journal
https://read.qxmd.com/read/34933341/an-introduction-to-the-callithrix-genus-and-overview-of-recent-advances-in-marmoset-research
#21
JOURNAL ARTICLE
Joanna Malukiewicz, Vanner Boere, Maria Adélia Borstelmann de Oliveira, Mirela D'arc, Jéssica V A Ferreira, Jeffrey French, Genevieve Housman, Claudia Igayara de Souza, Leandro Jerusalinsky, Fabiano R de Melo, Mônica M Valença-Montenegro, Silvia Bahadian Moreira, Ita de Oliveira E Silva, Felipe Santos Pacheco, Jeffrey Rogers, Alcides Pissinatti, Ricardo C H Del Rosario, Corinna Ross, Carlos R Ruiz-Miranda, Luiz C M Pereira, Nicola Schiel, Fernanda de Fátima Rodrigues da Silva, Antonio Souto, Vedrana Šlipogor, Suzette Tardif
We provide here a current overview of marmoset (Callithrix) evolution, hybridization, species biology, basic/biomedical research, and conservation initiatives. Composed of 2 subgroups, the aurita group (C aurita and C flaviceps) and the jacchus group (C geoffroyi, C jacchus, C kuhlii, and C penicillata), this relatively young primate radiation is endemic to the Brazilian Cerrado, Caatinga, and Atlantic Forest biomes. Significant impacts on Callithrix within these biomes resulting from anthropogenic activity include (1) population declines, particularly for the aurita group; (2) widespread geographic displacement, biological invasions, and range expansions of C jacchus and C penicillata; (3) anthropogenic hybridization; and (4) epizootic Yellow Fever and Zika viral outbreaks...
December 22, 2021: ILAR Journal
https://read.qxmd.com/read/34864994/livestock-and-risk-group-4-pathogens-researching-zoonotic-threats-to-public-health-and-agriculture-in-maximum-containment
#22
JOURNAL ARTICLE
Charles E Lewis, Bradley Pickering
Maximum-containment laboratories are a unique and essential component of the bioeconomy of the United States. These facilities play a critical role in the national infrastructure, supporting research on a select set of especially dangerous pathogens, as well as novel, emerging diseases. Understanding the ecology, biology, and pathology at the human-animal interface of zoonotic spillover events is fundamental to efficient control and elimination of disease. The use of animals as human surrogate models or as target-host models in research is an integral part of unraveling the interrelated components involved in these dynamic systems...
December 3, 2021: ILAR Journal
https://read.qxmd.com/read/34428796/outside-the-box-working-with-wildlife-in-biocontainment
#23
JOURNAL ARTICLE
Elizabeth A Falendysz, Dana M Calhoun, Carrie A Smith, Jonathan M Sleeman
Research with captive wildlife in Animal Biosafety Level 2 (ABSL2) and 3 (ABSL3) facilities is becoming increasingly necessary as emerging and re-emerging diseases involving wildlife have increasing impacts on human, animal, and environmental health. Utilizing wildlife species in a research facility often requires outside the box thinking with specialized knowledge, practices, facilities, and equipment. The USGS National Wildlife Health Center (NWHC) houses an ABSL3 facility dedicated to understanding wildlife diseases and developing tools to mitigate their impacts on animal and human health...
August 23, 2021: ILAR Journal
https://read.qxmd.com/read/34370840/neuroethics-and-animals-report-and-recommendations-from-the-university-of-pennsylvania-animal-research-neuroethics-workshop
#24
JOURNAL ARTICLE
Adam J Shriver, Tyler M John
Growing awareness of the ethical implications of neuroscience in the early years of the 21st century led to the emergence of the new academic field of "neuroethics," which studies the ethical implications of developments in the neurosciences. However, despite the acceleration and evolution of neuroscience research on nonhuman animals, the unique ethical issues connected with neuroscience research involving nonhuman animals remain underdiscussed. This is a significant oversight given the central place of animal models in neuroscience...
August 9, 2021: ILAR Journal
https://read.qxmd.com/read/34352091/the-symbiotic-relationship-between-scientific-quality-and-animal-research-ethics
#25
JOURNAL ARTICLE
Samuel A Brill, Selena M Guerrero-Martin, Kelly A Metcalf Pate
Researchers have worked with animals as models for decades to expand our knowledge of basic biological processes and to systematically study the physiology of disease. In general, the public has an expectation that work with animals has a purpose and will ultimately reap benefits. The likelihood of such an outcome is directly dependent on the quality of the science being conducted with those animals. However, not all frameworks for consideration of the ethics around animal research overtly consider scientific quality...
August 5, 2021: ILAR Journal
https://read.qxmd.com/read/34181728/a-brief-history-of-use-of-animals-in-biomedical-research-and-perspective-on-non-animal-alternatives
#26
JOURNAL ARTICLE
Lewis B Kinter, Ron DeHaven, David K Johnson, Joseph J DeGeorge
Animals have been closely observed by humans for at least 17 000 years to gain critical knowledge for human and later animal survival. Routine scientific observations of animals as human surrogates began in the late 19th century driven by increases in new compounds resulting from synthetic chemistry and requiring characterization for potential therapeutic utility and safety. Statistics collected by the United States Department of Agriculture's Animal and Plant Health Inspection Service and United Kingdom Home Office show that animal usage in biomedical research and teaching activities peaked after the mid-20th century and thereafter fell precipitously until the early 21st century, when annual increases (in the UK) were again observed, this time driven by expansion of genetically modified animal technologies...
June 25, 2021: ILAR Journal
https://read.qxmd.com/read/34161585/the-evaluation-of-the-containment-efficacy-of-semi-rigid-isolators-for-housing-cages-of-laboratory-animals-infected-with-bsl-3-agents
#27
JOURNAL ARTICLE
Louis DeTolla, David K Johnson, Scott D Reynolds, Rigoberto Sanchez, Robert H Weichbrod, Matthew C Terzi
Research animals models infected with Biosafety Level-3 (BSL-3) agents need to be housed in specialized biocontainment caging. Most of these specialized cages have input and exhaust that is high efficiency particulate air filtered and sealed to prevent escape of the BSL-3 agent. An alternative to the use of the above BSL-3 biocontainment caging is the use of a flexible film or modified semi-rigid plastic film isolator that has its own high efficiency particulate air-filtered input and exhaust and is sealed with respect to the animal room environment, thus preventing BSL-3 agent escape...
June 23, 2021: ILAR Journal
https://read.qxmd.com/read/34157067/type-i-hypersensitivity-in-ferrets-following-exposure-to-sars-cov-2-inoculum-lessons-learned
#28
JOURNAL ARTICLE
Daniel Layton, Kathie Burkett, Glenn A Marsh, Nagendrakumar B Singanallur, Jennifer Barr, Rachel Layton, Sarah-Jane Riddell, Sheree Brown, Lee Trinidad, Gough G Au, Alexander J McAuley, Suzanne Lowther, James Watson, Seshadri S Vasan
This case report discusses Type I hypersensitivity in ferrets following exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculum, observed during a study investigating the efficacy of candidate COVID-19 vaccines. Following a comprehensive internal root-cause investigation, it was hypothesized that prior prime-boost immunization of ferrets with a commercial canine C3 vaccine to protect against the canine distemper virus had resulted in primary immune response to fetal bovine serum (FBS) in the C3 preparation...
June 23, 2021: ILAR Journal
https://read.qxmd.com/read/34129672/research-relevant-conditions-and-pathology-in-nonhuman-primates
#29
JOURNAL ARTICLE
Chandra Saravanan, Thierry Flandre, Carolyn L Hodo, Anne D Lewis, Lars Mecklenburg, Annette Romeike, Oliver C Turner, Hsi-Yu Yen
Biomedical research involving animal models continues to provide important insights into disease pathogenesis and treatment of diseases that impact human health. In particular, nonhuman primates (NHPs) have been used extensively in translational research due to their phylogenetic proximity to humans and similarities to disease pathogenesis and treatment responses as assessed in clinical trials. Microscopic changes in tissues remain a significant endpoint in studies involving these models. Spontaneous, expected (ie, incidental or background) histopathologic changes are commonly encountered and influenced by species, genetic variations, age, and geographical origin of animals, including exposure to infectious or parasitic agents...
June 15, 2021: ILAR Journal
https://read.qxmd.com/read/34097730/biomonitoring-and-digital-data-technology-as-an-opportunity-for-enhancing-animal-study-translation
#30
JOURNAL ARTICLE
Erwin B Defensor, Maria A Lim, Laura R Schaevitz
The failure of animal studies to translate to effective clinical therapeutics has driven efforts to identify underlying cause and develop solutions that improve the reproducibility and translatability of preclinical research. Common issues revolve around study design, analysis, and reporting as well as standardization between preclinical and clinical endpoints. To address these needs, recent advancements in digital technology, including biomonitoring of digital biomarkers, development of software systems and database technologies, as well as application of artificial intelligence to preclinical datasets can be used to increase the translational relevance of preclinical animal research...
June 7, 2021: ILAR Journal
https://read.qxmd.com/read/34003261/challenges-and-solutions-with-agricultural-animal-high-containment-waste-disposal
#31
JOURNAL ARTICLE
John R Henneman, Julie A Johnson, Mark A Minihan
Waste disposal in Agricultural Animal High Containment Animal Biosafety Level 3Ag and Animal Biosafety Level 4Ag (ABSL-3Ag and ABSL-4Ag) research facilities necessitates significantly more attention to detail in operations than that required in lower-containment-level laboratories. The unique features and requirements of agricultural-related research involve additional equipment and systems to safely transfer decontaminated waste out of the facility. The waste stream coming from ABSL-3Ag and ABSL-4Ag facilities, or high containment agricultural research waste, consists of many forms and differs from most research facility waste in that it is produced from research with livestock or other species loose housed, with the animal room serving as primary containment...
May 17, 2021: ILAR Journal
https://read.qxmd.com/read/33989417/clinical-management-of-gastrointestinal-disease-in-the-common-marmoset-callithrix-jacchus
#32
JOURNAL ARTICLE
Casey Fitz, Anna Goodroe, Lauren Wierenga, Andres Mejia, Heather Simmons
Gastrointestinal disease is a frequently encountered problem among captive common marmoset (Callithrix jacchus) colonies. Management can be challenging due to the number of etiologies responsible for gastrointestinal disease in this species, limitations on diagnostic capabilities, and lack of effective treatments. Understanding commonly described GI diseases in the captive marmoset can provide insight on the impact these diseases have on research studies and aid in the development of appropriate management strategies...
May 15, 2021: ILAR Journal
https://read.qxmd.com/read/33969870/marmoset-metabolism-nutrition-and-obesity
#33
JOURNAL ARTICLE
Corinna N Ross, Ricki Colman, Michael Power, Suzette Tardif
The use of marmosets as nonhuman primate models of human disease has undergone rapid expansion in the United States in the last decade, with an emphasis in the field of neuroscience. With this expanding need, there has been an increase in the formation of small marmoset colonies. The standardization in care and husbandry techniques for marmosets has historically lagged behind other established nonhuman primate models, resulting in a great deal of variation in practices between colonies. There remains a lack of consensus and evidence-based recommendations regarding best standards for nutrition, enrichment, weight management, and diagnostics for clinical metabolic disease...
May 10, 2021: ILAR Journal
https://read.qxmd.com/read/33951727/the-ferret-as-a-model-for-filovirus-pathogenesis-and-countermeasure-evaluation
#34
JOURNAL ARTICLE
Zachary Schiffman, Guodong Liu, Wenguang Cao, Wenjun Zhu, Karla Emeterio, Xiangguo Qiu, Logan Banadyga
The domestic ferret (Mustela putorius furo) has long been a popular animal model for evaluating viral pathogenesis and transmission as well as the efficacy of candidate countermeasures. Without question, the ferret has been most widely implemented for modeling respiratory viruses, particularly influenza viruses; however, in recent years, it has gained attention as a novel animal model for characterizing filovirus infections. Although ferrets appear resistant to infection and disease caused by Marburg and Ravn viruses, they are highly susceptible to lethal disease caused by Ebola, Sudan, Bundibugyo, and Reston viruses...
May 5, 2021: ILAR Journal
https://read.qxmd.com/read/33914873/animal-models-of-covid-19-ii-comparative-immunology
#35
JOURNAL ARTICLE
Rebecca T Veenhuis, Caroline J Zeiss
Developing strong animal models is essential for furthering our understanding of how the immune system functions in response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. The alarming speed at which SARS-CoV-2 has spread, and the high mortality rate of severe Coronavirus Disease 2019 (COVID-19), has required both basic science and clinical research to move at an unprecedented pace. Models previously developed to study the immune response against SARS-CoV have been rapidly deployed to now study SARS-CoV-2...
April 29, 2021: ILAR Journal
https://read.qxmd.com/read/33871642/high-containment-agriculture-animal-research-an-aaalac-international-perspective
#36
JOURNAL ARTICLE
Susan B Harper, Kathryn Bayne, Kenneth E Anderson
Institutions that conduct high-containment agricultural research involving domestic livestock represent a specialized category of programs that are accredited by AAALAC International. The accreditation process includes a comprehensive assessment of the overall program of animal care and use. However, the complex design of these facilities and the unique care required for animals in this type of environment often mean that additional attention will be directed at areas regarded as higher risk when the programs are evaluated...
April 19, 2021: ILAR Journal
https://read.qxmd.com/read/33836527/animal-models-of-covid-19-i-comparative-virology-and-disease-pathogenesis
#37
JOURNAL ARTICLE
Caroline J Zeiss, Susan Compton, Rebecca Terilli Veenhuis
The Coronavirus Disease 2019 (COVID-19) pandemic has fueled unprecedented development of animal models to understand disease pathogenesis, test therapeutics, and support vaccine development. Models previously developed to study severe acute respiratory syndrome coronavirus (SARS-CoV) have been rapidly deployed to study SARS-CoV-2. However, it has become clear that despite the common use of ACE2 as a receptor for both viruses, the host range of the 2 viruses does not entirely overlap. Distinct ACE2-interacting residues within the receptor binding domain of SARS-CoV and SARS-CoV-2, as well as species differences in additional proteases needed for activation and internalization of the virus, are likely sources of host differences between the 2 viruses...
April 9, 2021: ILAR Journal
https://read.qxmd.com/read/33782706/research-relevant-background-lesions-and-conditions-in-common-avian-and-aquatic-species
#38
JOURNAL ARTICLE
Lisa M Mangus, Monique S França, H L Shivaprasad, Jeffrey C Wolf
Non-mammalian vertebrates including birds, fish, and amphibians have a long history of contributing to ground-breaking scientific discoveries. Because these species offer several experimental advantages over higher vertebrates and share extensive anatomic and genetic homology with their mammalian counterparts, they remain popular animal models in a variety of fields such as developmental biology, physiology, toxicology, drug discovery, immunology, toxicology, and infectious disease. As with all animal models, familiarity with the anatomy, physiology, and spontaneous diseases of these species is necessary for ensuring animal welfare, as well as accurate interpretation and reporting of study findings...
March 30, 2021: ILAR Journal
https://read.qxmd.com/read/33782693/iacuc-and-veterinary-considerations-for-review-of-absl3-and-absl4-research-protocols
#39
JOURNAL ARTICLE
Curtis Klages
With the recent upswing of infectious disease outbreaks (coronavirus, influenza, Ebola, etc), there is an ever-increasing need for biocontainment animal use protocols to better address the research of emerging diseases and to increase the health of both animals and humans. It is imperative that we as a research community ensure these protocols are conducted with the utmost scrutiny and regulatory compliance for the welfare of the animals as well as the health and safety concerns of the individual conducting these studies...
March 30, 2021: ILAR Journal
https://read.qxmd.com/read/33712856/challenges-and-opportunities-in-the-use-of-high-and-maximum-biocontainment-facilities-in-developing-and-licensing-risk-group-3-and-risk-group-4-agent-veterinary-vaccines
#40
JOURNAL ARTICLE
David A Brake, Jens H Kuhn, Glenn A Marsh, Martin Beer, Joshua B Fine
New solutions are necessary for the singular global health security threat formed by endemic, epidemic, and emerging/re-emerging zoonoses, coupled with epizootic and enzootic transboundary animal diseases (TADs). This One Health issue is related to the daily interactions between wildlife, domesticated and indigenous livestock, and humans primarily associated with global trade, transboundary co-movement of humans and diverse livestock/livestock products, and agriculture production intensification and penetration into previously uninhabited areas...
March 13, 2021: ILAR Journal
journal
journal
32388
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.