journal
https://read.qxmd.com/read/38037191/altered-bile-acid-and-pouch-microbiota-composition-in-patients-with-chronic-pouchitis
#1
JOURNAL ARTICLE
Priscila Santiago, Kevin P Quinn, Jun Chen, Jessica J Friton, Chad R Rypstra, Purna C Kashyap, Laura E Raffals
BACKGROUND: Patients with ulcerative colitis and total abdominal proctocolectomy with ileal pouch-anal anastomosis have a 50% risk of pouchitis and a 5% to 10% risk of chronic pouchitis. AIMS: The goal of the study was to compare pouch microbiota and stool bile acid composition in patients with chronic pouchitis, chronic pouchitis and primary sclerosing cholangitis, and normal pouch. METHODS: Patients with ulcerative colitis and ileal pouch-anal anastomosis were recruited from March 20, 2014, to August 6, 2019, and categorized into normal pouch, chronic pouchitis, and chronic pouchitis/primary sclerosing cholangitis groups...
November 30, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38029420/hla-dqa1-05-not-associated-with-ustekinumab-loss-of-response-and-antidrug-antibodies-in-ulcerative-colitis-and-crohn-s-disease-patients
#2
JOURNAL ARTICLE
Jean-Frédéric Colombel, María D Martín-Arranz, Brigitta Brinkman, Meijian Guan, Amy Hart, Christopher Gasink
No abstract text is available yet for this article.
November 29, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38011813/pediatric-ibd-patients-treated-with-infliximab-and-proactive-drug-monitoring-benefit-from-early-concomitant-immunomodulatory-therapy-a-retrospective-analysis-of-a-10-year-real-life-cohort
#3
JOURNAL ARTICLE
Hannes Hoelz, Lena Bragagna, Anna Litwin, Sibylle Koletzko, Thu Giang Le Thi, Tobias Schwerd
BACKGROUND: Limited approval of second-line treatments in pediatric inflammatory bowel disease (pIBD) necessitates optimized use of infliximab (IFX) with proactive therapeutic drug monitoring (TDM). We investigated whether early combo-therapy with an immunomodulator (IMM) provides additional benefit. METHODS: In the retrospectively reviewed medical records of all children treated with IFX and proactive TDM between 2013 and 2022, IMMearly (IMM ≤3 months since IFX start) was evaluated against IMMother/no (late/short or no IMM) over follow-up of 3 to 60 months...
November 27, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38011801/early-intestinal-ultrasound-predicts-clinical-and-endoscopic-treatment-response-and-demonstrates-drug-specific-kinetics-in-moderate-to-severe-ulcerative-colitis
#4
JOURNAL ARTICLE
Floris A de Voogd, Steven J Bots, Elsa A van Wassenaer, Maria de Jong, Maarten J Pruijt, Geert R D'Haens, Krisztina B Gecse
BACKGROUND: Intestinal ultrasound (IUS) is an emerging modality in monitoring disease activity in ulcerative colitis (UC). Here, we aimed to identify early IUS predictors of treatment response as evaluated by endoscopy and assessed the kinetics of IUS changes. METHODS: This prospective, longitudinal study included UC patients with endoscopic disease activity (endoscopic Mayo score [EMS] ≥2) starting anti-inflammatory treatment. Clinical scores, biochemical parameters and IUS were assessed at baseline (W0), at week 2 (W2), at W6(W6), and at the time of second endoscopy (W8-W26)...
November 27, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38011673/automatic-segmentation-and-radiomics-for-identification-and-activity-assessment-of-cte-lesions-in-crohn-s-disease
#5
JOURNAL ARTICLE
Yankun Gao, Bo Zhang, Dehan Zhao, Shuai Li, Chang Rong, Mingzhai Sun, Xingwang Wu
BACKGROUND: The purpose of this article is to develop a deep learning automatic segmentation model for the segmentation of Crohn's disease (CD) lesions in computed tomography enterography (CTE) images. Additionally, the radiomics features extracted from the segmented CD lesions will be analyzed and multiple machine learning classifiers will be built to distinguish CD activity. METHODS: This was a retrospective study with 2 sets of CTE image data. Segmentation datasets were used to establish nnU-Net neural network's automatic segmentation model...
November 27, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38011655/machine-learning-and-radiomics-changing-the-horizon-of-crohn-s-disease-assessment
#6
JOURNAL ARTICLE
Raseen Tariq, Saam Dilmaghani
No abstract text is available yet for this article.
November 27, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38011652/inflammatory-bowel-diseases-is-moving-to-online-only-publication
#7
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38006201/a-case-of-stricturing-crohn-s-disease-treated-with-multiple-session-balloon-dilatation-and-self-expandable-metal-stent
#8
JOURNAL ARTICLE
Süleyman Sayar, Oğuzhan Öztürk
No abstract text is available yet for this article.
November 24, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38001043/m1-and-m2-macrophages-differentially-regulate-colonic-crypt-renewal
#9
JOURNAL ARTICLE
Sathuwarman Raveenthiraraj, Griselda Awanis, Marcello Chieppa, Amy E O'Connell, Anastasia Sobolewski
BACKGROUND: The colonic epithelium is the most rapidly renewing tissue in the body and is organized into a single cell layer of invaginations called crypts. Crypt renewal occurs through Lgr5 + gut stem cells situated at the crypt base, which divide, produce daughter cells that proliferate, migrate, differentiate into all the cells required for normal gut function, and are finally shed into the crypt lumen. In health, this rapid renewal helps maintain barrier function next to the hostile gut microbial luminal environment...
November 24, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38001042/differential-impact-of-smoking-on-methylome-and-transcriptome-in-crohn-s-disease-and-ulcerative-colitis
#10
JOURNAL ARTICLE
Qi Yan Ang, Damian Plichta, Sean Kim, Iris Hyun-A Kim, Sadie Gregory, Yan Xia, Helena Lau, Ramnik Xavier, Ashwin N Ananthakrishnan
BACKGROUND: Smoking is an environmental factor that differentially impacts Crohn's disease (CD) and ulcerative colitis (UC). The mechanism of impact of smoking on disease risk and clinical outcomes remains to be established. METHODS: This study used a prospective cohort of patients with CD or UC. Self-reported smoking status was validated using serum cotinine measurement. We profiled methylation changes in peripheral blood using the Illumina Methylation BeadChip...
November 24, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37995723/clusters-of-disease-activity-and-early-risk-factors-of-clinical-course-of-pediatric-crohn-s-disease
#11
JOURNAL ARTICLE
Manuela Distante, Silvia Rotulo, Marco Ranalli, Eugenio Pedace, Paolo Lionetti, Serena Arrigo, Patrizia Alvisi, Erasmo Miele, Massimo Martinelli, Giovanna Zuin, Matteo Bramuzzo, Mara Cananzi, Marina Aloi
BACKGROUND: This study aimed to define clusters of disease activity and prognostic factors of disease course in a well-characterized cohort of children with Crohn's disease (CD). METHODS: All patients from the SIGENP IBD (Italian Society of Pediatric Gastroenterology Hepatology and Nutrition Inflammatory Bowel Disease) registry with a 5-year follow-up and 6-monthly evaluation were included. Active disease was defined for each semester as follows: clinical activity (weighted Pediatric Crohn's Disease Activity Index ≥12...
November 23, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37987647/the-use-of-placebo-in-clinical-trials-of-inflammatory-bowel-disease
#12
JOURNAL ARTICLE
Pavel S Roshanov, Reena Khanna
No abstract text is available yet for this article.
November 21, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37982439/an-atlas-characterizing-the-shared-genetic-architecture-of-inflammatory-bowel-disease-with-clinical-and-behavioral-traits
#13
JOURNAL ARTICLE
Vikram R Shaw, Jinyoung Byun, Rowland W Pettit, Jason K Hou, Kyle M Walsh, Younghun Han, Christopher I Amos
BACKGROUND: Inflammatory bowel disease (IBD) development is a complex, multifactorial process that involves extrinsic and intrinsic factors such as host genetics, the immune system, the gut microbiome, and environmental risks. To help understand the genetic contribution of clinical, behavioral, psychiatric, and diet-related traits, we aim to provide a deep and comprehensive characterization of the shared genetic architecture between IBD and hundreds of potentially related traits. METHODS: Utilizing publicly available summary statistics from a previously published IBD genome-wide association study and hundreds of traits from the United Kingdom BioBank (UKBB), we performed linkage disequilibrium score regression (LDSR) analysis to estimate cross-trait genetic correlations between Crohn's disease (CD), ulcerative colitis (UC), and IBD summary statistics with the UKBB traits of interest...
November 20, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37982426/proactive-infliximab-monitoring-improves-the-rates-of-transmural-remission-in-crohn-s-disease-a-propensity-score-matched-analysis
#14
JOURNAL ARTICLE
Samuel Raimundo Fernandes, Sónia Bernardo, Sofia Saraiva, Ana Rita Gonçalves, Paula Moura Santos, Ana Valente, Luís Araújo Correia, Helena Cortez-Pinto, Fernando Magro
BACKGROUND: Few patients can reach transmural remission in Crohn's disease (CD) with currently available therapies. Proactive optimization of infliximab (IFX) based on trough levels may potentially improve these results. METHODS: Retrospective cohort study including consecutive CD patients starting treatment with IFX. Rates of transmural remission were compared between patients with and without therapeutic drug monitoring (target level: 5-7 µg/mL). A propensity score-matched analysis was performed to adjust for potential confounders...
November 20, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37978895/the-crohn-s-disease-exclusion-diet-a-comprehensive-review-of-evidence-implementation-strategies-practical-guidance-and-future-directions
#15
JOURNAL ARTICLE
Rotem Sigall Boneh, Catherine Westoby, Ilan Oseran, Chen Sarbagili-Shabat, Lindsey G Albenberg, Paolo Lionetti, Víctor Manuel Navas-López, Javier Martín-de-Carpi, Henit Yanai, Nitsan Maharshak, Johan Van Limbergen, Eytan Wine
Dietary therapy is increasingly recognized for the management of Crohn's disease (CD) over recent years, including the use of exclusive enteral nutrition (EEN) as first-line therapy for pediatric CD according to current guidelines. The Crohn's disease exclusion diet (CDED) is a whole-food diet designed to reduce exposure to dietary components that are potentially pro-inflammatory, mediated by negative effects on the gut microbiota, immune response, and the intestinal barrier. The CDED has emerged as a valid alternative to EEN with cumulative evidence, including randomized controlled trials, supporting use for induction of remission and possibly maintenance in children and adults...
November 18, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37963567/incidental-dysplasia-during-total-proctocolectomy-with-ileoanal-pouch-is-it-associated-with-worse-outcomes
#16
JOURNAL ARTICLE
Marianna Maspero, Ana Otero, Olga Lavryk, Stefan D Holubar, Jeremy Lipman, Emre Gorgun, David Liska, Hermann Kessler, Michael Valente, Scott R Steele, Tracy Hull
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal cancer. In cases of invisible or nonendoscopically resectable dysplasia found at colonoscopy, total proctocolectomy with ileal pouch anal anastomosis can be offered with good long-term outcomes; however, little is known regarding cancer-related outcomes when dysplasia is found incidentally after surgery on final pathology. METHODS: Using our prospectively collected pouch registry, we identified patients who had preoperative colonic dysplasia or dysplasia found only after colectomy...
November 14, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37951596/inflammatory-bowel-disease-and-the-risk-of-anal-squamous-intraepithelial-lesions-and-anal-cancer-in-men-who-have-sex-with-men
#17
JOURNAL ARTICLE
Justin Field, Cynthia Fenton, Li Zhang, Cristina Brickman, Uma Mahadevan
BACKGROUND: The risk of anal cancer is increased in patients with human immunodeficiency virus (HIV), inflammatory bowel disease (IBD), and among men who have sex with men (MSM). High grade squamous intraepithelial lesions (HSILs) are precursor lesions to anal squamous cell carcinoma (SCC), and treatment of these lesions can decrease progression to anal SCC. This study aims to determine the prevalence of HSIL and anal cancer among MSM patients with and without IBD referred for anal cancer screening...
November 10, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37951594/cancer-screening-in-patients-with-inflammatory-bowel-disease-don-t-forget-the-anus
#18
JOURNAL ARTICLE
Serre-Yu Wong, Jean-Frederic Colombel
No abstract text is available yet for this article.
November 10, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37951297/single-nucleotide-polymorphisms-of-the-mefv-gene-e148q-are-highly-associated-with-disease-phenotype-in-crohn-s-disease
#19
JOURNAL ARTICLE
Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Minoru Matsuura, Hiroki Kitamoto, Makoto Okabe, Nobuyuki Kakiuchi, Takahiko Toyonaga, Taku Kobayashi, Toshifumi Hibi, Hiroshi Seno, Hiroshi Nakase
BACKGROUND: Single nucleotide polymorphisms (SNPs) of the MEFV gene may modify inflammatory bowel disease (IBD) activity. The prevalence of MEFV gene SNPs in IBD patients and their involvement in IBD pathophysiology remains unclear. METHODS: We analyzed 12 MEFV gene SNPs in peripheral leukocytes of Japanese IBD patients (Crohn's disease [CD]: 69 patients, ulcerative colitis: 32 patients) by polymerase chain reaction using next-generation DNA sequencing and evaluated their prevalence and association with the disease characteristics...
November 10, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37951220/adalimumab-drug-levels-at-secondary-loss-of-response-do-not-predict-response-to-dose-intensification-in-crohn-s-disease-a-retrospective-international-multicenter-study
#20
JOURNAL ARTICLE
Robert D Little, Adrian Swaine, Rebecca Reynolds, David J Gibson, Mathilde Barrau, Francesca D'Errico, Rumneek Hampal, Miles P Sparrow, Xavier Roblin, Peter M Irving, Mark G Ward
BACKGROUND: The exposure-response relationship is less established for adalimumab (ADA) compared with infliximab in inflammatory bowel disease (IBD). Evidence supporting therapeutic drug monitoring post dose-intensification of ADA is limited. We aimed to explore the association between ADA drug levels and Crohn's disease (CD) activity at loss of response, and at 6 and 12 months post dose-intensification. METHODS: We performed a retrospective study of adult patients with CD receiving dose-intensified weekly ADA following secondary loss of response at 3 tertiary centers across 5 years...
November 10, 2023: Inflammatory Bowel Diseases
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