Kaili Lin, Yongfeng Wang, Fangyu Liu, Taifu You, Xiongxiong Liu, Runzhang Liu, Zeyang Li, Chunyu Zhen, Yunxia Zhang, Xingguang Liu, Hui Cai
OBJECTIVE: It has been demonstrated that IDO1, a target of immune checkpoint inhibition, functions as an oncogene in the majority of human malignancies. IDO1's function in human pan-cancers hasn't been thoroughly studied, though. MATERIALS AND METHODS: The Kaplan-Meier (K-M) and COX analyses were applied to the survival analysis. Furthermore, we used Spearman's correlation analysis to examine the associations between IDO1 and microsatellite instability (MSI), DNA methyltransferases (DNMTs), tumor mutational burden (TMB), the associated genes of mismatch repair (MMR), and immune checkpoint biomarkers...
March 27, 2024: European Journal of Medical Research