journal
https://read.qxmd.com/read/38685809/ayurvedic-and-chinese-herbs-against-coronaviruses
#21
JOURNAL ARTICLE
Amin Gasmi, Sonia Kanwal, Petro Oliinyk, Roman Lysiuk, Mariia Shanaida, Asma Gasmi Benahmed, Walallawita Kankanamge Tharindu Dushmantha, Maria Arshad, Ivanna Kernychna, Larysa Lenchyk, Taras Upyr, Volodymyr Shanaida, Geir Bjørklund
COVID-19 is a viral disease that infects the lower airways, causing severe acute respiratory syndrome (SARS) and fatal pneumonia. The ripple effect of the COVID-19 outbreak has created serious problems in the healthcare systems of many countries and had far-reaching consequences for the global economy. Thus, effective control measures should be implemented for this coronavirus infection in the future. The ongoing episode of the SARS-CoV-2 sickness, COVID-19, in China, and the subsequent irregular spread of contamination to different nations, has alarmed the clinical and academic community primarily due to the deadly nature of this disease...
April 29, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38685791/nanoparticles-as-drug-delivery-carrier-synthesis-functionalization-and-application
#22
JOURNAL ARTICLE
S Drishya, Ramakrishna Prasad Are, Prabhudutta Hota, Anju R Babu
In recent years, advancements in chemistry have allowed the tailoring of materials at the nanoscopic level as needed. There are mainly four main types of nanomaterials used as drug carriers:metal-based nanomaterials, organic nanomaterials, inorganic nanomaterials, and polymer nanomaterials. The nanomaterials as a drug carrier showed advantages for decreased side effects with a higher therapeutic index. The stability of the drug compounds is increased by encapsulation of the drug within the nano-drug carriers, leading to decreased systemic toxicity...
April 29, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38676525/comprehensive-overview-of-innovative-strategies-in-preventing-renal-ischemia-reperfusion-injury-insights-from-bibliometric-and-in-silico-analyses
#23
JOURNAL ARTICLE
Myltykbay S Rysmakhanov, Afshin Zare, Aibolat S Smagulov, Nurgul A Abenova, Nadiar M Mussin, Yerlan B Sultangereyev, Bazylbek S Zhakiyev, Gani K Kuttymuratov, Mehmet Haberal, Nazanin Jafari, Hanieh Baneshi, Shabnam Bakhshalizadeh, Mahdi Mahdipour, Farhad Rahmanifar, Amin Tamadon
BACKGROUND: Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological process with severe consequences, including irreversible loss of renal function. Various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion. AIM: This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods for preventing and treating renal IRI. METHODS: Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor (MR), and Toll-Like Receptor 4 (TLR4)...
April 26, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38676524/bear-bile-powder-improves-ulcerative-colitis-by-protecting-the-intestinal-mechanical-barrier-and-regulating-intestinal-flora
#24
JOURNAL ARTICLE
Zi-Bo Liu, Xun Ye, Chun-Jie Wu, Da-Neng Wei
BACKGROUND: Bear Bile Powder (BBP) is a traditional Chinese medicine. It has been widely used in clinical practices and has shown a good anti-inflammatory effect. However, its effectiveness in treating Ulcerative Colitis (UC) has not yet been studied. OBJECTIVE: To explore the therapeutic effect of BBP on ulcerative colitis and its potential mechanism by combining acute ulcerative colitis mouse models and comprehensively observing various physiological and biochemical indexes of mice...
April 26, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38676476/impact-of-combination-therapy-with-chemical-drugs-and-megavoltage-x-ray-exposure-on-breast-cancer-stem-cells-viability-and-proliferation-of-mcf-7-and-mda-mb-231-cell-lines
#25
JOURNAL ARTICLE
Fatemeh Banisharif Dehkordi, Mahdi Ghatrehsamani, Maryam Abdolvand, Amin Soltani, Seyed Hossein Masoumi
BACKGROUND: Breast Cancer (BC) is a serious malignancy among women. However, chemotherapy is an important tool for cancer treatments, but the long-term use of chemotherapy drugs may lead to drug resistance and tumor recurrence. Since Breast Cancer Stem Cells (BCSCs) can be the main factor to induce BC treatment resistance and recurrence, investigation of BCSCs signaling pathways can be an effective modality to enhance cancer treatment efficiency. OBJECTIVE: In this study, the effect of metformin, SB203580, and takinib alone or in combination with radiotherapy on MCF-7 and MDA-MB-231 breast cancer cell lines was evaluated...
April 25, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38661036/green-synthesis-of-silver-nanoparticles-using-cirsium-congestum-extract-modified-by-chitosan-alginate-bactericidal-activity-against-pathogenic-bacteria-and-cytotoxicity-analysis-in-normal-cell-line
#26
JOURNAL ARTICLE
Mahnaz Mohtasham, Alieh Rezagholizade-Shirvan, Zahra Hojat Bonab, Mohammad Reza Amiryousefi, Majid Darroudi, Mobina Sadat Ahmadi Solimani, Sajad Yaghoobi, Samaneh Dolatabadi, Ahmad Ghasemi, Amir Abbas Momtazi-Borojeni
AIM: The study aimed to determine in vitro pharmacological effects of modified Ag nanoparticles (AgNPs). BACKGROUND: AgNPs are considered antimicrobial agents. However, the cytotoxicity of chemically synthesized AgNPs (cAgNPs) has raised challenges that limit their use. OBJECTIVE: The purpose of the study was to examine the antimicrobial and cytotoxicity effects of AgNPs synthesized using Cirsium congestum extract modified by chitosan/alginate AgNPS (Ch/ALG-gAgNPs)...
April 24, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38659268/treatment-of-pulmonary-embolism-beyond-anticoagulation
#27
JOURNAL ARTICLE
Lampros Lakkas, Christos S Katsouras
No abstract text is available yet for this article.
April 24, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38716546/effect-of-raltitrexed-on-eca109-cellular-radiosensitivity-and-its-mechanism-in-esophageal-cancer
#28
JOURNAL ARTICLE
Li-Ben Xu, Chao-Yang Wu, Yan Wang, Ju-Ying Zhou
BACKGROUND: To investigate the effect of raltitrexed + X-ray irradiation on esophageal cancer ECA109 cells and analyze the potential action mechanism. METHODS: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to analyze the inhibitory effect of raltitrexed on cell proliferation. The effect of raltitrexed on radiosensitivity was studied through a clone-forming experiment. The scratch assay and invasion test were performed to understand the cell migration and invasion abilities...
April 23, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38644723/construction-of-gpc3-modified-lipopolymer-sirna-delivery-system
#29
JOURNAL ARTICLE
Dandan Sun, Xiaoyu Li, Yaru Liu, Jishan Quan, Guangyu Jin
BACKGROUND: Gene therapy has been widely concerned because of its unique therapeutic mechanism. However, due to the lack of safe and effective carries, it has not been widely used in clinical practice. Glypican 3 (GPC3) is a highly specific proteoglycan for hepatocellular carcinoma and is a potential diagnostic and therapeutic target for hepatocellular carcinoma. Herein, to monitor the effect of gene therapy and enhance the transfection efficiency of gene carriers, GPC3-modified lipid polyethyleneimine-modified superparamagnetic nanoparticle (GLPS), a type of visualized carrier for siRNA (small-interfering RNA) targeting the liver, was prepared...
April 19, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38644722/nanotechnology-in-orthodontics-unveiling-pain-mechanisms-innovations-and-future-prospects-of-nanomaterials-in-drug-delivery
#30
JOURNAL ARTICLE
Divya Sharma, Shiv Kumar, Yogesh Garg, Shruti Chopra, Amit Bhatia
Orthodontic pain is characterized by sensations of tingling, tooth discomfort, and intolerance. According to the oral health report, over forty percent of children and adolescents have undergone orthodontic treatment. The efficacy of orthodontic treatment involving braces can be compromised by the diverse levels of discomfort and suffering experienced by patients, leading to suboptimal treatment outcomes and reduced patient adherence. Nanotechnology has entered all areas of science and technology. This review provides an overview of nanoscience, its application in orthodontics, the underlying processes of orthodontic pain, effective treatment options, and a summary of recent research in Nano-dentistry...
April 19, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38639271/the-impact-of-spironolactone-co-administration-on-cyclosporin-initial-dosage-optimization-for-pediatric-refractory-nephrotic-syndrome
#31
JOURNAL ARTICLE
Huan-Huan Han, Min Rui, Yang Yang, Jia-Fang Cui, Xue-Ting Huang, Shi-Jia Zhang, Su-Mei He, Dong-Dong Wang, Xiao Chen
OBJECTIVES: Cyclosporin has been used for the treatment of pediatric refractory nephrotic syndrome (PRNS). However, the narrow therapeutic window and large pharmacokinetic variability make it difficult to individualize cyclosporin administration. Meanwhile, spironolactone has been reported to affect cyclosporin metabolism in PRNS patients. This study aims to explore the initial dosage optimization of cyclosporin in PRNS based on the impact of spironolactone co-administration. METHODS: Monte Carlo simulation based on a previously established cyclosporin population pharmacokinetic model for PRNS was used to design cyclosporin dosing regimen...
April 18, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38638053/the-therapeutic-application-of-hydrogen-in-cancer-the-potential-and-challenges
#32
JOURNAL ARTICLE
Morteza Nazari Khiji, Faezeh Arghidash, Ghazaleh Khalili Tanha, Rasoul Hossein Zadeh, Elnaz Ghorbani, Majid Khazaei, Seyed Mahdi Hassanian, Ibrahim Saeed Gataa, Alfred King-Yin Lam, Elisa Giovannetti, Gordon A Ferns, Elham Nazari, Amir Avan
Hydrogen therapy has emerged as a possible approach for both preventing and treating cancer. Cancers are often associated with oxidative stress and chronic inflammation. Hydrogen, with its unique physiological functions and characteristics, exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties, making it an attractive candidate for cancer treatment. Through its ability to mitigate oxidative damage, modulate inflammatory responses, and sustain cellular viability, hydrogen demonstrates significant potential in preventing cancer recurrence and improving treatment outcomes...
April 17, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38638052/recent-advances-in-the-treatment-strategies-of-friedreich-s-ataxia-a-review-of-potential-drug-candidates-and-their-underlying-mechanisms
#33
JOURNAL ARTICLE
Aman Kumar Saini, Neha Anil, Ardra N Vijay, Bharti Mangla, Shamama Javed, Pankaj Kumar, Waquar Ahsan
BACKGROUND: Friedreich's ataxia (FRDA) is a rare hereditary neurodegenerative disorder characterized by progressive ataxia, cardiomyopathy, and diabetes. The disease is caused by a deficiency of frataxin, a mitochondrial protein involved in iron-sulfur cluster synthesis and iron metabolism. OBJECTIVE: This review aims to summarize recent advances in the development of treatment strategies for FRDA, with a focus on potential drug candidates and their mechanisms of action...
April 17, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38629355/effect-of-statins-on-serum-levels-of-tnf-alpha-and-interleukin-6-in-patients-with-kidney-disease-a-meta-analysis-of-randomized-clinical-trials
#34
Bahman Razi, Saeed Aslani, Danyal Imani, Sajad Salehiyeh, Mahdieh Fasihi, Željko Reiner, Amirhossein Sahebkar
BACKGROUND AND OBJECTIVES: Some clinical trials have indicated the beneficial effects of statins in patients with kidney disease, while others have reported no positive effect of statins in these patients. We conducted this meta-analysis to identify the effects of statins on serum levels of interleukin-6 (IL-6) and Tumor Necrosis Factor Alpha (TNF-α) in patients with kidney disease. DESIGNS AND METHODS: A systematic literature search was performed using PubMed, Scopus, and Web of Science databases to identify all studies published from inception to August, 2022...
April 16, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38629357/lipase-and-protease-production-ability-of-multi-drug-resistant-bacteria-worsens-the-outcomes-of-wound-infections
#35
JOURNAL ARTICLE
Attaur Rahman, Saiqa Sardar, Zeeshan Niaz, Asif Khan, Sheheryar, Abdulwahed Fahad Alrefaei, Muhammad Hamayun, Sajid Ali
BACKGROUND: Surgical site infections are one of the major clinical problems in surgical departments that cost hundreds of millions of dollars to healthcare systems around the world. AIM: The study aimed to address the pressing issue of surgical site infections, which pose significant clinical and financial burdens on healthcare systems globally. Recognizing the substantial costs incurred due to these infections, the research has focused on understanding the role of lipase and protease production by multi-drug resistant bacteria isolated from surgical wounds in the development of post-surgical wound infections...
April 15, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38629356/network-pharmacology-combined-with-molecular-docking-approach-to-investigate-the-mechanism-of-chushiweiling-decoction-against-perianal-eczema
#36
JOURNAL ARTICLE
Ying Liu, Min Hao, Xinyue Fang, Yifei Qian, Yahui Wang, Shuai Yan
BACKGROUND: ChuShiWeiLing Decoction (CSWLD) is a famous classical Chinese prescription for the treatment of eczema with desirable effect in clinical practice. It has gradually exerted good curative effects on perianal eczema (PE) in recent years, but its specific mechanism is not elucidated yet. OBJECTIVE: This research explores the underlying pharmacological mechanism of CSWLD in addressing PE through network pharmacology combined with molecular docking strategy...
April 15, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38623974/preclinical-pharmacokinetics-and-pharmacology-study-of-rc98-a-programmed-cell-death-ligand-1-monoclonal-antibody-in-cynomolgus-monkeys
#37
JOURNAL ARTICLE
Ling Wang, Qiaoning Li, Chenglian Deng, Zhihao Liu, Fang Wang, Shenjun Li, Lihou Dong, Jing Jiang
INTRODUCTION: RC98 is the monoclonal antibody against Programmed Cell Death Ligand 1 (PD-L1). Relevant reports have confirmed that the influence of PD-L1 expressed by tumor cells on antitumor CD8+ T cell responses is well characterized, but the impact of PD-L1 expressed by immune cells has not been well defined. OBJECTIVE: This study aimed to design a Pharmacokinetics/Pharmacology (PK/PD) study of RC98 in normal cynomolgus monkeys to research the effect on the immune system...
April 15, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38623973/synthesis-of-rupestonic-acid-l-ephedrine-derivatives-with-preliminary-in-vitro-anti-influenza-viral-activity
#38
JOURNAL ARTICLE
Jianping Yong, Canzhong Lu
BACKGROUND: Influenza virus is a kind of RNA virus. Nowadays, the high incidence of influenza and the morbidity and mortality of epidemic influenza are substantial. It has been reported that one hundred million people in the world are infected with influenza viruses, and two hundred and fifty thousand to five hundred thousand people die from the flu per year. In 2021, the number of infected persons in China was reported to be 654,700, and 0.07% of the infected persons died. The flu has caused a serious threat to human survival...
April 15, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38623972/colorectal-cancer-stem-cell-biomarkers-biological-traits-and-prognostic-insights
#39
JOURNAL ARTICLE
Atena Soleimani, Nikoo Saeedi, Abdulridha Mohammed Al-Asady, Elnaz Nazari, Reyhane Hanaie, Majid Khazaei, Elnaz Ghorbani, Hamed Akbarzade, Mikhail Ryzhikov, Amir Avan, Seyed Mahdi Hasanian Mehr
Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions...
April 15, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38623971/evaluating-the-imperative-role-of-pre-and-post-ectd-standards-in-dossier-validation-an-inevitable-outlook
#40
EDITORIAL
Niraj S Patil, Animesh Ranjan, Raj Kumar Narang, Amandeep Singh
No abstract text is available yet for this article.
April 15, 2024: Current Pharmaceutical Design
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