Applied Neuropsychology

Sensory and motor functions are good markers of neurocognitive decline due to their proximity and hierarchical relationship to high-order processes. The current study investigated if patients with Alzheimer's disease (AD) differed from a healthy control group in two tactile perceptual processes: astereognosis and agraphesthesia. Analyses were also conducted to see if these tactile processes were predictive of higher-order cognitive functioning. Twenty-eight patients with AD (mean age = 75.86) were compared to 28 healthy control subjects (mean age = 76...

We examined whether there are selective deficits in early-stage Alzheimer's disease (AD; n = 27) and in unipolar depression (UD; n = 17) patients on recall and recognition of spatial and visual components of nonverbal memory (NVM) and whether the two groups can be differentiated based on their performance on such tasks. We also investigated which NVM measures had the best discrimination power. We tested spatial, visuospatial, and visuoconstructive abilities in AD and UD patients. AD patients' scores on NVM tasks were significantly lower than those of healthy subjects (HS; n = 30) and consistently lower than those of the UD group...

Using a sample of 72 university students, we determined whether administering the Boston Naming Test (BNT) before the Test of Memory Malingering (TOMM) affects scores on the latter test and whether administration of a visual test during the interval between TOMM Trial 2 and the TOMM Retention Trial (TOMM-R) influences results on TOMM-R. Four orders of administration were used. A series of nonparametric tests indicated that when the BNT was given before the TOMM, a lower median TOMM Trial 1 (TOMM-1) score emerged...

The assessment of suspected dementia often involves the analysis of change scores from neuropsychological tests administered on two occasions. Frequently, no information is available to allow the significance of a change to be evaluated. Our aim was to prepare data useful for estimating the statistical significance of retest changes for persons older than the age of 65 on the Ruff 2 and 7 Selective Attention Test, one of the few paper-and-pencil tests of attention available to the clinician. The sample tested was composed of 234 healthy adults taking part in a randomized double-blind trial of the effect on cognitive performance of lowering homocysteine using dietary supplements, during which no treatment effects were detected...

No abstract text is available yet for this article.

Cognitive impairment is now recognized as a frequent consequence of treatments for cancers localized outside the central nervous system (CNS). In contrast, little attention has been given to the potentially deleterious cognitive effects from non-CNS cancers themselves. The present case study proposes that cognitive deficits occur in a subset of treatment-naive patients with diffuse large B-cell lymphoma in whom no gross evidence of lymphoma-related CNS involvement is apparent. Evidence is presented from a case study and elaborate putative mechanisms centering on deleterious effects of B-cell-mediated inflammatory cytokine secretion on neurons...

Neuropsychologists are ethically charged with communicating their qualifications and credentials in ways that promote understanding and avoid deception. However, there exist few if any concrete guidelines about how and when to cite qualifications when rendering professional neuropsychological opinions. This article attempts to clarify the issues relevant to the signatory process, offering guidelines based on principles of accuracy, relevancy, and necessity. Common practices and problems are outlined, and recommended solutions offered...

The current study represents an examination of the construct validity of the Wechsler Test of Adult Reading (WTAR) among a sample of U.S. military veterans referred for outpatient neuropsychological evaluation that included a measure of negative response bias, namely, the Test of Memory Malingering (TOMM). This retrospective data analysis examined the relationship between the WTAR and measures of current verbal general intellectual function and current cognitive skills. Findings showed that, among patients passing the TOMM (N = 98), WTAR scores were most highly correlated with current verbal IQ but also showed significant correlations with verbal memory and lesser, but still significant, correlations with measures of visual-spatial memory...

The objective of the study was to develop and validate a translated and culturally adapted Mini-Mental State Examination (MMSE) for the Persian-speaking population. The MMSE was translated into Persian. Two groups of neurologically intact subjects (n = 100) and subjects with Alzheimer's disease (n = 13) were studied. The difference between groups on the mean total scores of the Persian MMSE was statistically significant (control = 28.62 +/- 2.09; subjects with Alzheimer's disease = 11.77 +/- 5.66; p < .001)...

This study examined three scales of the Personality Assessment Inventory (PAI; Anxiety, Anxiety-Related Disorders, and Depression) in 88 participants 1 year after they suffered a moderate-severe traumatic brain injury (TBI). Participants were all enrolled in the federally funded Traumatic Brain Injury Model System project at Carolinas Rehabilitation. The following variables were assessed at the time of injury: age, sex, employment and marital status, and length of loss of consciousness. Disability status, using the Disability Rating Scale (DRS), was assessed at the time of discharge from the rehabilitation hospital...

The Word Memory Test (WMT) has been considered one of the best assessment tools for assessing memory malingering in spite of some reported false-positive results. Our goal was to examine the sensitivity and specificity of Green's 2003 criteria for memory malingering using a Portuguese adaptation of the WMT. We applied the WMT to three groups of participants, including 20 healthy subjects asked to simulate memory impairment, 29 healthy adults asked to produce their best performance, and 21 patients with the diagnosis of mild cognitive impairment (MCI)...

There is limited research examining the relationship between cognition in severe dementia and functional skills. The aim of the present study was to examine the relationship between the Severe Impairment Battery (SIB) and functional abilities as measured by the Assessment of Instrumental Function (AIF) in an acute inpatient geriatric psychiatry setting. Analyses showed significant correlation between the SIB and the AIF. Multiple regression demonstrated that SIB scores accounted for 44% of the variance in adaptive functioning...

The current study examined the relationship between a standardized dementia battery (Repeatable Battery for the Assessment of Neuropsychological Status [RBANS]) and a test of olfactory discrimination (University of Pennsylvania Smell Identification Test [UPSIT]) in a heterogeneous sample of patients referred for a dementia assessment (N = 103). Significant moderate correlations were found between the UPSIT and each of the RBANS indexes, with the strongest correlation for Total Scale score, followed by the Delayed Memory Index and the Language Index...

Exposure to environmental toxins, such as pesticides, has been shown to have adverse effects in humans, particularly neurological effects. Cases of acute pesticide poisoning occur less frequently and are less well documented; specific deficits (e.g., in processing speed, working memory) have not consistently been discussed. This is a case study of a preschooler who underwent a neuropsychological assessment due to a pesticide poisoning. His parents reported attention, speech, social, and gross and fine motor concerns after the poisoning...

Klinefelter syndrome (KS) is a genetic disorder in males characterized by the presence of an extra X chromosome. Its most consistent endocrinological manifestations include lower testosterone production and impaired spermatogenesis. KS individuals have a general typical appearance with taller stature, and they demonstrate a characteristic cognitive phenotype involving weaknesses in verbal processing. Anomalous cerebral lateralization involves the inverse or weak dominance of hand, language, and visuospatial abilities and has been associated with the cognitive deficits of KS individuals...

Recent studies conducted at American post-secondary institutions report that a high proportion of college students seeking evaluations for either attention-deficit/hyperactivity disorder or learning disorders fail symptom validity tests (SVTs), calling into question the validity of their performance on standardized assessment measures. The current study undertook to investigate the rate of SVT failure in a Canadian post-secondary sample, drawing on assessment data from a large regional assessment facility. Evaluating the data from 144 consecutively tested students, the present study found that 14...

UNLABELLED: Attention deficit in schizophrenia may be underestimated due to limited sensitivity of attention tests. Comparing the frequency of attention deficits in schizophrenia to attention deficit hyperactivity disorder (ADHD) may solve this problem, since all subjects with ADHD should demonstrate impaired attention. Twenty-seven subjects with schizophrenia were compared to 74 clinical controls with ADHD on tests of focused/divided/sustained attention and impulsivity. RESULTS: The frequency of impaired attention was equal among subjects with schizophrenia and ADHD-combined (ADHD-C), while ADHD-inattentive (ADHD-I) subjects were more impaired...

The current article serves as the concluding remarks to this special issue on the assessment and treatment of traumatic brain injury in children and adolescents. The article provides a brief discussion of the changing landscape of clinical and research endeavors within this population and potential directions for the future.

The purpose of this review is to provide a summary of the empirical research on rehabilitation in pediatric traumatic brain injury (TBI). Studies of the effectiveness of interventions with children with TBI are hampered by difficulty with combining subjects with various levels of TBI, problems with random assignment to treatment groups, and varying age levels at injury. While these are areas of concern, there are emerging studies that indicate both applied behavioral analysis (ABA) and positive behavioral interventions are helpful to many children...

This article reviews the current literature surrounding the emotional and behavioral consequences as a result of traumatic brain injury (TBI) for children and adolescents. The use of a treatment planning model incorporating developmental theory, recovery, and family needs is advocated. The article reviews the current literature for treatment of primary emotional and psychiatric problems associated with TBI. Additional research into the treatment and intervention of psychiatric, emotional, and behavioral problems in children with TBI remains necessary...