journal
https://read.qxmd.com/read/38696366/patient-reported-outcomes-after-oral-cancer-reconstructions-with-radial-and-ulnar-forearm-free-flaps
#21
JOURNAL ARTICLE
Maged Ali Al-Aroomi, Naseem Ali Al-Worafi, Yujie Ma, Khaled Alkebsi, Abdo Ahmed Saleh Mohamed, Canhua Jiang
OBJECTIVES: This study aimed to evaluate patient-reported quality of life and incidence of decision regret in patients undergoing radial (RFFF) and ulnar forearm-free flaps (UFFF) reconstruction. MATERIALS AND METHODS: Patients undergoing either RFFF or UFFF were assessed with the University of Washington Quality of Life (UW-QOL) and Oral Health Impact Profile (OHIP-14) questionnaires, and the Decision Regret Scale (DRS), both before and at least 12 months post-reconstruction...
May 2, 2024: Oral Diseases
https://read.qxmd.com/read/38696357/fadd-amplification-is-associated-with-cd8-t-cell-exclusion-and-malignant-progression-in-hnscc
#22
JOURNAL ARTICLE
Yang Zheng, Surui Sheng, Yanni Ma, Yinan Chen, Ruixin Liu, Wuchang Zhang, Li Zhang, Zhonglong Liu, Yue He, Hanlin Zeng, Zhiyuan Zhang
OBJECTIVE: This study aimed to clarify the relationship between FADD amplification and overexpression and the tumor immune microenvironment. METHODS: Immunohistochemical staining and bioanalysis were used to analyze the association between FADD expression in tumor cells and cells in tumor microenvironment. RNA-seq analysis was used to detect the differences in gene expression upon FADD overexpression. Flow cytometry and multicolor immunofluorescence staining (mIHC) were used to detect the differences in CD8+ T-cell infiltration in FADD-overexpressed cells or tumor tissues...
May 2, 2024: Oral Diseases
https://read.qxmd.com/read/38693647/comparative-clinicopathological-study-of-the-main-anatomic-locations-of-oral-squamous-cell-carcinoma
#23
JOURNAL ARTICLE
Iñaut Amezaga-Fernandez, José Manuel Aguirre-Urizar, José Manuel Suárez-Peñaranda, Cintia Chamorro-Petronacci, Irene Lafuente-Ibáñez de Mendoza, Xabier Marichalar-Mendia, José Manuel Somoza-Martín, Andrés Blanco-Carrión, José Antúnez-López, Abel García-García
OBJECTIVE: To analyze the clinicopathological and evolutionary profile of the main locations of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: This is a retrospective study on 133 patients treated for OSCC. The group was composed of 48 women and 85 men, with a mean age 63.9 ± 12.73 years. Most cases involved the lingual border of tongue (63), followed by the gingiva (36) and the floor of mouth (34). A comparative analysis was performed using multinomial regression...
May 1, 2024: Oral Diseases
https://read.qxmd.com/read/38693620/targeted-therapies-in-ameloblastomas-and-amelobastic-carcinoma-a-systematic-review
#24
REVIEW
Ronell Bologna-Molina, Lauren Schuch, Kelly Magliocca, Willie van Heerden, Liam Robinson, Elizabeth Ann Bilodeau, Haizal Mohd Hussaini, Merva Soluk-Tekkesin, Akinyele Olumuyiwa Adisa, Wanninayake Mudiyanselage Tilakaratne, Jiang Li, Ricardo Santiago Gomez, Keith David Hunter
Targeted therapy has the potential to be used in the neoadjuvant setting for odontogenic tumors, reducing the morbidities associated with major surgery. In this regard, the aim of this study was to summarize the current evidence on the different forms of targeted therapy, effectiveness, and drawbacks of this course of treatment. Four databases were searched electronically without regard to publication date or language. Grey literature searches and manual searches were also undertaken. Publications with sufficient clinical data on targeted therapy for odontogenic tumors were required to meet the criteria for eligibility...
May 1, 2024: Oral Diseases
https://read.qxmd.com/read/38656694/leucine-rich-alpha-2-glycoprotein-1-affects-bone-destruction-via-il-6-in-mouse-periodontitis-model
#25
JOURNAL ARTICLE
Kazuhisa Ouhara, Tasuku Takemura, Yuri Taniguchi, Ryousuke Fujimori, Tetsuya Tamura, Yuki Akane, Shinji Matsuda, Yuta Hamamoto, Tomoaki Shintani, Mikihito Kajiya, Syuichi Munenaga, Tomoyuki Iwata, Tsuyoshi Fujita, Noriyoshi Mizuno
OBJECTIVE: To investigate the production of leucine-rich α-2-glycoprotein-1 (LRG1) in periodontitis patients and its effectiveness as a new diagnostic marker for periodontitis. SUBJECTS AND METHODS: In vitro experiments were conducted to analyze LRG1 mRNA expression in human gingival epithelial cells and fibroblasts via quantitative real-time PCR. In vivo experiments were conducted to analyze LRG1 localization in periodontitis patients. The correlation between the serum LRG1 levels and alveolar bone resorption in the mouse periodontitis model was also investigated...
April 24, 2024: Oral Diseases
https://read.qxmd.com/read/38655689/dendritic-cell-subpopulations-in-carcinoma-ex-pleomorphic-adenoma-a-multicenter-study
#26
JOURNAL ARTICLE
Bárbara Azevedo Machado, Ana Guadalupe Gama-Cuellar, João Scarini, Katya Pulido Díaz, Fernanda Viviane Mariano, Ricardo Luiz Cavalcanti Albuquerque-Junior, Rogério Gondak
OBJECTIVE: Carcinoma ex-pleomorphic adenoma (CEXPA) represents a malignant transformation from a recurrent or primary pleomorphic adenoma (PA), and the immune response may be essential in this process. Therefore, in this study, we aimed to identify and quantify subpopulations of dendritic cells (DCs) in CEXPA, residual PA in CEXPA (rPA), and PA. MATERIALS AND METHODS: A multicenter study was performed collecting salivary gland tumor (SGT) samples from three Oral and Maxillofacial Pathology Centers...
April 24, 2024: Oral Diseases
https://read.qxmd.com/read/38655682/lncrna-in-periodontal-tissue-derived-cells-on-osteogenic-differentiation-in-the-periodontitis-field
#27
REVIEW
Yuanhang Du, Xiaoyan Guan, Yinci Zhu, Suhan Jin, Jianguo Liu
OBJECTIVE: Periodontitis can lead to the destruction of periodontal tissues and potentially tooth loss. Numerous periodontal tissue-derived cells display osteogenic differentiation potential. The presence of differentially expressed long non-coding RNAs (lncRNAs) in these cells indicate their ability to regulate the process of osteogenic differentiation. We aim to elucidate the various lncRNA-mediated regulatory mechanisms in the osteogenic differentiation of periodontal tissue-derived cells in the field of periodontitis at epigenetic modification, transcriptional, and post-transcriptional levels...
April 24, 2024: Oral Diseases
https://read.qxmd.com/read/38655600/panoptosis-induced-by-inflammatory-cytokines-promotes-salivary-glands-radiation-injury
#28
JOURNAL ARTICLE
Yi Qu, Dan Li, Guanzheng Chen, Shuqi Zhao, Zhengxue Han, Lizheng Qin
OBJECTIVE: Salivary glands are frequently damaged in patients undergoing radiotherapy for head and neck cancer. Whether PANoptosis, which is characterized by pyroptosis, apoptosis, and necroptosis, occurs during radiation injury to the salivary glands and its role remain unclear. MATERIALS AND METHODS: Radiation-induced injury models of mouse submandibular gland, as well as primary acinar cells and HSG cell lines were established to determine the presence of radiation-induced PANoptosis...
April 24, 2024: Oral Diseases
https://read.qxmd.com/read/38654678/gustatory-dysfunction-and-long-covid-in-chinese-patients-with-covid-19-a-6-month-follow-up-study
#29
JOURNAL ARTICLE
Jie Wei, Chenghui Lu, Yan Ding, Yongjian Lu, Xin Yang, Xi Zhang, Guoyao Tang
AIMS: To evaluate long COVID of gustatory dysfunction and the associated risk factors regarding onset and recovery in Chinese patients. METHODS: We conducted a cross-sectional study of patients with SARS-CoV-2 Omicron infection at Changxing Mobile Cabin Hospital in Shanghai, China, from March to May 2022. A prospective follow-up of patients with gustatory dysfunction was conducted at 6 months after discharge. RESULTS: In total, 18.48% (241/1304) reported gustatory dysfunction...
April 24, 2024: Oral Diseases
https://read.qxmd.com/read/38654673/oral-leukoplakia-treated-with-laser-and-scalpel-interim-trial-results-of-recurrence-and-malignancy
#30
JOURNAL ARTICLE
Mariana de Pauli Paglioni, Isabel Schausltz Pereira Faustino, Caique Mariano Pedroso, Manoela Domingues Martins, Pablo Augustin Vargas, Márcio Ajudarte Lopes, Alan Roger Santos-Silva
No abstract text is available yet for this article.
April 24, 2024: Oral Diseases
https://read.qxmd.com/read/38654640/xanthan-based-chlorhexidine-gel-effects-in-non-surgical-periodontal-therapy-a-meta-analysis
#31
REVIEW
Mensi Magda, Antonino Palazzolo, Gianluca Garzetti, Diego Lops, Stefano Calza, Matteo Rota
OBJECTIVE: To carry out a systematic review and meta-analysis of randomized controlled clinical trials (RCTs) and controlled clinical trials (CCTs) comparing scaling and root planing (SRP) or placebo with subgingival application of xanthan-based CHX (chlorhexidine) gel as adjunct to SRP. MATERIALS AND METHODS: The literature search was carried out in PubMed/MEDLINE, EMBASE, and SCOPUS; primary outcomes were probing pocket depth (PPD) reduction and gain in clinical attachment level (CAL)...
April 24, 2024: Oral Diseases
https://read.qxmd.com/read/38623870/tra2%C3%AE-exerts-tumor-promoting-effects-via-gsk3-%C3%AE-catenin-signaling-in-oral-squamous-cell-carcinoma
#32
JOURNAL ARTICLE
Xiaofen Wu, Xinyue Zhou, Xiaozhen Sun, Yi Ning, Xiaona Song, Guohua Song, Xiaohong Guo, Rui Sun
OBJECTIVES: The splicing factor transformer-2 homolog beta (Tra2β) plays a pivotal role in various cancers. Nonetheless, its role in oral squamous cell carcinoma (OSCC) has not been comprehensively explored. This study sought to discern the influence of Tra2β on OSCC and its underlying mechanisms. MATERIALS AND METHODS: We assessed Tra2β expression in OSCC utilizing immunohistochemistry, qRT-PCR, and western blotting techniques. siRNA transfection was used to silence Tra2β...
April 16, 2024: Oral Diseases
https://read.qxmd.com/read/38623775/transcriptomic-features-of-programmed-and-inflammatory-cell-death-in-gingival-tissues
#33
JOURNAL ARTICLE
Jeffrey L Ebersole, Sreenatha S Kirakodu, Linh M Nguyen, Octavio A Gonzalez
UNLABELLED: The local gingival tissue environment with homeostasis and tissue-destructive events of periodontitis demonstrates major changes in histological features and biology of the oral/sulcular epithelium, fibroblasts, vascular cells, inflammatory cell infiltration, and alveolar bone. OBJECTIVE: This study used an experimental periodontitis model to detail the gingival transcriptome related to cell death processes of pyroptosis, necroptosis, ferroptosis, and cuproptosis...
April 16, 2024: Oral Diseases
https://read.qxmd.com/read/38623066/dental-caries-and-developmental-defects-of-enamel-in-cerebral-palsy-a-meta-analysis
#34
REVIEW
Thaynara Nascimento de Oliveira, Victor Zanetti Drumond, José Alcides Almeida de Arruda, Sharat Chandra Pani, Fabiana Vargas-Ferreira, Ricardo Rabelo Eustachio, Ricardo Alves Mesquita, Lucas Guimarães Abreu
OBJECTIVE: This systematic review and meta-analysis aimed to compare the occurrence of dental caries and developmental defects of enamel (DDE) in individuals with and without cerebral palsy (CP). MATERIALS AND METHODS: We conducted searches across five databases and the grey literature. Data were organized using EndNote 20. Reporting followed the MOOSE checklist. A random-effects model meta-analyses were conducted using RStudio, presenting results as mean difference (MD), odds ratio (OR), and 95% confidence interval (CI)...
April 16, 2024: Oral Diseases
https://read.qxmd.com/read/38622964/clinical-characteristics-and-salivary-biomarkers-of-burning-mouth-syndrome
#35
JOURNAL ARTICLE
Mi-Sun Kong, Moon-Jong Kim, Yoon-Young Kim, Ji-Youn Chang, Hong-Seop Kho
OBJECTIVES: To investigate the clinical characteristics and salivary biomarkers in each type of burning mouth syndrome (BMS) patients. MATERIALS AND METHODS: Ninety-eight postmenopausal female patients with BMS were included. Fifty and 21 patients were assigned to the primary and secondary groups, respectively. Twenty-seven patients with both primary and secondary characteristics were assigned to the intermediate group. Comprehensive clinical characteristics and salivary biomarkers were analyzed...
April 15, 2024: Oral Diseases
https://read.qxmd.com/read/38622925/professor-emeritus-newell-walter-johnson-cmg
#36
JOURNAL ARTICLE
Saman Warnakulasuriya, Edward W Odell
No abstract text is available yet for this article.
April 15, 2024: Oral Diseases
https://read.qxmd.com/read/38622909/knockdown-of-circxpo1-inhibits-the-development-of-oral-squamous-cell-carcinoma-cells
#37
JOURNAL ARTICLE
Yao Lu, Jiaqi Bian, Darwin Omaña Ferrolino, Fatemeh Movahed
BACKGROUND: Circular RNAs (circRNAs) have emerged as pivotal regulators of cellular processes in human malignancies, including oral squamous cell carcinoma (OSCC). METHODS: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect RNA expression levels of circXPO1, miR-524-5p and cyclin D1 (CCND1). Colony formation assay and 5-Ethynyl-2'-deoxyuridine (EdU) assay were performed to analyze cell proliferation, while transwell assay was carried out to investigate the cell migration and invasion...
April 15, 2024: Oral Diseases
https://read.qxmd.com/read/38622872/the-roles-of-5-ht-in-orofacial-pain
#38
REVIEW
Zhishan Zou, Wenguo Fan, Haotian Liu, Qing Liu, Hongwen He, Fang Huang
OBJECTIVES: Acute and chronic orofacial pain are very common and remain a vexing health problem that has a negative effect on the quality of life. Serotonin (5-HydroxyTryptamine, 5-HT) is a kind of monoamine neurotransmitter that is involved in many physiological and pathological processes. However, its role in orofacial pain remains inconclusive. Therefore, this review aims to summarize the recent advances in understanding the effect exerted by 5-HT on the modulation of orofacial pain...
April 15, 2024: Oral Diseases
https://read.qxmd.com/read/38622839/amitriptyline-at-low-dose-for-burning-mouth-syndrome
#39
JOURNAL ARTICLE
Takahiko Nagamine
No abstract text is available yet for this article.
April 15, 2024: Oral Diseases
https://read.qxmd.com/read/38591808/osteoradionecrosis-incidence-in-pre-radiation-teeth-extractions-a-prospective-study
#40
JOURNAL ARTICLE
C Rupe, G Gioco, M Massaccesi, L Tagliaferri, F Pastore, F Micciché, J Galli, D Mele, M L Specchia, A Cassano, M Cordaro, C Lajolo
AIMS: To evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers. METHODS: The study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (ID-2132) and registered at clinicaltrials.gov (ID: NCT04009161). TE was performed in case of signs of pericoronitis, periapical lesions, restorative impossibility, severe periodontitis. ORN was defined as exposed bone at an unhealed post-extraction socket in the absence of oncological recurrence...
April 9, 2024: Oral Diseases
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