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Parkinsonism & related Disorders

Jagan A Pillai, Guiyun Wu, Babak Tousi, Mykol Larvie, Gabriel C Léger, James B Leverenz
BACKGROUND: Biomarkers are being used increasingly to support the diagnosis of dementia with Lewy bodies (DLB). Novel biomarkers that increase diagnostic specificity of DLB are needed. We assessed previously known FDG-PET occipital cortex hypometabolism, and cingulate island sign biomarkers of DLB against a novel amygdala signature. METHODS: Retrospective analysis of 49 patients evaluated at one tertiary memory clinic. All had a FDG-PET brain scan performed as part of their diagnostic work up evaluating three common neurodegenerative etiologies: Alzheimer dementia (AD), Frontotemporal dementia (FTD) and DLB...
March 15, 2019: Parkinsonism & related Disorders
Niccolò E Mencacci, Norbert Brüggemann
No abstract text is available yet for this article.
March 15, 2019: Parkinsonism & related Disorders
Xiaofeng Xu, Jinchi Liao, Qing Dong, Feng Qin, Jing Li, Xiaobo Sun, Tingting Lu, Ling Fang, Fuhua Peng, Zhengqi Lu, Wei Qiu
INTRODUCTION: Autonomic neuropathy is common in Parkinson's disease (PD). We evaluated whether SUDOSCAN, a novel electrophysiological device that provides a simple and quantitative assessment of sudomotor function, was able to detect PD-related autonomic neuropathy. We also used the device to examine potential risk factors for PD-related autonomic neuropathy. METHODS: Forty-three hospitalized patients in the later stages of PD underwent assessments including a clinical history, the Unified Parkinson's Disease Rating Scale (UPDRS), the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT), and measurement of homocysteine (HCY) and vitamin B12 levels...
March 15, 2019: Parkinsonism & related Disorders
A Kuzkina, L Schulmeyer, C-M Monoranu, J Volkmann, C Sommer, K Doppler
INTRODUCTION: Phosphorylated α-synuclein (p-α-syn) can be detected in dermal nerve fibers of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Here we investigated whether p-α-syn in the cutaneous nerve fibers represents misfolded aggregated protein. METHODS: Using immunofluorescence with conformation specific antibodies and digestion with proteinase K (PK), we studied skin biopsies from a cohort of patients with early stage PD (Hoehn and Yahr I/II, n=27), MSA with predominant parkinsonism (MSA-P, n=8) and normal controls (n=21)...
March 9, 2019: Parkinsonism & related Disorders
J R Bedarf, L Nitsch, R Malotki, R Andrié, J Reimann
Myoclonus is a sudden and brief involuntary muscle contraction presenting with jerk-like movements that can occasionally involve the trunk muscles or the diaphragm as in the case of spinal myoclonus1 . We here present an unusual case with unilateral diaphragmatic myoclonus owing to electrode dislocation of an implantable cardioverter defibrillator.
March 9, 2019: Parkinsonism & related Disorders
Roozbeh Behroozmand, Karim Johari, Ryan M Kelley, Efthymia C Kapnoula, Nandakumar S Narayanan, Jeremy D W Greenlee
INTRODUCTION: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for limb motor symptoms in Parkinson's disease (PD); however, its effect on vocal motor function has yielded conflicted and highly variable results. The present study investigated the effects of STN-DBS on the mechanisms of vocal production and motor control. METHODS: A total of 10 PD subjects with bilateral STN-DBS implantation were tested with DBS ON and OFF while they performed steady vowel vocalizations and received randomized upward or downward pitch-shift stimuli (±100 cents) in their voice auditory feedback...
March 7, 2019: Parkinsonism & related Disorders
Marta Manes, Antonella Alberici, Eleonora Di Gregorio, Loredana Boccone, Enrico Premi, Nico Mitro, Maria Pia Pasolini, Claudia Pani, Barbara Paghera, Laura Orsi, Chiara Costanzi, Marta Ferrero, Filippo Tempia, Donatella Caruso, Alessando Padovani, Alfredo Brusco, Barbara Borroni
INTRODUCTION: Spinocerebellar Ataxia 38 (SCA38) is caused by ELOVL5 gene mutation, with significant reduction of serum docosahexaenoic acid (DHA) levels. DHA supplementation has been proven effective at short-term follow-up. In the present paper, we evaluated long-term safety and efficacy of 600 mg/day oral DHA in SCA38 by a 2-year open label extension study. METHODS: Nine SCA38 patients underwent standardised clinical assessment at 62 (T1), 82 (T2) and 104 (T3) weeks, and compared to pre-treatment scores (T0)...
March 7, 2019: Parkinsonism & related Disorders
Matthias Boerger, Sebastian Funke, Andreas Leha, Anna-Elisa Roser, Ann-Katrin Wuestemann, Fabian Maass, Mathias Bähr, Franz Grus, Paul Lingor
BACKGROUND: The diagnosis of Parkinson's disease (PD) is still challenging and biomarkers could contribute to an improved diagnostic accuracy. Tear fluid (TF) is an easily accessible body fluid reflecting pathophysiological changes in systemic and ocular diseases and is already used as a biomarker source for several ophthalmological disorders. Here, we analyzed the TF of patients with PD and controls (CTR) to describe disease-related changes in TF and identify putative biomarkers for the diagnosis of PD...
March 6, 2019: Parkinsonism & related Disorders
Ana Marques, Tiphaine Vidal, Bruno Pereira, Eve Benchetrit, Julie Socha, Fanny Pineau, Alexis Elbaz, Fanny Artaud, Graziella Mangone, Hana You, Florence Cormier, Monique Galitstky, Elsa Pomies, Olivier Rascol, Pascal Derkinderen, Daniel Weintraub, Jean Christophe Corvol, Franck Durif
INTRODUCTION: The management of impulse control disorders (ICDs) in Parkinson's disease (PD) relies on their early identification, allowing adjustment of antiparkinsonian treatment before these manifestations lead to major social, financial or legal consequences. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) is an English-developed and -validated PD-specific rating scale constructed to support the rating of ICDs and related disorders and the assessment of changes in symptom severity over time, but it has not to date been validated in French...
March 4, 2019: Parkinsonism & related Disorders
Daniele Belvisi, Isabella Berardelli, Gina Ferrazzano, Matteo Costanzo, Valentina Corigliano, Giovanni Fabbrini, Alfredo Berardelli, Maurizio Pompili
INTRODUCTION: Suicidal ideation is increased in Parkinson's disease (PD) patients. The possible relationship between parkinsonian motor and non-motor symptoms and suicidal ideation in PD is unknown. The aim of the study was to evaluate suicidal ideation in patients with PD in a controlled study specifically designed to identify the clinical correlates of PD suicidal ideation. METHODS: We consecutively enrolled 100 patients with PD, 76 patients with psoriasis and 80 healthy subjects...
March 3, 2019: Parkinsonism & related Disorders
Margherita Fabbri, Miguel Coelho, Daisy Abreu, Leonor Correia Guedes, Mario M Rosa, Catarina Godinho, Rita Cardoso, Isabel Guimaraes, Angelo Antonini, Maurizio Zibetti, Leonardo Lopiano, Joaquim J Ferreira
BACKGROUND: Few data exist on the rate of clinical progression for Parkinson's disease (PD) patients who have entered a late stage of the disease. OBJECTIVE: Study the clinical progression of a late-stage PD (LSPD) population over one year follow-up. METHODS: 50 LSPD patients (Schwab and England ADL Scale <50 or Hoehn Yahr Stage >3 in MED ON) underwent an extensive clinical assessment at baseline and after one year and an acute levodopa test at baseline...
March 2, 2019: Parkinsonism & related Disorders
C Hubsch, V D'Hardemare, M Ben Maacha, M Ziegler, N Patte-Karsenti, J B Thiebaut, O Gout, J P Brandel
Spinal cord stimulation (SCS) is an effective surgical therapy used for the treatment of chronic neuropathic pain. Tonic SCS is safe and improve not only gait disorders, motor symptoms, but also quality of life in Parkinson patients even with dopa-resistant symptoms with or without associated deep brain stimulation.
March 2, 2019: Parkinsonism & related Disorders
Elan D Louis, Jillian L Joyce, Stephanie Cosentino
INTRODUCTION: Although the hallmark feature of essential tremor (ET) is tremor, there is growing appreciation that cognitive impairment also occurs, including increased prevalence of mild cognitive impairment (MCI) and increased prevalence and incidence of dementia. With emerging knowledge of ET-cognitive impairment, come fundamental questions regarding its course, bases, predictors and clinical outcomes. Studies in the general population and in Parkinson's disease (PD), a related movement disorder, offer a starting point from which to begin filling these clinically important knowledge gaps...
March 1, 2019: Parkinsonism & related Disorders
Maria Salsone, Maria Eugenia Caligiuri, Virginia Vescio, Gennarina Arabia, Andrea Cherubini, Giuseppe Nicoletti, Maurizio Morelli, Andrea Quattrone, Basilio Vescio, Rita Nisticò, Fabiana Novellino, Giuseppe Lucio Cascini, Umberto Sabatini, Michaela Montilla, Ivan Rektor, Aldo Quattrone
OBJECTIVE: Several evidences demonstrated the role of white matter (WM) lesions in the pathogenesis of Vascular Parkinsonism (VP), a clinical entity characterized by parkinsonism, postural instability, marked gait difficulty and poor response to levodopa. However, the involvement of normal appearing white matter (NAWM) in VP still remains unknown. This study aimed to investigate the microstructural integrity of NAWM in VP compared to Parkinson's disease (PD) and controls using neuroimaging approach...
March 1, 2019: Parkinsonism & related Disorders
Edoardo Monfrini, Letizia Straniero, Sara Bonato, Giacomo Monzio Compagnoni, Andreina Bordoni, Robertino Dilena, Paola Rinchetti, Rosamaria Silipigni, Dario Ronchi, Stefania Corti, Giacomo P Comi, Nereo Bresolin, Stefano Duga, Alessio Di Fonzo
INTRODUCTION: Neurofascin, encoded by NFASC, is a transmembrane protein that plays an essential role in nervous system development and node of Ranvier function. Anti-Neurofascin autoantibodies cause a specific type of chronic inflammatory demyelinating polyneuropathy (CIDP) often characterized by cerebellar ataxia and tremor. Recently, homozygous NFASC mutations were recently associated with a neurodevelopmental disorder in two families. METHODS: A combined approach of linkage analysis and whole-exome sequencing was performed to find the genetic cause of early-onset cerebellar ataxia and demyelinating neuropathy in two siblings from a consanguineous Italian family...
March 1, 2019: Parkinsonism & related Disorders
Daniel J van Wamelen, Aleksandra M Podlewska, Valentina Leta, Katarzyna Śmiłowska, Alexandra Rizos, Pablo Martinez-Martin, Bas R Bloem, K Ray Chaudhuri
INTRODUCTION: Although circadian variation of (motor) symptoms in Parkinson disease (PD) patients has been described, it remains unclear what effect seasonal variation may have on non-motor symptoms (NMS). METHODS: Cross-sectional retrospective study on 372 consecutive PD patients taking part in the Non-motor Longitudinal International Study at King's College Hospital London between November 2011 and July 2018. Patients were divided into three groups based on their date of assessment, using a simplified seasonal model: group 1: November-February (n = 107); group 2: March-15 June (n = 107); and group 3: 16 June-October (n = 158)...
February 28, 2019: Parkinsonism & related Disorders
Rektorova Irena
Cognitive and behavioral symptoms are common in Parkinson's disease, may occur even in the prodromal stages of the disease, worsen with disease progression, and surpass motor symptoms as the major factors affecting patient quality of life and caregiver burden. The symptoms may be caused by the disease pathology or they may represent adverse effects of treatment, or both etiological factors may contribute. Although many of these symptoms are related to dopaminergic dysfunction or dopaminergic medication, other neurotransmitters are involved as well...
February 28, 2019: Parkinsonism & related Disorders
Yong Wook Kim, In-Soo Shin, Hyun Im Moon, Sang Chul Lee, Seo Yeon Yoon
INTRODUCTION: To investigate the effect of non-invasive brain stimulation (NIBS), including repetitive transcranial magnetic stimulation and transcranial direct current stimulation, on freezing of gait (FOG) in parkinsonism. METHODS: The PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Physiotherapy Evidence Database (PEDro) databases were searched up to October 2018 for articles published in English or Korean. Quality assessment was performed using the PEDro scale...
February 27, 2019: Parkinsonism & related Disorders
Clara Rodriguez-Sabate, Ingrid Morales, Fernando Monton, Manuel Rodriguez
Current basal ganglia models integrate information obtained from humans and animals to explain motor disorders in Parkinson's disease. These models explain some motor disturbances of Parkinson's disease (PD), but different clinical observations which remain unexplained have promoted the development of new basal ganglia (BG) models. The present study uses the time-relationship (partial correlation) of the BOLD-signal fluctuations to study the influence of PD on BG interactions of 17 age-matched controls (58...
February 27, 2019: Parkinsonism & related Disorders
Wei Hu, Valerie Rundle-Gonzalez, Shankar J Kulkarni, Daniel Martinez-Ramirez, Leonardo Almeida, Michael S Okun, Aparna Wagle Shukla
BACKGROUND: Physical therapy (PT) for cervical dystonia is not well studied, and the underlying physiological effects are not known. METHODS: We enrolled 26 subjects comprising of 16 cervical dystonia and 10 healthy controls for normative physiological data. We randomized cervical dystonia patients who reported suboptimal benefits on botulinum toxin (BoNT) injections to BoNT alone (BoNT arm) or BoNT plus PT (PT-BoNT arm). PT-BoNT arm received manual PT on the injection day followed by six weeks of home-exercise program...
February 25, 2019: Parkinsonism & related Disorders
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