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Oral Diseases

Anura Ariyawardana, Milda Chmieliauskaite, Arwa M Farag, Rui Albuquerque, Heli Forssell, Cibele Nasri-Heir, Gary D Klasser, Andrea Sardella, Michele D Mignogna, Mark Ingram, Charles R Carlson, Craig S Miller
OBJECTIVE: To conduct a systematic review analyzing disease definitions and diagnostic criteria used in randomized controlled trials (RCTs) involving burning mouth syndrome (BMS). METHODS: A systematic search conducted in PubMed, Web of Science, PsycINFO, Cochrane Database/Cochrane Central, and Google Scholar that included RCTs on BMS published between 1994 and 2017 was performed. RESULTS: Considerable variability in BMS disease definitions and diagnostic criteria used created substantial heterogeneity in the selection of participants and weakened the rigor of the 36 RCTs identified...
February 20, 2019: Oral Diseases
Khrystyna Zhurakivska, Eugenio Maiorano, Riccardo Nocini, Michele D Mignogna, Gianfranco Favia, Giuseppe Troiano, Claudia Arena, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio
OBJECTIVE: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. The aim of this paper is to report a series of Italian patients affected by NS associated with an unusual high presence of neoplasms of minor and major salivary glands. STUDY DESIGN: Clinical and histological features of twelve patients with NS were retrospectively evaluated...
February 18, 2019: Oral Diseases
Jaijam Suwanwela, Kanokporn Hansamuit, Jeeranan Manokawinchoke, Noppadol Sa-Ard-Iam, Rangsini Mahanonda, Prasit Pavasant, Thanaphum Osathanon
OBJECTIVE: Jagged1 regulates several biological functions in human periodontal ligament cells (hPDLs). The present study aimed to evaluate mRNA expression profiling of Jagged1 treated hPDLs using microarray technique. METHODS: Notch ligands, Jagged1, were indirectly immobilized on tissue culture surface. Subsequently, hPDLs were seeded on Jagged1 immobilized surface and maintained in growth medium for 48 h. Total RNA was collected and processed. Gene expression profiling was examined using microarray technique...
February 18, 2019: Oral Diseases
Chun-Yan Liu, Hai-Cheng Wang
OBJECTIVE: To investigate the alternative spliced isoforms of Fibronectin (FN) in the stroma of radicular cysts; and analyze the associations between these isoforms and the osteoclastogenic effects of fibroblasts. METHODS AND MATERIALS: The specimens of radicular cysts were stained with immunohistochemistry, and the associations between each FN isoform and clinical parameters were assessed. The fibroblasts isolated from cysts or jaw bone were cultured to induce the Trap+MNCs...
February 16, 2019: Oral Diseases
Chao Liu, Shengfeng Li, Fawei Pang, Haiwei Wu, Li Chai, Cheng Liang, Dongsheng Zhang
OBJECTIVES: Salivary adenoid cystic carcinoma (SACC) is one of the most common malignant salivary gland tumors. Our study aims to investigate whether hypoxia-induced autophagy was up-regulated in the progression of SACC. MATERIALS AND METHODS: We performed differentially expressed gene analysis, pathway enrichment analysis and then calculated the correlation analysis on GSE59701 and GSE28996 datasets. The expression of HIF-1ɑ and MAP1LC3B was analyzed in the paraffin-embedded specimens by immunohistochemical method and in the hypoxic SACC-LM cells by immunofluorescence...
February 11, 2019: Oral Diseases
João Daniel Paganella Chaves, Taize Franciele Massignani Figueredo, Stephanie Von Stein Cubas Warnavin, Cláudio Mendes Pannuti, João Paulo Steffens
OBJECTIVE: To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans. MATERIALS AND METHODS: Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/Medline. Human observational and interventional studies that evaluated the following parameters were included: Clinical Attachment Loss (CAL), Probing Pocket Depth (PPD), Bleeding on Probing (BOP), Radiographic Bone Loss (RBL) or osseointegration...
February 10, 2019: Oral Diseases
Z Tasdemir, M N Oskaybas, B A Alkan, O Cakmak
OBJECTIVES: The aim of this randomized split-mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non-surgical periodontal therapy. METHODS: A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL were evaluated at baseline and 3 months following periodontal therapy...
February 10, 2019: Oral Diseases
Na Xu, Baoyin Li, Zhuanzhuan Liu, Ruifang Gao, Shujuan Wu, Ziyu Dong, Huifang Li, Feiyan Yu, Fang Zhang
OBJECTIVES: Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear pathological mechanism. IκB kinase α (IKKα)-regulated mammary serine protease inhibitor (MASPIN) has been shown to mediate inflammation, particularly in cancers. Here, we explored the expression of MASPIN in OLP and its role in the inflammatory response. MATERIALS AND METHODS: Immunohistochemistry staining and reverse transcription-polymerase chain reaction assays were used to detect the subcellular localisation and expression of MASPIN and IKKα in OLP and healthy control tissues...
February 9, 2019: Oral Diseases
Ni Zhou, Hai Ming Wong, Colman McGrath
OBJECTIVE: To investigate the oral health status and associated factors among preschool children with special health care needs. SUBJECTS AND METHODS: This was designed as a cross-sectional study. Dental examination were provided to 383 children at Special Child Care Centres. Covariates of interest included children's age, developmental profile, oral health-related behaviours and family social-economic status. The association between children's dental caries experiences, dental plaque deposition and gingival health status were analysed by Negative Binomial Regression, Multiple Factor ANOVA and Binary Logistic Regression when appropriate...
February 6, 2019: Oral Diseases
Núbia Braga Pereira, Juliana Cristina de Souza, Victor Coutinho Bastos, Felipe Paiva Fonseca, Gleide Fernandes de Avelar, Wagner Henriques Castro, Adriana Abalen Martins Dias, Adalberto Mosqueda-Taylor, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
Ameloblastic Fibrodentinoma (AFD) is a benign odontogenic tumour of unclear pathogenesis. It is usually diagnosed before the age of 20 years and treatment is conservative surgery, with occasional segmental resection (Philipsen et al., 1997, Chrcanovic & Gomez, 2017). AFD can perforate cortical bone and recur. AFD is composed of odontogenic ectomesenchyme resembling the dental papilla and epithelial strands and nests resembling dental lamina and enamel organ, in addition to scattered dentinoid deposits (Slootweg, 1981, Cassidy et al, 1987, Bavle et al...
February 5, 2019: Oral Diseases
J G Messer, J M Jiron, J L Mendieta Calle, E J Castillo, R Israel, E G Phillips, J F Yarrow, C Van Poznak, L Kesavalu, D B Kimmel, J I Aguirre
OBJECTIVES: To determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD); characterize structural and tissue-level features of BRONJ-like lesions in this model; and examine the specific anti-resorptive role of ZOL in BRONJ. MATERIALS AND METHODS: Rice rats (n=228) consumed high-sucrose-casein diet to enhance generalized PD. Groups of rats received 0, 8, 20, 50 or 125μg/kg IV ZOL/4wks encompassing osteoporosis and oncology ZOL doses...
February 3, 2019: Oral Diseases
Wei Zhao, Yi Yang, Fanglong Wu, Hongmei Zhou
We read with interest the article by Otero Rey E. M. and colleagues that was recently published in Oral Diseases (Otero Rey E. M. et al., 2018). They provided evidence showed that the prevalence of diabetes mellitus (DM) among patients with oral lichen planus (OLP) ranges from 1.6% to 37.7% while the prevalence of OLP among patients with DM ranges from 0.5% to 6.1%. This article is protected by copyright. All rights reserved.
January 30, 2019: Oral Diseases
Haruka Nakata, Koichiro Matsuo, Hitomi Suzuki, Akihiro Yoshihara
OBJECTIVES: Perioperative oral health care can prevent postoperative complications, but it is also important to maintain oral health afterwards to avoid later adverse events. This study examined 1) the relationship between knowledge and attitude towards oral health (KAOH) and oral/periodontal status (OPS) in patients receiving surgery, and 2) the changes in KAOH by perioperative oral health care and education. METHODS: Patients receiving surgery who visited our hospital's dental clinic beforehand were prospectively recruited...
January 30, 2019: Oral Diseases
Pengfei Diao, Yaping Wu, Han Ge, Jin Li, Wei Zhang, Rong Huang, Yanling Wang, Jie Cheng
OBJECTIVE: Circulating immune-inflammatory cells have been increasingly recognized as robust prognostic biomarkers in cancer. Here, we sought to evaluate the prognostic values of preoperative peripheral platelet, neutrophil, lymphocyte quantitation in patients with primary oral squamous cell carcinoma. MATERIALS AND METHODS: A total number of 309 patients with primary OSCC surgically treated at our institutions was retrospectively included. Detailed demographic, clinicopathological, laboratory and follow-up data were collected...
January 29, 2019: Oral Diseases
Jakob Beutler, Holger F R Jentsch, A C Rodloff, C S Stingu
OBJECTIVE: The aim of this study was to investigate the characteristics of bacteremia caused by professional mechanical plaque removal (PMPR) in 2 groups of patients with generalized moderate chronic periodontitis. MATERIAL AND METHODS: Venous blood samples were taken at multiple time points for one hour following PMPR in fifty patients with generalized moderate chronic periodontitis. Subjects consisted of two groups, one group was receiving supportive periodontal therapy (SPT, n = 25) and the other group was receiving initial periodontal therapy (IPT, n = 25)...
January 25, 2019: Oral Diseases
Ming Jiang, Zhuoneng Li, Guangxun Zhu
Periodontal disease is a chronic inflammatory disease leading to destruction of periodontal tissues. As a local inflammation, periodontopathic bacterium, pro-inflammatory mediators and local immune response play pivotal role in the progress of periodontal disease. Besides, cigarette smoke has long been associated with periodontal disease and tooth loss. Autophagy is an intracellular degradation process highly conserved from yeast to humans. As a lysosomal degradation pathway of self-digestion, it is critical for maintaining cells homeostasis and development...
January 23, 2019: Oral Diseases
Kelly McGowan, Caroline Acton, Saso Ivanovski, Newell W Johnson, Robert S Ware
OBJECTIVES: Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition developed in up to 15% of patients who take antiresorptive medications. Its underlying pathogenesis remains unclear. The association between systemic comorbidities and MRONJ was investigated. SUBJECTS AND METHODS: A case-control study was conducted in Brisbane, Australia. Hospital records were used to identify 68 cases of MRONJ between January 2003- March 2017. Each case was individually matched to 3 controls (204 in total) according to sex, age, primary disease, and type and duration of antiresorptive therapy...
January 23, 2019: Oral Diseases
Alexandre Arredondo, Vanessa Blanc, Carolina Mor, José Nart, Rubén León
OBJECTIVES: To study oral Prevotella spp. isolated from patients with chronic periodontitis, to determine their susceptibility to azithromycin and erythromycin and to screen the presence of macrolide resistance genes therein. MATERIAL AND METHODS: Isolates with a Prevotella-like morphology were obtained from subgingival samples of 52 patients with chronic periodontitis. Each isolate was identified to the species level by sequencing of the 16S rRNA gene. In 100 Prevotella spp...
January 22, 2019: Oral Diseases
Anri Ohtsu, Yasuo Takeuchi, Sayaka Katagiri, Wataru Suda, Shogo Maekawa, Takahiko Shiba, Rina Komazaki, Sayuri Udagawa, Naoki Sasaki, Masahira Hattori, Yuichi Izumi
OBJECTIVES: Increasing evidence suggests that periodontitis can exacerbate diabetes, and gut bacterial dysbiosis appears to be linked with the diabetic condition. The present study examined the effects of oral administration of the periodontopathic bacterium, Porphyromonas gingivalis, on the gut microbiota and systemic conditions in streptozotocin-induced diabetic mice. MATERIALS AND METHODS: Diabetes was induced by streptozotocin injection in C57BL/6J male mice (STZ)...
January 22, 2019: Oral Diseases
Changyong Yuan, Penglai Wang, Shaoyue Zhu, Zongxiang Liu, Wen Wang, Tengyu Geng, Waruna Lakmal Dissanayaka, Lijian Jin, Chengfei Zhang
OBJECTIVES: we aimed to accelerate angiogenesis in pulp regeneration by modulating ephrinB2 expression in stem cells from apical papilla (SCAPs). MATERIALS AND METHODS: SCAPs were transducted with ephrinB2-lentiviral expression vector in experimental group (ephrinB2-SCAPs) and green fluorescent protein (GFP-SCAPs) in control group. The transduction efficiency was confirmed by real-time PCR and western blot assays. MTT assay was performed to detect the proliferative capacity of SCAPs after transduction...
January 22, 2019: Oral Diseases
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