Madalyn Hafenbreidel, Surya Pandey, Sherri B Briggs, Meghana Arza, Shalakha Bonthu, Cadence Fisher, Annika Tiller, Alice B Hall, Shayna Reed, Natasha Mayorga, Li Lin, Susan Khan, Michael D Cameron, Gavin Rumbaugh, Courtney A Miller
Preclinical studies show that inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory in male and female adult and adolescent rodents. The effect is highly selective, as NMII inhibition has no effect in other relevant brain regions (e.g., dorsal hippocampus [dPHC], nucleus accumbens [NAc]), nor does it interfere with associations for other aversive or appetitive stimuli, including cocaine (COC)...
November 21, 2023: Neurobiology of Learning and Memory