journal
Journals Inflammation Research : Offici...

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]

https://read.qxmd.com/read/38507068/author-correction-porphyromonas-gingivalis-promotes-the-progression-of-oral-squamous-cell-carcinoma-by-stimulating-the-release-of-neutrophil-extracellular-traps-in-the-tumor-immune-microenvironment
#1
Zhi-Chen Guo, Si-Li Jing, Xin-Yu Jia, Sadam Ahmed Elayah, Lin-Yang Xie, Hao Cui, Jun-Bo Tu, Si-Jia Na
No abstract text is available yet for this article.
March 20, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38507067/identification-of-a-novel-adcc-related-gene-signature-for-predicting-the-prognosis-and-therapy-response-in-lung-adenocarcinoma
#2
JOURNAL ARTICLE
Liangyu Zhang, Xun Zhang, Maohao Guan, Jianshen Zeng, Fengqiang Yu, Fancai Lai
BACKGROUND: Previous studies have largely neglected the role of ADCC in LUAD, and no study has systematically compiled ADCC-associated genes to create prognostic signatures. METHODS: In this study, 1564 LUAD patients, 2057 NSCLC patients, and more than 5000 patients with various cancer types from diverse cohorts were included. R package ConsensusClusterPlus was utilized to classify patients into different subtypes. A number of machine-learning algorithms were used to construct the ADCCRS...
March 20, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38498178/tricarboxylic-acid-cycle-metabolites-new-players-in-macrophage
#3
REVIEW
Ying Yang, Bing-Bing Cui, Jian Li, Jiao-Jiao Shan, Jun Xu, Cheng-Yong Zhang, Xiao-Tong Wei, Ri-Ran Zhu, Jing-Yi Wang
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the current review, we summarize recent advances in the metabolic reprogramming of the TCA cycle during macrophage activation and polarization and address the effects of these metabolites in modulating macrophage function. Deciphering the crosstalk between the TCA cycle and the immune response might provide novel potential targets for the intervention of immune reactions and favor the development of new strategies for the treatment of infection, inflammation, and cancer...
March 18, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38493256/the-nadase-cd38-is-a-central-regulator-in-gouty-inflammation-and-a-novel-druggable-therapeutic-target
#4
JOURNAL ARTICLE
Paulo Gil Alabarse, Patricia Oliveira, Huaping Qin, Tiffany Yan, Marie Migaud, Robert Terkeltaub, Ru Liu-Bryan
OBJECTIVES: Cellular NAD+ declines in inflammatory states associated with increased activity of the leukocyte-expressed NADase CD38. In this study, we tested the potential role of therapeutically targeting CD38 and NAD+ in gout. METHODS: We studied cultured mouse wild type and CD38 knockout (KO) murine bone marrow derived macrophages (BMDMs) stimulated by monosodium urate (MSU) crystals and used the air pouch gouty inflammation model. RESULTS: MSU crystals induced CD38 in BMDMs in vitro, associated with NAD+ depletion, and IL-1β and CXCL1 release, effects reversed by pharmacologic CD38 inhibitors (apigenin, 78c)...
March 16, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38492049/bridging-the-divide-unveiling-mutual-immunological-pathways-of-cancer-and-pregnancy
#5
REVIEW
Teodora Maria Toadere, Andra Ţichindeleanu, Daniela Andreea Bondor, Ioan Topor, Şerban Ellias Trella, Iuliana Nenu
The juxtaposition of two seemingly disparate physiological phenomena within the human body-namely, cancer and pregnancy-may offer profound insights into the intricate interplay between malignancies and the immune system. Recent investigations have unveiled striking similarities between the pivotal processes underpinning fetal implantation and successful gestation and those governing tumor initiation and progression. Notably, a confluence of features has emerged, underscoring parallels between the microenvironment of tumors and the maternal-fetal interface...
March 16, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38489048/association-of-systemic-immune-inflammation-index-and-systemic-inflammation-response-index-with-chronic-kidney-disease-observational-study-of-40-937-adults
#6
JOURNAL ARTICLE
Peixian Huang, Yanpei Mai, Jun Zhao, Yushan Yi, Yaqing Wen
BACKGROUND: Chronic kidney disease (CKD) is linked to immunity and inflammation. Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are novel measures for gauging an individual's systemic inflammatory activity. We aim to investigate the potential associations between them. METHODS: This study encompassed a cohort of 40,937 adults from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. SII and SIRI were log2-transformed before conducting regression analysis, considering that these inflammatory markers were right skewed distributed...
March 15, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38483556/complex-alterations-in-inflammatory-pain-and-analgesic-sensitivity-in-young-and-ageing-female-rats-involvement-of-asic3-and-nav1-8-in-primary-sensory-neurons
#7
JOURNAL ARTICLE
Diego N Messina, Emanuel D Peralta, Cristian G Acosta
OBJECTIVE AND DESIGN: Our aim was to determine an age-dependent role of Nav1.8 and ASIC3 in dorsal root ganglion (DRG) neurons in a rat pre-clinical model of long-term inflammatory pain. METHODS: We compared 6 and 24 months-old female Wistar rats after cutaneous inflammation. We used behavioral pain assessments over time, qPCR, quantitative immunohistochemistry, selective pharmacological manipulation, ELISA and in vitro treatment with cytokines. RESULTS: Older rats exhibited delayed recovery from mechanical allodynia and earlier onset of spontaneous pain than younger rats after inflammation...
March 14, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38472395/long-chain-acyl-coa-synthetase-4-mediated-mitochondrial-fatty-acid-metabolism-and-dendritic-cell-antigen-presentation
#8
JOURNAL ARTICLE
Yan Li, Wenlong Fu, JinYing Xiang, Yinying Ren, Yuehan Li, Mi Zhou, Jinyue Yu, Zhengxiu Luo, Enmei Liu, Zhou Fu, Bo Liu, Fengxia Ding
OBJECTIVE: This study aims to investigate the role of Acyl-CoA synthetase 4 (ACSL4) in mediating mitochondrial fatty acid metabolism and dendritic cell (DC) antigen presentation in the immune response associated with asthma. METHODS: RNA sequencing was employed to identify key genes associated with mitochondrial function and fatty acid metabolism in DCs. ELISA was employed to assess the levels of fatty acid metabolism in DCs. Mitochondrial morphology was evaluated using laser confocal microscopy, structured illumination microscopy, and transmission electron microscopy...
March 12, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38467875/imbalance-of-t%C3%A2-follicular-helper-cell-subsets-trigger-the-differentiation-of-pathogenic-b-cells-in-idiopathic-membranous-nephropathy
#9
JOURNAL ARTICLE
Bishun Deng, Huijie Huang, Li Deng, Ziling Zhao, Miao Liu, Haibiao Lin, Xiaowan Wang, Ruimin Tian, Xiaoxin Tu, Anping Peng, Enyu Liang, Kun Bao, Yuting Zhou, Peng Xu, Min He
OBJECTIVE: This study aims to elucidate the role of T follicular helper (Tfh) cells and their subsets in idiopathic membranous nephropathy (IMN). METHODS: The frequencies of Tfh cell subsets and B cell subsets in peripheral blood (PB) were detected in both IMN patients and healthy controls (HCs). The involvement of Tfh cells in the disease pathogenesis was examined by coculturing human Tfh cells with B cells. The dynamic changes of Tfh cells in PB or spleen were monitored in passive Heymann nephritis (PHN) rats...
March 11, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38433131/genetic-correlations-shared-risk-genes-and-immunity-landscapes-between-covid-19-and-venous-thromboembolism-evidence-from-gwas-and-bulk-transcriptome-data
#10
JOURNAL ARTICLE
Langchao Yan, Shifu Li, Qian Hu, Di Liao
BACKGROUND: Patients with coronavirus disease 2019 (COVID-19) were vulnerable to venous thromboembolism (VTE), which further increases the risk of unfavorable outcomes. However, neither genetic correlations nor shared genes underlying COVID-19 and VTE are well understood. OBJECTIVE: This study aimed to characterize genetic correlations and common pathogenic mechanisms between COVID-19 and VTE. METHODS: We used linkage disequilibrium score (LDSC) regression and Mendelian Randomization (MR) analysis to investigate the genetic associations and causal effects between COVID-19 and VTE, respectively...
March 3, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38411635/altered-vacuole-membrane-protein-1-vmp1-expression-is-associated-with-increased-nlrp3-inflammasome-activation-and-mitochondrial-dysfunction
#11
JOURNAL ARTICLE
Stephanie R Zack, Meghana Venkatesan, Roman Nikolaienko, Ben Cook, Ronald Melki, Aleksey V Zima, Edward M Campbell
BACKGROUND: Altered expression of vacuole membrane protein 1 (VMP1) has recently been observed in the context of multiple sclerosis and Parkinson's disease (PD). However, how changes in VMP1 expression may impact pathogenesis has not been explored. OBJECTIVE: This study aimed to characterize how altered VMP1 expression affects NLRP3 inflammasome activation and mitochondrial function. METHODS: VMP1 expression was depleted in a monocytic cell line using CRISPR-Cas9...
February 27, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38411634/ss-31-inhibits-mtdna-cgas-sting-signaling-to-improve-pocd-by-activating-mitophagy-in-aged-mice
#12
JOURNAL ARTICLE
Yelong Ji, Yuanyuan Ma, Yimei Ma, Ying Wang, Xining Zhao, Danfeng Jin, Li Xu, Shengjin Ge
BACKGROUND: Neuroinflammation is crucial in the development of postoperative cognitive dysfunction (POCD), and microglial activation is an active participant in this process. SS-31, a mitochondrion-targeted antioxidant, is widely regarded as a potential drug for neurodegenerative diseases and inflammatory diseases. In this study, we sought to explore whether SS-31 plays a neuroprotective role and the underlying mechanism. METHODS: Internal fixation of tibial fracture was performed in 18-month-old mice to induce surgery-associated neurocognitive dysfunction...
February 27, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38393344/interleukin-19-enhances-eosinophil-infiltration-through-upregulation-of-epithelium-derived-rantes-expression-via-the-erk-nf-%C3%AE%C2%BAb-signalling-pathway-in-patients-with-eosinophilic-crswnp
#13
JOURNAL ARTICLE
Zizhen Huang, Xia Li, Yue Li, Weiqiang Huang, Xiaoping Lai, Haotian Wu, Xiaohong Chen, Yana Zhang, Lihong Chang, Gehua Zhang
BACKGROUD: The recurrence rate of chronic rhinosinusitis with nasal polyps (CRSwNP) is positively correlated with eosinophil infiltration. Increased interleukin (IL)-19 and eosinophil chemokine RANTES levels have been reported in patients with CRSwNP. This study aimed to clarify the role of IL-19 in mediating RANTES expression and eosinophilic infiltration in eosinophilic CRSwNP (Eos CRSwNP). METHODS: Nasal tissue samples were obtained from patients with CRSwNP and controls...
February 23, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38363325/deficiency-of-inpp4a-promotes-m2-macrophage-polarization-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#14
JOURNAL ARTICLE
Yingying Xu, Xiaoting Tong, Peiqiang Liu, Jingyu Huang, Siyuan Chen, Duo Liu, Tian Gu, Yulie Xie, Duo Guo, Yu Xu
OBJECTIVE: The treatment of eosinophilic chronic rhinosinusitis with nasal polyps (E-CRSwNP) remains a challenge due to its complex pathogenesis. Inositol polyphosphate-4-phosphatase type IA (INPP4A), a lipid phosphatase, has been implicated in allergic asthma. However, the expression and function of INPP4A in E-CRSwNP remain unclear. This study aims to investigate the role of INPP4A in macrophages in E-CRSwNP. METHODS: We assessed the expression of INPP4A in human and mouse nasal mucosal tissues via immunofluorescence staining...
February 16, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38353723/inflammatory-cell-death-panoptosis-is-induced-by-the-anti-cancer-curaxin-cbl0137-via-eliciting-the-assembly-of-zbp1-associated-panoptosome
#15
JOURNAL ARTICLE
Ya-Ping Li, Zhi-Ya Zhou, Liang Yan, Yi-Ping You, Hua-Yu Ke, Tao Yuan, Hai-Yan Yang, Rong Xu, Li-Hui Xu, Dong-Yun Ouyang, Qing-Bing Zha, Xian-Hui He
OBJECTIVE: PANoptosis, a new form of regulated cell death, concomitantly manifests hallmarks for pyroptosis, apoptosis, and necroptosis. It has been usually observed in macrophages, a class of widely distributed innate immune cells in various tissues, upon pathogenic infections. The second-generation curaxin, CBL0137, can trigger necroptosis and apoptosis in cancer-associated fibroblasts. This study aimed to explore whether CBL0137 induces PANoptosis in macrophages in vitro and in mouse tissues in vivo...
February 14, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38345635/challenges-and-opportunities-in-inflammatory-bowel-disease-from-current-therapeutic-strategies-to-organoid-based-models
#16
REVIEW
Lingjie Kong, Siyan Chen, Shenghao Huang, Anzhe Zheng, Sheng Gao, Jianzhong Ye, Chunyan Hua
BACKGROUND: Inflammatory bowel disease (IBD) is an increasingly prevalent global health concern that has garnered substantial attention. However, the underlying mechanisms are still unclear and the current treatments have significant limitations. Intestinal organoids provide an in vitro model to explore the pathogenesis, test the therapeutic effects, and develop regenerative treatments as well as offer the potential to transform drug discovery of IBD. METHODS: To advance our understanding of the whole story of IBD spanning from the pathogenesis to the current therapeutic strategies and latest advancements, a comprehensive search of major databases including PubMed, Scopus, and Web of Science was conducted to retrieve original articles and reviews related to IBD, organoids, pathogenesis and therapy...
February 12, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38345634/anti-cd20-treatment-attenuates-th2-cell-responses-implications-for-the-role-of-lung-follicular-mature-b-cells-in-the-asthmatic-mice
#17
JOURNAL ARTICLE
Jilong He, Jingling Li, Qibin Lin, Haiyang Ni, Sisi Huang, Hong Cheng, Xuhong Ding, Yi Huang, Hongying Yu, Yaqing Xu, Hanxiang Nie
BACKGROUND: B cells were believed to act as antigen-presenting cells (APCs) to promote T helper type 2 (Th2) cell responses. However, the role of lung B cells and its subpopulations in Th2 cell responses in asthma remains unclear. OBJECTIVE: We leveraged an anti-CD20 monoclonal antibody (mAb) treatment that has been shown to selectively deplete B cells in mice and investigated whether this treatment modulates Th2 cell responses and this modulation is related to lung follicular mature (FM) B cells in a murine model of asthma...
February 12, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38341813/genetically-proxied-pcsk9-inhibition-is-associated-with-reduced-psoriatic-arthritis-risk
#18
JOURNAL ARTICLE
Junhong Li, Jianfeng Li, Chengkai Lin, Jiaxiang Zhou, Jianmin Wang, Fuan Wang, Haizhen Li, Zhiyu Zhou
BACKGROUND: Lipid pathways play a crucial role in psoriatic arthritis development, and some lipid-lowering drugs are believed to have therapeutic benefits due to their anti-inflammatory properties. Traditional observational studies face issues with confounding factors, complicating the interpretation of causality. This study seeks to determine the genetic link between these medications and the risk of psoriatic arthritis. METHODS: This drug target study utilized the Mendelian randomization strategy...
February 11, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38308760/ccl18-chi3l1-ang2-il-6-systemic-levels-are-associated-with-the-extent-of-lung-damage-and-radiomic-features-in-sars-cov-2-infection
#19
JOURNAL ARTICLE
Ilaria Ferrigno, Laura Verzellesi, Marta Ottone, Martina Bonacini, Alessandro Rossi, Giulia Besutti, Efrem Bonelli, Rossana Colla, Nicola Facciolongo, Elisabetta Teopompi, Marco Massari, Pamela Mancuso, Anna Maria Ferrari, Pierpaolo Pattacini, Valeria Trojani, Marco Bertolini, Andrea Botti, Alessandro Zerbini, Paolo Giorgi Rossi, Mauro Iori, Carlo Salvarani, Stefania Croci
OBJECTIVE AND DESIGN: We aimed to identify cytokines whose concentrations are related to lung damage, radiomic features, and clinical outcomes in COVID-19 patients. MATERIAL OR SUBJECTS: Two hundred twenty-six patients with SARS-CoV-2 infection and chest computed tomography (CT) images were enrolled. METHODS: CCL18, CHI3L1/YKL-40, GAL3, ANG2, IP-10, IL-10, TNFα, IL-6, soluble gp130, soluble IL-6R were quantified in plasma samples using Luminex assays...
February 3, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38291238/identification-of-inflammatory-biomarkers-in-iga-nephropathy-using-the-nanostring-technology-a-validation-study-in-caucasians
#20
JOURNAL ARTICLE
Laurence Gaumond, Caroline Lamarche, Stéphanie Beauchemin, Nathalie Henley, Naoual Elftouh, Casimiro Gerarduzzi, Louis-Philippe Laurin
OBJECTIVE AND DESIGN: Immunoglobulin A nephropathy (IgAN) is a kidney disease characterized by the accumulation of IgA deposits in the glomeruli of the kidney, leading to inflammation and damage to the kidney. The inflammatory markers involved in IgAN remain to be defined. Gene expression analysis platforms, such as the NanoString nCounter system, are promising screening and diagnostic tools, especially in oncology. Still, their role as a diagnostic and prognostic tool in IgAN remains scarce...
January 31, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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