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Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]

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https://read.qxmd.com/read/30758522/aim2-levels-and-dna-triggered-inflammasome-response-are-increased-in-peripheral-leukocytes-of-patients-with-abdominal-aortic-aneurysm
#1
Markus Wortmann, Xianghui Xiao, Guido Wabnitz, Yvonne Samstag, Maani Hakimi, Dittmar Böckler, Susanne Dihlmann
OBJECTIVE AND DESIGN: Abdominal aortic aneurysm (AAA) is heavily infiltrated with leukocytes, expressing the DNA sensor absent in melanoma 2 (AIM2) and other inflammasome components. METHODS: Using multicolour flow cytometry, we here compared the expression of the inflammasome components AIM2, NLRP3, and ASC in different peripheral immune cells derived from AAA patients with those from non-AAA patients in a case-control study. In parallel, peripheral blood mononuclear cells (PBMC) of AAA patients and controls were stimulated in vitro with poly-dA:dT or lipopolysaccharide (LPS) to analyze inflammasome activation...
February 13, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30739130/toreforant-an-orally-active-histamine-h-4-receptor-antagonist-in-patients-with-active-rheumatoid-arthritis-despite-methotrexate-mechanism-of-action-results-from-a-phase-2-multicenter-randomized-double-blind-placebo-controlled-synovial-biopsy-study
#2
David L Boyle, Samuel E DePrimo, Cesar Calderon, Dion Chen, Paul J Dunford, William Barchuk, Gary S Firestein, Robin L Thurmond
OBJECTIVE/DESIGN: In a double-blind, placebo-controlled, multiple-dose study, we assessed the molecular mechanism of action of the selective histamine-4-receptor antagonist toreforant. PATIENTS/TREATMENT: Patients with active rheumatoid arthritis (RA) despite methotrexate were randomized (3:1) to toreforant 30 mg/day (weeks 0-52) or placebo (weeks 0-12) followed by toreforant 30 mg/day (weeks 12-52). METHODS: Primary biomarker analyses comprised 39 different proteins/mRNA transcripts measured in synovial biopsy (n = 39) and/or time-matched serum (n = 15) samples collected at baseline and week 6...
February 9, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30707255/artemisinin-and-its-derivatives-a-potential-therapeutic-approach-for-oral-lichen-planus
#3
REVIEW
Rui-Jie Ma, Ming-Jing He, Ya-Qin Tan, Gang Zhou
BACKGROUND: Oral lichen planus (OLP) is a common T-cell-mediated oral mucosal disease, whose pathogenesis mainly includes antigen-specific and non-specific mechanisms. As a refractory chronic inflammatory disease, there is still no curable management for OLP till now. FINDINGS: Artemisinins are a family of compounds that are widely used as frontline treatment for malaria worldwide. In addition to its well-established antimalarial properties, emerging evidence hints that artemisinin family drugs also possess preferential immunoregulatory and anti-inflammation properties, such as modifying T lymphocytes' activation and cytokines release, modulating Th1/Th2 balance, activating regulatory T cells (Tregs), modulating inflammatory signaling pathways, as well as acting on non-specific mechanisms of OLP...
February 1, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30706110/bazedoxifene-protects-cerebral-autoregulation-after-traumatic-brain-injury-and-attenuates-impairments-in-blood-brain-barrier-damage-involvement-of-anti-inflammatory-pathways-by-blocking-mapk-signaling
#4
Yu-Long Lan, Xun Wang, Yu-Jie Zou, Jin-Shan Xing, Jia-Cheng Lou, Shuang Zou, Bin-Bin Ma, Yan Ding, Bo Zhang
OBJECTIVE: Traumatic brain injury (TBI) is a significant cause of death and long-term deficits in motor and cognitive functions for which there are currently no effective chemotherapeutic drugs. Bazedoxifene (BZA) is a third-generation selective estrogen receptor modulator (SERM) and has been investigated as a treatment for postmenopausal osteoporosis. It is generally safe and well tolerated, with favorable endometrial and breast safety profiles. Recent findings have shown that SERMs may have therapeutic benefits; however, the role of BZA in the treatment of TBI and its molecular and cellular mechanisms remain poorly understood...
January 31, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30680411/current-progress-in-the-inflammatory-background-of-angiogenesis-in-gynecological-cancers
#5
REVIEW
Grzegorz Szewczyk, Tomasz M Maciejewski, Dariusz Szukiewicz
A tumor growth depends on the potency of the tumor to support itself with nutrients and oxygen. The development of a vascular network within the tumor is key to its survival. The permanent contest between the tumor and its host involves tumor cells on one side and an immunological system and tissue stroma on the other. The angiogenesis is not only a specialty of the tumor, but it also depends on this complex multidirectional interaction. The most common gynecological cancers, cervical, endometrial and ovarian carcinoma are good examples for studying this problem...
January 24, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30673803/mir-19a-mediates-the-negative-regulation-of-the-nf-%C3%AE%C2%BAb-pathway-in-lipopolysaccharide-induced-endometritis-by-targeting-tbk1
#6
Nannan Yin, Yaping Yang, Xiaoyan Wang, Chao Yang, Xiaofei Ma, Aftab Shaukat, Gan Zhao, Ganzhen Deng
OBJECTIVE: In both humans and animals, endometritis is severe inflammation of the uterus, and it causes great economic losses in dairy cow production. MicroRNAs have been reported to play an important role in various inflammatory diseases. However, the regulatory mechanisms of miR-19a in endometritis remain unclear. Thus, the aims of this study are to investigate the role of miR-19a in a mouse model of lipopolysaccharide (LPS)-induced endometritis and elucidate the possible mechanisms in bovine endometrial epithelial cells (bEECs)...
January 23, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30656387/il-33-in-obesity-where-do-we-go-from-here
#7
REVIEW
Marcos Felipe Andrade de Oliveira, André Talvani, Etel Rocha-Vieira
IL-33 is a cytokine that belongs to the IL-1 family and is classically associated with type 2-like immune responses. In the adipose tissue, IL-33 is related to the beiging of adipocytes and to the maintenance of adipose tissue-resident immune cells, such as innate lymphoid cells 2, alternatively activated macrophages and regulatory T cells, which contribute to the maintenance of adipose tissue homeostasis. In the obese adipose tissue, the number of these cells is diminished, unlike the expression of IL-33, which is up-regulated...
January 17, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30610292/giulio-gabbiani-and-the-discovery-of-myofibroblasts
#8
Domenico Ribatti, Roberto Tamma
Myofibroblasts, specialized fibroblasts expressing the protein alpha-smooth muscle actin, are instrumental in wound contraction during normal wound healing. Tissue shortening is then stabilized by the synthesis of extracellular matrix, collagen in particular. Alpha-smooth muscle actin within myofibroblasts becomes organized in filamentous bundles, called stress fibers, that allow the retractile movement producing wound contraction. During hypertrophic scarring, skin deformations depend on the inappropriate action of these stress fibers that for unknown reasons persist even after the epithelialization of the wound...
January 4, 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30564895/malt1-inactivation-attenuates-experimental-colitis-through-the-regulation-of-th17-and-th1-17-cells
#9
Yoshiki Nakamura, Keiko Igaki, Yusaku Komoike, Kazumasa Yokoyama, Noboru Tsuchimori
OBJECTIVE AND DESIGN: Protease activity of MALT lymphoma-translocation protein 1 (Malt1) plays an important role in the development of colitis, but the detailed mechanism has not been fully elucidated. METHOD: Effects of Malt1 protease on the activation of T cells and the development of experimental colitis was investigated using Malt1 protease-deficient (PD) mouse. RESULTS: IL-2 production from CD4+ T cells of Malt1 PD mice was decreased compared with that of wild-type (WT) mice...
December 18, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30560372/antiinflammatory-peptides-current-knowledge-and-promising-prospects
#10
REVIEW
Maryam Dadar, Youcef Shahali, Sandip Chakraborty, Minakshi Prasad, Fatemeh Tahoori, Ruchi Tiwari, Kuldeep Dhama
BACKGROUND: Inflammation is part of the regular host reaction to injury or infection caused by toxic factors, pathogens, damaged cells, irritants, and allergens. Antiinflammatory peptides (AIPs) are present in all living organisms, and many peptides from herbal, mammalian, bacterial, and marine origins have been shown to have antimicrobial and/or antiinflammatory properties. METHODS: In this study, we investigated the effects of antiinflammatory peptides on inflammation, and highlighted the underlying mechanisms responsible for these effects...
December 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30560371/mir-196a2-rs11614913-polymorphism-is-associated-with-coronary-artery-disease-but-not-with-in-stent-coronary-restenosis
#11
José Manuel Fragoso, Julian Ramírez-Bello, Marco Antonio Martínez-Ríos, Marco Antonio Peña-Duque, Rosalinda Posadas-Sánchez, Hilda Delgadillo-Rodríguez, Mayra Jiménez-Morales, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
OBJECTIVE: The aim of the study was to evaluate the association of miRNA-146a G/C (rs2910164), and miRNA-196a2 C/T (rs11614913) polymorphisms with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent. MATERIALS AND METHODS: The polymorphisms were determined in 218 patients with CAD who underwent coronary artery stenting (66 with restenosis and 152 without restenosis) and 611 healthy controls using 5' exonuclease TaqMan assays...
December 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30506263/immunological-modulation-following-bone-marrow-derived-mesenchymal-stromal-cells-and-th17-lymphocyte-co-cultures
#12
Mehdi Najar, Hussein Fayyad-Kazan, Wissam H Faour, Makram Merimi, Etienne M Sokal, Catherine A Lombard, Hassan Fahmi
OBJECTIVE AND DESIGN: The objective of the study is to uncover the influence of human bone marrow-derived mesenchymal stem cells (BM-MSCs) on the generation of Th17 lymphocytes in co-cultures of both BM-MSCs and T cells. MATERIALS AND METHODS: BM-MSCs, characterized according to the international society for cellular therapy (ISCT) criteria, were co-cultured with T cells isolated from peripheral blood. The expression levels of IL-17 receptor, RORγt and IL-23 receptor were evaluated using flow cytometry...
November 30, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30506262/intravenous-anesthetic-ketamine-attenuates-complete-freund-s-adjuvant-induced-arthritis-in-rats-via-modulation-of-mapks-nf-%C3%AE%C2%BAb
#13
Hui Lin, Zhe Wang, Jinmei Shen, Junmei Xu, Hui Li
BACKGROUND: The current study was intended to investigate the effect of ketamine (KET) on complete Freund's adjuvant (CFA)-induced arthritis in rats. METHODS: The CFA was administered in the hind paw of the rats for the induction of adjuvant-induced arthritis. The paw swelling of experimental animals was measured as hind paw volume. Hematoxylin and eosin staining was estimated and pathological changes in the joint tissues were observed under a light microscope. Furthermore, the bicinchoninic acid assay was used for protein quantification...
November 30, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30470856/promotion-of-microtubule-acetylation-plays-an-important-role-in-degranulation-of-antigen-activated-mast-cells
#14
Atsushi Shiki, Yoshikazu Inoh, Satoru Yokawa, Tadahide Furuno
OBJECTIVE: The aim of this study was to investigate whether microtubule acetylation is triggered by antigen stimulation and how it affects mast cell degranulation. METHODS: The RBL-2H3 cell line was used as a model for mast cells. Acetylation of α-tubulin was analyzed by Western blotting. Intracellular distribution of α-tubulin and acetylated α-tubulin was observed by immunostaining. Degranulation was monitored by measuring the activity of β-hexosaminidase secreted into cell supernatants...
November 23, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30470857/an-association-study-in-ptpn22-suggests-that-is-a-risk-factor-to-takayasu-s-arteritis
#15
María Elena Soto, Isela Montufar-Robles, Silvia Jiménez-Morales, Ricardo Gamboa, Claudia Huesca-Gómez, Julian Ramírez-Bello
OBJECTIVES: Takayasu's arteritis (TA) represents a rare autoimmune disease (AD) characterized by systemic vasculitis that primarily affects large arteries, especially the aorta and the aortic arch and its main branches. Genetic components in TA are largely unknown. PTPN22 is a susceptibility loci for different ADs; however, the role of different PTPN22 single-nucleotide polymorphisms (SNPs) in the susceptibility to TA is not clear. METHODS: We evaluated the PTPN22 R620W (C1858T), R263Q (G788A), and - 123G/C SNPs in a group of patients with TA and in healthy individuals from Mexico...
March 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30604212/coevolution-of-the-coagulation-and-immune-systems
#16
REVIEW
Borros Arneth
BACKGROUND: Higher organisms rely on the coagulation and immune systems to fight disease-causing pathogens and other foreign invaders in the body. Coagulation has an important role as a barrier against foreign bodies, including bacteria, viruses, and protozoa. The protective responses associated with the coagulation and immune systems can protect the host organism from a wide range of pathogens, such as viruses, parasites, fungi, and even bacteria. AIM: The purpose of this paper was to review available research on the evolution of the coagulation and immune systems...
February 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30604211/constant-hypoxia-inhibits-osteoclast-differentiation-and-bone-resorption-by-regulating-phosphorylation-of-jnk-and-i%C3%AE%C2%BAb%C3%AE
#17
Zhenzhen Ma, Ruohan Yu, Jinxia Zhao, Lin Sun, Leilei Jian, Changhong Li, Xiangyuan Liu
BACKGROUND: Osteoclasts are responsible for the bone loss in rheumatoid arthritis (RA). Hypoxia has been suggested to play key roles in pathological bone loss. However, the current understanding of the effects of hypoxia on osteoclastogenesis is controversial. Effects of hypoxia on both the formation and function of osteoclasts requires examination. In the current study, we aimed to explore the effect of hypoxia on osteoclast differentiation and the underlying mechanisms. METHODS: RAW264...
February 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30178100/a-comprehensive-review-on-the-treatment-approaches-of-multiple-sclerosis-currently-and-in-the-future
#18
REVIEW
Mehrdad Gholamzad, Masoumeh Ebtekar, Mehdi Shafiee Ardestani, Maryam Azimi, Zeinab Mahmodi, Mohammad Javad Mousavi, Saeed Aslani
BACKGROUND: Multiple sclerosis (MS) is a chronic and autoimmune disease of the central nervous system (CNS), mainly characterized by inflammatory demyelination, which manifests as relapses and diffuse damage and brain volume loss, both accounting for neurodegeneration, and therefore, physical disability. MS typically affects young adults and is commonly diagnosed in the early years by acute relapses, which then followed through partial or complete remission period. The clinical course of MS is characterized as four major classifications, including relapsing-remitting (RRMS), primary progressive (PPMS), progressive relapsing (PRMS), and secondary progressive (SPMS)...
January 2019: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30370484/naringenin-mitigates-titanium-dioxide-tio-2-induced-chronic-arthritis-in-mice-role-of-oxidative-stress-cytokines-and-nf%C3%AE%C2%BAb
#19
Marília F Manchope, Nayara A Artero, Victor Fattori, Sandra S Mizokami, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Thiago M Cunha, José C Alves-Filho, Fernando Q Cunha, Rubia Casagrande, Waldiceu A Verri
OBJECTIVE: To evaluate the effect and mechanisms of naringenin in TiO2 -induced chronic arthritis in mice, a model resembling prosthesis and implant inflammation. TREATMENT: Flavonoids are antioxidant and anti-inflammatory molecules with important anti-inflammatory effect. Mice were daily treated with the flavonoid naringenin (16.7-150 mg/kg, orally) for 30 days starting 24 h after intra-articular knee injection of 3 mg of TiO2 . METHODS: TiO2 -induced arthritis resembles cases of aseptic inflammation induced by prosthesis and/or implants...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/30334065/microrna-429-regulates-the-expression-of-chmp5-in-the-inflammatory-colitis-and-colorectal-cancer-cells
#20
Ji-Su Mo, Seol-Hee Han, Ki-Jung Yun, Soo-Cheon Chae
OBJECTIVE AND DESIGN: MicroRNAs (miRNAs) play an important role in the pathogenesis of human diseases by regulating the expression of target genes in specific cells or tissues. In this study, we analyzed the association between the MIR429 and its target gene, charged multivesicular body protein 5 (CHMP5), in human colon cancer cells and in a DSS-induced colitis mouse model. MATERIALS AND METHODS: A luciferase reporter system was used to confirm the effect of MIR429 on CHMP5 expression...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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