugs or treatment strategies that can restore the apoptotic signaling pathways have the potential to eliminate cancer. Caspase 8 (CASP8) plays a vital role in the propagation of an enzymatic cascade that results in cell apoptosis. METHODS AND RESULTS: In this study, the authors investigated the inhibitory effects of a HIV Gag virus-like particles (VLPs) that are incorporated with an active CASP8 (Gag-CASP8-VLPs) on the growth of breast cancer...
January 8, 2019: Cancer Biotherapy & Radiopharmaceuticals
Giandomenico Roviello, Silvia Paola Corona, Michele Aieta, Raheleh Roudi
BACKGROUND: Novel hormonal therapies (NHTs) have enriched the therapeutic armamentarium available for patients with castration-resistant prostate cancer. However, there is a need for clinical indicators able to drive treatment decisions and timing. The aim of this report is to perform a pooled analysis based on all available literature focused on prediction of efficacy and survival in patients treated with NHTs before and postchemotherapy. METHODS: After reviewing the studies included in this work, the efficacy and the survival of NHTs according to age and Gleason score (GS) was focused...
January 8, 2019: Cancer Biotherapy & Radiopharmaceuticals
Xia Zheng, Min Liu, YingChun Song, ChunHua Feng
OBJECTIVE: Long non-coding RNA-ATB (Lnc-ATB) have been reported to promote tumor proliferation and metastasis via regulation of tumor suppressive miRNA-related signals. Patients with endometrial cancer (EC) have advanced stage disease or metastasis have poor prognosis. We here investigated the role of Lnc-ATB in endometrial cancer. METHODS: Endometrial cancer tissues and normal tissues (n = 35) were collected to determine the expression and clinical significance of Lnc-ATB, and bioinformatics analysis was used to predict the miRNA target...
January 2, 2019: Cancer Biotherapy & Radiopharmaceuticals
Massimo Fantini, Justin M David, Hing C Wong, Christina M Annunziata, Philip M Arlen, Kwong Y Tsang
BACKGROUND: A major mechanism of action for therapeutic antibodies is antibody-dependent cell-mediated cytotoxicity (ADCC). ALT-803 is an interleukin-15 superagonist complex that enhances ADCC against human carcinoma cells in vitro and exerts an antitumor activity in murine, rat, and human carcinomas in vivo. The authors investigated the ability of ALT-803 to modulate ADCC mediated by the humanized IgG1 monoclonal antibody (mAb) NEO-201 against human carcinoma cells. MATERIALS AND METHODS: ALT-803 modulating activity on ADCC mediated by NEO-201 was evaluated on several NEO-201 ligand-expressing human carcinoma cells...
January 2, 2019: Cancer Biotherapy & Radiopharmaceuticals
Pengfei Shi, Cheng Chen, Yufeng Yao
OBJECTIVE: The incidence of breast cancer in females is gradually increasing. Expression of HER-2 gene and protein is critical for predicting the prognosis of breast cancer. This study examined amplification of HER-2 gene and protein expression in breast cancer patients to analyze their correlation with clinical and pathological features. MATERIALS AND METHODS: Specimens of breast gland tissues were collected from breast cancer patients for measuring HER-2 protein expression by immunohistochemistry (IHC) method...
December 26, 2018: Cancer Biotherapy & Radiopharmaceuticals
Lv-Xia Dai, Jing Yang, Jian-Min Liu, Sizhou Huang, Bao-Ning Wang, Hong Li, Jie Yang, Zhong-Yi Zhao, Kang Cao, Ming-Yuan Li
PURPOSE: The cross-reacting material 197 (CRM197) is a mutation of the diphtheria toxin. The protein of CRM197 was used successfully for the therapy of various tumors in the recent studies. In this study, the recombinant adenoviruses containing the CRM197gene(AdCRM197) were used to enhance the cellar toxicity of gemcitabine in human glioma U87, U251, and H4 cells. PROCEDURES: MTT assay and flow cytometric analysis were performed to test the apoptosis of the U87, U251 and H4 cells with the combined treatment of AdCRM197 plus gemcitabine...
December 26, 2018: Cancer Biotherapy & Radiopharmaceuticals
Jian Liu, Gang Liu, Xiaolin Liu, Xiaohu Zhu, Yan Wang, Bo Gou, Lanlan You
OBJECTIVE: To investigate and discuss the clinical value of positron emission tomography-computed tomography (PET-CT) combined with ultrasound in detection of primary tumors in patients with malignant ascites (MA). MATERIALS AND METHODS: A total of 122 malignant tumor patients with ascites as the initial symptom and 48 patients with benign ascites were enrolled in this study. All patients underwent PET-CT and abdominal B-ultrasound examinations. The corresponding specificity, sensitivity, accuracy rate, positive predictive value, and negative predictive value of PET-CT, abdominal B-ultrasound, and combined detection group were recorded, respectively, with pathological findings as the gold standards...
December 26, 2018: Cancer Biotherapy & Radiopharmaceuticals
You-Ming Zhang, Ming-Na Chen, Jian-Ming Gao, Chun-Hui Zhou, Jing-Xing Xiao, Zhong-Yi Sun, Wei-Hua Liao, Xiao-Ping Yi, Chishing Zee, Bihong T Chen
OBJECTIVE: To predict the early identification of recurrence based on magnetic resonance imaging (MRI) in nasopharyngeal cancer (NPC) patients. METHODS: The clinical and MRI data of 215 patients with local recurrent NPC were retrospectively reviewed. Logistic regression analysis was performed to distinguish the independent risk factors for the short-term (less than 24 months) local recurrence of NPC. The predictive score model was based on the regression coefficients of significant independent variables...
December 26, 2018: Cancer Biotherapy & Radiopharmaceuticals
Bo Song, Lu Wang, Yang Zhang, Ning Li, Hao Dai, Huafang Xu, Haifeng Cai, Jinyin Yan
OBJECTIVE: Breast cancer (BC) is a common malignant tumor in females. The combined assay of multiple molecular markers benefits the diagnosis and prognostic prediction. Human epidermal growth factor receptor 2 (HER2) facilitates the proliferation and differentiation of cancer cells through ligand binding. Ki67 is a tumor proliferation-related gene, whereas GSTP1 is a DNA repair-related gene. This study thus investigated the significance of HER2 and Ki67/GSTP1 gene combined assay in the diagnosis and prognosis of BC...
December 26, 2018: Cancer Biotherapy & Radiopharmaceuticals
Zhi-Yuan Zhu, Xiao-Le Wang, Da-Peng Li
BACKGROUND: Prostate cancer (PC), the most commonly diagnosed malignancy, is also the second leading cause of cancer-related deaths. Although tremendous efforts have been achieved to improve the early detection of PC, it is still urgent to find out novel markers and therapeutic targets for PC patients. Homeobox protein MOX-1 (MEOX1) is found to be ectopically expressed in human cancers. This study aims to test the hypothesis that MEOX1 gene silencing might suppress the proliferation and invasion of LNCaP cells in PC...
December 12, 2018: Cancer Biotherapy & Radiopharmaceuticals
Fang Zheng, Xinyi Xiao, Chunmei Wang
OBJECTIVE: Patched (PTCH1) is an important receptor protein in the Hedgehog pathway and plays a tumor suppressor role in a variety of tumors. This study was to detect the expression of PTCH1 in ovarian cancer (OC) tissues to analyze the relationship between expression of PTCH1 and prognosis, and to explore its role in regulating OC cell proliferation and apoptosis. MATERIALS AND METHODS: OC tissues and normal ovarian tissues were collected to detect PTCH1 expression...
December 6, 2018: Cancer Biotherapy & Radiopharmaceuticals
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