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Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association

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https://read.qxmd.com/read/30720004/cox-2-c-met-kras-status-based-prognostic-nomogram-for-colorectal-cancer-a-multicenter-cohort-study
#1
Jianhua Liu, Chengzhi Huang, Junjiang Wang, Ling Huang, Shaojie Chen
Background/Aim: To construct quantitative prognostic models for colorectal cancer (CRC) based on COX-2/C-MET/KRAS expression status in clinical practice. Patients and Methods: Clinical factors and COX-2/C-MET/KRAS expression status of 578 eligible patients from two Chinese hospitals were included. The patients were randomly allocated into training and validation datasets. We created several models using Cox proportional hazard models: SignatureC contained clinical factors, SignatureG contained COX-2/C-MET/KRAS expression status, and SignatureCG contained both...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30720003/the-regulatory-roles-of-long-noncoding-rnas-in-the-biological-behavior-of-pancreatic-cancer
#2
REVIEW
Ying Li, Xiaojuan Yang, Xiaoning Kang, Shanglong Liu
Long noncoding RNAs (lncRNAs) are a new class of regulators. LncRNAs are defined as endogenous transcribed RNA molecules with transcript length of >200 nt. Accumulating evidence has shown that lncRNAs are involved in many physiological processes such as cell cycle regulation, cell apoptosis and survival, cancer migration and metabolism. However, the biological and molecular mechanisms of lncRNAs in pancreatic cancer are still unclear. Recent studies have reported that many lncRNAs are dysregulated in pancreatic cancer and closely associated with tumorigenesis, diagnosis and prognosis...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30720002/greater-prevalence-of-comorbidities-with-increasing-age-cross-sectional-analysis-of-chronic-hepatitis-b-patients-in-saudi-arabia
#3
Faisal M Sanai, Hamdan Alghamdi, Khalid A Alswat, Mohammed A Babatin, Mona H Ismail, Waleed K Alhamoudi, Abduljaleel M Alalwan, Yaser Dahlan, Abdullah S Alghamdi, Faleh Z Alfaleh, Abdulrahman A Aljumah, Ibrahim H Altraif, Khalid Albeladi, Faisal Batwa, Waleed Alshumrani, Drifa Belhadi, Victor Genestier, Ayman A Abdo
Background/Aims: Middle Eastern countries, including Saudi Arabia to some extent, are endemic for chronic hepatitis B (CHB) infection which could be associated with high mortality and comorbidities risk. However, limited data characterizing this CHB population exists. Our aim was to characterize and compare CHB patients in 2015 with those in 2010 and 2012 in Saudi Arabia. Patients and Methods: We conducted and compared three cross-sectional analyses of adult patients with CHB defined as either positive hepatitis B surface antigen or documented CHB history in 2010, 2012, and 2015...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30720001/comparison-of-long-term-efficacy-between-endoscopic-and-percutaneous-biliary-drainage-for-resectable-extrahepatic-cholangiocarcinoma-with-biliary-obstruction-a-systematic-review-and-meta-analysis
#4
Lei Wang, Nanping Lin, Fuli Xin, Yongyi Zeng, Jingfeng Liu
Background/Aim: For resectable extrahepatic cholangiocarcinoma with biliary obstruction, it remains a controversy whether to choose percutaneous transhepatic biliary drainage (PTBD) or endoscopic biliary drainage (EBD). A systematic review was conducted to compare the long-term efficacy between the two techniques. Materials and Methods: Eligible studies were searched from January 1990 to May 2018, comparing the long-term efficacy between EBD and PTBD for extrahepatic cholangiocarcinoma...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30720000/hepatitis-b-care-pathway-in-saudi-arabia-current-situation-gaps-and-actions
#5
REVIEW
Abdulrahman A Aljumah, Mohamed Babatin, Almoataz Hashim, Faisal Abaalkhail, Nathalie Bassil, Mohamed Safwat, Faisal M Sanai
Hepatitis B virus (HBV) infection remains a public health problem worldwide. In this review, we aim to assess the current situation of the HBV care pathway in the Kingdom of Saudi Arabia (KSA), identify gaps/barriers therein, and recommend initiatives to be taken to improve the management of such patients. Towards this end, a literature search was conducted in PubMed and free Internet searches. Interviews with individuals and focus group discussions were held with HBV experts in KSA. Although significant improvements have been made in the past 30 years in KSA in terms of the decline in prevalence (currently estimated to be around 1...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30719999/development-and-validation-of-a-nomogram-to-individually-predict-survival-of-young-patients-with-nonmetastatic-gastric-cancer-a-retrospective-cohort-study
#6
Chaorui Wu, Nianchang Wang, Hong Zhou, Tongbo Wang, Dongbing Zhao
Background/Aims: Evidence regarding gastric cancer (GC) patients <40 years old is limited. The aim of the study was to identify risk factors affecting overall survival (OS) of young patients with nonmetastatic GC and to establish a nomogram for prognostic prediction using data from the Surveillance, Epidemiology and End Results (SEER) database. Furthermore, this study sought to externally validate this nomogram in an independent patient cohort. Patients and Methods: In this retrospective cohort study, the records of patients aged <40 years with nonmetastatic GC (n = 559), from the SEER database, between 2006 and 2015, were examined...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30719998/circular-rna-arhgap26-is-over-expressed-and-its-downregulation-inhibits-cell-proliferation-and-promotes-cell-apoptosis-in-gastric-cancer-cells
#7
L V Wangxia, Yang Fang, Yongjun Liu, Yazhen Zhao, Zhong Shi, Haijun Zhong
Background/Aims: This study aimed to explore the effect of circular RNA ARHGAP26 (circ-ARHGAP26) on cell proliferation and apoptosis in gastric cancer (GC) cell lines. Materials and Methods: Human GC cell lines including HGC-27, AGS, SGC-7901, BGC-823, NCI-N87 and human normal gastric mucosal cells GSE-1 were cultured. The circ-ARHGAP26 expression was determined by quantitative polymerase chain reaction assay. Blank inhibitor and circ-ARHGAP26 inhibitor plasmids were transfected into HGC-27 or AGS cells as NC (-) and circ-ARHGAP26(-) groups...
February 1, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30665995/colorectal-cancer-screening-in-middle-eastern-countries-current-status-and-future-strategies-to-enhance-screening
#8
EDITORIAL
Martin C S Wong, Francis K L Chan
No abstract text is available yet for this article.
January 21, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30638188/one-more-reason-to-avoid-purgatives-before-capsule-endoscopy-examinations-hypokalemia-and-low-completion-rates
#9
LETTER
Elena Macias, Alfonso Elosua, Ignacio Fernández-Urién
No abstract text is available yet for this article.
January 14, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30638187/bone-mineral-density-loss-in-patients-with-cirrhosis
#10
LETTER
Mahmood Dhahir Al-Mendalawi
No abstract text is available yet for this article.
January 14, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30632484/endoscopic-ultrasound-guided-pancreatic-duct-drainage
#11
REVIEW
Yousuke Nakai, Hirofumi Kogure, Hiroyuki Isayama, Kazuhiko Koike
Endoscopic transpapillary or transanastomotic pancreatic duct drainage (PD) is the mainstay of drainage in symptomatic pancreatic duct obstruction or leakage. However, transpapillary or transanastomotic PD can be technically difficult due to the tight stricture or surgically altered anatomy (SAA), and endoscopic ultrasound (EUS)-guided PD (EUS-PD) is now increasingly used as an alternative technique. There are two approaches in EUS-PD: EUS-guided rendezvous (EUS-RV) and EUS-guided transmural drainage (EUS-TMD)...
January 10, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30618441/the-gap-between-knowledge-and-undergoing-colorectal-cancer-screening-using-the-health-belief-model-a-national-survey
#12
Majid A Almadi, Faisal Alghamdi
Background/Aims: Colorectal cancer (CRC) is a public health issue, and before the initiation of a national cancer screening program, there is a need to examine the acceptance of the public to undergo CRC screening and explore potential barriers. Materials and Methods: A nationwide survey was conducted using an electronic platform to collect demographic variables and using the Health Belief Model to assess attitudes and behavior of participants as well as the knowledge about and intent to undergo CRC screening...
January 4, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30618440/comparison-between-laparoscopic-and-endoscopic-resections-for-gastric-submucosal-tumors
#13
Huaying Zhang, Xinyu Huang, Chao Qu, Cheng Bian, Huiguang Xue
Background/Aims: Open resection/laparoscopic resection (LR) is the traditional treatment of gastric submucosal tumor (G-SMT). The endoscopic resection (ER) technology provides good results for G-SMT treatment but lacks sufficient evidence-based evidence. This retrospective study aimed to compare the clinical efficacy of ER [endoscopic submucosal dissection (ESD), endoscopic submucosal excavation (ESE), and endoscopic full-thickness resection (EFR)] and LR [laparoscopic wedge resection (LWR) and laparoscopic subtotal gastrectomy (LSG)] for G-SMT...
January 4, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30618439/recovery-of-cognitive-function-after-sedation-with-propofol-for-outpatient-gastrointestinal-endoscopy
#14
Sanath Allampati, Sijin Wen, Feiyu Liu, Justin T Kupec
Background/Aim: Most endoscopies performed in the United States utilize sedation. Anesthesia provides patient comfort and improved procedural quality but adds to the complexity of scheduling routine outpatient procedures. We aimed to assess the return of cognitive function after propofol administration in patients undergoing outpatient endoscopies. Patients and Methods: Cognitive recovery for patients undergoing endoscopy under monitored anesthesia care was evaluated using EncephalApp...
January 4, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30618438/-helicobacter-pylori-dna-promotes-cellular-proliferation-migration-and-invasion-of-gastric-cancer-by-activating-toll-like-receptor-9
#15
Xiang-Rong Qin, Jia Wu, Xin-Yu Yao, Jin Huang, Xiao-Yong Wang
Background/Aim: Helicobacter pylori (H. pylori) infection is a well-known risk factor for gastric cancer. Toll-like receptor 9 (TLR9) plays an important role in many cancers and is important for immunity to H. pylori infection. Thus, the present study aimed to evaluate the influence of H. pylori on TLR9 and explore its roles in gastric cancer. Materials and Methods: TLR9 expression in MKN45 cells, which were cocultured with or without H. pylori or H. pylori DNA, was detected using quantitative reverse transcription-polymerase chain reaction and Western blot assays...
January 4, 2019: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30588954/use-of-image-enhanced-endoscopy-in-the-characterization-of-colorectal-polyps-still-some-ways-to-go
#16
Othman R Alharbi, Nouf S Alballa, Areej S AlRajeh, Lulwah S Alturki, Ibrahim M Alfuraih, Mouhab R Jamalaldeen, Majid A Almadi
Background/Aim: Instrument-based image-enhanced endoscopy (IEE) is of benefit in detecting and characterizing lesions during colonoscopy. We aimed to study the ability of community-based gastroenterologists to differentiate between neoplastic and non-neoplastic lesions using IEE modalities and to identify predictors of correct classification and the confidence of the optical diagnosis made. Materials and Methods: An electronic survey was sent to practicing gastroenterologists using electronic tablets during a gastroenterology meeting...
December 27, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30588953/inflammation-and-pancreatic-cancer-an-updated-review
#17
REVIEW
Kamleshsingh Shadhu, Chunhua Xi
Pancreatic cancer is a devastating disease with poor prognosis in the modern era. Inflammatory processes have emerged as key mediators of pancreatic cancer development and progression. Recently, studies have been carried out to investigate the underlying mechanisms that contribute to tumorigenesis induced by inflammation. In this review, the role of inflammation in the initiation and progression of pancreatic cancer is discussed.
December 27, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30588952/presence-of-pink-color-sign-within-1-min-after-iodine-staining-has-high-diagnostic-accordance-rate-for-esophageal-high-grade-intraepithelial-neoplasia-invasive-cancer
#18
Jia-Yao Zheng, Ya-Hua Chen, Yang-Yang Chen, Xiao-Ling Zheng, Shi-Shun Zhong, Wan-Yin Deng, Jin-Hui Zheng, Xian-Bin Guo, Li-Ying Gao, Wei Liang
Background/Aim: The dramatic color change after iodine staining (from white-yellow to pink after 2-3 min), designated as the "pink-color sign" (PCS), is indicative of esophageal high-grade intraepithelial neoplasia (HGIN) or an invasive lesion. However, no study has yet examined the association between the time of PCS appearance and histopathology. We investigated the association between the time of PCS appearance and esophageal histopathology in 456 lesions of 438 patients who were examined for suspected esophageal cancer...
December 27, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30588951/high-hoxd4-protein-expression-in-gastric-adenocarcinoma-tissues-indicates-unfavorable-clinical-outcomes
#19
Hui Liu, Hequn Tian, Jing Zhao, Yong Jia
Background/Aim: Homeobox D4 (HOXD4) belongs to the homeobox (HOX) family, which plays a crucial role in the early embryo development and cell differentiation. The role of HOXD4 in human gastric adenocarcinoma has not been elucidated. In the present study, we aimed to examine the expression levels of HOXD4 and dissect whether the HOXD4 expression is associated with aggressive clinicopathological outcomes of patients with gastric adenocarcinoma. Patients and Methods: Clinicopathological analyses were performed in 127 patients with gastric adenocarcinoma...
December 27, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/30479322/association-between-hypokalemia-and-small-bowel-capsule-endoscopy-completion-rates-in-patients-in-south-china-a-prospective-single-center-study
#20
Huo-Ye Gan, Tie-Li Peng, Kai-Hua Su, Lin-Li Zhao, Li-Qin Jian, Rong-Jiao Yang, Han-Xian Zhang, Ru-Yin Pan
Background/Aims: Approximately 20-30% of small bowel capsule endoscopies (SBCEs) do not reach the cecum at the completion of the examination. We aimed to determine whether hypokalemia influences the completion rate and small bowel transit time (SBTT) of SBCE. Patients and Methods: From January to December 2017, 112 patients (18-75 years old) who underwent SBCE were assessed consecutively for enrolment in our study. On the day of the procedure, a blood test was performed prior to capsule ingestion...
November 27, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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