Xinhui Wang, Pei Huang, Ewart Mark Haacke, Peng Wu, Xiaobing Zhang, Huihui Zhang, Zenghui Cheng, Rongbiao Tang, Fangtao Liu, Yu Liu, Xiaofeng Shi, Peng Liu, Youmin Zhang, Zhijia Jin, Shengdi Chen, Naying He, Fuhua Yan
INTRODUCTION: Although locus coeruleus (LC) has been demonstrated to play a critical role in the cognitive function of Parkinson's disease (PD), the underlying mechanism has not been elucidated. The objective was to investigate the relationship among LC degeneration, cognitive performance, and the glymphatic function in PD. METHODS: In this retrospective study, 71 PD subjects (21 with normal cognition; 29 with cognitive impairment (PD-MCI); 21 with dementia (PDD)) and 26 healthy controls were included...
March 15, 2024: Parkinsonism & related Disorders