Catherine E Stanley, Rebecca Adams, Jeremy Nadolski, Ellora Amrit, Matthew Barrett, Catherine Bohnett, Kelsey Campbell, Keegan Deweese, Sabbyasachi Dhar, Barbara Gillis, Carson Hill, Morgan Inks, Katrina Kozak, Alexa Larson, Ibraheem Murtaza, Destaneh Nichols, Rafael Roberts, Hannah Tyger, Courtney Waterbury, Robin L Cooper
Tricaine mesylate, also known as MS-222, was investigated to characterize its effects on sensory neurons, synaptic transmission at the neuromuscular junction, and heart rate in invertebrates. Three species were examined: Drosophila melanogaster, blue crab (Callinectes sapidus), and red swamp crayfish (Procambarus clarkii). Intracellular measures of action potentials in motor neurons of the crayfish demonstrated that MS-222 dampened the amplitude, suggesting that voltage-gated Na + channels are blocked by MS-222...
May 30, 2020: Invertebrate Neuroscience: IN