journal
https://read.qxmd.com/read/36219753/visuomotor-misalignment-induced-through-immersive-virtual-reality-to-improve-spatial-neglect-a-case-series-study
#21
JOURNAL ARTICLE
Peii Chen, Olga Boukrina, Denise Krch
One evidence-based treatment for spatial neglect is prism adaptation (PA) treatment. PA after-effects, i.e., the implicit shifts in the arm reaching position toward the neglected side of space after prism removal, are considered fundamental to PA treatment effects. In the present study, the arm reaching position was shifted through a visuomotor misalignment procedure using immersive virtual reality (VR). To examine whether this procedure might have a beneficial impact on spatial neglect, we conducted a multi-baseline experiment in three individuals with chronic left-sided neglect post stroke...
October 11, 2022: Neurocase
https://read.qxmd.com/read/36209511/a-1p31-3-deletion-encompassing-the-nuclear-factor-1a-gene-presenting-as-possible-temporal-lobe-epilepsy-in-association-with-schizoaffective-disorder
#22
JOURNAL ARTICLE
Mark A Colijn, Monica Hrynchak, Chantelle T Hrazdil, Veerle Willaeys, Randall F White, Robert M Stowe
Chromosome 1p32-p31 deletion syndrome, which is characterized by a variety of neurodevelopmental abnormalities, is thought to occur as a result of nuclear factor 1A ( NFIA ) haploinsufficiency. We present a case of a right-handed 40-year-old female with a 1p31.3 deletion, who exhibited numerous common features of this syndrome, in addition to treatment resistant schizoaffective disorder and possible temporal lobe epilepsy, making her presentation unique. While neither psychosis nor temporal lobe epilepsy has been described in this syndrome previously, these conditions likely occurred in our patient as a result of NFIA haploinsufficiency...
October 9, 2022: Neurocase
https://read.qxmd.com/read/36548912/examining-the-role-of-the-uncinate-fasciculus-in-proper-noun-naming-awake-brain-tumor-resections-and-stereo-eeg-targeted-electrical-stimulation-multiple-case-study
#23
JOURNAL ARTICLE
Jun Min Koay, Karen E Blackmon, Erik H Middlebrooks, Alfredo Quinones-Hinojosa, Kaisorn L Chaichana, Anteneh M Feyissa, Sanjeet S Grewal, David S Sabsevitz
While there is strong evidence from lesion and functional imaging studies implicating the left anterior temporal pole (LTP) in naming unique entities, less is known about white matter tracts in category-specific naming. We present evidence that implicates the uncinate fasciculus (UF) in proper noun naming. First, we describe two patients with left LTP gliomas who developed category specific worsening in proper noun naming in real time during awake surgery when the UF was surgically involved . We then describe a third case involving targeted electrical stimulation of the UF using stereo-electroencephalography (sEEG) that resulted in category specific naming disturbance for proper nouns...
October 2022: Neurocase
https://read.qxmd.com/read/36450280/visual-and-social-differences-in-dyslexia-deep-phenotyping-of-four-cases-with-spared-phonology
#24
JOURNAL ARTICLE
Eleanor R Palser, Zachary A Miller, Abigail E Licata, Nicole A Yabut, Swati P Sudarsan, Boon Lead Tee, Jessica A Deleon, Maria Luisa Mandelli, Eduardo Caverzasi, Virginia E Sturm, Robert Hendren, Katherine L Possin, Bruce L Miller, Maria Luisa Gorno Tempini, Christa Watson Pereira
Diagnostic criteria for dyslexia describe specific reading difficulties, and single-deficit models, including the phonological deficit theory, have prevailed. Children seeking diagnosis, however, do not always show phonological deficits, and may present with strengths and challenges beyond reading. Through extensive neurological, neuropsychological, and academic evaluation, we describe four children with visuospatial, socio-emotional, and attention impairments and spared phonology, alongside long-standing reading difficulties...
October 2022: Neurocase
https://read.qxmd.com/read/36374938/treatment-resistant-diabetic-chorea-manifesting-with-psychiatric-symptoms-a-case-report
#25
JOURNAL ARTICLE
Tsubasa Miyauchi, Masami Yoshii, Takeo Oshima, Ken Tomotsune, Kazuhiro Tomiyasu
We report a case of a 69-year-old man with treatment-resistant diabetic chorea presenting psychiatric symptoms. The right chorea lasted for 3 months and was refractory to control of diabetes mellitus or administration of haloperidol and benzodiazepines. Only administration of tiapride was efficacious. Magnetic resonance spectrometry and dopamine transporter-single photon emission computed tomography suggested that sustained ischemia at the striatum may lead to impaired expression of dopamine transporters, thereby resulting in deterioration in the indirect pathway...
October 2022: Neurocase
https://read.qxmd.com/read/36130333/better-conversations-a-language-and-communication-intervention-for-aphasia-in-posterior-cortical-atrophy
#26
JOURNAL ARTICLE
A Volkmer, C Farrington-Douglas, Sj Crutch, S Beeke, Jd Warren, Kxx Yong
Posterior cortical atrophy (PCA) describes a neurodegenerative syndrome characterized by progressive difficulties in cortical visual and other posterior cortical functions consistent with parieto-occipital and occipito-temporal involvement. It is increasingly recognized that many patients develop difficulties with other aspects of daily living, in particular, with language and communication. We present a case emphasizing how language difficulties may emerge in PCA. Difficulties are interpreted as arising from interacting effects of linguistic deficits and impaired detection of nonverbal (particularly, visual) turns that normally facilitate, schedule, and disambiguate the exchange of verbal messages between speakers...
September 21, 2022: Neurocase
https://read.qxmd.com/read/36062415/chronic-hematoma-superimposed-to-a-large-frontotemporal-arachnoid-cyst-evidence-against-crowding-of-audioverbal-memory
#27
JOURNAL ARTICLE
Panayiotis Patrikelis, Stefanos Korfias, Lambros Messinis, Alexandros Kossivas, Christina Zournatzidi, Athanasia Alexoudi, Giuliana Lucci, Stylianos Gatzonis, Grigorios Nasios
We report a patient with a chronic subdural/epidural hematoma superimposed to a large arachnoid cyst occupying the left frontotemporal region. Both were discovered accidentally because of a trigeminal neuralgia and concomitant subjective memory complaints. Patient's sudden selective audioverbal memory impairment probably links to a primary cortical tone deregulation and expressed through deficits of arousal-mediating structures subtly impacted by the hematoma's progression. This case illustrates that in early-onset asymmetrical brain damage (usually left), language, audioverbal memory in particular, should not always come to dominate intact hemisphere function...
September 3, 2022: Neurocase
https://read.qxmd.com/read/35993136/combination-therapy-of-modified-electroconvulsive-therapy-and-long-acting-injectable-aripiprazole-for-dopamine-supersensitivity-psychosis-a-case-report
#28
JOURNAL ARTICLE
Yusuke Matsuzaka, Manabu Noguchi, Shigeki Kanamura, Kengo Maeda, Takahiro Hisano, Daizo Tanaka, Yukihiro Ando, Tomokazu Yamamoto, Yoshiro Morimoto, Hiroki Ozawa, Toshihiro Otsuka
In the treatment of schizophrenia, long-term pharmacotherapy with D2-receptor antagonists can induce dopamine supersensitivity psychosis (DSP). We report a male patient with schizophrenia with suspected DSP due to excessive polypharmacy. He was hospitalized for several years. Most psychotropic drugs were reduced and subsequently stopped without the exacerbation of symptoms by administering modified electroconvulsive therapy (mECT). Aripiprazole was then selected as the main drug for treatment, which was subsequently changed to the long-acting injection formulation...
August 21, 2022: Neurocase
https://read.qxmd.com/read/36369699/later-onset-of-childhood-disintegrative-disorder-cdd-a-case-report
#29
JOURNAL ARTICLE
Silvia Di Vara, Silvia Guerrera, Giovanni Valeri, Stefano Vicari
Childhood Disintegrative Disorder (CDD) is a rare condition characterized by regression of developmental and behavioral functioning after a period of apparently normal development, with an age of onset around 4 years. CDD is not included within the latest edition of the Diagnostic and Statistical Manual of Mental Disorders. We present a case report of an 11-year-old male who achieved normal development for up to 7 years followed by a deterioration of previously acquired linguistic, intellectual, and social skills...
August 2022: Neurocase
https://read.qxmd.com/read/36269675/proton-pump-inhibitors-induced-psychiatric-symptoms
#30
JOURNAL ARTICLE
Li Zhao, Dajiang Xie
Proton pump inhibitors are widely used in cure of digestive tract diseases and drug-induced psychiatric symptoms are rare. In this study, we aim to investigate the presentations, diagnostic approaches, treatments and prognosis. We present one case of proton pump inhibitors-induced motor hallucination underwent drug withdrawal and recovery subsequently. Delirium Rating Scale and Hamilton Anxiety Scale examinations showed transient delirium and anxiety. Proton pump inhibitors-induced psychiatric symptoms are benign and affect patients' prognosis...
August 2022: Neurocase
https://read.qxmd.com/read/36103716/cortical-activity-involved-in-perception-and-imagery-of-visual-stimuli-in-a-subject-with-aphantasia-an-eeg-case-report
#31
JOURNAL ARTICLE
Mariano Furman, Pablo Fleitas-Rumak, Pilar Lopez-Segura, Martín Furman, Gustavo Tafet, Gabriel A de Erausquin, Tomás Ortiz
Aphantasia has been described as the inability to voluntarily evoke mental images using the "mind's eye." We studied a congenital aphantasic subject using neuropsychological testsand 64 channel EEG recordings, in order to studycortical activity involved in perception and imagery evaluating event-related potentials(N170, P200, N250). The subject is in the normal range of the neuropsychological tests performed, except for specific imagery tests. The EEG results show that when he evokes the same mental image, he starts the evoking process from left temporal instead of frontal areas, he does not activate occipital visual nor left anterior parietal areas...
August 2022: Neurocase
https://read.qxmd.com/read/35914121/community-based-practical-behavioral-intervention-in-public-transportation-for-people-with-acquired-brain-injury-study-of-two-cases-using-a-single-case-experimental-design-study
#32
JOURNAL ARTICLE
Daisuke Shimizu, Tomoko Miyahara, Rumi Tanemura
The purpose of this paper was to report on the progress of a behavioral approach to enable patients with acquired brain injury (age 57, male, stroke and age 36, old, female, TBI) using a community activity support center to commute alone using public transportation. In this study, two ABI patients were intervened to enable them to use public transportation. The frequency of intervention was once a month or once a week. The two community-dwelling adults each had post-ABI attention and memory deficits and anxiety...
August 1, 2022: Neurocase
https://read.qxmd.com/read/35912569/a-case-of-new-cognitive-changes-in-a-patient-with-seronegative-paraneoplastic-limbic-encephalitis-encephalitis-relapse-or-wernicke-s-encephalopathy
#33
JOURNAL ARTICLE
Li Zhang, Amir Adeli
Wernicke's encephalopathy (WE) and paraneoplastic limbic encephalitis (PLE) can both present with acute-to-subacute memory impairment and cognitive dysfunction. Both can lead to significant morbidity and mortality without rapid identification and treatment. Often patients with WE may not have the typical clinical triad of ophthalmoplegia, gait ataxia, and altered mental status. Furthermore, both WE and PLE may share similar MRI findings. Here, we present a case of a patient with a history of seronegative PLE presenting with acute-to-subacute cognitive changes and gait imbalance...
July 30, 2022: Neurocase
https://read.qxmd.com/read/35858044/effect-of-motor-tasks-with-left-monocular-eyeglasses-on-visual-search-and-line-bisection-performance-in-people-with-left-unilateral-spatial-neglect
#34
JOURNAL ARTICLE
Sachiko Fujimori, Kei Tabaru, Yoshiyuki Kawano
Training with an eyepatch or eyeglasses is one of the effective approaches for unilateral spatial neglect (USN), and it usually uses a device that covers the right side. However, few approaches are available for the left side. In this study, we examine the effect of motor tasks with left/right monocular eyeglasses on visual search and line-bisection performance in people with left USN. Seven participants with left USN admitted to convalescent hospitals were included. We conducted the Bells test, line-crossing test, and line-bisection test of the behavioral inattention test before/after the motor task...
July 20, 2022: Neurocase
https://read.qxmd.com/read/35852094/a-four-month-home-based-tdcs-study-on-patients-with-alzheimer-s-disease
#35
JOURNAL ARTICLE
Ole K Grønli, Ingrid Daae Rasmussen, Per M Aslaksen, Martin Bystad
      In the present open-label study, our first aim was to study the tolerability and feasibility of long-term treatment with transcranial direct current stimulation (tDCS) and the second aim was to measure whether the treatment led to cognitive improvement. Participants with AD used a tDCS home-treatment kit inducing a low current (2 mA) via two scalp electrodes 30 minutes daily for 4 months. A total of 8 participants were recruited. The treatment technique was manageable for the participants and their spouses, and no troublesome side effects were reported...
July 19, 2022: Neurocase
https://read.qxmd.com/read/35833217/-fus-as-a-cause-of-familial-amyotrophic-lateral-sclerosis-a-case-report-in-a-pregnant-patient
#36
JOURNAL ARTICLE
Lisette Bazán-Rodríguez, Jesús A Ruíz-Avalos, Oscar Bernal-López, Edmar O Benitez-Alonso, Jesica Villaseñor-Sánchez, Francisca Fernandez-Valverde, Steven Vargas-Cañas
  Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. In 10% the disease is familial and rarely occurs in childbearing age women. A 28-year-old female pregnancy patient presented a two-month history of dropped head syndrome, dysphagia, muscle weakness, atrophy, and lingual wasting. Electromyography supported the diagnosis of ALS. Due to family history and background, we carried out molecular genetic testing. We identified a novel variant of uncertain significance: c. 1566 G > C (p.Arg522Ser) in exon 15 in FUS gene...
July 13, 2022: Neurocase
https://read.qxmd.com/read/35767773/pupillometry-as-an-index-for-cognitive-processing-in-behavioral-variant-frontotemporal-dementia-a-series-of-case-studies
#37
JOURNAL ARTICLE
Mohamad El Haj, Dimitrios Kapogiannis, Claire Boutoleau-Bretonnière
We investigated whether pupil size can variate with the intensity of cognitive processing in patients with behavioral-variant-Frontotemporal-Dementia (bvFTD). We invited five bvFTD participants and 21 controls to perform forward spans and backward spans, and, in a control condition, to count aloud. We recorded pupil activity using eye-tracking-glasses during the spans and control condition. Analysis demonstrated larger pupil sizes during backward spans than during forward spans, and larger pupil sizes during forward spans than during counting in both bvFTD and control participants...
June 29, 2022: Neurocase
https://read.qxmd.com/read/35654103/a-novel-galc-gene-mutation-associated-with-adult-onset-krabbe-disease-a-case-report
#38
JOURNAL ARTICLE
Zhengqing He, Xinyuan Pang, Jiongming Bai, Haoran Wang, Feng Feng, Rongrong Du, Xusheng Huang
To analyze the clinical, imaging, and genetic characteristics of a patient diagnosed with adult-onset Krabbe disease (KD). Clinical and imaging features of the patient were retrospectively reviewed. The patient, a 40-year-old female, presented adult-onset spastic paraplegia. Brain magnetic resonance imaging (MRI) showed white matter hyperintensities along bilateral optic radiations. Colorimetry of galactocerebrosidase enzyme activity showed low enzyme levels. A heterozygous missense mutation: c.1658G>A (p...
June 2, 2022: Neurocase
https://read.qxmd.com/read/35654085/neuralgic-amyotrophy-triggered-by-cytomegalovirus-to-be-aware-of-this-clinical-diagnosis
#39
JOURNAL ARTICLE
Quentin Scanvion, Sandrine Morell-Dubois
Neuralgic amyotrophy (NA) is a multifocal inflammatory neuropathy. Although the exact etiopathogenesis of the latter is unknown, the literature reports frequent associations with immunological events such as different infectious diseases. Our case reveals a rarely described etiology of NA. NA is mainly a clinical diagnosis. The etiology shown in our case study is interesting for the scientific community, because CMV is an ubiquitous disease. NA is frequently under-recognized and misdiagnosed. This is particularly common in the early phase of the disease, when neurologic signs have not yet developed...
June 2, 2022: Neurocase
https://read.qxmd.com/read/36031874/one-time-paroxysm-of-artistic-talent-in-focal-epilepsy
#40
JOURNAL ARTICLE
Sreya Malladi, Kenneth Heilman, Giridhar Kalamangalam
Despite having unremarkable artistic talent, an 8-year-old male with chronic focal epilepsy from the right lateral frontal lobe drew a complex visual pattern during a 15-minute spell when he looked physically unwell. He underwent epilepsy surgery shortly thereafter and has been seizure-free since. In the ensuing 16 years of follow-up there have been no other such artistic incidents. We deduce that emergence of paroxysmal de novo artistic ability in our patient was caused by seizure discharge disinhibiting the ipsilateral parietal cortex and/or transient ictal engagement of distant salience and default mode sites...
June 2022: Neurocase
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