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Journals Journal of Interferon & Cytoki...

Journal of Interferon & Cytokine Research

https://read.qxmd.com/read/38153396/c-c-motif-chemokine-2-regulates-macrophage-polarization-and-contributes-to-myocardial-infarction-healing
#21
JOURNAL ARTICLE
Liangwei Chen, Dihao Pan, Yiran Zhang, Enfan Zhang, Liang Ma
Macrophages are crucial immune cells that play essential roles in the healing of myocardial infarction (MI), undergoing continuous polarization throughout this process. C-C motif chemokine 2 (CCL2) is a chemokine that regulates inflammatory responses during MI. However, the extent to which CCL2 influences macrophage polarization and MI healing remains incompletely understood. In this study, we investigate the role of CCL2 in macrophage polarization and MI healing. Our findings reveal that CCL2 is differentially expressed in lipopolysaccharide (LPS)-induced M1 and interleukin (IL)-4-induced M2 RAW264...
December 28, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/38153389/association-of-polymorphisms-of-the-il-17a-and-il-17f-genes-with-increased-risk-of-hypertension-and-obesity-in-mexican-patients-with-covid-19
#22
JOURNAL ARTICLE
Richard Salama-Frisbie, Cinthia A Molina-Flores, Arguiñe I Urraza-Robledo, María E Gutiérrez-Pérez, Alberto A Miranda-Pérez, Alhi A Gutiérrez-Salas, Jorge Haro-Santa Cruz, Francisco C López-Márquez
Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2). COVID-19 can cause a cytokine release syndrome in which cytokines, including interleukin 17 (IL-17), are massively secreted in response to a specific stimulus. This can contribute to mortality and severe forms of COVID-19. The study aimed to determine the association of SARS-CoV2 infection with the IL-17A rs2275913 and IL-17F rs763780 variants, as well as with the associated comorbidities in COVID-19-positive Mexican patients...
December 28, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/38126912/acknowledgment-of-reviewers-2023
#23
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 21, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/38048299/biohabana-2022-preventive-and-immunotherapeutic-strategies-against-covid-19-and-cancer-in-cuba
#24
JOURNAL ARTICLE
Iraldo Bello-Rivero, Tania Crombet-Ramos, Circe Mesa-Pardillo, Yanelys Morera-Díaz, Zaima Mazorra-Herrera, Dagmar Garcia-Rivera, Hugo Nodarse-Cuní, Francisco Hernández-Bernal, Verena Muzio-Gonzalez, Ana Aguilera-Barreto, Dania Vazquez-Blomquist, Maria Del Carmen Domínguez-Horta, Gerardo Guillen-Nieto
The convergence of life sciences with neurosciences, nanotechnology, data management, and engineering has caused a technological diversification of the biotechnology, pharmaceutical, and medical technology industries, including the phenomenon of digital transformation, which has given rise to the so-called Fourth Industrial Revolution (Industry 4.0). Confronting the COVID-19 pandemic revealed the outstanding response capacity of the scientific community and the biopharmaceutical industry, based on a multidisciplinary and interinstitutional approach that has achieved an unprecedented integration in the history of biomedical science...
December 4, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/38126935/the-association-of-serum-midkine-level-with-invasion-in-placenta-previa-a-case-control-study-from-a-tertiary-reference-center
#25
JOURNAL ARTICLE
Nihat Farisoğullari, Atakan Tanaçan, Bedri Sakcak, Ramazan Denizli, Osman Onur Özkavak, Ezgi Turgut, Özgür Kara, Nuray Yazihan, Dilek Şahin
We aimed to examine the relationship between serum midkine levels and placental invasion in pregnant women with placenta previa. The study group consisted of 43 pregnant women diagnosed with placenta previa, whereas the control group consisted of 60 healthy pregnant women. Serum midkine levels were compared between pregnant women with placenta previa and the control group in this study's first part. Thereafter, the utility of midkine in the prediction of the abnormally invasive placenta (AIP) was investigated and optimal cutoff values were calculated...
December 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37967433/cytokine-profile-response-of-human-peripheral-blood-mononuclear-cells-stimulated-by-bartonella-bacilliformis
#26
JOURNAL ARTICLE
Barbara Ymaña, Javier Enciso-Benavides, Gemma Moncunill, Maria J Pons
Carrion's disease is a neglected endemic disease found in remote Andean areas. As an overlooked disease, knowledge of innate immune responses to Bartonella bacilliformis , the etiological agent, is scarce. This study aimed to evaluate the cytokine response to B. bacilliformis using in vitro human peripheral blood mononuclear cells (PBMCs) stimulations. PBMCs from naive adults were isolated by gradient centrifugation and cocultured with heat-inactivated (HI) B. bacilliformis at different incubation times (3, 6, 12, 24, and 36 h)...
November 15, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37962860/impact-of-chronic-moderate-exercise-on-immune-cells-and-cytokine-levels-in-rats-focus-on-the-endocannabinergic-pathway
#27
JOURNAL ARTICLE
Salvador Valencia-Sánchez, Karen Elizabeth Nava-Castro, Claudia Angélica Garay-Canales, Víctor Hugo Del Río-Araiza, Jorge Morales-Montor
Although the modulation of immunity by exercise has been a long-studied paradigm, the molecular pathways connecting the two are still not fully understood. Regular moderate aerobic exercise is associated with improved health and directly impacts the immune system by changing the proportion of cell subpopulations, their function, and interleukin production. The endocannabinoid system has gained importance as an immune modulator, affected by moderate aerobic promoting the production of endocannabinoids, which are ligands of the cannabinoid receptors (CBRs) expressed on the surface of all immune cells...
November 14, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37934469/activation-of-the-interleukin-18-signaling-pathway-via-direct-receptor-dimerization-in-the-absence-of-interleukin-18
#28
JOURNAL ARTICLE
Yasaman Mortazavi, Robert Herrera, Matthieu Masureel, Timurs Maculins, Isabelle Lehoux, Jonathan Sockolosky, Nathan West, Beyza Bulutoglu, Yue Zhao
Interleukin 18 (IL-18) is a key cytokine involved in the activation of T and NK cells, which are major effector cells in tumor killing. However, recombinant IL-18 showed limited efficacy in clinical trials. A recent study showed the lack of efficacy was largely due to the existence of IL-18BP, a soluble decoy receptor for IL-18. It was shown that engineered IL-18 variants that maintained pathway activation, but avoided IL-18BP binding, could exert potent antitumor effects. In this study, we demonstrated an alternative strategy to activate IL-18 signaling through direct receptor dimerization...
November 6, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37956249/linc00641-mir-378a-and-their-cross-talk-with-tnf-%C3%AE-ifn-%C3%AE-as-potential-biomarkers-in-ulcerative-colitis-and-crohn-s-diseases
#29
JOURNAL ARTICLE
Nour A Abdel Hameed, Olfat G Shaker, Nabil A Hasona
The most well-known forms of inflammatory bowel disease (IBD) that affect the entire gastrointestinal tract are ulcerative colitis (UC) and Crohn's disease (CD). The serum profile of inflammatory biomarkers and noncoding RNA and their role in the propagation of the inflammatory process remains controversial. Thus, this study was designed to examine the relationship between hematological profile, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interferon-gamma (INF-γ), and the expression of LINC00641 and miR-378a in individuals with IBDs...
November 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37751211/the-many-faces-of-oligoadenylate-synthetases
#30
REVIEW
Saumendra N Sarkar, Munesh K Harioudh, Lulu Shao, Joseph Perez, Arundhati Ghosh
2'-5' Oligoadenylate synthetases (OAS) are interferon-stimulated genes that are most well-known to protect hosts from viral infections. They are evolutionarily related to an ancient family of Nucleotidyltransferases, which are primarily involved in pathogen-sensing and innate immune response. Classical function of OAS proteins involves double-stranded RNA-stimulated polymerization of adenosine triphosphate in 2'-5' oligoadenylates (2-5A), which can activate the latent RNase (RNase L) to degrade RNA. However, accumulated evidence over the years have suggested alternative mode of antiviral function of several OAS family proteins...
November 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37906115/high-anti-interferon-alpha-autoantibody-levels-in-severe-critical-covid-19-patients-from-peru
#31
JOURNAL ARTICLE
Maria J Pons, Ana Mayanga-Herrera, Luciano A Palomino-Kobayashi, Antonio M Quispe, Manuel F Ugarte-Gil
Innate immune responses through the production of type I interferon-α (anti-IFN-α) play an essential role in the defense against viruses. The autoantibodies (auto-Abs) anti-IFN-α are implicated in COVID-19 pathogenesis with higher levels among patients with worse prognoses. The study aimed to assess the levels of anti-IFN-α auto-Abs in Peruvian patients with severe/critical hospitalized COVID-19 compared to asymptomatic/mild COVID-19 outpatients and healthy controls. We analyzed 101 serum samples, including 56 (55...
October 31, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37906101/trpm2-l-participates-in-the-interleukin-6-pathway-to-enhance-tumor-growth-in-prostate-cancer-by-hypoxia-inducible-factor-1%C3%AE
#32
JOURNAL ARTICLE
Kai Cheng, Qingmei Jia, Christopher Batbatan, Zhihua Guo, Fengtao Cheng
Interleukin-6 (IL-6) can promote cell proliferation in prostate cancer (PCa). Full-length transient receptor potential melastatin 2 (TRPM2-L) is highly expressed in PCa. However, the association between IL-6 and TRPM2-L in PCa is unclear. Here, human PCa cell lines, PC-3 and DU-145, were treated with 10 μg/mL tocilizumab, an IL-6 receptor (IL-6R) inhibitor, and the TRPM2-L protein expression in cells was significantly decreased. Cells were stably transfected with TRPM2 short-interfering RNA (siRNA) and cell survival clearly declined...
October 31, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37878764/conversation-with-dr-daniela-novick
#33
JOURNAL ARTICLE
Daniela Novick
No abstract text is available yet for this article.
October 25, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37824200/biology-of-interleukin-17-and-novel-therapies-for-hidradenitis-suppurativa
#34
JOURNAL ARTICLE
Robert Sabat, Johann Eli Gudjonsson, Nicolo Costantino Brembilla, Kelsey R van Straalen, Kerstin Wolk
Skin disorders affect ∼40% of the human population. One of the most debilitating cutaneous disorders is Hidradenitis suppurativa (HS), a noncommunicable chronic inflammatory disease with an estimated global prevalence of 0.4% to 2.5%. In January 2011, high levels of IL-17 were discovered in skin lesions of HS patients. In the following years, translational and clinical research led to a better understanding of the pathogenesis of HS. In June 2023, more than 12 years after the initial note, secukinumab, an anti-IL-17A monoclonal antibody, was approved for the treatment of moderate to severe HS...
October 12, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37819735/proinflammatory-bone-marrow-mesenchymal-stem-cell-derived-exosomal-mir-150-3p-suppresses-proinflammatory-polarization-of-alveolar-macrophages-in-sepsis-by-targeting-inhibin-subunit-beta-a
#35
JOURNAL ARTICLE
Guojin Liang, Yueying Feng, Wan Tang, Lifeng Yao, Changshun Huang, Yijun Chen
Bone marrow mesenchymal stem cell (BMSC)-derived exosomes can protect lung tissues against sepsis, but its related mechanism remains elusive. BMSCs were primed with or without lipopolysaccharide (LPS) before extracting exosomes. The isolated exosomes were identified by transmission electron microscopy, nanoparticle tracking analysis, and western blot. LPS-stimulated macrophages were cocultured with exosomes for 24 h, followed by enzyme-linked immunosorbent assay, flow cytometry, and molecular experiments...
October 11, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37815793/association-between-serum-chemokine-ligand-20-levels-and-disease-activity-and-th1-th2-th17-related-cytokine-levels-in-rheumatoid-arthritis
#36
JOURNAL ARTICLE
Liuqing Wang, Xuelian Hong, Hongwei Du
Rheumatoid arthritis (RA) is a type of arthritis autoimmune disease characterized by systemic chronic inflammation. C-C Chemokine ligand 20 (CCL20) is the same as most chemokines with immunomodulatory and inflammatory processes. The correlation of CCL20 in RA remains unclear. This study aimed to explore the association among levels of CCL20, T helper cell (TH) subset (Th1/Th2/Th17)-related cytokine levels, and clinical indices of RA disease activity. Serum CCL20 levels were quantified by enzyme-linked immunosorbent assay, and a flow-fluorescence technique was used to assess Th1/Th2/Th17-related cytokine levels...
October 9, 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37819622/the-role-and-potential-regulatory-mechanism-of-sting-modulated-macrophage-apoptosis-and-differentiation-in-severe-acute-pancreatitis-associated-lung-injury
#37
JOURNAL ARTICLE
Yiqiu Peng, Yingying Li, Yuxi Yang, Tingjuan Shi, Ruixia Liu, Yingyi Luan, Chenghong Yin
This study aims to investigate the role of STING in promoting macrophage apoptosis and regulating macrophage polarization in severe acute pancreatitis (SAP)-associated lung injury in vitro and in vivo . A murine model was established by intraperitoneal injection of caerulein and lipopolysaccharide (LPS). Meanwhile, ANA-1 cells were stimulated with LPS to induce apoptosis in vitro . More primary alveolar macrophages underwent apoptosis and M1 macrophage polarization in the SAP group compared with the control group, which was reversed by inhibiting STING...
October 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37819621/annihilation-of-non-small-cell-lung-cancer-by-nkg2d-car-t-cells-produced-from-t-cells-from-peripheral-blood-of-healthy-donors
#38
JOURNAL ARTICLE
Jinhong Jiang, Yonghua Liu, Yuxiao Zeng, Bingmu Fang, Yongping Chen
Some progress has been made in immunotherapy with chimeric antigen receptor (CAR)-T cells targeting NKG2D-NKG2DL with the purpose of eradicating solid tumors. Non-small cell lung cancer (NSCLC) has been shown to express NKG2DL. This study hence evaluated the therapeutic effect of NKG2D CAR-T cells on NSCLC. Accordingly, NKG2D CAR-T cells were obtained from diverse human autologous T cell sources. T cells from peripheral blood T lymphocytes of healthy volunteers (without NKG2D CAR insertion) were used as NT-T cells...
October 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37819620/-call-for-special-issue-papers-the-yin-yang-activities-of-tumor-induced-inflammatory-cytokines-for-cancer-immunotherapy-detection-and-prognosis
#39
JOURNAL ARTICLE
Yan Ma, Sanjay Mukherjee, Jing Ma
No abstract text is available yet for this article.
October 2023: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/37819619/a-conversation-with-judy-lieberman
#40
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
October 2023: Journal of Interferon & Cytokine Research
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