Shivani Choudhary, James G Tipton, Melanie Abongwa, Matthew T Brewer, Jeba Jesudoss Chelladurai, Nicole Musselman, Richard J Martin, Alan P Robertson
Parasitic nematode infections are treated using anthelmintic drugs, some of which target nicotinic acetylcholine receptors (nAChRs) located in different parasite tissues. The limited arsenal of anthelmintic agents and the prevalence of drug resistance imply that future defense against parasitic infections will depend on the discovery of novel targets and therapeutics. Previous studies have suggested that Ascaris suum ACR-16 nAChRs are a suitable target for the development of antinematodal drugs. In this study, we characterized the pharmacology of the Ancylostoma caninum ACR-16 receptor using two-electrode voltage-clamp electrophysiology...
September 5, 2019: Invertebrate Neuroscience: IN