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European Journal of Medical Research | Page 2

Wei Liu, Weijie Chen, Jiemin Chen, Tao Hong, Binglu Li, Qiang Qu, Xiaodong He
BACKGROUND: Neuroendocrine carcinoma (NEC) of gallbladder is a rare tumor. The clinical manifestation, treatment, and prognosis of gallbladder NEC are rarely reported. CASE PRESENTATION: Eight gallbladder NEC patients were admitted into our hospital. The major complaint was right upper quadrant pain. Two patients underwent a radical resection of gallbladder and liver quadrate lobe. One of them underwent chemotherapies and had no recurrence of NEC during a 25-month followed-up period...
February 4, 2019: European Journal of Medical Research
Hong-Mei Wang, Yu-Ye Li, Li-Ping He, Ying-Kui Cao, Tian-Xiang Dong, Yi-Qun Kuang
BACKGROUND: Early diagnosis of congenital syphilis (CS) is difficult. This study aimed to determine the serological response discipline of syphilis passive antibody (SPA) in infants born to mothers with syphilis and provide the basis for the early diagnosis of CS. METHODS: Thirty-three infants born to mothers with syphilis and six infants with CS were recruited. The toluidine red unheated serum test (TRUST) and Treponema pallidum particle agglutination (TPPA) titers were followed up after birth...
February 2, 2019: European Journal of Medical Research
Paul S Wiggenhauser, Elizabeth R Balmayor, Nicole Rotter, Jan T Schantz
BACKGROUND: Alternative techniques for nasal dorsum augmentation are of paramount importance in reconstructive and plastic surgery. In contrast to autologous cartilage grafts, tissue-engineered grafts can be created de novo and yield low-none donor site morbidity as compared to autologous grafts like rib or ear cartilage. To address this demand, this study investigated the in vivo regenerative potential of polycaprolactone-based implants as an alternative to autologous cartilage grafting during rhinoplasty...
January 28, 2019: European Journal of Medical Research
Manuela Malsy, Diane Bitzinger, Bernhard Graf, Anika Bundscherer
BACKGROUND: Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled cellular growth. Thus, the current aim of cancer research is to increase the apoptosis rate in tumor cells-while limiting the concurrent death of healthy cells-and to induce controlled apoptosis in abnormal cells. Staurosporine is a very potent inducer of apoptosis because it inhibits many different kinases...
January 28, 2019: European Journal of Medical Research
Johannes Gleich, Daniel Pfeufer, Christian Zeckey, Wolfgang Böcker, Markus Gosch, Christian Kammerlander, Carl Neuerburg
BACKGROUND: Multimorbidity and polypharmacy are common challenges in the treatment of older trauma patients. Therefore, various integrated care models were developed over the last few years, merging the expertise of geriatricians and trauma surgeons. The aim of this study was to evaluate, if the number of prescriptions of potentially inappropriate medication (PIM) could be reduced in these patients by an interdisciplinary co-managed concept compared to conventional trauma care. METHODS: We conducted a retrospective, dual-center cohort study, including all patients aged 70 years and older admitted with a fracture of the hip or the proximal humerus within the study period...
January 22, 2019: European Journal of Medical Research
Ozgur Erdogan, Volkan Gurkan
BACKGROUND: OO (osteoid osteoma) is a common, osteoblastic, benign bone tumor but rarely seen in the hand region. There is still some debate about the diagnosis and treatment of hand OOs. In the present study, we aimed to evaluate the epidemiology, radiologic features, surgical treatment options and functional outcomes. METHODS: Between January 2003 and December 2014, surgically treated and pathologically verified 9 hand OO cases were investigated retrospectively...
January 21, 2019: European Journal of Medical Research
G Siebenbürger, B Grabein, T Schenck, C Kammerlander, W Böcker, C Zeckey
BACKGROUND: Multi-drug-resistant bacteria (e.g. Carbapenem-resistant Acinetobacter baumannii, extended-spectrum betalactamase or carbapenemase-producing enterobacteriaceae) are emerging in early-onset infections. So far, there is no report describing the eradication of these bacteria in a osseous infection of an open proximal tibial fracture in combination with the hexapod technology to address both osseous consolidation and closed drop foot correction. CASE PRESENTATION: After sustaining a proximal tibial fracture (Gustilo 3B), a 41-year-old man was primarily treated with open reduction and internal fixation by a locking plate and split-thickness skin graft in the home country...
January 19, 2019: European Journal of Medical Research
Lars Michel, Tienush Rassaf
Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer survivors currently live in the USA. The number of cancer survivors is expected to increase by 68% until 2040. Moreover, the portion of cancer survivors at the age of 65 years or older will increase from 62% to approximately 73% in 2040 which in turn enhances comorbidities in cancer survivors...
January 3, 2019: European Journal of Medical Research
Mayumi Tsuji, Chihaya Koriyama, Yasuhiro Ishihara, Christoph F A Vogel, Toshihiro Kawamoto
BACKGROUND: Recent studies have reported that endocrine-disrupting compound (EDC) exposure is related to food sensitization. Bisphenol A diglycidyl ether (BADGE) is one of the most widespread EDCs and its biological effects are considered to be greater on children than on adults. This study investigated the relationship between serum BADGE-specific immunoglobulin G (IgG) concentrations and food sensitization in young children by measuring food-specific IgE levels. METHODS: In total, 98 young children (59 boys and 39 girls; median age: 7 months; 25th and 75th percentile ages: 6 and 8 months, respectively) were enrolled...
December 26, 2018: European Journal of Medical Research
Michael K Cerny, Ursula Hopfner, Manuela Kirsch, Elisabeth-Maria Haas, Fan Wu, Riccardo Giunta, Hans-Guenther Machens, Dominik Duscher, Holger Erne, Arndt F Schilling
BACKGROUND: Fingertip injuries treated with occlusive dressings (ODs) lead to nearly scar-free, functionally, and aesthetically pleasing results. We hypothesized that paracrine factors in the wound fluid (secretome) may influence migration and proliferation of mesenchymal stem cells (MSCs) and fibroblasts and modulate the wound-healing process. METHODS: We could collect wound fluid samples from 4 fingertip injuries and 7 split skin donor sites at the 5th day during dressing change...
December 26, 2018: European Journal of Medical Research
Joel Aissa, Edwin Bölke, Lino M Sawicki, Elisabeth Appel, Christoph Thomas, Philipp Heusch, Martin Sedlmair, Karl Krzymyk, Patric Kröpil, Gerald Antoch, Johannes Boos
BACKGROUND: To evaluate the detection rate and image quality in CT-body-packer-screening at different radiation-dose levels and to determine a dose threshold that enables a reliable detection of incorporated body packs and incidental findings with a maximum of dose saving. MATERIALS AND METHODS: We retrospectively included 27 individuals who underwent an abdominal CT with automated exposure control due to suspected body packing. CT images were reconstructed at different radiation-dose levels of 50%, 10, 5% and 1% using iterative reconstructions...
December 7, 2018: European Journal of Medical Research
Joel M Mor, Mario Matthaei, Holger Schrumpf, Konrad R Koch, Edwin Bölke, Ludwig M Heindl
PURPOSE: External dacryocystorhinostomy (DCR) is considered as the gold standard in the treatment of acquired nasolacrimal duct obstruction. However, many advances have been made towards the development of modern minimally invasive therapies. These new techniques were proven less harmful to the patients' skin and medial palpebral structures with their palpebral-canalicular pump mechanism. Options include endonasal and transcanalicular procedures. Here, we report on our 2-year experience with the surgical technique, results and complications of transcanalicular laser-assisted DCR...
November 16, 2018: European Journal of Medical Research
Hua Qu, Yan-Yan Meng, Hua Chai, Fang Liang, Jia-Yi Zhang, Zhu-Ye Gao, Da-Zhuo Shi
BACKGROUND: The effect of statin treatment on circulating coenzyme Q10 (CoQ10) has been studied in numerous randomized controlled trails (RCTs). However, whether statin treatment decreases circulating CoQ10 is still controversial. METHODS: PubMed, EMBASE, and the Cochrane Library were searched to identify RCTs to investigate the effect of statin treatment on circulating CoQ10. We calculated the pooled standard mean difference (SMD) using a fixed effect model or random effect model to assess the effect of statin treatment on circulating CoQ10...
November 10, 2018: European Journal of Medical Research
D Patschan, N Sugiarto, E Henze, R Mößner, J Mohr, G A Müller, S Patschan
BACKGROUND: Both psoriasis (Ps) and psoriasis arthritis (PsA) have been associated with increased cardiovascular risk. Also, both are characterized by increased neovascularization. Endothelial progenitor cells (EPCs) have been implicated in promoting vascular repair in ischemic diseases. The aim of the study was to correlate the EPC system with CV risk factors and with parameters of vascular stiffness in Ps and PsA. METHODS: Twenty-six healthy subjects, 30 patients with Ps, and 31 patients PsA were included in the study...
November 9, 2018: European Journal of Medical Research
Yuejin Li, Le Xiao, Jinyuan Li, Ping Sun, Lei Shang, Jian Zhang, Quan Zhao, Yiming Ouyang, Linhai Li, Kunmei Gong
OBJECTIVE: The incidence of diabetic atherosclerosis (DA) is increasing worldwide. The study aim was to identify differentially expressed microRNAs (DE-miRs) potentially associated with the initiation and/or progression of DA, thereby yielding new insights into this disease. METHODS: Matched iliac artery tissue samples were isolated from 6 male rats with or without DA. The Affymetrix GeneChip microRNA 4.0 Array was used to detect miRs. Differential expression between atherosclerotic group and non-atherosclerotic group samples was analyzed using the Gene-Cloud of Biotechnology Information platform...
November 3, 2018: European Journal of Medical Research
Henryk Skarżyński, Elżbieta Gos, Danuta Raj-Koziak, Piotr H Skarżyński
BACKGROUND: Many tinnitus scales are available, but all of them have certain limitations. The aim of the current study was to present a psychometric data of a new brief and reliable questionnaire that could be conveniently used for evaluating tinnitus complaint in adults (either with normal or impaired hearing)-Skarzynski Tinnitus Scale (STS). METHODS: The study included 125 participants with at least 1 month of tinnitus duration. All participants were asked to complete the STS, Tinnitus and Hearing Survey (THS), Tinnitus Functional Index (TFI), Tinnitus Handicap Inventory (THI), and Beck Depression Inventory...
November 1, 2018: European Journal of Medical Research
G C Weber, P Firouzi, A M Baran, E Bölke, H Schrumpf, B A Buhren, B Homey, P A Gerber
BACKGROUND: Currently available treatment options for onychomycosis such as topical and systemic antifungals are often of limited efficacy, difficult to administer or associated with relevant side effects. Non-ablative laser therapy is proposed to represent a safe alternative without the disadvantages of drugs. Yet, to date, the efficacy of laser therapy for onychomycosis is discussed controversially. Against this background, we performed a systematic retrospective analysis of our clinical experience of 4 years of onychomycosis treatment applying a long-pulsed 1...
October 24, 2018: European Journal of Medical Research
Ivan Delgado-Enciso, Juan Paz-Garcia, Jose Valtierra-Alvarez, Jorge Preciado-Ramirez, Roman Almeida-Trinidad, Jose Guzman-Esquivel, Martha A Mendoza-Hernandez, Alberto Garcia-Vega, Alejandro D Soriano-Hernandez, Jose L Cortes-Bazan, Hector R Galvan-Salazar, Ariana Cabrera-Licona, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Josuel Delgado-Enciso, Brenda Paz-Michel
BACKGROUND: A promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate the efficacy and safety of BIOF2 for intra-articular application in patients with severe osteoarthritis of the knee. METHODS: A prospective, randomized, 3-arm, parallel group clinical trial was conducted. It included 24 patients with severe osteoarthritis of the knee (WOMAC score 65...
October 24, 2018: European Journal of Medical Research
Stefan Reers, Georg Karanatsios, Matthias Borowski, Michael Kellner, Michael Reppel, Johannes Waltenberger
BACKGROUND: To assess the frequency of left atrium/left atrial appendage (LA/LAA) thrombus under treatment with non-vitamin K oral anticoagulants (NOACs) in comparison with vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation (AF). METHODS: PubMed, Web of Science™, EMBASE and the Cochrane Library databases were searched for studies comparing NOACs with VKAs in AF patients who underwent diagnostic transoesophageal echocardiography (TEE)...
October 23, 2018: European Journal of Medical Research
Azin Jafari, Hanno Matthaei, Vittorio Branchi, Edwin Bölke, Rene H Tolba, Jörg C Kalff, Steffen Manekeller
BACKGROUND: The ever growing demand for liver transplantation inevitably necessitates an expansion of the donor pool. Utilization of "shock organs" is considered suboptimal to date while the associated outcome has hardly been investigated. MATERIALS AND METHODS: Male Wistar rats underwent a period of 30 min of hypovolemic shock. After 24 h livers were explanted and prior to reperfusion underwent either 18 h of cold storage (CS; N = 6) or 17 h of CS followed by 60 min venous systemic oxygen persufflation (VSOP; N = 6)...
October 23, 2018: European Journal of Medical Research
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