journal
https://read.qxmd.com/read/38700893/prestigio-ring-a-59-year-old-man-with-multidrug-resistant-hiv-1-infection-failing-a-regimen-including-dolutegravir-rilpivirine-atazanavir-cobicistat-successful-treatment-tailoring-based-on-genotypic-and-phenotypic-resistance-tests
#1
JOURNAL ARTICLE
Francesca Panza, Francesco Saladini, Niccolò Bartolini, Federica Gianmarino, Francesca Montagnani, Vincenzo Spagnuolo, Mario Tumbarello, Maria Mercedes Santoro, Antonella Castagna, Maurizio Zazzi, Massimiliano Fabbiani
Management of virological failure in heavily treatment-experienced people with multidrug-resistant (MDR) HIV infection is a serious clinical challenge. New drugs with novel mechanisms of action have recently been approved, and their use has improved the outcome of subjects with limited treatment options (LTO). In this setting, the choice of antiretroviral therapy (ART) should be tailored based on the pattern of resistance, treatment history and patients' individual characteristics. While genotypic resistance testing is the reference method for analysing residual drug susceptibility, phenotypic resistance testing can provide additional support when facing LTO...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700892/lamivudine-plus-dolutegravir-as-a-switch-strategy-in-children-three-case-reports
#2
JOURNAL ARTICLE
Laura Labate, Claudia Bartalucci, Lucia Taramasso, Giorgia Brucci, Antonio Vena, Matteo Bassetti, Antonio Di Biagio
Lamivudine (3TC)/dolutegravir (DTG) single tablet regimen (STR) has shown long-term efficacy and tolerability in people living with HIV (PLWH). Dolutegravir has been approved for use in children, while data on the efficacy of 3TC plus DTG in maintaining virological suppression in this population are still under evaluation. In this case series, we describe three children with perinatally acquired HIV who maintained virological suppression after switching antiretroviral therapy to DTG/3TC. We present three case reports of three children enrolled in the Italian Register for HIV Infection in Children: a 9-year-old boy, a 10-year-old girl, and a 2-year-old girl with perinatally acquired HIV who immediately started antiretroviral therapy with a three-drug regimen upon diagnosis, which occurred at delivery, after 6 months of life, and after 2 years of life, respectively...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700891/evaluation-of-an-automated-rapid-phenotypic-antimicrobial-susceptibility-testing-astar-q-linea-ab-applied-directly-on-blood-cultures-bottles-positive-for-gram-negative-pathogens
#3
JOURNAL ARTICLE
Isabella Banchini, Eva Caterina Borgatti, Claudio Foschi, Tiziana Lazzarotto, Simone Ambretti
We evaluated the performance of a new rapid phenotypic antimicrobial susceptibility test (ASTar; Q-linea AB) on Gram-negative bacilli, directly from positive blood cultures bottles. MIC values obtained by the routine reference method (Microscan, Beckman Coulter) were compared to the ones provided by the tested method (ASTar). ASTar demonstrated an overall essential agreement of 98% and a category agreement of 96.1%. The overall rate of major errors and very major errors was 2.5% and 3.3%, respectively. ASTar can represent a rapid, simple, and reliable method to speed up information about antimicrobial susceptibility of Gram-negative pathogens from positive blood culture bottles...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700890/the-presence-of-trichomonas-vaginalis-in-urogenital-samples-can-affect-the-sensitivity-of-mycoplasma-hominis-identification-techniques-leading-to-an-underestimation-of-bacterial-infections
#4
JOURNAL ARTICLE
Valentina Margarita, Gavino Carboni, Pier Luigi Fiori, Paola Rappelli
Trichomonas vaginalis and Mycoplasma hominis, two microorganisms causing infections of the urogenital tract, are closely associated in that they establish an endosymbiosis relationship, the only case among human pathogens. As a result, the presence of one microorganism may be considered a sign that the other is present as well. Identification of the two pathogens in clinical samples is based on cultivation techniques on specific media, even though in recent years, new sensitive and rapid molecular techniques have become...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700889/analysis-of-cases-with-co-infection-of-covid-19-and-pulmonary-aspergillosis
#5
JOURNAL ARTICLE
Hui Zheng Hu, Li Bo Wu, Qian Liu, Bin Yan Wu, Yu Wang, Rui Ying Wang
The objective of this study was to investigate the risk factors and diagnosis measure of COVID-19-associated pulmonary aspergillosis (CAPA). This study included 201 COVID-19 patients from December 1, 2022, to January 31, 2023; 7 (3.5%) were diagnosed with CAPA. The main risk factors were age, MV, ICU admission and COPD, and the presence of comorbidities such as ARDS and hypoproteinemia in COVID-19 patients, more susceptible to Aspergillus infection. In addition to specimen culture in the lower respiratory tract, the 1,3-β-D-glucan antigen test can serve as an important screening indicator for early CAPA diagnosis in non-granulocytopenia patients...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700888/high-risk-human-papilloma-virus-genotype-distribution-and-correlation-with-cervical-cytomorphological-data-in-turkish-and-immigrant-women-in-mersin-province
#6
JOURNAL ARTICLE
Murat Yaman, Hacer Ece Arslan Özcan, Ayfer Bakir
Human papilloma virus (HPV) is the most common sexually transmitted viral agent in the world and the most common cause of cervical cancer. HPV prevalence and genotype distribution vary by region and demographic data. In a province in the south of Turkey that constantly receives immigration, we aimed to determine the prevalence of high-risk HPV (HR-HPV) genotypes, evaluate the compatibility between cervical Pap smear cytology results patients and HR-HPVs, and make an up-to-date contribution to the elucidation of epidemiological data...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700887/epidemiology-and-molecular-characterization-of-respiratory-viruses-at-the-end-of-covid-19-pandemic-in-lombardy-northern-italy
#7
JOURNAL ARTICLE
Leonardo Sclavi, Marta Bertelli, Serena Messali, Arnaldo Caruso, Francesca Caccuri
The COVID-19 pandemic forced the adoption of non-pharmaceutical interventions (NPIs) which influenced the circulation of other respiratory pathogens, such as Influenza virus (FLU), Parainfluenza virus (PIV), Respiratory Syncytial virus (RSV), Rhinovirus (RV), Enterovirus (EV), Adenovirus (AdV), Human Metapneumovirus (hMPV), and Human Coronavirus (CoV). The aim of the current study was to investigate how, with the end of the pandemic, the withdrawal of the NPIs impacted on the circulation and distribution of common respiratory viruses...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700886/a-new-intestinal-supplement-synbiotics-therapeutically-regulates-gut-microbiota-and-activates-ppars-pathway-to-inhibit-alzheimer-s-disease-progression-in-mouse-models
#8
JOURNAL ARTICLE
Yanan Tong, Guoxiu Lu, Jia Guo, Miao Liu, Yinxing Dai, Jinxin Zhang, Xinru Xu, Zhiguo Wang, Guoxu Zhang
We aimed to investigate the role of Synbiotic preparations on the interaction of gut microbiota with AD development. APP/PS1 mice were randomized into APP/PS1 and Synbiotics groups, and C57BL/6J mice were used as wild type (WT) control group. The mice in the Synbiotics group and the APP/PS1 group were given Synbiotics and xylo-oligosaccharides for 3 months, respectively. The mice in the WT group were given the same amount of normal saline. Cognitive function was measured. Positron emission computed tomography/magnetic resonance imaging (PET/MRI) was used to detect fasting blood glucose level...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700885/coinfection-with-respiratory-syncytial-virus-and-rhinovirus-increases-ifn-%C3%AE-1-and-cxcl10-expression-in-human-primary-bronchial-epithelial-cells
#9
JOURNAL ARTICLE
Nipaporn Sankuntaw, Nuntaya Punyadee, Wasun Chantratita, Viraphong Lulitanond
Acute respiratory tract infection (ARTI) is common in all age groups, especially in children and the elderly. About 85% of children who present with bronchiolitis are infected with respiratory syncytial virus (RSV); however, nearly one-third are coinfected with another respiratory virus, such as human rhinovirus (HRV). Therefore, it is necessary to explore the immune response to coinfection to better understand the molecular and cellular pathways involving virus-virus interactions that might be modulated by innate immunity and additional host cell response mechanisms...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700884/comparison-of-whole-blood-and-plasma-for-monitoring-cytomegalovirus-and-epstein-barr-virus
#10
COMPARATIVE STUDY
Yuto Fukuda, Yuka Torii, Ken-Ichi Iwata, Kazunori Haruta, Makoto Yamaguchi, Takako Suzuki, Atsushi Narita, Hideki Muramatsu, Yasuhiro Ogura, Yoshiyuki Takahashi, Yoshinori Ito, Jun-Ichi Kawada
Monitoring Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection after transplantation is recommended to enable preemptive therapy. However, the most suitable sample type remains unclear. Patients who underwent hematopoietic stem cell or liver transplantation were included in this study. Viral loads in sequential whole-blood and plasma samples were retrospectively analyzed. EBV DNA was detected more frequently in whole blood (55%) than in plasma (18%). The detection rate of CMV DNA was similar between the two sample types...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700883/tenofovir-disoproxil-fumarate-in-the-treatment-of-covid-19-evaluation-of-78-patients
#11
JOURNAL ARTICLE
Gamze Şanlıdağ İşbilen, Isabel Raika Durusoy Onmuş, Ilkin Çankayalı, Kubilay Demirağ, Mehmet Uyar, Candan Çiçek, Tansu Yamazhan, Hüsnü Pullukçu, Oğuz Reşat Sipahi
One of the drugs that has been suggested for the treatment of SARS-CoV-2 infection is tenofovir disoproxil (TDF). Herein, it was aimed to evaluate the outcomes of TDF receiving COVID-19 cases in terms of day 7-10 PCR negativity and day 30 survival. Patients who received TDF due to PCR-confirmed COVID-19 between 27.04.2021 and 31.12.2021 were included in our study. The primary outcome was considered to be 7-10 days of PCR negativity, while the secondary outcome was considered 30-day survival after diagnosis of COVID-19...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700882/in-vitro-analysis-of-porcine-endogenous-retroviruses-in-different-pig-cell-types
#12
JOURNAL ARTICLE
Andrea Cacciamali, Silvia Dotti, Riccardo Villa
The shortage of organs for human transplantation is a topic of extreme interest, and xenotransplantation with porcine organs has been recognized as a promising solution. However, the potential spillover linked to infectious agents present in pigs remains a concern. Among these, Pig Endogenous Retroviruses (PERVs), whose proviral DNAs are integrated in the genome of all pig breeds, represent an extremely important biological risk. This study aims to evaluate PERVs distribution in several swine cell lines and samples of domestic and feral pigs...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700881/evaluation-of-the-pneumonia-panel-on-laboratory-samples-from-an-italian-pediatric-center-results-from-a-monocentric-study
#13
JOURNAL ARTICLE
Cristiana de Luca, Emanuela Gallo, Gabriella Tripepi, Ornella Leone
Lower respiratory tract infections (LRTI) are still burdened by considerable morbidity and mortality. Rapid and appropriate treatment imply knowledge of the underlying causative pathogen; while it is tempting to offer broad spectrum antibiotics, Antimicrobial Stewardship Practices invite a judicious use of the latter, especially when bacteria are not the cause. However, the epidemiology shifts to multidrug resistant (MDR) pathogens that require optimization of molecules in order to provide optimal treatment...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700880/epidemiology-and-clinical-impact-of-single-and-multi-viral-respiratory-infections-in-post-pandemic-era
#14
JOURNAL ARTICLE
Maria Vittoria Mauro, Sonia Greco, Maura Pellegrini, Tommaso Campagna, Federica Caprino, Nadia Elia, Antonio Mastroianni, Francesca Greco
Acute respiratory tract infections (ARI) are common diseases in children and adults and could cause severe infections in high-risk patients, like the immunocompromised and elderly, and are the leading cause of morbidity, hospitalization and mortality. This study aimed to explore the prevalence of respiratory viruses and the clinical impact of single- and multi-infection among hospitalized patients in various age groups. 3578 nasopharyngeal swabs (NPS) were analyzed for pathogen detection of acute respiratory tract infections...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700879/long-covid-lights-and-shadows-on-the-clinical-characterization-of-this-emerging-pathology
#15
REVIEW
Viola Cogliandro, Paolo Bonfanti
More than 800 million individuals have contracted SARSCOV2 infection worldwide. It was estimated that almost 10-20% of these might suffer from Long COVID. It is a multisystemic syndrome, which negatively affects the quality of life with a significant burden of health loss compared to COVID negative individuals. Moreover, the risk of sequelae still remains high at 2 years in both nonhospitalized and hospitalized individuals. This review summarizes studies regarding long COVID and clarifies the definitions, the risk factors and the management of this syndrome...
May 2024: New Microbiologica
https://read.qxmd.com/read/38700878/mechanisms-of-bacterial-drug-resistance-with-special-emphasis-on-phenotypic-and-molecular-characterization-of-extended-spectrum-beta-lactamase
#16
REVIEW
Daniel Geleta, Gemeda Abebe, Bikila Alemu, Netsanet Workneh, Getenet Beyene
Antibiotics are designed to effectively treat bacterial infections while minimizing harm to the human body. They work by targeting specific components of bacteria or by disrupting essential processes such as cell wall synthesis, membrane function, protein production, and metabolic pathways. However, the misuse and overuse of antibiotics have led to the emergence of drug resistance in humans, animals, and agriculture, contributing to the global spread of this problem. Drug resistance can be either innate or acquired, with acquired resistance involving changes in the bacterial chromosomes or transferable elements...
May 2024: New Microbiologica
https://read.qxmd.com/read/38252055/clinical-characteristics-of-14-cases-of-chlamydia-psittaci-pneumonia
#17
JOURNAL ARTICLE
Binbin Cheng, Jun Wang, Lin Lin, Dexiang Yang, Xiaofeng Liu, Hao Wu
Among 14 patients with C. psittaci pneumonia, there were 9 critical and 5 non-critical cases. Ten patients improved clinically and were discharged to home; however, four patients died. Seven patients had a history of contact with birds or poultry. All 14 patients had a high fever as the presenting symptom, but most had a normal white blood cell count. Most of the patients had a significant increase in high-sensitivity C-reactive protein and procalcitonin levels. The lymphocyte count in the critical group was considerably lower than in the non-critical group...
January 2024: New Microbiologica
https://read.qxmd.com/read/38252054/first-case-of-chryseobacterium-gallinarum-bloodstream-infection-a-diagnostic-and-therapeutic-challenge-for-an-emerging-pathogen
#18
JOURNAL ARTICLE
Mattia Genco, Antonio Curtoni, Paolo Bottino, Silvia Scabini, Silvia Corcione, Davide Vita, Luisa Guarrasi, Gabriele Bianco, Alessandro Bondi, Daniela Risso, Rossana Cavallo, Cristina Costa
Chryseobacterium spp. belongs to the Flavobacteriaceae family and is a rod-shaped gram-negative, glucose non-fermenting, non-motile bacterium ubiquitous in the environment. In humans, Chryseobacterium may be responsible for infections such as urinary tract infections (UTI) and ventriculitis with a pathogenic burden increasing in recent years. Chryseobacterium gallinarum was isolated for the first time in 2014 in a pharyngeal scrape sample of chicken and, until now, only one case of human UTI has been described in a pregnant 20-year-old Indian patient...
January 2024: New Microbiologica
https://read.qxmd.com/read/38252053/prestigio-ring-an-80-year-old-man-living-with-hiv-resistant-to-all-four-antiretroviral-classes-and-desiring-treatment-simplification
#19
JOURNAL ARTICLE
Maria Mazzitelli, Maurizio Zazzi, Giulia Marchetti, Vincenzo Spagnuolo, Maria Mercedes Santoro, Emanuele Focà, Annamaria Cattelan, Antonella Castagna
People aging with 4 antiretroviral class resistant HIV are a very challenging population. It is difficult to build up a fully suppressive regimen, and the high prevalence of comorbidities and polypharmacy may cause drug-drug interactions and put adherence at risk. We herein present the case of an 80-year-old man, participating in the PRESTIGIO registry, asking for a reduction in his antiretroviral burden while on polypharmacy for his comorbidities.
January 2024: New Microbiologica
https://read.qxmd.com/read/38252052/18s-rrna-sequencing-and-homology-analysis-of-post-traumatic-bloodstream-infection-with-saprochaete-clavata-magnusiomyces-clavatus-and-a-case-report
#20
JOURNAL ARTICLE
Wei Jia, Guang Chen, Wanxiang Li, Jie Ma, Xue Zhao
We present a case of bloodstream infection with Saprochaete clavata following an abdominal steel impact injury in a 52-year-old man, whose non-healing abdominal wound was also highly suspected of being caused by Saprochaete clavata. Saprochaete clavata is a very uncommon fungal pathogen. Our case is distinctive in that previous reports have typically involved immunocompromised, malignant, or leukemic patients. In contrast, our case involved a middle-aged man in good health who had ileal perforation repair for gastrointestinal perforation...
January 2024: New Microbiologica
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