journal
https://read.qxmd.com/read/38300738/ion-transport-basis-of-diarrhea-paneth-cell-metaplasia-and-upregulation-of-mechanosensory-pathway-in-anti-cd40-colitis-mice
#21
JOURNAL ARTICLE
Dulari Jayawardena, Arivarasu N Anbazhagan, Apurba Majumder, Ramsha Akram, Ali Nazmi, Ramandeep Kaur, Anoop Kumar, Seema Saksena, Danyvid Olivares-Villagómez, Pradeep K Dudeja
BACKGROUND: Anti-Cluster of differentiation (CD)-40-induced colitis, driven by innate inflammatory responses in the intestine, is a potent animal model exhibiting IBD pathophysiology including diarrhea. However, the ion transport basis of diarrhea and some key mucosal pathways (Paneth cells, stem cell niche, and mechanosensory) in this model have not been investigated. METHODS: Mucosal scrapings and intestinal tissue from control and CD40 antibody (150 µg) treated Rag2-/- mice were examined for gut inflammation, Paneth cell numbers, expression of key transporters, tight/adherens junction proteins, stem cell niche, and mechanosensory pathway via hematoxylin and eosin staining, quantitative polymerase chain reaction, and western blotting...
February 1, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38289995/crohn-s-disease-associated-pathogenic-mutation-in-the-manganese-transporter-zip8-shifts-the-ileal-and-rectal-mucosal-microbiota-implicating-aberrant-bile-acid-metabolism
#22
JOURNAL ARTICLE
Kristi Briggs, Vartika Tomar, Nicholas Ollberding, Yael Haberman, Arno R Bourgonje, Shixian Hu, Lara Chaaban, Laxmi Sunuwar, Rinse K Weersma, Lee A Denson, Joanna M P Melia
BACKGROUND: A pathogenic mutation in the manganese transporter ZIP8 (A391T; rs13107325) increases the risk of Crohn's disease. ZIP8 regulates manganese homeostasis and given the shared need for metals between the host and resident microbes, there has been significant interest in alterations of the microbiome in carriers of ZIP8 A391T. Prior studies have not examined the ileal microbiome despite associations between ileal disease and ZIP8 A391T. METHODS: Here, we used the Pediatric Risk Stratification Study (RISK)  cohort to perform a secondary analysis of 16S ribosomal RNA gene sequencing data obtained from ileal and rectal mucosa to study associations between ZIP8 A391T carrier status and microbiota composition...
January 30, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38289587/methodological-standards-when-reporting-from-national-databases
#23
EDITORIAL
Hassam Ali
No abstract text is available yet for this article.
January 30, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38280217/unveiling-colitis-a-journey-through-the-dextran-sodium-sulfate-induced-model
#24
JOURNAL ARTICLE
Chunhua Yang, Didier Merlin
Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran sodium sulfate (DSS)-induced model of colitis is arguably the most widely used animal model for studying the pathogenesis of and potential treatments for ulcerative colitis (UC), which is a primary form of IBD. This model offers several advantages as a research tool: it is highly reproducible, relatively easy to generate and maintain, and mimics many critical features of human IBD...
January 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38280053/breaking-down-barriers-epithelial-contributors-to-monogenic-ibd-pathogenesis
#25
JOURNAL ARTICLE
Jodie D Ouahed, Alexandra Griffith, Lauren V Collen, Scott B Snapper
Monogenic causes of inflammatory bowel diseases (IBD) are increasingly being discovered. To date, much attention has been placed in those resulting from inborn errors of immunity. Therapeutic efforts have been largely focused on offering personalized immune modulation or curative bone marrow transplant for patients with IBD and underlying immune disorders. To date, less emphasis has been placed on monogenic causes of IBD that pertain to impairment of the intestinal epithelial barrier. Here, we provide a comprehensive review of monogenic causes of IBD that result in impaired intestinal epithelial barrier that are categorized into 6 important functions: (1) epithelial cell organization, (2) epithelial cell intrinsic functions, (3) epithelial cell apoptosis and necroptosis, (4) complement activation, (5) epithelial cell signaling, and (6) control of RNA degradation products...
January 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38271618/correction-to-comparison-of-performances-of-adalimumab-biosimilars-sb5-abp501-gp2017-and-msb11022-in-treating-patients-with-inflammatory-bowel-diseases-a-real-life-multicenter-observational-study
#26
https://read.qxmd.com/read/38271615/risk-of-common-neurological-disorders-in-adult-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Mohammad Zamani, Forough Ebrahimtabar, Shaghayegh Alizadeh-Tabari, Scott E Kasner, Mitchell S V Elkind, Ashwin N Ananthakrishnan, Tenzin Choden, David T Rubin, Reza Malekzadeh
BACKGROUND: Several studies investigated the risks of neurological conditions in patients with inflammatory bowel disease (IBD), with some variability in findings. We aimed to perform a systematic review and meta-analysis of available evidence to elucidate the association between IBD and the risks of common neurological disorders. METHODS: We conducted a literature search through Embase, PubMed, Scopus, and ProQuest databases from inception to June 30, 2023, to identify cohort studies assessing the risk of developing stroke, all-cause dementia, Parkinson's disease (PD), multiple sclerosis (MS), seizure/epilepsy, and peripheral neuropathy in adult IBD patients compared with non-IBD population...
January 25, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38271613/extended-induction-and-prognostic-indicators-of-response-in-patients-treated-with-mirikizumab-with-moderately-to-severely-active-ulcerative-colitis-in-the-lucent-trials
#28
JOURNAL ARTICLE
Geert D'Haens, Peter D R Higgins, Laurent Peyrin-Biroulet, Bruce E Sands, Scott Lee, Richard E Moses, Isabel Redondo, Rodrigo Escobar, Theresa Hunter Gibble, Anthony Keohane, Nathan Morris, Xin Zhang, Vipin Arora, Taku Kobayashi
BACKGROUND: Efficacy and safety of mirikizumab, a p19-targeted anti-interleukin-23 monoclonal antibody, for moderately to severely active ulcerative colitis was demonstrated previously. We evaluated clinical response, baseline characteristics, and clinical status in patients not responding by 12 weeks (W) of induction who then received extended induction treatment. METHOD: Patients unresponsive to 300 mg of intravenous (IV) mirikizumab every 4 weeks by W12 received 3 additional 300 mg IV doses every 4 weeks...
January 25, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38267832/long-term-efficacy-and-safety-of-tacrolimus-plus-ustekinumab-combination-therapy-in-children-with-steroid-refractory-ulcerative-colitis
#29
JOURNAL ARTICLE
Ryusuke Nambu, Ayako Miyazawa, Masashi Yoshida, Tomoko Hara, Itaru Iwama
No abstract text is available yet for this article.
January 24, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38267826/pregnancy-outcomes-in-the-ozanimod-clinical-development-program-in-patients-with-ulcerative-colitis-crohn-s-disease-and-relapsing-multiple-sclerosis
#30
JOURNAL ARTICLE
Marla C Dubinsky, Lorna Charles, Krzysztof W Selmaj, Giancarlo Comi, Anthony Krakovich, Melissa Rosen, C Janneke van der Woude, Uma Mahadevan
No abstract text is available yet for this article.
January 24, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38262631/preoperative-exclusive-enteral-nutrition-is-associated-with-reduced-skin-and-soft-tissue-and-intra-abdominal-infections-in-patients-with-crohn-s-disease-undergoing-intestinal-surgery-results-from-a-meta-analysis
#31
JOURNAL ARTICLE
Lev Krasnovsky, Andrew T Weber, Victoria Gershuni, Erica Pettke, James D Lewis
BACKGROUND: Malnutrition is an independent risk factor for adverse postoperative outcomes and is common among patients with Crohn's disease (CD). The objective of this meta-analysis was to precisely quantify the association of preoperative exclusive enteral nutrition (EEN) and total parenteral nutrition (TPN) with surgical outcomes in patients undergoing intestinal surgery for CD. METHODS: PubMed, Embase, and Scopus were queried for comparative studies evaluating the impact of preoperative nutritional support on postoperative outcomes in patients undergoing surgery for CD...
January 23, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38253467/the-ileal-pouch-anal-anastomosis-identifying-structural-disorders
#32
JOURNAL ARTICLE
David M Schwartzberg, Maia Kayal, Edward L Barnes
No abstract text is available yet for this article.
January 22, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38244236/dietary-emulsifier-exposure-in-people-with-inflammatory-bowel-disease-compared-with-healthy-controls-is-there-a-cause-for-concern
#33
JOURNAL ARTICLE
Natasha Katsoudas, Paris Tavakoli, Nan Wu, Amanda Shapiro, Steven T Leach, Astrid-Jane Williams, Ramesh Paramsothy, Simon Ghaly, Susan J Connor, Dorit Samocha-Bonet, Kelly Lambert, Georgina L Hold
BACKGROUND: Emulsifiers are implicated in the pathogenesis of inflammatory bowel disease (IBD). Few studies have examined emulsifier intake in people with existing IBD. We aimed to describe the frequency of exposure to 6 selected emulsifiers in a contemporary cohort of people with IBD and compare intake with healthy controls (HCs). METHODS: Baseline food records from participants in an Australian prospective cohort study examining the microbiome of IBD patients and HCs were analyzed...
January 19, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38243814/intralesional-injections-of-a-tnf-%C3%AE-inhibitor-to-treat-orofacial-granulomatosis
#34
JOURNAL ARTICLE
Jasmine Lee, Lisa Kurien, Tuvia Marciano
No abstract text is available yet for this article.
January 19, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38241516/performance-of-ascvd-risk-prediction-models-in-individuals-with-inflammatory-bowel-disease-a-uk-biobank-study
#35
JOURNAL ARTICLE
Quazim A Alayo, Daniel Famutimi, Malek Ayoub, Lisa De Las Fuentes, Parakkal Deepak
No abstract text is available yet for this article.
January 18, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38217539/increasing-exposure-to-inflammatory-bowel-diseases-education-in-gastroenterology-fellowship-the-pilot-ibd-101-experience
#36
JOURNAL ARTICLE
Lisa Malter, Simon J Hong, Sarah Lopatin, Megan Murphy, David Hudesman, Sunanda Kane, David T Rubin
BACKGROUND: Inflammatory bowel disease (IBD) management has become increasingly complex, and education varies across fellowship programs. IBD 101 was designed to introduce first-year gastroenterology (GI) fellows to IBD care and training. METHODS: In 2019, a cohort of fellows participated in a 1-day course with small group learning and group observed structured clinical examinations. Pre- and postcourse surveys were administered to evaluate the course. To assess the long-term impact, surveys were emailed in May 2022 to all third-year fellows from previously participating programs...
January 13, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38215029/real-world-effectiveness-and-safety-of-risankizumab-in-patients-with-moderate-to-severe-multirefractory-crohn-s-disease-a-belgian-multicentric-cohort-study
#37
JOURNAL ARTICLE
Dahham Alsoud, João Sabino, Denis Franchimont, Anneline Cremer, Julie Busschaert, François D'Heygere, Peter Bossuyt, Anne Vijverman, Séverine Vermeire, Marc Ferrante
BACKGROUND: As real-world data on risankizumab in patients with moderate to severe Crohn's disease (CD) are scarce, we evaluated its effectiveness and safety in multirefractory Belgian patients. METHODS: Data from consecutive adult CD patients who started risankizumab before April 2023 were retrospectively collected at 6 Belgian centers. Clinical remission and response were defined using the 2-component patient-reported outcome. Endoscopic response was defined as a decrease in baseline Simple Endoscopic Score with ≥50%...
January 12, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38207012/failure-rate-of-anti-tumor-necrosis-factor-%C3%AE-biologics-in-very-early-onset-inflammatory-bowel-disease
#38
EDITORIAL
Ashleigh Watson, Lina B Karam, Richard Kellermayer
No abstract text is available yet for this article.
January 11, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38206426/the-impact-of-inflammatory-bowel-disease-on-intimacy-a-multimethod-examination-of-patients-sexual-lives-and-associated-healthcare-experiences
#39
JOURNAL ARTICLE
Katherine M Fretz, Katherine E Hunker, Dean A Tripp
BACKGROUND: Inflammatory bowel disease (IBD) can negatively impact sexual well-being, and some patients desire healthcare for these issues. Research capturing the lived experiences of patients in these areas is lacking. The present study investigated the sexual well-being impacts of IBD (objective 1) and patients' experiences accessing support for these concerns in the healthcare system (objective 2) through multimethod analyses. METHODS: A total of 480 adults with IBD were recruited for an online survey study...
January 11, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38206353/response-to-letter-to-the-editor-failure-rate-of-antitumor-necrosis-factor-alpha-biologics-in-very-early-onset-inflammatory-bowel-disease
#40
EDITORIAL
Lauren V Collen, Scott B Snapper
No abstract text is available yet for this article.
January 11, 2024: Inflammatory Bowel Diseases
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