journal
Journals Multiple Sclerosis : Clinical ...

Multiple Sclerosis : Clinical and Laboratory Research

https://read.qxmd.com/read/38619037/teriflunomide-in-pediatric-patients-with-relapsing-multiple-sclerosis-open-label-extension-of-terikids
#21
JOURNAL ARTICLE
Tanuja Chitnis, Brenda Banwell, Ludwig Kappos, Douglas L Arnold, Kivilcim Gücüyener, Kumaran Deiva, Stephane Saubadu, Wenruo Hu, Myriam Benamor, Annaig Le-Halpere, Philippe Truffinet, Marc Tardieu
BACKGROUND: The double-blind TERIKIDS study demonstrated the efficacy and safety of teriflunomide. OBJECTIVE: To evaluate the efficacy, safety, and tolerability of continuous teriflunomide treatment in the TERIKIDS open-label extension. METHODS: In the double-blind period, children with relapsing MS were randomized to placebo or teriflunomide (14 mg adult-equivalent dose) for ⩽ 96 weeks. Participants received teriflunomide for ⩽ 192 weeks post-randomization in the open-label extension...
April 15, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38616532/multiple-sclerosis-can-be-diagnosed-solely-with-dissemination-in-space-no
#22
JOURNAL ARTICLE
Christopher C Hemond, Andrew J Solomon
No abstract text is available yet for this article.
April 14, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38616523/multiple-sclerosis-can-be-diagnosed-solely-with-dissemination-in-space-commentary
#23
JOURNAL ARTICLE
Marisa P McGinley, Jeffrey A Cohen
No abstract text is available yet for this article.
April 14, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38616522/multiple-sclerosis-can-be-diagnosed-solely-with-dissemination-in-space-yes
#24
JOURNAL ARTICLE
Ahmed T Toosy, Frederik Barkhof
No abstract text is available yet for this article.
April 14, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38616520/therapeutic-lag-is-treatment-effect-delayed-in-progressive-ms
#25
JOURNAL ARTICLE
Noemi Montobbio, Francesca Bovis, Alessio Signori, Marta Ponzano, Irene Schiavetti, Maria Pia Sormani
BACKGROUND: Randomized clinical trials (RCTs) in progressive multiple sclerosis (MS) often revealed non-significant treatment effects on disability progression. OBJECTIVES: To investigate whether the failure to detect a significant benefit from treatment may be motivated by a delay in treatment effect, possibly related to baseline characteristics. METHODS: We re-analyzed data from two RCTs testing interferon-beta and glatiramer-acetate versus placebo in progressive MS with no significant effect on EDSS progression...
April 14, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38616518/prevalence-and-incidence-of-multiple-sclerosis-in-turkey-a-nationwide-epidemiologic-study
#26
JOURNAL ARTICLE
Bilgin Öztürk, Esra Taşkıran, Serkan Demir, Meryem Aslı Tuncer, Murat Kürtüncü, Rana Karabudak, Aksel Siva, Hüsnü Efendi, Naim Ata, Mustafa Mahir Ülgü, Şuayip Birinci
BACKGROUND: Many studies on multiple sclerosis (MS) reveal different prevalence and epidemiologic results. OBJECTIVES: In this study, we aimed to determine the epidemiologic profile of MS using official health records in Turkey. METHODS: Patients diagnosed with MS from the official health data of the Ministry of Health, representing the entire population of Turkey, were included in the study. Prevalence and incidence calculations were performed using the data on gender, age, year of birth, city of residence, and year of diagnosis...
April 14, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38605496/new-onset-lymphopenia-in-patients-with-relapsing-multiple-sclerosis-switching-from-long-standing-dimethyl-fumarate-treatment-to-diroximel-fumarate-a-case-series
#27
JOURNAL ARTICLE
Megan Schneider, John Kramer, Aimee Banks, Harold Moses
Lymphopenia is a known adverse effect in patients with relapsing multiple sclerosis (RMS) treated with fumaric acids. We present a case series of four patients diagnosed with RMS with prolonged lymphocyte stability on dimethyl fumarate for over 1 year who developed significant lymphopenia after transitioning to diroximel fumarate. This case series highlights the need for further research to elucidate the risk of lymphopenia in patients switching between fumaric acids.
April 11, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38605492/drug-induced-lymphopenia-are-all-fumarates-the-same
#28
JOURNAL ARTICLE
Ralf Gold, Jeremias Motte
No abstract text is available yet for this article.
April 11, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38605490/neurofilament-in-clinical-practice-is-the-multiple-sclerosis-community-ready
#29
JOURNAL ARTICLE
Marcello Moccia, Daniela Terracciano, Vincenzo Brescia Morra, Giuseppe Castaldo
No abstract text is available yet for this article.
April 11, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38561953/risk-of-depression-and-anxiety-in-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder-a-nationwide-cohort-study-in-south-korea
#30
JOURNAL ARTICLE
Soonwook Kwon, Kyung-Do Han, Jin Hyung Jung, Eun Bin Cho, Yeon Hak Chung, Junhee Park, Hea Lim Choi, Hong Jin Jeon, Dong Wook Shin, Ju-Hong Min
BACKGROUND: We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD). OBJECTIVES: MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded...
April 1, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38551315/prediction-of-disease-activity-and-treatment-failure-in-relapsing-remitting-ms-patients-initiating-daily-oral-dmts
#31
JOURNAL ARTICLE
Agustin Pappolla, Cristina Auger, Augusto Sao-Aviles, Carmen Tur, Marta Rodriguez-Barranco, Álvaro Cobo-Calvo, Neus Mongay-Ochoa, Breogán Rodríguez-Acevedo, Ana Zabalza, Luciana Midaglia, Pere Carbonell-Mirabent, Rene Carvajal, Joaquín Castilló-Justribó, Nathane Braga, Luca Bollo, Angela Vidal-Jordana, Georgina Arrambide, Carlos Nos, Annalaura Salerno, Ingrid Galán, Manuel Comabella, Jaume Sastre-Garriga, Mar Tintoré, Alex Rovira, Xavier Montalban, Jordi Río
BACKGROUND: Limited data exist regarding treatment response prediction to oral disease-modifying therapies (DMTs) in multiple sclerosis (MS). OBJECTIVES: We assessed the capacity of available scoring systems to anticipate disease activity parameters in naïve relapsing-remitting MS (RRMS) patients initiating daily oral DMTs, hypothesizing that they exhibit different predictive potentials. METHODS: We conducted a retrospective study and applied the Rio Score (RS), modified Rio Score (mRS), and MAGNIMS Score 12 months after DMT initiation...
March 29, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38525561/structural-mri-measures-are-associated-with-fatigue-severity-and-persistence-in-a-large-real-world-cohort-of-people-with-multiple-sclerosis
#32
JOURNAL ARTICLE
Alexandra C Simpson, Chen Hu, Ellen M Mowry, Robert T Naismith, Kathryn C Fitzgerald, Bardia Nourbakhsh
BACKGROUND: Results of research on radiological hallmarks of multiple sclerosis (MS) fatigue have been conflicting. OBJECTIVE: To investigate the associations of lesion and brain compartment volumes with fatigue severity and persistence in people with multiple sclerosis (PwMS). METHODS: The Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) network collects standardized data during routine care of PwMS from 10 healthcare institutions...
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38525548/autologous-hematopoietic-stem-cells-transplantation-in-mogad
#33
JOURNAL ARTICLE
Sara Mariotto, Sara Carta
No abstract text is available yet for this article.
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38523325/torben-fog-a-danish-pioneer-in-a-multi-faceted-spectrum-of-multiple-sclerosis-research
#34
JOURNAL ARTICLE
Per Soelberg Sørensen, Stephan Bramow, Melinda Magyari, Lene Werdelin, Nils Koch-Henriksen, Patrick Vermersch, Finn Sellebjerg
Torben Fog was committed to multiple sclerosis (MS) research for more than four decades, starting before the defence of his thesis in 1948 and lasting until his death in 1987. His research was multi-facetted, making him one of the great pioneers in the study of essential parts of the pathology, immunology and treatment of MS. He has contributed with meticulous studies of the MS plaques, documenting the perivenous distribution of plaques in the spinal cord. He constructed a scoring system for the disability in MS and used a computer programme to calculate a total neurological deficit...
March 24, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38519434/clinical-correlates-of-respiratory-disorders-in-patients-with-severe-multiple-sclerosis-a-cross-sectional-cohort
#35
JOURNAL ARTICLE
Elisabeth Maillart, Stefania Redolfi, Céline Louapre, Marion Houot, Emeline Chaugne, Pierantonio Laveneziana, Aurelian Ungureanu, Bruno Stankoff, Isabelle Arnulf, Caroline Papeix, Benedetta Bodini, Thomas Similowski, Catherine Lubetzki, Capucine Morélot-Panzini
BACKGROUND: Respiratory disorders remain incompletely described in multiple sclerosis (MS), even though they are a frequent cause of death. METHODS: The objective was to describe respiratory disorders in MS patients with Expanded Disability Status Score (EDSS) ⩾ 6.5. Diaphragm dysfunction was defined by at least two of the seven criteria: clinical signs, inspiratory recruitment of neck muscles during wakefulness, reduced upright vital capacity (VC) < 80%, upright-to-supine VC ⩾ 15% of upright VC, decrease in Maximal Inspiratory Pressure < 60%, phasic activation of inspiratory neck muscles during sleep, and opposition of thoracic and abdominal movements during sleep...
March 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38511853/no-evidence-for-association-between-rs10191329-severity-locus-and-longitudinal-disease-severity-in-1813-relapse-onset-multiple-sclerosis-patients-from-the-msbase-registry
#36
JOURNAL ARTICLE
Maria Pia Campagna, Eva Kubala Havrdova, Dana Horakova, Guillermo Izquierdo, Fuencisla Matesanz, Sara Eichau, Jeannette Lechner-Scott, Bruce V Taylor, Maria-Isabel García-Sanchéz, Antonio Alcina, Anneke van der Walt, Helmut Butzkueven, Vilija G Jokubaitis
BACKGROUND: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. METHODS: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity...
March 21, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38511833/infectious-mononucleosis-and-risk-of-multiple-sclerosis-proxy-or-culprit
#37
EDITORIAL
Henrik Hjalgrim, Klaus Rostgaard
No abstract text is available yet for this article.
March 21, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38511730/risk-of-multiple-sclerosis-in-individuals-with-infectious-mononucleosis-a-national-population-based-cohort-study-using-hospital-records-in-england-2003-2023
#38
JOURNAL ARTICLE
Raphael Goldacre
BACKGROUND: Epstein-Barr virus (EBV) is thought to be a necessary causative agent in the development of multiple sclerosis (MS). Infectious mononucleosis (IM), which occurs up to 70% of adolescents and young adults with primary EBV infection, appears to be a further risk factor but few studies have been highly powered enough to explore this association by time since IM diagnosis. OBJECTIVE: The objective was to quantify the risk of MS in individuals with IM compared with the general population, with particular focus on time since IM diagnosis...
March 21, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38509661/facial-pain-in-ms-when-to-think-of-trigeminal-autonomic-cephalalgia
#39
JOURNAL ARTICLE
Sanjay Cheema, Manjit Matharu
No abstract text is available yet for this article.
March 20, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38481083/serum-neurofilament-light-for-detecting-disease-activity-in-individual-patients-in-multiple-sclerosis-a-48-week-prospective-single-center-study
#40
JOURNAL ARTICLE
M Johnsson, Y T Stenberg, H H Farman, K Blennow, H Zetterberg, C Malmeström, S Sandgren, I Rosenstein, J Lycke, M Axelsson, L Novakova
BACKGROUND: Serum neurofilament light (sNfL) reflects neuroaxonal damage and is now used as an outcome in treatment trials of relapsing-remitting multiple sclerosis (RRMS). However, the diagnostic properties of sNfL for monitoring disease activity in individual patients warrant further investigations. METHOD: Patients with suspected relapse and/or contrast-enhancing lesions (CELs) were consecutively included and performed magnetic resonance imaging (MRI) of the brain at baseline and weeks 28 and 48...
March 13, 2024: Multiple Sclerosis: Clinical and Laboratory Research
journal
journal
32305
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.