Kenta Nagahori, Kazuhiko Iwahashi, Shin Narita, Maki Numajiri, Eiji Yoshihara, Daisuke Nishizawa, Kazutaka Ikeda, Jun Ishigooka
Schizophrenia and bipolar disorder show high comorbidity with smoking dependence. Several previous studies reported that glycogen synthase kinase 3β (GSK3β), which is widely expressed in the brain including the dopamine projection areas such as the amygdala, nucleus accumbens and hippocampus, may play a role in neuropsychiatric disorders and dopamine- and serotonin-mediated behavior. In this study, we have analyzed the association of three single nucleotide polymorphisms (SNPs) within GSK3β gene (rs3755557, rs334558, rs6438552) with the smoking habits and age at smoking initiation in a sample of 384 young adult Japanese, which included 172 smokers and 212 non-smokers...
June 2015: Japanese Journal of Psychopharmacology