journal
Journals Microbial Drug Resistance : MD...

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease

https://read.qxmd.com/read/38364190/a-florfenicol-resistant-plasmid-shuttling-between-actinobacillus-pleuropneumoniae-and-glaesserella-parasuis
#1
JOURNAL ARTICLE
Chenguang Zhu, Jinshuang Cai, Jiahui An, Baoge Zhang, Yufeng Li
Porcine contagious pleuropneumonia, caused by Actinobacillus pleuropneumoniae , has resulted in significant economic losses to the swine industry. Although antibiotics are commonly employed to control this disease, their widespread use or misuse can lead to the development of antibiotic resistance in A. pleuropneumoniae. Consequently, it is crucial to conduct antimicrobial susceptibility testing on clinical isolates. In our study, we identified one strain of A. pleuropneumoniae with resistance to florfenicol and extracted a 5919 bp plasmid named pAPPJY, which confers florfenicol resistance...
February 16, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38350157/-in-vitro-assessment-of-antimicrobial-activity-of-novel-fluoroquinolone-levonadifloxacin-wck-771-against-multi-drug-resistant-clinical-isolates-from-cancer-patients-in-india
#2
JOURNAL ARTICLE
Vijeta Bajpai, Shashank Tiwari, Anwita Mishra, Rashmi Sure, Rahul Sarode, Sujit Bharti, Himanshu Pandey, Akhil Kapoor
Introduction: Rapid increase in antimicrobial-resistance is leading to urgent need for newer broad-spectrum antimicrobials. Therefore, we have evaluated the antimicrobial résistance spectrum of India-discovered novel antibiotics (levonadifloxacin) against clinical isolates recovered from cancer patients. Materials and Methods: The study was conducted in the microbiology department, over a period of 1 year between May 2021 and June 2022 and 374 consecutive and nonduplicate Gram-positive (GPC) and MDR Gram Negative Bacteria (GNB) isolate were analyzed from 3,880 cancer patients in study...
February 13, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38346314/rapid-tetra-primer-amplification-refractory-mutation-system-polymerase-chain-reaction-protocol-for-detection-of-y132f-mutation-in-fluconazole-resistant-candida-parapsilosis
#3
JOURNAL ARTICLE
Sevgi Öztürk, Kübra Çam, Gizem Babuccu, Uzay Altay Onem, Serhat Aydın, Mert Kuşkucu, Özlem Doğan
There is an emerging fluconazole resistance in Candida parapsilosis in recent years. The leading mechanism causing azole resistance in C. parapsilosis is the Y132F codon alteration in the ERG11 gene which encodes the target enzyme of azole drugs. In this study, we evaluated the sensitivity, compatibility, and specificity of a novel tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) method for rapid detection of the Y132F mutation in fluconazole nonsusceptible C. parapsilosis...
February 12, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38330414/phenotypic-and-molecular-characterization-of-a-hospital-outbreak-clonal-lineage-of-salmonella-enterica-subspecies-enterica-serovar-mikawasima-containing-bla-tem-1b-and-bla-shv-2-that-emerged-on-a-neonatal-ward-during-the-covid-19-pandemic
#4
JOURNAL ARTICLE
Anita Novak, Mia Dzelalija, Ivana Goic-Barisic, Ana Kovacic, Mario Pirija, Ana Maravic, Marina Radic, Jelena Marinovic, Zana Rubic, Merica Carev, Marija Tonkic
Nontyphoid salmonella can cause severe infections in newborns and is therefore declared a pathogen of major health significance at this age. The aim of the study was molecular and antimicrobial characterization of β-lactamase-producing Salmonella Mikawasima outbreak clone on a Neonatal ward, University Hospital of Split (UHS), Croatia during the COVID-19 pandemic. From April 2020, until April 2023, 75 nonrepetitive strains of Salmonella Mikawasima were isolated from stool specimens and tested for antimicrobial resistance...
February 7, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38315778/evaluation-of-phenotypic-tests-for-carbapenemase-detection-in-enterobacteriaceae-in-tunisia
#5
JOURNAL ARTICLE
Khouloud Ben Dhaou, Asma Ghariani, Leila Essalah, Imen Bouzouita, Samia Mahdhi, Hamida Ben Nsir, Marwa Frikha, Naceur El Marzouk, Emna Zghal Mhiri, Noura Leila Slim-Saidi
Introduction: Resistance to carbapenems in Enterobacteriaceae is a challenge for public health. Carbapenemase production is the leading mechanism. This work aims to evaluate four phenotypic methods for carbapenemase detection in comparison with a molecular method. Materials and Methods: Thirty-seven nonrepeating Enterobacteriaceae strains with decreased susceptibility to ertapenem were included. Imipenem MIC, Modified Hodge Test (MHT), Neo-Rapid Carb Kit® and KPC, MBL, and OXA-48 Confirm Kit® were performed...
February 6, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38215246/affinity-of-%C3%AE-lactam-antibiotics-for-neisseria-gonorrhoeae-penicillin-binding-protein-2-having-wild-cefixime-reduced-susceptible-and-cephalosporin-ceftriaxone-resistant-pena-alleles
#6
JOURNAL ARTICLE
Yoshiki Hiyama, Soh Yamamoto, Toyotaka Sato, Noriko Ogasawara, Naoya Masumori, Satoshi Takahashi, Shin-Ichi Yokota
Multidrug-resistant Neisseria gonorrhoeae is a serious concern worldwide. Resistance to β-lactam antibiotics occurs through mutations in penicillin-binding proteins (PBPs), acquisition of β-lactamases, and alteration of antibiotic penetration. Mosaic structures of penA , which encodes PBP2, play a major role in resistance to β-lactams, especially cephalosporins. Ceftriaxone (CRO) is recognized as the only satisfiable antibiotic for the treatment of gonococcal infections; however, CRO-resistant isolates have emerged in the community...
January 12, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38181173/discovery-of-a-novel-integrative-conjugative-element-ice-apl-chn2-related-to-sxt-r391-in-actinobacillus-pleuropneumoniae
#7
JOURNAL ARTICLE
Jinshuang Cai, Yan Geng, Baoge Zhang, Yufeng Li
Objective: The objective of this study was to characterize ICE Apl Chn2, a novel SXT/R391-related integration and conjugation element (ICE) carrying 19 drug resistance genes, in a clinical isolate of Actinobacillus pleuropneumoniae from swine. Methods: Whole genome sequencing (WGS) of A. pleuropneumoniae CP063424 strain was completed using a combination of third-generation PacBio and second-generation Illumina. The putative ICE was predicted by the online tool ICEfinder. ICE Apl Chn2 was analyzed by PCR, conjugation experiments, and bioinformatics tools...
January 5, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38165645/different-oxa-carbapenemases-in-genetically-unrelated-klebsiella-pneumoniae-strains-isolated-in-a-north-italian-hospital-during-multidrug-resistance-screening
#8
JOURNAL ARTICLE
Elena Addis, Ilaria Unali, Anna Bertoncelli, Anna Ventura, Riccardo Cecchetto, Annarita Mazzariol
Klebsiella pneumoniae is one of the main opportunistic pathogens that cause a broad spectrum of diseases with increasingly frequent acquisition of resistance to antibiotics, namely carbapenems. This study focused on the characterization of 23 OXA-48-like carbapenemase-producing K. pneumoniae isolates using phenotypic and molecular tests. Phenotypic determination of the presence of β-lactamases was performed using the extended-spectrum beta-lactamase (ESBL) NP test, and phenotypic determination of the presence of carbapenemase was based on the Carba NP test...
January 2, 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38150703/co-occurrence-of-tet-x4-and-bla-ndm-5-in-escherichia-coli-isolates-of-inpatient-origin-in-guangzhou-china
#9
JOURNAL ARTICLE
Haijun Chen, Yi Zhan, Linjing Wang, Zhirou Xiao, Donghua Feng, Zhemei Chen, Haitao Liu, Dingqiang Chen, Zhenbo Xu, Ling Yang
Tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant pathogens, especially carbapenem-resistant Enterobacterales and Acinetobacter in recent years. The emergence of antibiotic-resistant bacteria and antibiotic-resistant genes has threatened the effectiveness of antibiotics and public health with the excessive use of antibiotics in clinics. However, the emergence and dissemination of high-level mobile tigecycline-resistance gene tet(X) is challenging for clinical effectiveness of antimicrobial agent...
December 28, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38150701/an-approach-to-track-and-analyze-the-trend-of-antimicrobial-resistance-using-python-a-pilot-study-for-anand-gujarat-india-may-2022-august-2023
#10
JOURNAL ARTICLE
Priyanshu Khound, Himanshu Pandya, Rupal Patel, Naimika Patel, Siddhi A Darji, Purvi Trivedi, Vandan Mehta, Avani Raulji, Devjani Banerjee
The present work deals with the analysis and monitoring of bacterial resistance in using Python for the state of Gujarat, India, where occurrences of drug-resistant bacteria are prevalent. This will provide an insight into the portfolio of drug-resistant bacteria reported, which can be used to track resistance behavior and to suggest a treatment regime for the particular bacteria. The present analysis has been done using Python on Jupyter Notebook as the integrated development environment and its data analysis libraries such as Pandas, Seaborn, and Matplotlib...
December 28, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38150122/genomic-characterization-of-escherichia-coli-co-producing-kpc-2-and-ndm-5-carbapenemases-isolated-from-intensive-care-unit-in-a-chinese-hospital
#11
JOURNAL ARTICLE
Qian Xu, Haoyi Lin, Wanting Liu, Yuxia Zhong, Yingchun Zhou, Zhenbo Xu, Dingqiang Chen
Background: Around the world, carbapenemase-producing Escherichia coli is becoming more prevalent. The purpose of this research was to analyze the whole plasmid sequences from YL03 isolates of the E. coli strain that produce both KPC-2 and NDM-5 carbapenemases. Materials and Methods: Whole-genome sequencing (WGS) and analysis of E. coli strain YL03, which was isolated from a wound sample, was performed by Illumina Novaseq 6000 and Pacific Biosciences Sequel (PacBio, Menlo Park, CA) sequencers. Following that, the WGS results were used to predict and analyze the YL03 genome composition and function...
December 26, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38150043/characterization-of-verona-integron-encoded-metallo-%C3%AE-lactamase-type-carbapenemase-producing-escherichia-coli-isolates-collected-over-a-16-year-period-in-bolzano-northern-italy
#12
JOURNAL ARTICLE
Irene Bianconi, Manuela Spath, Richard Aschbacher, Renato Pedron, Stefanie Wieser, Elisabetta Pagani
Multidrug-resistant Escherichia coli , particularly carbapenemase producers, are a major source of concern. This study aims to investigate the long-term epidemiology of Verona integron-encoded metallo-β-lactamase (VIM)-producing E. coli in the health district of Bolzano, Northern Italy, by examining the phenotypic and genotypic characteristics of 26 isolates obtained during 2005-2020. Isolates were identified with matrix-assisted laser desorption/ionization time-of-flight, susceptibility testing was by Vitek 2, Sensititre, and Etest; carbapenemase activity was confirmed by Etest and Carbapenemase Inactivation Method (CIM) test; and the VIM-antigen was identified by the NG-Test CARBA 5...
December 26, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38150012/-in-silico-screening-and-experimental-validation-of-novel-mexab-oprm-efflux-pump-inhibitors-of-pseudomonas-aeruginosa
#13
JOURNAL ARTICLE
Suzanne Abdelmalek, Malak Hajar, Luma Salah, Heba Abdel-Halim
The emergence of multidrug-resistant Pseudomonas aeruginosa possesses a significant public health concern. Constitutively expressed MexAB-OprM efflux pumps in P. aeruginosa significantly contribute to its resistance to a variety of antibiotics. The development of efflux pump inhibitors (EPIs) has emerged as an attractive strategy in reversing antibiotic resistance. In this study, structure-based virtual screening techniques were used for the identification of new MexAB-OprM efflux inhibitors. The predicted poses were thoroughly filtered by induced fit docking procedures followed by in vitro microbiological assays for the validation of in silico results...
December 26, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38133499/the-changing-epidemiology-and-antimicrobial-susceptibility-of-staphylococcus-aureus-isolated-from-blood-cultures-in-a-university-hospital-from-argentina
#14
JOURNAL ARTICLE
Lucía Gulone, Sabrina Di Gregorio, Maia Morales, María Sol Haim, Susana García, Beatriz Perazzi, Angela Famiglietti, Marta Mollerach
Staphylococcus aureus bacteremia (SAB) is one of the most common serious bacterial infections worldwide. In this study, we demonstrated changes in SAB epidemiology in an Argentinean University Hospital during an 8-year period (2009-2016). A total of 326 S. aureus clinical isolates were recovered in three periods: P1: 2009-2010, P2: 2012-2014, and P3: 2015-2016. Among these, 127 were methicillin-resistant S. aureus (MRSA) and were characterized by phenotypic and molecular methods. We hereby report a significant decline in multiple drug resistance among MRSA isolates associated with an increase in SCC mec IV between the three periods...
December 22, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38127781/acknowledgment-of-reviewers-2023
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 22, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38100132/molecular-epidemiological-characterization-of-methicillin-resistant-staphylococcus-aureus-from-bloodstream-infections-in-northern-japan-increasing-trend-of-cc1-and-identification-of-st8-scc-mec-iva-usa300-like-isolate-lacking-arginine-catabolic-mobile-element
#16
JOURNAL ARTICLE
Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Yuuki Kimura, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi
Methicillin-resistant Staphylococcus aureus (MRSA) is a major infectious disease pathogen, and its molecular epidemiological profile has been changing. In this study, a total of 279 MRSA isolates were collected from patients with bloodstream infection (BSI) in Hokkaido, northern main island of Japan, for a 2-year period from August 2019 to July 2021. CC5 (ST5/ST764)-MRSA-IIa (SCC mec -IIa) (47%, n  = 132) and CC1 (ST1/ST2725/ST2764)-MRSA-IVa (42%, n  = 116) were found to be major lineages, with CC8-MRSA-IVa being lower prevalence (5%, n  = 13)...
December 14, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38060816/description-of-a-case-of-helicobacter-pylori-infection-with-in-vitro-resistance-to-tetracycline-an-exceptional-event-with-no-consequences
#17
JOURNAL ARTICLE
Sylvain Merle, Stéphane Bland, Lucie Bénéjat, Astrid Ducournau, Quentin Jehanne, Emilie Bessède, Marine Jauvain, Fréderic Heluwaert, Philippe Lehours
Resistance in Helicobacter pylori to tetracycline is rare. We describe the case of an H. pylori strain with a high level of resistance to tetracycline (minimum inhibitory concentration = 12 mg/L). However, despite tetracycline resistance, bismuth quadritherapy was effective. Analysis of the patient's antibiotic treatment history over the previous 25 years revealed repeated 3-month courses of tetracycline for the treatment of acne, suggesting in vivo selection pressure responsible for the emergence of the triple mutation (AGA→TTC) in 16S rDNA associated with tetracycline resistance...
December 7, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38060805/antimicrobial-resistance-of-genital-mycoplasma-and-ureaplasma-a-multicentre-study-over-a-5-year-period-in-italy-2017-2021
#18
JOURNAL ARTICLE
Matteo Pavoni, Luigi Principe, Claudio Foschi, Elisa Meroni, Elena Briozzo, Tiziana Lazzarotto, Simone Ambretti, Stefano Di Bella
Updated data on genital Mollicutes prevalence and antimicrobial susceptibility can help provide guidance for antibiotic stewardship and set up effective strategies for infection control policies. In this multicentre study, we assessed the prevalence and the resistance profile of Mycoplasma hominis (MH) and Ureaplasma species ( U. parvum/U. urealyticum ), analyzing data from 21,210 subjects who provided urogenital samples for Mollicutes detection by culture over a 5-year period (2017-2021) in two high-density urban areas in the North of Italy ( i...
December 7, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38252794/enhanced-biofilm-formation-by-tetracycline-in-a-staphylococcus-aureus-naturally-lacking-ica-operon-and-atl
#19
JOURNAL ARTICLE
Yimin Zou, Xuejie Li, Yanxiong Mao, Wenjuan Song, Qing Liu
Staphylococcus aureus is a major, widespread pathogen, and its biofilm-forming characteristics make it even more difficult to eliminate by biocides. Tetracycline (TCY) is a major broad-spectrum antibiotic, the residues of which can cause deleterious health impacts, and subinhibitory concentrations of TCY have the potential to increase biofilm formation in S. aureus . In this study, we showed how the biofilm formation of S. aureus 123786 is enhanced in the presence of TCY at specific subinhibitory concentrations...
February 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/38215245/acknowledgment-of-reviewers-2023
#20
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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