Nozomi Fujisawa, Tomochika Matsushita, Saori Matsuo, Mayumi Hiranuma, Hiroko Azabu, Ryota Saito, Shun-Ichiro Komatsu, Atsuhiko Kato, Naoto Toyota, Junko Taketo, Hiromi Suzuki
Animals frequently eat less after test-article treatment in non-clinical toxicological studies, and it can be difficult to distinguish test article-derived toxicities from secondary changes related to this reduced food intake. Therefore, in this study, we restricted the food intake of cynomolgus monkeys (Cambodian, male, n=2 or 3, 4-year ± 3-month-old) to 25% of control for two weeks, and evaluated its effect on toxicological parameters (general conditions, body weight, electrocardiography, urinalysis, hematology, blood chemistry, bone marrow analysis, pathological examination)...
August 29, 2023: Experimental Animals