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Archives of Physiology and Biochemistry

M D Morsy, I Bin-Jaliah, S O Bashir, A Shatoor, M A Haidara
Endothelial dysfunction in type 1 diabetes mellitus (T1DM) is an important factor in the pathogenesis of micro- and macrovascular complications. The present study was to investigate the impact of combined vanadium and insulin for proper control and protection against endothelial dysfunction in T1DM rats. Sixty male Sprague-Dawley rats were randomly divided into six groups; control non-treated; control vanadium treated; T1DM; T1DM + insulin; T1DM + vanadium; T1DM + insulin + vanadium treated groups...
February 21, 2019: Archives of Physiology and Biochemistry
Ehab M M Ali, Thoria Diab, Afaf Elsaid, Hamada A Abd El Daim, Rami M Elshazli, Ahmad Settin
BACKGROUND: Several studies addressed the contribution of fat mass and obesity-associated (FTO) and leptin receptor (LEPR) polymorphisms for the susceptibility to obesity among different ethnic subjects. The main purpose of this work is to evaluate the association of these polymorph\isms with obesity among Egyptian subjects. SUBJECTS AND METHODS: This case-control study was carried out on 110 unrelated obese Egyptian subjects who were compared with 122 controls...
February 15, 2019: Archives of Physiology and Biochemistry
Petya Hadzhibozheva, Anna Tolekova, Reni Kalfin, Tsvetelin Georgiev
OBJECTIVE: An application of a specific analysis on recordings obtained from urinary bladder (UB) preparations influenced with Angiotensin II (AngII) and AngII receptor (ATR) blockers was performed. METHODS: UB preparations were divided as follows: group 1 stimulated with AngII only; group 2:PD123319 (ATR type-2 blocker)+AngII; group 3:Losartan (ATR type-1 blocker)+AngII. The averaged time and force parameters of the contractions were processed by a spline interpolation and graphic images of the different patterns of the contractile activity were obtained...
February 10, 2019: Archives of Physiology and Biochemistry
V V Sathibabu Uddandrao, P Rameshreddy, P Brahmanaidu, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, Ravindar Naik Ramavat, K Swapna, Suresh Pothani, Harishankar Nemani, Balaji Meriga, S Vadivukkarasi, Nivedha P R, Saravanan Ganapathy
In the current study, we evaluated the effects of Asiatic acid (AA) on lipid metabolic markers in HFD-induced obese Sprague-Dawley rat model. AA (20 mg/kg BW) was administered orally to HFD-fed rats for 42 days. Changes in body composition, glucose, insulin resistance (IR) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and its target genes fatty-acid synthase (FAS), adipocyte protein-2 (aP2) and uncoupling protein-2 (UCP-2) and pro-inflammatory factor tumor necrosis factor (TNF)-α were observed in experimental rats...
February 10, 2019: Archives of Physiology and Biochemistry
Stian Jelstad, Thorhildur Ditta Valsdottir, Egil I Johansen, J Rgen Jensen
Exercise improves metabolic regulation and reduces the risk of developing type 2 diabetes and other metabolic diseases. The recommendations for exercise are rather general and the health benefits of controlled training studies are important to make better recommendations. In the present study, we report that eight endurance training sessions over 3 weeks reduced fasting glucose, and improved glucose tolerance and plasma lipids in sedentary middle-aged males (44-64 years) with overweight or obesity (BMI: 27-38)...
January 26, 2019: Archives of Physiology and Biochemistry
Sukumar Babukumar, Veerasamy Vinothkumar, Duraisamy Ramachandhiran
Oral squamous cell carcinoma (OSCC) is widespread malignant neoplasm and refractory cancers in worldwide. Here, we studied the chemopreventive potential of hesperetin on 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis (HBPCs). Oral tumours were developed in the buccal pouches of male golden Syrian hamsters by topical application of 0.5% DMBA three times a week for 10 weeks. This causes sequentially hyperplasia, dysplasia and well differentiates squamous cell carcinoma (SCC) with up-regulation of molecular markers like mutant-p53, Caspase-3 and caspase-9 and cyclin-D1...
January 20, 2019: Archives of Physiology and Biochemistry
Tomasz Szkudelski, Katarzyna Szkudelska
AMP-activated protein kinase (AMPK) is a key intracellular energy sensor and regulates processes associated with energy metabolism. In the present study, effects of AICAR, a pharmacological activator of AMPK, on metabolism of adipocytes of non-fasted and 12-h fasted rats were compared. It was shown that in fat cells of control rats, epinephrine- and dibutyryl-cAMP-induced lipolysis was markedly reduced in the presence of AICAR. However, in adipocytes of fasted animals, the lipolytic response was not significantly affected by AICAR...
January 19, 2019: Archives of Physiology and Biochemistry
Ying Feng, Ming-Yue Jin, Dong-Wei Liu, Li Wei
Mesangial cells played a central role in the pathophysiology of diabetic nephropathy (DN). Our goal was to evaluate the molecular mechanism that regulates loss of BMP7 protein expression in DN. The mRNA and protein levels of BMP7 or UBE4A were detected using qRT-PCR and Western blot respectively. Mass spectrometry and co-immunoprecipitation were used to explore the E3 ligase which regulated BMP7 post-translationally. We initially confirmed that BMP7 protein, but not mRNA, is downregulated when cultured under high glucose mimicking DN conditions, which was rescued by MG-132 treatment...
January 19, 2019: Archives of Physiology and Biochemistry
Maya V Gulubova, Anna N Tolekova, Koni Ivanova, Sevinch Hamza, Mehmed Hadzhi, Dimitar Chonov, Julian Ananiev
CONTEXT: Gastric ghrelin-positive endocrine cells (GHR + EC) were most dense in the oxyntic mucosa. OBJECTIVE: We evaluated ECs and contractile activity in rat stomach with metabolic disorders. MATERIALS AND METHODS: Male Wistar rats were divided into two groups: Control (n = 9) received tap water and Fructose (n = 9) drank 15% fructose solution for 12 weeks. Streptozotocin was applied in a dose of 20 mg/kg b.w. two weeks after the beginning of the experiment on Fructose group...
January 11, 2019: Archives of Physiology and Biochemistry
Günter A Müller
Insulin was first discovered in extracts of vertebrate pancreas during a focused search for a therapy for diabetes. Subsequent efforts to discover and isolate a similar active principle from yeast and plants driven by the hope to identify insulin-like/mimetic molecules with critical advantages in the pharmacokinetic profile and expenditure of production compared to authentic human insulin were not successful. As a consequence, it has generally been assumed that hormones evolved exclusively during course of the evolution of vertebrate endocrine organs, implying a rather recent origin...
January 11, 2019: Archives of Physiology and Biochemistry
Jovana Bradic, Nevena Jeremic, Anica Petkovic, Jovana Jeremic, Vladimir Zivkovic, Ivan Srejovic, Jasmina Sretenovic, Stevan Matic, Vladimir Jakovljevic, Marina Tomovic
The aim of our study was to determine a chemical composition of methanol extract of Galium verum as well as to assess its effects on functional recovery and redox status of isolated rat heart after ischemia. Rats were divided into control and G. verum group, which included animals treated with 500 mg/kg of methanol extract of G. verum for 28 days. Parameters of heart function and oxidative stress markers were estimated. Cell morphology was evaluated by hematoxylin and eosin (HE) staining. Our results demonstrated for the first time that G...
January 11, 2019: Archives of Physiology and Biochemistry
Sašenka Vidičević, Jelena Tošić, Željka Stanojević, Aleksandra Isaković, Dragana Mitić, Dušica Ristić, Dragana Dekanski
The protective activity of dry olive leaf extract (DOLE) in carbon tetrachloride (CCl4 )-induced liver damage and possible mechanisms involved in this protection were investigated in rats. Acute CCl4 intoxication resulted in a massive hepatic necrosis, in increased serum transaminases, and in a perturbation of oxidative stress parameters in liver tissue [malondyaldehide, glutathione (GSH), catalase]. CCl4 did not affect the expression of caspase-3 and cytochrome c as markers of apoptosis; however, CCl4 increased the AMP-activated protein kinase (AMPK) activity and the expression of autophagy-related protein LC3II and decreased the expression of p62 protein...
January 11, 2019: Archives of Physiology and Biochemistry
Antoaneta Gateva, Zdravko Kamenov, Vera Karamfilova, Yavor Assyov, Tsvetelina Velikova, Yosif El-Darawish, Haruki Okamura
BACKGROUND: Overweight and obesity are linked to low-grade chronic inflammation that can impair normal insulin function and induce insulin resistance. The aim of this study was to compare IL-18 levels between patients with prediabetes and obese normoglycaemic controls. PATIENTS AND METHODS: In this study, we included 131 patients with mean age 54.9 ± 9.1 years, divided into two groups - group 1 with obesity without glycaemic disturbances (n = 66) and group 2 with prediabetes (n = 65)...
January 11, 2019: Archives of Physiology and Biochemistry
Maha M Sabry, Amal F Dawood, Laila A Rashed, Seham M Sayed, Sherif Hassan, Sheren F Younes
Obesity and atherosclerosis are inflammatory states involving variable metabolic signals. The adipokine resistin is implicated in adipose tissue dysfunction and is modulated by PPARγ. In this study, resistin and PPARγ role is investigated in the development of CVS disease. Forty-eight Adult male albino rats were divided into control, obesity and atherosclerotic groups; each group is divided into two subgroups; with and without PPARγ agonist administration for 8 weeks. To assess pathological changes; lipid profile, inflammatory mediator, serum resistin level and resistin expression in adipose tissue were measured...
January 7, 2019: Archives of Physiology and Biochemistry
Zhila Maghbooli, Solaleh Emamgholipour, Sima Aliakbar, Manouchehr Amini, Sattar Gorgani-Firuzjaee, Arash Hossein-Nezhad
This study investigated the mRNA and protein levels of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells (PBMCs) from type 2 diabetes patients with retinopathy (diabetic retinopathy (DR) patients) (n = 86) and those without retinopathy (n = 103). The mRNA expression of SIRT1 and SIRT3 was found to be significantly higher in diabetic patients with retinopathy compared to those without retinopathy. Notably, protein levels of SIRT1, SIRT3, and SIRT4 were higher in patients with DR compared with controls after adjusting for diabetes duration and taking metformin (p = ...
December 20, 2018: Archives of Physiology and Biochemistry
Victor Udo Nna, Ainul Bahiyah Abu Bakar, Azlina Ahmad, Mahaneem Mohamed
CONTEXT: Metformin's effect on glycaemic control is well documented, but its effect on diabetes-induced testicular impairment has been scarcely reported. OBJECTIVE: To investigate the effects of metformin on testicular oxidative stress, inflammation, and apoptosis, which largely contribute to fertility decline in diabetic state. METHODS: Male Sprague-Dawley rats were divided into 3 groups (n = 6/group) namely: normal control (NC), diabetic control (DC), and metformin (300 mg/kg b...
December 4, 2018: Archives of Physiology and Biochemistry
Houda Hamed, Salha Boulila, Ferdaws Ghrab, Rim Kallel, Tahia Boudawara, Abdelfattah El Feki
The present study aimed to evaluate the performance effect of aqueous extract of Rosmarinus officinalis (AERO) against the kidney toxicity induced by CCl4 in mice. The results showed that the renal damage induced by CCl4 was associated with a rise in oxidative stress monitored by a significant increase of TBARS and PCO levels (+89% and +136% respectively, p < .001) and a significant decrease of GSH level (-68%, p < .001) and antioxidants enzymes such as SOD, CAT, and GPX activities (-41.7%, -47...
November 30, 2018: Archives of Physiology and Biochemistry
Siddhartha Singh, Ajeya Nandi, Oly Banerjee, Ankita Bhattacharjee, Shilpi Kumari Prasad, Bithin Kumar Maji, Adipa Saha, Sandip Mukherjee
CONTEXT: Alteration of redox signalling and RANK-L expression in FBMCs of mice exposed to different intensities of cold stress (15 °C, 8 °C and 4 °C) were studied. OBJECTIVE: To understand the effects of varying intensities of cold stress on murine FBMCs and its impact on osteoclastogenesis. MATERIALS AND METHODS: FBMCs were isolated from mice exposed to different intensities of cold stress and used for immunoblotting and biochemical assays...
November 23, 2018: Archives of Physiology and Biochemistry
Samuel Nuno Pereira Lima, Cláudio Daniel Cerdeira, Gérsika Bitencourt Santos, Mateus de Mello Fernandes, Alexandre Giusti-Paiva, Maísa Ribeiro Pereira Lima Brigagão
BACKGROUND AND AIMS: Lipopolysaccharide (LPS), an endotoxin, is a component of the outer membrane of Gram-negative bacteria that is able to activate the peripheral immune system, leading to changes in signalling pathways that act locally and systemically to achieve adaptive responses. Sickness behaviour is a motivational state in response to endotoxin exposure and includes depressed activity and a reduction of exploratory behaviour, potentially reorganising organism priorities to cope with infectious diseases...
November 22, 2018: Archives of Physiology and Biochemistry
Mohammad A Dallak, Bahjat Al-Ani, Abbas O El Karib, Mohamed Abd Ellatif, Refaat A Eid, Rihab Al-Ani, Hesham M Mahmoud, Mohamed A Haidara
BACKGROUND: We tested the hypothesis that vitamin E may protect against pre-diabetes-induced aortic injury (aortopathy), and exercise can augment the action of vitamin E. MATERIAL AND METHODS: Rats were either fed with a high fat and fructose diet (HFD) (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrificed. The three protective groups were treated with vitamin E (HFD + Vit E), swimming exercises (HFD + Ex), and vitamin E plus swimming exercises (HFD + VitE + Ex), respectively...
November 22, 2018: Archives of Physiology and Biochemistry
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