journal
Journals Multiple Sclerosis : Clinical ...

Multiple Sclerosis : Clinical and Laboratory Research

https://read.qxmd.com/read/38605496/new-onset-lymphopenia-in-patients-with-relapsing-multiple-sclerosis-switching-from-long-standing-dimethyl-fumarate-treatment-to-diroximel-fumarate-a-case-series
#41
JOURNAL ARTICLE
Megan Schneider, John Kramer, Aimee Banks, Harold Moses
Lymphopenia is a known adverse effect in patients with relapsing multiple sclerosis (RMS) treated with fumaric acids. We present a case series of four patients diagnosed with RMS with prolonged lymphocyte stability on dimethyl fumarate for over 1 year who developed significant lymphopenia after transitioning to diroximel fumarate. This case series highlights the need for further research to elucidate the risk of lymphopenia in patients switching between fumaric acids.
April 11, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38605492/drug-induced-lymphopenia-are-all-fumarates-the-same
#42
JOURNAL ARTICLE
Ralf Gold, Jeremias Motte
No abstract text is available yet for this article.
April 11, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38605490/neurofilament-in-clinical-practice-is-the-multiple-sclerosis-community-ready
#43
JOURNAL ARTICLE
Marcello Moccia, Daniela Terracciano, Vincenzo Brescia Morra, Giuseppe Castaldo
No abstract text is available yet for this article.
April 11, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38561953/risk-of-depression-and-anxiety-in-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder-a-nationwide-cohort-study-in-south-korea
#44
JOURNAL ARTICLE
Soonwook Kwon, Kyung-Do Han, Jin Hyung Jung, Eun Bin Cho, Yeon Hak Chung, Junhee Park, Hea Lim Choi, Hong Jin Jeon, Dong Wook Shin, Ju-Hong Min
BACKGROUND: We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD). OBJECTIVES: MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded...
April 1, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38551315/prediction-of-disease-activity-and-treatment-failure-in-relapsing-remitting-ms-patients-initiating-daily-oral-dmts
#45
JOURNAL ARTICLE
Agustin Pappolla, Cristina Auger, Augusto Sao-Aviles, Carmen Tur, Marta Rodriguez-Barranco, Álvaro Cobo-Calvo, Neus Mongay-Ochoa, Breogán Rodríguez-Acevedo, Ana Zabalza, Luciana Midaglia, Pere Carbonell-Mirabent, Rene Carvajal, Joaquín Castilló-Justribó, Nathane Braga, Luca Bollo, Angela Vidal-Jordana, Georgina Arrambide, Carlos Nos, Annalaura Salerno, Ingrid Galán, Manuel Comabella, Jaume Sastre-Garriga, Mar Tintoré, Alex Rovira, Xavier Montalban, Jordi Río
BACKGROUND: Limited data exist regarding treatment response prediction to oral disease-modifying therapies (DMTs) in multiple sclerosis (MS). OBJECTIVES: We assessed the capacity of available scoring systems to anticipate disease activity parameters in naïve relapsing-remitting MS (RRMS) patients initiating daily oral DMTs, hypothesizing that they exhibit different predictive potentials. METHODS: We conducted a retrospective study and applied the Rio Score (RS), modified Rio Score (mRS), and MAGNIMS Score 12 months after DMT initiation...
March 29, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38525561/structural-mri-measures-are-associated-with-fatigue-severity-and-persistence-in-a-large-real-world-cohort-of-people-with-multiple-sclerosis
#46
JOURNAL ARTICLE
Alexandra C Simpson, Chen Hu, Ellen M Mowry, Robert T Naismith, Kathryn C Fitzgerald, Bardia Nourbakhsh
BACKGROUND: Results of research on radiological hallmarks of multiple sclerosis (MS) fatigue have been conflicting. OBJECTIVE: To investigate the associations of lesion and brain compartment volumes with fatigue severity and persistence in people with multiple sclerosis (PwMS). METHODS: The Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) network collects standardized data during routine care of PwMS from 10 healthcare institutions...
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38525548/autologous-hematopoietic-stem-cells-transplantation-in-mogad
#47
JOURNAL ARTICLE
Sara Mariotto, Sara Carta
No abstract text is available yet for this article.
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38523325/torben-fog-a-danish-pioneer-in-a-multi-faceted-spectrum-of-multiple-sclerosis-research
#48
JOURNAL ARTICLE
Per Soelberg Sørensen, Stephan Bramow, Melinda Magyari, Lene Werdelin, Nils Koch-Henriksen, Patrick Vermersch, Finn Sellebjerg
Torben Fog was committed to multiple sclerosis (MS) research for more than four decades, starting before the defence of his thesis in 1948 and lasting until his death in 1987. His research was multi-facetted, making him one of the great pioneers in the study of essential parts of the pathology, immunology and treatment of MS. He has contributed with meticulous studies of the MS plaques, documenting the perivenous distribution of plaques in the spinal cord. He constructed a scoring system for the disability in MS and used a computer programme to calculate a total neurological deficit...
March 24, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38519434/clinical-correlates-of-respiratory-disorders-in-patients-with-severe-multiple-sclerosis-a-cross-sectional-cohort
#49
JOURNAL ARTICLE
Elisabeth Maillart, Stefania Redolfi, Céline Louapre, Marion Houot, Emeline Chaugne, Pierantonio Laveneziana, Aurelian Ungureanu, Bruno Stankoff, Isabelle Arnulf, Caroline Papeix, Benedetta Bodini, Thomas Similowski, Catherine Lubetzki, Capucine Morélot-Panzini
BACKGROUND: Respiratory disorders remain incompletely described in multiple sclerosis (MS), even though they are a frequent cause of death. METHODS: The objective was to describe respiratory disorders in MS patients with Expanded Disability Status Score (EDSS) ⩾ 6.5. Diaphragm dysfunction was defined by at least two of the seven criteria: clinical signs, inspiratory recruitment of neck muscles during wakefulness, reduced upright vital capacity (VC) < 80%, upright-to-supine VC ⩾ 15% of upright VC, decrease in Maximal Inspiratory Pressure < 60%, phasic activation of inspiratory neck muscles during sleep, and opposition of thoracic and abdominal movements during sleep...
March 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38864542/actrims-forum-2024-author-index
#50
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
June 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38864541/actrims-forum-2024
#51
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
June 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38751221/improving-explanation-of-motor-disability-with-diffusion-based-graph-metrics-at-onset-of-the-first-demyelinating-event
#52
JOURNAL ARTICLE
Michael A Foster, Ferran Prados, Sara Collorone, Baris Kanber, Niamh Cawley, Indran Davagnanam, Marios C Yiannakas, Lola Ogunbowale, Ailbhe Burke, Frederik Barkhof, Claudia Am Gandini Wheeler-Kingshott, Olga Ciccarelli, Wallace Brownlee, Ahmed T Toosy
BACKGROUND: Conventional magnetic resonance imaging (MRI) does not account for all disability in multiple sclerosis. OBJECTIVE: The objective was to assess the ability of graph metrics from diffusion-based structural connectomes to explain motor function beyond conventional MRI in early demyelinating clinically isolated syndrome (CIS). METHODS: A total of 73 people with CIS underwent conventional MRI, diffusion-weighted imaging and clinical assessment within 3 months from onset...
June 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38469809/natalizumab-reduces-loss-of-gray-matter-and-thalamic-volume-in-patients-with-relapsing-remitting-multiple-sclerosis-a-post-hoc-analysis-from-the-randomized-placebo-controlled-affirm-trial
#53
RANDOMIZED CONTROLLED TRIAL
Kunio Nakamura, Zhaonan Sun, Claire Hara-Cleaver, Karthik Bodhinathan, Robin L Avila
BACKGROUND: Loss of brain gray matter fractional volume predicts multiple sclerosis (MS) progression and is associated with worsening physical and cognitive symptoms. Within deep gray matter, thalamic damage is evident in early stages of MS and correlates with physical and cognitive impairment. Natalizumab is a highly effective treatment that reduces disease progression and the number of inflammatory lesions in patients with relapsing-remitting MS (RRMS). OBJECTIVE: To evaluate the effect of natalizumab on gray matter and thalamic atrophy...
May 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38602260/ebv-infection-drives-ms-pathology-yes
#54
JOURNAL ARTICLE
Francesca Aloisi, Marco Salvetti
No abstract text is available yet for this article.
April 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38602259/ebv-infection-drives-ms-pathology-commentary
#55
JOURNAL ARTICLE
Marianna Cortese, Alberto Ascherio
No abstract text is available yet for this article.
April 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38602258/ebv-infection-drives-ms-pathology-no
#56
JOURNAL ARTICLE
Bert A 't Hart, Marvin M van Luijn
No abstract text is available yet for this article.
April 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38465484/letter-to-the-editor-mobile-health-interventions-in-multiple-sclerosis-a-systematic-review
#57
LETTER
Rainer Ehling, Barbara Seebacher, Christian Brenneis
No abstract text is available yet for this article.
April 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38420930/reply-mobile-health-interventions-in-multiple-sclerosis-a-systematic-review
#58
JOURNAL ARTICLE
Christoph Heesen, Dagmar Lühmann
No abstract text is available yet for this article.
April 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38362861/a-custom-built-step-exergame-training-programme-to-prevent-falls-in-people-with-multiple-sclerosis-a-multicentre-randomised-controlled-trial
#59
RANDOMIZED CONTROLLED TRIAL
Phu Hoang, Daina L Sturnieks, Anna Butler, Carly Chaplin, Cameron Hicks, Joanne Lo, Mayna Ratanapongleka, Sophie Robinson, Natassia Smith, Jessica Turner, Arun V Krishnan, Michael Barnett, Simon Gandevia, Stephen R Lord, Jasmine C Menant
BACKGROUND: Cognitive-motor step training can improve stepping, balance and mobility in people with multiple sclerosis (MS), but effectiveness in preventing falls has not been demonstrated. OBJECTIVES: This multisite randomised controlled trial aimed to determine whether 6 months of home-based step exergame training could reduce falls and improve associated risk factors compared with usual care in people with MS. METHODS: In total, 461 people with MS aged 22-81 years were randomly allocated to usual care (control) or unsupervised home-based step exergame training (120 minutes/week) for 6 months...
April 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38333909/drop-out-adherence-and-compliance-in-randomized-controlled-trials-of-exercise-training-in-multiple-sclerosis-short-report
#60
JOURNAL ARTICLE
Robert W Motl, Daniel I Russell, Lara A Pilutti, Alexandra P Metse, Claudia H Marck, Bryan Chan, Peixuan Zheng, Yvonne C Learmonth
We documented reporting and rates of drop-out, adherence, and compliance from 40 randomized controlled trials (RCTs) included in our meta-analysis on safety of exercise training (ET) in MS. We adopted definitions and metrics of adherence and compliance provided by the MoXFo adherence group. Drop-out was reported in 100% of the RCTs and approximated 10% for intervention and control conditions. Adherence and compliance were reported in approximately 50% and 10% of the RCTs, respectively, and approximated 80% and 70%, respectively...
April 2024: Multiple Sclerosis: Clinical and Laboratory Research
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