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EDITORIAL
Anupa A Vijayakumari, Virendra R Mishra
No abstract text is available yet for this article.
September 14, 2023: Parkinsonism & related Disorders
#2
JOURNAL ARTICLE
Maria Paula C Azevedo, Camila C Lobo, Gabriel S Schmitt, Paula C A A P Matos, Orlando G P Barsottini, José Luiz Pedroso, Wilson Marques, Juliana Pasquotto Souza, Bárbara J Amorim, Marcondes C França
INTRODUCTION: Parkinsonism is now recognized as an additional feature in RFC1/CANVAS syndrome; however, no systematic evaluation of nigrostriatal dopaminergic function has been published so far. METHODS: This is an observational, single-center study, which analyzed 13 patients with molecular confirmation of RFC1/CANVAS. Disease severity was assessed with the SARA scale. Each subject was carefully evaluated for the presence of parkinsonian features. Dopamine transporter (DAT) imaging was acquired and reconstructed in the transverse, coronal and sagittal planes 4 h after venous injection of 99mTc-TRODAT-1...
September 12, 2023: Parkinsonism & related Disorders
#3
JOURNAL ARTICLE
Christine Kindler, Neeraj Upadhyay, Veronika Purrer, Frederic Carsten Schmeel, Valeri Borger, Lukas Scheef, Ullrich Wüllner, Henning Boecker
BACKGROUND: Magnetic resonance-guided focused ultrasound (MRgFUS) of the thalamic ventral intermediate nucleus is an incisionless lesional treatment for essential tremor. OBJECTIVE: To examine relationships between tremor severity and functional connectivity in patients with essential tremor and to assess long-term changes in the tremor network after sonication of the ventral intermediate nucleus. METHODS: Twenty-one patients with essential tremor (70...
September 12, 2023: Parkinsonism & related Disorders
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JOURNAL ARTICLE
Marcello Mario Mascia, Daniele Belvisi, Marcello Esposito, Roberta Pellicciari, Assunta Trinchillo, Carmen Terranova, Salvatore Bertino, Laura Avanzino, Francesca Di Biasio, Francesco Bono, Vincenzo Laterza, Christian Lettieri, Roberto Eleopra, Giovanni Fabbrini, Pierangelo Barbero, Laura Bertolasi, Maria Concetta Altavista, Roberto Erro, Roberto Ceravolo, Anna Castagna, Maurizio Zibetti, Anna Rita Bentivoglio, Giovanni Cossu, Luca Magistrelli, Cesa Scaglione, Alberto Albanese, Maria Sofia Cotelli, Salvatore Misceo, Antonio Pisani, Tommaso Schirinzi, Luca Maderna, Giovanna Squintani, Alfredo Berardelli, Giovanni Defazio
BACKGROUND: Although acquired dystonia may develop following ischaemic/haemorrhagic stroke, the relationship between cerebrovascular disease and idiopathic dystonia has been poorly investigated. This cross sectional study aimed at evaluating the impact of cerebrovascular risk factors on the clinical expression of idiopathic adult onset dystonia (IAOD), with reference to dystonia localization and dystonia-associated features. METHODS: Data were obtained from the Italian Dystonia Registry...
September 12, 2023: Parkinsonism & related Disorders
#5
JOURNAL ARTICLE
Negin Eissazade, Afagh Alavi, Anthony E Lang, Mohammad Rohani, Maziar Emamikhah, Tara Khoeini
There are various neurodegenerative or hereditary causes of Parkinsonism. Therefore, clinicians should consider an increasing range of differential diagnoses when facing a patient with Parkinsonism, especially when associated with additional clinical features. Young-onset Parkinsonism, especially when accompanied by features uncommon in idiopathic Parkinson's disease raises the possibility of genetic etiology. Herein, we present a case of a 40-year-old man with genetic Parkinson's disease, presenting with rapidly progressive dementia...
September 9, 2023: Parkinsonism & related Disorders
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JOURNAL ARTICLE
Petr Hollý, Tereza Duspivová, David Kemlink, Olga Ulmanová, Jan Rusz, Radim Krupička, Robert Jech, Evžen Růžička
INTRODUCTION: Head tremor is a common symptom of essential tremor (ET) and cervical dystonia (CD). In clinical practice, it is often difficult to distinguish between these two conditions, especially in cases where head tremor predominates. OBJECTIVES: To investigate which clinical and instrumental methods best differentiate ET and CD in patients with head tremor. METHODS: 65 patients were included, of which 23 were diagnosed with ET and head tremor (HT+), 21 with ET without head tremor (HT-) and 21 with CD and dystonic head tremor...
September 9, 2023: Parkinsonism & related Disorders
#7
JOURNAL ARTICLE
Tanushree Chawla, Natasha K Kumar, Vinay Goyal
No abstract text is available yet for this article.
September 8, 2023: Parkinsonism & related Disorders
#8
JOURNAL ARTICLE
Alberto Imarisio, Andrea Pilotto, Enrico Premi, Silvia Paola Caminiti, Luca Presotto, Arianna Sala, Cinzia Zatti, Alessandro Lupini, Rosanna Turrone, Barbara Paghera, Barbara Borroni, Daniela Perani, Alessandro Padovani
INTRODUCTION: Brain hypometabolism patterns have been previously associated with cognitive decline in Parkinson's disease (PD). Our aim is to evaluate the impact of single-subject fluorodeoxyglucose (FDG)-PET brain hypometabolism on long-term cognitive and motor outcomes in PD. METHODS: Forty-nine non-demented PD patients with baseline brain FDG-PET data underwent an extensive clinical follow-up for 8 years. The ability of FDG-PET to predict long-term cognitive and motor progression was evaluated using Cox regression and mixed ANCOVA models...
September 7, 2023: Parkinsonism & related Disorders
#9
REVIEW
Brendan Baugher, Nathaniel Szewczyk, James Liao
No abstract text is available yet for this article.
September 7, 2023: Parkinsonism & related Disorders
#10
JOURNAL ARTICLE
Merle C Hoenig, Verena Dzialas, Magdalena Banwinkler, Adrian Asendorf, Alexander Drzezga, Thilo van Eimeren
BACKGROUND: According to the cognitive-reserve concept, higher educated dementia patients tolerate more brain pathology than lower educated patients with similar impairment. Here, we examined whether higher education is associated with more severe dopamine terminal loss at the diagnosis of Parkinson's disease (PD). METHODS: Dopamine transporter (DaT) SPECT information of 352 de novo PD patients and 172 healthy controls (HC) were retrieved from PPMI. Correlation analyses were performed between education years and regional DaT signal (i...
September 5, 2023: Parkinsonism & related Disorders
#11
JOURNAL ARTICLE
Comparative safety of antimuscarinics versus mirabegron for overactive bladder in Parkinson disease.
Danielle S Abraham, Thanh Phuong Pham Nguyen, Craig W Newcomb, Shelly L Gray, Sean Hennessy, Charles E Leonard, Qing Liu, Daniel Weintraub, Allison W Willis
BACKGROUND: Overactive bladder (OAB) is a common non-motor symptom of Parkinson disease (PD), often treated with antimuscarinics or beta-3 agonists. There is lack of evidence to guide OAB management in PD. OBJECTIVES: To assess the comparative safety of antimuscarinics versus beta-3 agonists for OAB treatment in PD. METHODS: We employed a new-user, active-comparator cohort study design. We included Medicare beneficiaries age ≥65 years with PD who were new users of either antimuscarinic or beta-3 agonist...
September 4, 2023: Parkinsonism & related Disorders
#12
REVIEW
Bradley McDaniels, Gregory M Pontone, Soania Mathur, Indu Subramanian
BACKGROUND: Despite the myriad motor and non-motor challenges associated with Parkinson's disease (PD) diagnosis, the hidden issue of stigma may be among the most influential factors negatively affecting quality of life. A number of qualitative studies have been published assessing various aspects of stigma in PD, and quantitative studies assert that most people with PD experience stigma during the course of their disease. Stigma is associated with poorer mental and physical health, poorer quality of life, decreased levels of hope, self-esteem and self-efficacy...
September 4, 2023: Parkinsonism & related Disorders
#13
JOURNAL ARTICLE
Laura Arnaldo, Aintzane Urbizu, Mònica Serradell, Carles Gaig, Ana Anillo, Mireia Gea, Dolores Vilas, Lourdes Ispierto, Amaia Muñoz-Lopetegi, Gerard Mayà, Pau Pastor, Ramiro Álvarez, Joan Santamaria, Alex Iranzo, Katrin Beyer
INTRODUCTION: Isolated REM sleep behavior disorder (IRBD) represents an early manifestation of the synucleinopathies Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Aggregation of abnormal α-synuclein and its increased expression in the brain is crucial in the development of the synucleinopathies. Whereas α-synuclein gene (SNCA) transcripts are overexpressed in brain, a concomitant reduction occurs in blood of DLB patients. We assessed whether this decrease is also detectable in IRBD...
September 3, 2023: Parkinsonism & related Disorders
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JOURNAL ARTICLE
James M Holcomb, Joseph A Maldjian, Yin Xi, Padraig E O'Suilleabhain, Elan D Louis, Bhavya R Shah
The Archimedes spiral is a clinical tool that aids in the diagnosis and monitoring of essential tremor. However, spiral ratings may vary based on experience and training of the rating physician. This study sought to generate an objective standard model for tremor evaluation using convolutional neural networks. One senior movement disorders neurologist (Neurologist 1) with over 30 years of clinical experience used the Bain and Findley Spirography Rating Scale to rate 1653 Archimedes spiral images from 46 essential tremor patients (mild to severe tremor) and 75 control subjects (no to mild tremor)...
September 1, 2023: Parkinsonism & related Disorders
#15
JOURNAL ARTICLE
Kyurim Kang, Adonay S Nunes, Mansi Sharma, A J Hall, Ram Kinker Mishra, Jose Casado, Rylee Cole, Marc Derhammer, Gregory Barchard, Bijan Najafi, Ashkan Vaziri, Anne-Marie Wills, Alexander Pantelyat
INTRODUCTION: Distinguishing Parkinson's disease (PD) from Progressive supranuclear palsy (PSP) at early disease stages is important for clinical trial enrollment and clinical care/prognostication. METHODS: We recruited 21 participants with PSP(n = 11) or PD(n = 10) with reliable caregivers. Standardized passage reading, counting, and sustained phonation were recorded on the BioDigit Home tablet (BioSensics LLC, Newton, MA USA), and speech features from the assessments were analyzed using the BioDigit Speech platform (BioSensics LLC, Newton, MA USA)...
September 1, 2023: Parkinsonism & related Disorders
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LETTER
Luigi Michele Romito, Fabio Paio, Nico Golfrè Andreasi, Celeste Panteghini, Sara Rinaldo, Ahmet Kaymak, Alberto Mazzoni, Fabiana Colucci, Vincenzo Levi, Giuseppe Messina, Barbara Garavaglia, Roberto Eleopra
No abstract text is available yet for this article.
August 30, 2023: Parkinsonism & related Disorders
#17
JOURNAL ARTICLE
Natália Mariano Barboza, Martina Mancini, Suhaila Mahmoud Smaili, Fay B Horak, Patricia Carlson-Kuhta, Rosie Morris, Laurie A King
INTRODUCTION: The relationship between mobility and cognition has been studied in the aging population and associations have been also reported in people with Parkinson's disease (PD). OBJECTIVE: To compare different aspects of gait and balance between individuals with PD who have normal cognition and those with impaired cognition, using both clinical and instrumented measures. METHODS: One-hundred forty-three participants with PD were divided into two groups: 1) normal cognition (n = 71) and 2) impaired cognition (n = 72) based on the Montreal Cognitive Assessment (MoCA) cut-off...
August 28, 2023: Parkinsonism & related Disorders
#18
JOURNAL ARTICLE
Krishna A Pucha, Thong Ma, William York, Un Jung Kang, Horacio Kaufmann, Dimitrios Kapogiannis, Jose-Alberto Palma
INTRODUCTION: Impaired autophagy is a pathogenic mechanism in the synucleinopathies. Sirolimus, a potent mTOR inhibitor and autophagy activator, had no beneficial effects in a randomized placebo-controlled trial in patients with multiple system atrophy (MSA). Whether sirolimus effectively inhibited brain mTOR activity was unknown. We aimed to evaluate if patients with MSA treated with sirolimus had evidence of inhibited brain mTOR pathways by measuring neuron-derived serum extracellular vesicles (NEVs)...
August 25, 2023: Parkinsonism & related Disorders
#19
LETTER
Hansashree Padmanabha, Nagaraj Ar, Gautham Arunachal, Raghavendra K, Maya Bhat, Pooja M, Mathuranath Ps, Rohan Mahale
No abstract text is available yet for this article.
August 25, 2023: Parkinsonism & related Disorders
#20
JOURNAL ARTICLE
Chongyao Jin, YiQing Jiang, Huihui Wu
INTRODUCTION: Physical activity benefits patients with Parkinson's disease (PD) and is assumed to possess disease-modifying potential. PD-related biomarkers, such as dopamine transporter (DAT) imaging and cerebrospinal fluid (CSF) α-synuclein (α-syn) and amyloid β (Aβ), correlate with disease severity and, to some extent, reflect disease progression and pathology. However, the association between regular physical activity and PD biomarker changes remains unknown...
August 24, 2023: Parkinsonism & related Disorders
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