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Clinical and Applied Thrombosis/hemostasis

Zhi-Hua Zhou, Yuan Chen, Bai-Hui Zhao, Ying Jiang, Qiong Luo
The aim of our study was to quantify risk factors for venous thromboembolism (VTE) during the puerperal period. The case-control study was conducted in Women's Hospital, Zhejiang University, China, from January 2006 to December 2016; cases of hospitalized VTE within 1 week after delivery were identified according to International Classification of Diseases, Ninth Revision, Clinical Modification codes. Control postpartum women without VTE were randomly selected, matched on birth day, age, delivery mode, and number of fetus with 4:1 ratio...
December 23, 2018: Clinical and Applied Thrombosis/hemostasis
Ahmed Mousa, Ossama M Zakaria, Ibrahim Hanbal, Mohammed A Nasr, Tamer A Sultan, Mohamed Abd El-Hamid, Amr M El-Gibaly, Haytham Al-Arfaj, Ahmed S Daha, Mohammed A Buhalim, Mohamed Y Zakaria, Dina E El Metwally, Bosat E Bosat, Alaa Sharabi, Mohamed Nienaa, Mahsoub M Amin, Khaled A Rashed
We aimed to evaluate the outcome of different treatment modalities for extremity venous thrombosis (VT) in neonates and infants, highlighting the current debate on their best tool of management. This retrospective study took place over a 9-year period from January 2009 to December 2017. All treated patients were referred to the vascular and pediatric surgery departments from the neonatal intensive care unit. All patients underwent a thorough history-taking as well as general clinical and local examination of the affected limb...
December 6, 2018: Clinical and Applied Thrombosis/hemostasis
Christopher F Tirotta, Richard G Lagueruela, Danielle Madril, Daria Salyakina, Weize Wang, Thomas Taylor, Jorge Ojito, Kathleen Kubes, Hyunsoo Lim, Robert Hannan, Redmond Burke
This study evaluated whether rotational thromboelastometry (ROTEM; Tem International GmbH, Munich, Germany) FIBTEM maximum clot firmness (MCF) can be used to predict plasma fibrinogen level in pediatric patients undergoing cardiac surgery. Linear regression was conducted to predict plasma fibrinogen level using FIBTEM MCF (0.05 level of significance). Scatter plot with the regression line for the model fit was created. Fifty charts were retrospectively reviewed, and 87 independent measurements of FIBTEM MCF paired with plasma fibrinogen levels were identified for analysis...
December 5, 2018: Clinical and Applied Thrombosis/hemostasis
Katsunori Mochizuki, Kotaro Mori, Yuta Nakamura, Ryo Uchimido, Hiroshi Kamijo, Kanako Takeshige, Kenichi Nitta, Hiroshi Imamura
It is unclear whether initial infection control or anticoagulant therapy exerts a greater effect on early changes in the Sequential Organ Failure Assessment (SOFA) score among patients with sepsis-induced disseminated intravascular coagulation (DIC). This retrospective propensity score cohort study aimed to evaluate whether adequacy of infection control or anticoagulation therapy had a greater effect on early changes in the SOFA scores among 52 patients with sepsis-induced DIC. Inadequate initial infection control was associated with a lower 28-day survival rate among patients with sepsis-induced DIC (odds ratio [OR]: 0...
November 28, 2018: Clinical and Applied Thrombosis/hemostasis
Gaisa T Kairov, Maksim A Solovev, Larisa Y Kotlovskaya, Vladimir V Udut
One of the crucial risk factors for development of severe postthrombotic disease (PTD) is the recurrence of deep vein thrombosis (DVT). New opportunities for pharmacological thromboprophylaxis of secondary thrombophilia were associated with the direct thrombin inhibitor-Dabigatran (Pradaxa; Boehringer Ingelheim, Germany). We aimed to investigate the daily pharmacodynamics of dabigatran in healthy volunteers and patients with PTD. Treatment with dabigatran in patients with PTD having chronic chronometric hypercoagulation and structural hypocoagulation before the administration of the drug is fraught with excessive anticoagulation and a high risk of clinically significant bleeding...
November 28, 2018: Clinical and Applied Thrombosis/hemostasis
Eduardo Ramacciotti, Valéria Cristina Resende Aguiar, Valter Castelli Júnior, Ivan Benaducce Casella, Antonio Eduardo Zerati, Jawed Fareed
Edoxaban, a direct factor Xa inhibitor (FXa), is the fourth direct oral anticoagulant (DOAC) approved for clinical use in the treatment of venous thromboembolism (VTE) in Latin America, following global approvals for this indication. Edoxaban features some particular characteristics when compared to the previously approved DOACs. This review summarizes the main properties of edoxaban, the outcomes results of its pivotal global clinical trials and the peculiar clinical features of this compound. This practical guide aims to help Latin America clinicians understand edoxaban, its proper indication and its use for the appropriate patients with VTE...
November 28, 2018: Clinical and Applied Thrombosis/hemostasis
Asmaa M Zahran, Ismail L Mohamed, Osama M El Asheer, Deiaaeldin M Tamer, Mohamed G M Abo-ELela, Mona H Abdel-Rahim, Omnia H B El-Badawy, Khalid I Elsayh
BACKGROUND AND AIM: Hyperglycemia in type 1 diabetes (T1D) is accompanied by endothelial cell dysfunction which is known to contribute to the pathogenesis of cardiovascular disorders. The aim of the current study was to explore the profile of circulating endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), endothelial and platelet derived micropaticles (EMPs, PMPs) and total microparticles (TMPs), in T1D children in relation to each other and to the metabolic disorders accompanying T1D...
January 2019: Clinical and Applied Thrombosis/hemostasis
Chase Thorson, Kevin Galicia, Andrew Burleson, Olivia Bouchard, Debra Hoppensteadt, Jawed Fareed, William Hopkinson
Osteoarthritis, a degenerative disease of the joints, is the most common form of arthritis in the knee. Total joint arthoplasty is a commonly used treatment for joint degeneration and osteoarthritis, and due to these factors, TJA for hip and knee joints is projected to grow by 137% and 601% between 2005 and 2030. Matrix metalloproteases are enzymes found in the extracellular matrix that cleave matrix components. Normally MMPs are downregulated in tissues by Tissue Inhibitors of Metalloproteases, or TIMPs. The relative concentration of TIMPs also may denote some of the activity of the MMPs found in serum...
January 2019: Clinical and Applied Thrombosis/hemostasis
Junxun Li, Fan Zhang, Chujia Liang, Zhuangjian Ye, Shaoqian Chen, Jing Cheng
This study seeks to evaluate the diagnostic value of D-Dimer Plus and Innovance D-Dimer as well as the age-adjusted cutoff value for D-dimer detection in combination with 4 pretest probability (PTP) scores for deep venous thrombosis (DVT). A total of 688 patients referred for lower extremity vascular compression venous ultrasonography for suspected DVT from January 2016 to May 2018 in the First Affiliated Hospital of Sun Yat-sen University underwent D-dimer tests combining with 4 PTP scores. The diagnostic efficacy of the Wells score was the highest of the 4 PTP scores...
January 2019: Clinical and Applied Thrombosis/hemostasis
Chen Tingting, Wang Yuzhu, Zhang Lin, Li Ran, Li Jing, Wu Yi, Li Xiaoyu, Lv Qianzhou
Both vitamin K antagonists (VKAs) and novel oral anticoagulants (NOACs) are effective for stroke prevention in nonvalvular atrial fibrillation (NVAF) patients. This study evaluated the utilization of VKA and NOACs in NVAF patients before and after catheter ablation in China. Prescription data were retrospectively collected between January 1, 2016, and December 31, 2016, including indication of use, dose, renal function, and risk assessment (CHA2 DS2 -VASc score and HAS-BLED score) in Zhongshan Hospital of Fudan University...
January 2019: Clinical and Applied Thrombosis/hemostasis
Asmaa M Zahran, Khalid I Elsayh, Khaled Saad, Mostafa M Embaby, Mervat A M Youssef, Yasser F Abdel-Raheem, Shaban M Sror, Shereen M Galal, Helal F Hetta, Mohamed Diab Aboul-Khair, Mohamd A Alblihed, Amira Elhoufey
Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and function and circulating microparticles (MPs) derived from multiple cell sources. This study was carried out to determine MPs profiles in patients with sickle cell anemia (either on hydroxyurea (HU) therapy or those with no disease-modifying therapy) and to compare these profiles with healthy children...
January 2019: Clinical and Applied Thrombosis/hemostasis
Mateo Porres-Aguilar, Javier E Anaya-Ayala, Gustavo A Heresi, Belinda N Rivera-Lebron
Pulmonary embolism represents the third most common cause of cardiovascular death in the United States. Reperfusion therapeutic strategies such as systemic thrombolysis, catheter directed therapies, surgical pulmonary embolectomy, and cardiopulmonary support devices are currently available for patients with high- and intermediate-high-risk pulmonary embolism. However, deciding on optimal therapy may be challenging. Pulmonary embolism response teams have been designed to facilitate multidisciplinary decision-making with the goal to improve quality of care for complex cases with pulmonary embolism...
November 19, 2018: Clinical and Applied Thrombosis/hemostasis
Steven Deitelzweig, Jennifer D Guo, Patrick Hlavacek, Jay Lin, Gail Wygant, Lisa Rosenblatt, Anu Gupta, Xianying Pan, Jack Mardekian, Melissa Lingohr-Smith, Brandy Menges, Alexander Marshall, Anagha Nadkarni
A real-world US database analysis was conducted to evaluate the hospital resource utilization and costs of patients hospitalized for venous thromboembolism (VTE) treated with warfarin versus apixaban. Additionally, 1-month readmissions were evaluated. Of 28 612 patients with VTE identified from the Premier Hospital database (August 2014-May 2016), 91% (N = 26 088) received warfarin and 9% (N = 2524) received apixaban. Outcomes were assessed after controlling for key patient/hospital characteristics. For index hospitalizations, the average length of stay (LOS) was longer (3...
November 15, 2018: Clinical and Applied Thrombosis/hemostasis
Antonio Girolami, Silvia Ferrari, Elisabetta Cosi, Claudia Santarossa, Maria Luigia Randi
Vitamin K-dependent clotting factors are commonly divided into prohemorrhagic (FII, FVII, FIX, and FX) and antithrombotic (protein C and protein S). Furthermore, another protein (protein Z) does not seem strictly correlated with blood clotting. As a consequence of this assumption, vitamin K-dependent defects were considered as hemorrhagic or thrombotic disorders. Recent clinical observations, and especially, recent advances in molecular biology investigations, have demonstrated that this was incorrect. In 2009, it was demonstrated that the mutation Arg338Leu in exon 8 of FIX was associated with the appearance of a thrombophilic state and venous thrombosis...
November 14, 2018: Clinical and Applied Thrombosis/hemostasis
Justin Lee, Ryan McMillan, Leonidas Skiadopoulos, Vinod Bansal, José Biller, Debra Hoppensteadt, Jawed Fareed
The prevalence of neurocognitive deficits remains high in patients with stage 5 chronic kidney disease (CKD5D). Major contributors to such deficits include stroke, cervical carotid artery disease (CCAD), and intracranial atherosclerotic disease (ICAD). The risk of developing these dysfunctional vascular processes is facilitated by the chronic inflammation associated with renal failure. Plasma levels of 10 circulating biomarkers in patients with CKD5D (n = 78-90) were quantified using the sandwich enzyme linked immune sorbent assay method...
November 14, 2018: Clinical and Applied Thrombosis/hemostasis
Erin R Weeda, Sofia Butt
Select patients with acute deep vein thrombosis (DVT) can be managed as outpatients. We sought to conduct a systematic review of real-world studies describing either (1) the clinical characteristics associated with outpatient DVT treatment in all-comers or (2) emergency department (ED) programs designed to facilitate outpatient DVT treatment. MEDLINE and SCOPUS were searched (January 1, 2012, to May 1, 2018) to identify citations meeting the aforementioned criteria. Twenty-one real-world studies were included...
November 14, 2018: Clinical and Applied Thrombosis/hemostasis
Margaret Prechel, Susan Hudec, Elizabeth Lowden, Vicki Escalante, Nicholas Emanuele, Maryann Emanuele, Jeanine M Walenga
Heparin (H) anticoagulation in populations characterized by elevated platelet factor 4 (PF4) frequently elicits PF4/H antibodies, presenting a risk of heparin-induced thrombocytopenia. Recent studies have shown that anti-PF4/H enzyme-linked immunosorbent assays (ELISAs) detect antibodies in individuals never exposed to heparin. Platelet factor 4/H cross-reactive antibodies may result from PF4-mediated defense responses to injury or infection. This study questioned whether patients with diabetes are more likely to develop the endogenous cross-reactive antibodies...
November 12, 2018: Clinical and Applied Thrombosis/hemostasis
Denise Bichuyen Mai, Mary R Smith, William T Gunning
The purpose of this study was to determine the reliability of test results dependent upon blood and plasma sample stability when shipped by airfreight courier for reference laboratory assessment. Of particular interest was evaluation of von Willebrand profile assays and platelet dense granule storage pool analysis. Peripheral venous blood was obtained from healthy volunteers. von Willebrand factor (VWF) activity, VWF antigen, and factor VIII coagulant activity assays were performed immediately following venipuncture with additional aliquots of plasma frozen and stored at -70°C for subsequent analysis 48 hours later...
November 2018: Clinical and Applied Thrombosis/hemostasis
Barbora Korpallová, Matej Samoš, Tomáš Bolek, Ingrid Škorňová, František Kovář, Peter Kubisz, Ján Staško, Marián Mokáň
The monitoring of coagulation by viscoelastometric methods-thromboelastography and rotational thromboelastometry-may detect the contributions of cellular and plasma components of hemostasis. These methods might overcome some of the serious limitations of conventional laboratory tests. Viscoelastic testing can be repeatedly performed during and after surgery and thus provides a dynamic picture of the coagulation process during these periods. Several experiences with the use of these methods in cardiovascular surgery have been reported, but there is perspective for more frequent use of these assays in the assessment of platelet response to antiplatelet therapy and in the assessment of coagulation in patients on long-term dabigatran therapy...
November 2018: Clinical and Applied Thrombosis/hemostasis
Asem Mansour, Salwa S Saadeh, Nayef Abdel-Razeq, Omar Khozouz, Mahmoud Abunasser, Ayat Taqash
Patients with cancer have an increased risk of venous thromboembolism. Upper extremity venous system is a peculiar site, and little is known about the clinical course in patients with cancer. Electronic medical records were searched for patients with cancer with a diagnosis of upper extremity venous thrombosis. Individual patient data were reviewed. Eighty-seven patients were identified, and the median age was 52.4. The most common underlying malignancies were breast (23.0%), colorectal (18.4%), and gastroesophageal (18...
November 2018: Clinical and Applied Thrombosis/hemostasis
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