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JOURNAL ARTICLE
Yuto Ishibashi, Nami Nagafuku, Shingo Kimura, Xiaobo Han, Ikuro Suzuki
Addiction is known to occur through the consumption of substances such as pharmaceuticals, illicit drugs, food, alcohol and tobacco. These addictions can be viewed as drug addiction, resulting from the ingestion of chemical substances contained in them. Multiple neural networks, including the reward system, anti-reward/stress system and central immune system in the brain, are believed to be involved in the onset of drug addiction. Although various compound evaluations using microelectrode array (MEA) as an in vitro testing methods to evaluate neural activities have been conducted, methods for assessing addiction have not been established...
October 2024: Addiction Biology
#2
JOURNAL ARTICLE
Mariel Molina-Castro, Neda Seyedsadjadi, Danisa Nieto, Lorenzo Leggio, Blair Rowitz, Marta Yanina Pepino
Glucagon-like peptide-1 (GLP-1)-based therapies, effective in treating obesity and type 2 diabetes, hold potential for reducing alcohol-seeking behaviour. However, the understanding of how alcohol consumption affects endogenous GLP-1 responses-important for understanding GLP-1-based therapies' potential in addressing alcohol misuse-is limited, given the absence of placebo-controlled studies examining these effects. This study aimed to determine the acute effects of alcohol ingestion on GLP-1 and other peptides and evaluate whether metabolic surgery, which increases GLP-1 responses, blood alcohol concentrations (BAC) and alcohol misuse risk, influences this effect...
October 2024: Addiction Biology
#3
JOURNAL ARTICLE
Setareh Azizzadeh, Milad Rahimpour, Kamran Rakhshan, Bahador Makkiabadi, Esmail Riahi
Increased allocation of behaviour to substance abuse at the expense of personal and social rewards is a hallmark of addiction that is reflected in several of DSM-5 criteria for diagnosis of substance use disorder. Previous studies focused on refining the self-administration (SA) model to better emulate an addictive state in laboratory animals. Here, we employed concurrent SA of sucrose pellets and morphine as two competing natural and drug rewards, respectively, to validate the feasibility of capturing pathological behavioural allocation in rats...
October 2024: Addiction Biology
#4
JOURNAL ARTICLE
Hongyu Lin, Adedayo Olaniran, Xiang Luo, Jessica Strauch, Megan A M Burke, Chloe L Matheson, Xuan Li
Relapse is a major challenge in treating opioid addiction, including oxycodone. During abstinence, oxycodone seeking progressively increases, a phenomenon termed incubation of oxycodone craving. We previously demonstrated a causal role of orbitofrontal cortex (OFC) in this incubation. Here, we studied the interaction between glutamatergic projections from OFC and dopamine 1-family receptor (D1R) signaling in dorsal striatum (DS) in this incubation in male rats. We first examined the causal role of D1R signalling in DS in incubated oxycodone seeking...
October 2024: Addiction Biology
#5
REVIEW
Hollis C Karoly, Katelyn T Kirk-Provencher, Joseph P Schacht, Joshua L Gowin
Alcohol exposure affects brain structure, but the extent to which its effects differ across development remains unclear. Several countries are considering changes to recommended guidelines for alcohol consumption, so high-quality evidence is needed. Many studies have been conducted among small samples, but recent efforts have been made to acquire large samples to characterize alcohol's effects on the brain on a population level. Several large-scale consortia have acquired such samples, but this evidence has not been synthesized across the lifespan...
September 2024: Addiction Biology
#6
JOURNAL ARTICLE
Cagdas Türkmen, Haoye Tan, Sarah Gerhardt, Emilie Bougelet, Maria Bernardo, Noah Machunze, Yasmin Grauduszus, Maurizio Sicorello, Traute Demirakca, Falk Kiefer, Sabine Vollstädt-Klein
BACKGROUND: Previous studies have established a connection between adverse childhood experiences (ACE) and alcohol use disorder (AUD), both of which are associated with alterations in grey matter volume (GMV) and cortical thickness (CT). The current study aimed to assess the neurobiological impact of ACE specifically in the context of AUD, as well as the role of maltreatment type (i.e., abuse or neglect) and timing. METHODS: Structural MRI data were collected from 35 adults with AUD (mean age: 40; 31% female) and 28 healthy controls (mean age: 36; 61% female)...
September 2024: Addiction Biology
#7
JOURNAL ARTICLE
Cherish E Ardinger, Yueyi Chen, Adam Kimbrough, Nicholas J Grahame, Christopher C Lapish
Frontloading is an alcohol drinking pattern where intake is skewed towards the onset of access. This study aimed to identify brain regions involved in frontloading. Whole brain imaging was performed in 63 C57Bl/6J (32 female, 31 male) mice that underwent 8 days of binge drinking using drinking-in-the-dark (DID). On Days 1-7 mice received 20% (v/v) alcohol or water for 2 h. Intake was measured in 1-min bins using volumetric sippers. On Day 8 mice were perfused 80 min into the DID session and brains were extracted...
September 2024: Addiction Biology
#8
JOURNAL ARTICLE
Lee Hogarth
Heinz et al. (2024) recently criticised habit/compulsion theory of human addiction but nevertheless concluded that 'habit formation plays a significant role in drug addiction'. To challenge this causal claim, the current article develops four further methodological criticisms, that publications supporting the habit/compulsion account of human addiction: (1) under-report contradictory observations; (2) exaggerate the process purity of positive observations; (3) under-emphasise the low quality of epidemiological support for a causal hypothesis; (4) recapitulate the social injustice of racial intelligence era by prematurely attributing lower task performance to drug user group membership (endophenotype) without having adequately tested social, psychological, economic and environmental inequalities...
August 2024: Addiction Biology
#9
(no author information available yet)
No abstract text is available yet for this article.
August 2024: Addiction Biology
#10
EDITORIAL
Karen D Ersche
No abstract text is available yet for this article.
August 2024: Addiction Biology
#11
JOURNAL ARTICLE
Zhongqiang Ruan, Shilin Liu, Yu An Liu, Qiong Yang, Ziwen Peng
While previous research has shown that compulsivity is related to an imbalance between goal-directed and habitual learning systems, very little is known about whether this effect is due to the impairment of a single system or the impairment of the arbitration mechanism that determines which system controls behaviour at any given moment; the current study aims to address this disagreement. Nineteen alcohol use disorder, 30 obsessive-compulsive disorder (OCD) and 20 major depressive disorder patients and corresponding sex- and age-matched controls performed two-choice, three-stage Markov decision-making paradigm...
August 2024: Addiction Biology
#12
JOURNAL ARTICLE
Bailey C Sarka, Shuai Liu, Anjishnu Banerjee, Cheryl L Stucky, Qing-Song Liu, Christopher M Olsen
Approximately 50 million Americans suffer from chronic pain, and nearly a quarter of chronic pain patients have reported misusing opioid prescriptions. Repeated drug seeking is associated with reactivation of an ensemble of neurons sparsely scattered throughout the dorsomedial prefrontal cortex (dmPFC). Prior research has demonstrated that chronic pain increases intrinsic excitability of dmPFC neurons, which may increase the likelihood of reactivation during drug seeking. We tested the hypothesis that chronic pain would increase oxycodone-seeking behaviour and that the pain state would differentially increase intrinsic excitability in dmPFC drug-seeking ensemble neurons...
August 2024: Addiction Biology
#13
JOURNAL ARTICLE
Idaira Oliva, Fezaan Kazi, Lucas N Cantwell, Ganesh A Thakur, Jonathon D Crystal, Andrea G Hohmann
The endocannabinoid system interacts with the reward system to modulate responsiveness to natural reinforcers, as well as drugs of abuse. Previous preclinical studies suggested that direct blockade of CB1 cannabinoid receptors (CB1R) could be leveraged as a potential pharmacological approach to treat substance use disorder, but this strategy failed during clinical trials due to severe psychiatric side effects. Alternative strategies have emerged to circumvent the side effects of direct CB1 binding through the development of allosteric modulators...
August 2024: Addiction Biology
#14
JOURNAL ARTICLE
Erica N Grodin, Kaitlin R McManus, Lara A Ray
Inflammation appears to be a critical mechanism in the development of alcohol use disorder (AUD) and a consequence of chronic alcohol use. The potential anti-inflammatory properties of cannabis may modulate the proinflammatory effects of alcohol. This study sought to extend previous work investigating the relationship between alcohol consumption, cannabis use and circulating interleukin (IL)-6 levels in a sample with AUD. One hundred and thirty-three individuals with an AUD provided blood samples to assess IL-6 and answered questions regarding alcohol and cannabis use...
August 2024: Addiction Biology
#15
JOURNAL ARTICLE
Esteban S Urena, Cody C Diezel, Mauricio Serna, Grace Hala'ufia, Lisa Majuta, Kara R Barber, Todd W Vanderah, Arthur C Riegel
The increasing rates of drug misuse highlight the urgency of identifying improved therapeutics for treatment. Most drug-seeking behaviours that can be modelled in rodents utilize the repeated intravenous self-administration (SA) of drugs. Recent studies examining the mesolimbic pathway suggest that Kv 7/KCNQ channels may contribute to the transition from recreational to chronic drug use. However, to date, all such studies used noncontingent, experimenter-delivered drug model systems, and the extent to which this effect generalizes to rats trained to self-administer drugs is not known...
August 2024: Addiction Biology
#16
RANDOMIZED CONTROLLED TRIAL
Jinbo Chen, Zixuan Chen, Yanli Zhang, Xiaohe Fan, Changchun Zhang, Jun Zhu, Chuanfu Song, Shuangli Zhang, Danwei Zhang, Lijuan Tang, Benhan Li, Weibian Yang, Qiang Hu
Benzodiazepine (BZD) dependence poses a significant challenge in mental health, prompting the exploration of treatments like repetitive transcranial magnetic stimulation (rTMS). This research aims to assess the impact of rTMS on alleviating symptoms of BZD dependence. A randomized control trial was employed to study 40 BZD-dependent inpatients. Their symptoms were quantified using the Hamilton Anxiety Rating Scale (HAMA), Montgomery-Åsberg Depression Rating Scale (MADRS) and Pittsburgh Sleep Quality Index (PSQI)...
July 2024: Addiction Biology
#17
JOURNAL ARTICLE
Tamaki Hayase
The addictive use of nicotine contained in tobacco is associated with stressor-like emotional and cognitive effects such as anxiety and working memory impairment, and the involvement of epigenetic mechanisms such as histone acetylation has recently been reported. Although the precise nature of behavioural plasticity remains unclear, both anxiogenic- and working memory impairment-like effects were observed in the present experimental model of mice treated with repeated subcutaneous nicotine and/or immobilization stress, and these effects were commonly attenuated by the histone deacetylase (HDAC) inhibitors that induce histone acetylation...
July 2024: Addiction Biology
#18
REVIEW
Rainer Spanagel, Patrick Bach, Tobias Banaschewski, Anne Beck, Felix Bermpohl, Rick E Bernardi, Christian Beste, Lorenz Deserno, Daniel Durstewitz, Ulrich Ebner-Priemer, Tanja Endrass, Karen D Ersche, Gordon Feld, Martin Fungisai Gerchen, Björn Gerlach, Thomas Goschke, Anita Christiane Hansson, Christine Heim, Stefan Kiebel, Falk Kiefer, Peter Kirsch, Clemens Kirschbaum, Georgia Koppe, Bernd Lenz, Shuyan Liu, Michael Marxen, Marcus W Meinhardt, Andreas Meyer-Lindenberg, Christiane Montag, Christian P Müller, Wolfgang E Nagel, Ana M M Oliveria, David Owald, Maximilian Pilhatsch, Josef Priller, Michael A Rapp, Markus Reichert, Stephan Ripke, Kerstin Ritter, Nina Romanczuk-Seiferth, Florian Schlagenhauf, Emanuel Schwarz, Sarah Schwöbel, Michael N Smolka, Surjo R Soekadar, Wolfgang H Sommer, Ann-Kathrin Stock, Andreas Ströhle, Heike Tost, Sabine Vollstädt-Klein, Henrik Walter, Tina Waschke, Stephanie H Witt, Andreas Heinz
Substance use disorders (SUDs) are seen as a continuum ranging from goal-directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real-life conditions...
July 2024: Addiction Biology
#19
JOURNAL ARTICLE
Laura Agulló, Mónica Escorial, Samantha Orutño, Javier Muriel, Juan Sandoval, César Margarit, Ana M Peiró
Opioid use disorder (OUD) is a multifaceted condition influenced by sex, genetic and environmental factors that could be linked with epigenetic changes. Understanding how these factors interact is crucial to understand and address the development and progression of this disorder. Our aim was to elucidate different potential epigenetic and genetic mechanisms between women and men that correlate with OUD under real-world pain unit conditions. Associations between analgesic response and the DNA methylation level of the opioid mu receptor (OPRM1) gene (CpG sites 1-5 selected in the promoter region) were evaluated in 345 long opioid-treated chronic non cancer pain: cases with OUD (n = 67) and controls (without OUD, n = 278)...
July 2024: Addiction Biology
#20
JOURNAL ARTICLE
Xin Huang, Yawei Qi, Ran Zhang, Yu Pu, Xi Chen, Shanping Chen, Haichao Zhao, Qinghua He
In recent years, electronic cigarettes (e-cigs) have gained popularity as stylish, safe, and effective smoking cessation aids, leading to widespread consumer acceptance. Although previous research has explored the acute effects of combustible cigarettes or nicotine replacement therapy on brain functional activities, studies on e-cigs have been limited. Using fNIRS, we conducted graph theory analysis on the resting-state functional connectivity of 61 male abstinent smokers both before and after vaping e-cigs...
July 2024: Addiction Biology
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