journal
https://read.qxmd.com/read/38591808/osteoradionecrosis-incidence-in-pre-radiation-teeth-extractions-a-prospective-study
#1
JOURNAL ARTICLE
C Rupe, G Gioco, M Massaccesi, L Tagliaferri, F Pastore, F Micciché, J Galli, D Mele, M L Specchia, A Cassano, M Cordaro, C Lajolo
AIMS: To evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers. METHODS: The study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (ID-2132) and registered at clinicaltrials.gov (ID: NCT04009161). TE was performed in case of signs of pericoronitis, periapical lesions, restorative impossibility, severe periodontitis. ORN was defined as exposed bone at an unhealed post-extraction socket in the absence of oncological recurrence...
April 9, 2024: Oral Diseases
https://read.qxmd.com/read/38591787/neutrophil-response-to-porphyromonas-gingivalis-is-modulated-by-low-level-laser-application
#2
JOURNAL ARTICLE
Yerda Özkan Karasu, Fatma Öner, Alpdogan Kantarci
OBJECTIVES: Neutrophil response is critical in inflammatory regulation and immune response to bacterial infections. During periodontal disease, pathogenic bacteria lead to exaggerated neutrophil responses. We hypothesized that low-level laser application (LLLT), therapeutic strategy for dampening inflammatory processes, will regulate neutrophil activity in response to periodontopathogens. MATERIALS AND METHODS: The impact of LLLT on neutrophil responses was measured by light delivered at wavelength of 850 nm...
April 9, 2024: Oral Diseases
https://read.qxmd.com/read/38591765/molecular-study-of-patients-with-odontohypophosphatasia-resulting-from-missense-mutation-in-alpl
#3
JOURNAL ARTICLE
Haitang Yue, Haiyan Cao, Yusheng Zhi, Guangtai Song, Jing Cheng, Miao He
No abstract text is available yet for this article.
April 9, 2024: Oral Diseases
https://read.qxmd.com/read/38569076/rapamycin-alleviates-irradiation-induced-parotid-injury-by-enhancing-the-whole-gland-homeostasis
#4
JOURNAL ARTICLE
Zhao Zhu, Jiaxin Song, Chunmei Zhang, Jing Zhang, Zhaochen Shan
OBJECTIVES: Salivary gland injury is one of the most common complications of radiotherapy in head-and-neck cancers. This study investigated the mechanism by which rapamycin prevents irradiation (IR)-induced injury in the parotid glands. MATERIALS AND METHODS: Miniature pigs either received (a) no treatment (NT), (b) IR in the right parotid gland for 5 consecutive days (IR), or intraperitoneal administration of rapamycin (Rap) 1 h prior to IR (IR + Rap)...
April 3, 2024: Oral Diseases
https://read.qxmd.com/read/38569071/saliva-and-tongue-microbiota-in-burning-mouth-syndrome-an-exploratory-study-of-potential-roles
#5
JOURNAL ARTICLE
Shuangshuang Wu, Linman Li, Xu Wang, Zhimin Yan
OBJECTIVES: Burning mouth syndrome (BMS) is a chronic orofacial pain disorder with unclear etiology, in which the tongue is most commonly affected. This study aims to provide implication of the possible relationship between oral microbiota and the pathogenesis of BMS. MATERIALS AND METHODS: Saliva and tongue swabs of 15 primary BMS patients and 10 healthy controls were collected and assessed by 16S rRNA gene amplicon sequencing. The microbiota compositions were compared and bioinformatic analysis was conducted...
April 3, 2024: Oral Diseases
https://read.qxmd.com/read/38568959/sorcs2-is-involved-in-promoting-periodontitis-induced-depression-like-behaviour-in-mice
#6
JOURNAL ARTICLE
Yingxue Li, Yao Yang, Xiaoyue Guan, Zhijun Liu, Lifei Pan, Yuting Wang, Xiangbin Jia, Jianmin Yang, Tiezhou Hou
BACKGROUND: Emerging evidence supports the association between periodontitis and depression, although the mechanisms are unclear. This study investigated the role of SorCS2 in the pathogenesis of periodontitis-induced depression. MATERIALS AND METHODS: An experimental periodontitis model was established using SorCS2 knockout mice and their wild-type littermates, and depression-like behaviour was evaluated. The expression of proBDNF signalling, neuronal activity, and glutamate-associated signalling pathways were further measured by western blotting and immunofluorescence...
April 3, 2024: Oral Diseases
https://read.qxmd.com/read/38566601/fibroblast-regulates-angiogenesis-in-assembled-oral-cancer-organoid-a-possible-role-of-nnmt
#7
JOURNAL ARTICLE
Mohammed Holkom, Xiao Yang, Rui Li, Yang Chen, Hui Zhao, Zhengjun Shang
OBJECTIVE: Tumour angiogenesis is affected by various cell types in the tumour microenvironment (TME), including cancer cells and cancer-associated fibroblasts (CAFs). Here, an assembled organoid model was generated to investigate the mechanism by which the TME regulates angiogenesis in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: Secretion of vascular endothelial growth factor-A (VEGFA) was analysed to compare the proangiogenic properties of OSCC cells and corresponding CAFs...
April 3, 2024: Oral Diseases
https://read.qxmd.com/read/38566541/areca-nut-and-oral-cancer
#8
REVIEW
Arjun Gurmeet Singh, Pankaj Chaturvedi
INTRODUCTION: The association between areca nut consumption and oral cancer has been a subject of increasing concern in global public health. GLOBAL PERSPECTIVE: Areca nut, often chewed in various forms such as betel quid, is deeply rooted in cultural practices across Asia and other parts of the world. Epidemiological studies consistently reveal a significant correlation between areca nut use and the incidence of oral cancer, emphasizing the need for targeted preventive measures...
April 2, 2024: Oral Diseases
https://read.qxmd.com/read/38566464/macrophage-derived-exosomes-rescue-the-tnf-%C3%A9-suppressed-osteo-cementogenic-differentiation-of-hpdlcs
#9
JOURNAL ARTICLE
Yifei Deng, Junhong Xiao, Xin Huang, Zhengguo Cao
OBJECTIVE: Inflammatory stimuli compromise the differentiation potency of human periodontal ligament cells (hPDLCs). Macrophage-derived exosomes (M-Exo) play a role in several aspects of cellular activity. This study investigated how M-Exo contributes to the osteo-/cementogenic differentiation of hPDLCs under inflammation and the mechanism involved. METHODS: M-Exo was identified by transmission electron microscopy, western blotting (WB), and dynamic light scattering...
April 2, 2024: Oral Diseases
https://read.qxmd.com/read/38566452/oral-conditions-are-associated-with-salt-taste-disability-among-american-adults
#10
JOURNAL ARTICLE
Luisa Schertel Cassiano, Fábio R M Leite, Silas Alves-Costa, Susilena Arouche Costa, Gustavo G Nascimento
AIM: To explore the association between oral conditions and their interaction with salt taste disability among American adults. METHODS: Data from the 2013-2014 NHANES cycle were used (n = 2373). The exposures were periodontitis, defined by the 2017 EFP-AAP classification, dental caries, missing teeth, and edentulism, as per the DMF-T index, and xerostomia. The outcome was salt taste disability, objectively assessed. Covariates included sex, age, educational level, poverty index, obesity, diabetes, smoking, alcohol consumption, and medications related to mouth dryness...
April 2, 2024: Oral Diseases
https://read.qxmd.com/read/38566363/root-resorptions-induced-by-genetic-disorders-a-systematic-review
#11
REVIEW
Nicolas Dupre, Margot C Riou, Juliane Isaac, François Ferre, Valérie Cormier-Daire, Stéphane Kerner, Muriel de La Dure-Molla, Nunthawan Nowwarote, Ana Carolina Acevedo, Benjamin P J Fournier
OBJECTIVES: Root resorption in permanent teeth is a common pathological process that often follows dental trauma or orthodontic treatment. More rarely, root resorption is a feature of genetic disorders and can help with diagnosis. Thus, the present review aims to determine which genetic disorders could induce pathological root resorptions and thus which mutated genes could be associated with them. METHODS: We conducted a systematic review following the PRISMA guidelines...
April 2, 2024: Oral Diseases
https://read.qxmd.com/read/38566281/topological-insight-of-immune-vascular-distribution-in-peri-implantitis-lesions
#12
JOURNAL ARTICLE
Veronica Villalobos, Ian Silva, Diego Morales, Javiera Canelo, Mauricio Garrido, Leandro J Carreño, Franco Cavalla, Nicolas Dutzan, Monica Caceres
OBJECTIVE: To characterize the distribution of macrophages, neutrophils, NK cells, and blood vessels in peri-implantitis compared to healthy aged gingiva samples. MATERIALS AND METHODS: This observational study included eight gingival samples from peri-implantitis and eight from periodontally healthy individuals. By immunofluorescence were identified neutrophils, NK cells, macrophages, and their pro-inflammatory or pro-healing phenotypes, and blood vessels. Two ROIs were designated as zone 1, connective tissue closest to the epithelium and zone 2, connective tissue over 200 microns from the rete ridges...
April 2, 2024: Oral Diseases
https://read.qxmd.com/read/38566274/differentiation-of-submandibular-sialadenitis-based-on-apparent-diffusion-coefficient
#13
JOURNAL ARTICLE
Hirotaka Muraoka, Takashi Kaneda, Takumi Kondo, Naohisa Hirahara, Yuta Kohinata, Satoshi Tokunaga
OBJECTIVES: This study aimed to quantify the submandibular gland in suppurative sialadenitis, primary Sjögren's syndrome (pSS) and radiation-induced sialadenitis using the apparent diffusion coefficient (ADC) for differential diagnosis. SUBJECTS AND METHODS: This retrospective study included 16 patients with suppurative sialadenitis (n = 9), pSS (n = 3) and radiation-induced sialadenitis (n = 4) who underwent magnetic resonance imaging between June 2006 and May 2022...
April 2, 2024: Oral Diseases
https://read.qxmd.com/read/38566263/impact-of-preoperative-haemoglobin-albumin-lymphocyte-and-platelet-score-on-oral-cancer-prognosis
#14
JOURNAL ARTICLE
Yu Ito, Atsushi Abe, Hiroki Hayashi
OBJECTIVE: To evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery. SUBJECTS AND METHODS: Patients (83 men, 32 women; 65.80 ± 11.47 years) who underwent radical surgery between 2012 and 2022 were included. Factors affecting overall survival and disease-free survival according to the haemoglobin, albumin, lymphocyte, and platelet score were examined...
April 2, 2024: Oral Diseases
https://read.qxmd.com/read/38525676/considering-the-role-of-epigenetic-mitotic-indices-in-oral-cancer-screening-and-risk-stratification
#15
LETTER
Jamaji C Nwanaji-Enwerem
No abstract text is available yet for this article.
March 25, 2024: Oral Diseases
https://read.qxmd.com/read/38523365/mucoadhesive-delivery-systems-for-oral-candidiasis-treatment-a-systematic-review-and-meta-analysis
#16
REVIEW
Carolina Yoshi Campos Sugio, Amanda Aparecida Maia Neves Garcia, Klaryssa Akemi de Araujo Kitamoto, Joel Ferreira Santiago Júnior, Simone Soares, Vinicius Carvalho Porto, Vanessa Migliorini Urban, Priscileila Colerato Ferrari, Maria Helena Fernandes, Karin Hermana Neppelenbroek
OBJECTIVES: This systematic review and meta-analysis aimed to evaluate the clinical and mycological effectiveness of mucoadhesives as vehicles for drugs or natural products in the treatment of oral candidiasis. MATERIALS AND METHODS: The search for articles was carried out in the Medline/PubMed, SCOPUS, EMBASE, Web of Science, Cochrane Library, and SciELO databases before August 2023. We selected the studies, extracted the data, evaluated the study quality, graded the evidence, performed the risk of bias, and carried out meta-analysis...
March 24, 2024: Oral Diseases
https://read.qxmd.com/read/38515263/identification-and-functional-study-of-a-novel-variant-of-pax9-causing-tooth-agenesis
#17
JOURNAL ARTICLE
Rong Lei, Xili Qiu, Ying Han, Fenghua Li, Xin Dong, Saimin Pei, Ting Zeng, Minmin Ge, Zhengmao Hu, Qi Tian, Ling Peng, Junhui Huang
OBJECTIVES: To search for pathogenic gene of a family with non-syndromic tooth agenesis, and explore the possible pathogenesis. MATERIALS AND METHODS: A Chinese family with non-syndromic tooth agenesis was recruited and screened for the pathogenic variants by whole exome sequencing technology and co-segregation analysis. The subcellular localization of wild-type and mutant protein was detected by immunofluorescence assay. Cycloheximide chase assay was performed to examine the difference in degradation rate between mutant protein and wild-type one...
March 21, 2024: Oral Diseases
https://read.qxmd.com/read/38515006/investigating-the-role-of-salivary-interleukin-40-levels-in-diagnosing-periodontal-diseases
#18
JOURNAL ARTICLE
Fatma Köksel Babun, Nezahat Arzu Kayar, Mükerrem Hatipoğlu
BACKGROUND: The present study aimed to analyze IL-40, IL-1β, and MMP-8 levels in periodontitis as well as gingivitis and periodontal health, and to explore potential correlations between these biomarkers and standard clinical parameters. MATERIALS AND METHODS: We collected saliva samples from 120 systemically healthy, non-smoking individuals aged between 18 and 63 years. These individuals were divided into three groups: healthy controls [S], gingivitis [G], and stage III grade B periodontitis [P]...
March 21, 2024: Oral Diseases
https://read.qxmd.com/read/38515001/visualising-cervical-lymph-nodes-in-jaw-osteonecrosis-using-diffusion-weighted-imaging
#19
JOURNAL ARTICLE
Hirotaka Muraoka, Takashi Kaneda, Takumi Kondo, Kohei Otsuka, Satoshi Tokunaga
OBJECTIVES: This study aimed to apply diffusion-weighted imaging to the evaluation of cervical lymph nodes affected by medication-related osteonecrosis of the jaw (MRONJ). METHODS: This retrospective study analysed the diffusion-weighted imaging data of 70 patients with or without MRONJ (Stages 0-3). The mean apparent diffusion coefficient (ADC) values of the submandibular (level IB) and superior internal jugular (level IIA) nodes in the control and MRONJ groups were calculated, and differences were analysed using the Mann-Whitney test...
March 21, 2024: Oral Diseases
https://read.qxmd.com/read/38514965/characterization-of-orofacial-features-in-sclerodermatous-chronic-graft-versus-host-disease
#20
JOURNAL ARTICLE
Amal Bajonaid, Praveen Kumar Guntaka, Matthew Harper, Corey Cutler, Christine Duncan, Alessandro Villa, Hervé Y Sroussi, Sook-Bin Woo, Nathaniel S Treister
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (alloHCT). The sclerodermatous form of cGVHD can be particularly debilitating; however, orofacial sclerodermatous involvement remains poorly described. OBJECTIVE: To characterize orofacial features of sclerodermatous cGVHD in a single center cohort of patients who underwent alloHCT. STUDY DESIGN: Retrospective data were collected from electronic medical records and analyzed descriptively...
March 21, 2024: Oral Diseases
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