journal
MENU ▼
Read by QxMD icon Read
search

Journal of Peptide Science: An Official Publication of the European Peptide Society

journal
https://read.qxmd.com/read/30784138/phosphorogenic-and-spontaneous-formation-of-tris-bipyridine-ruthenium-in-peptide-scaffolds
#1
Marziyeh Karimiavargani, Seiichi Tada, Noriko Minagawa, Yoshihiro Shimizu, Takuji Hirose, Yoshihiro Ito, Takanori Uzawa
Redox-active ruthenium complexes have been widely used in various fields; however, the harsh conditions required for their synthesis are not always conducive to their subsequent use in biological applications. In this study, we demonstrate the spontaneous formation of a derivative of tris(bipyridine)ruthenium at 37°C through the coordination of three bipyridyl ligands incorporated into a peptide to a ruthenium ion. Specifically, we synthesized six bipyridyl-functionalized peptides with randomly chosen sequences...
February 19, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30784133/the-mechanism-of-phosphatidylcholine-induced-interference-of-pap-248-286-aggregation
#2
Vijay Kumar, Shalini Gour, Nidhi Verma, Suman Kumar, Kundlik Gadhave, Pushpendra Mani Mishra, Pankaj Goyal, Janmejay Pandey, Rajanish Giri, Jay Kant Yadav
Seminal amyloids are well known for their role in enhancing HIV infection. Among all the amyloidogenic peptides identified in human semen, PAP248-286 was found to be the most active and was termed as semen-derived enhancer of viral infection (SEVI). Although amyloidogenic nature of the peptide is mainly linked with enhancement of the viral infection, the most active physiological conformation of the aggregated peptide remains inconclusive. Lipids are known to modulate aggregation pathway of a variety of proteins and peptides and constitute one of the most abundant biomolecules in human semen...
February 19, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30767370/peptide-based-building-blocks-as-structural-elements-for-supramolecular-gd-containing-mri-contrast-agents
#3
REVIEW
Carlo Diaferia, Eliana Gianolio, Antonella Accardo
Magnetic resonance imaging (MRI) is one of the most important clinic diagnostic tool used to obtain high-quality body images. The administration of low-molecular-weight Gd complex-based MRI contrast agents (CAs) permits to increase the 1 H relaxation rate of nearby water molecules, thus modulating signal intensity and contrast enhancement. Even if highly accurate, MRI modality suffers from its low sensitivity. Moreover, low-molecular-weight CAs rapidly equilibrate between the intravascular and extravascular spaces after their administration...
February 15, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30746861/an-inhibitory-mechanism-of-action-of-coiled-coil-peptides-against-type-three-secretion-system-from-enteropathogenic-escherichia-coli
#4
Mariano Larzábal, Hector A Baldoni, Fernando D Suvire, Lucrecia M Curto, Gabriela E Gomez, Wanderson Marques Da Silva, Silvana L Giudicessi, Silvia A Camperi, Jose M Delfino, Angel A Cataldi, Daniel Enriz
Human pathogenic gram-negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled-coil domains present in the structural proteins of T3SS are conformed by amphipathic alpha-helical structures that play an important role in the protein-protein interaction and are essential for the assembly of the translocation complex. To investigate the inhibitory capacity of these domains on the T3SS of EPEC, we synthesized peptides between 7 and 34 amino acids based on the coiled-coil domains of proteins that make up this secretion system...
February 11, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30740816/the-dual-functionality-of-antimicrobial-peptides-os-and-os-c-in-human-leukocytes
#5
Helena Taute, Megan J Bester, Anabella R M Gaspar
Antimicrobial peptides (AMPs), Os and Os-C, have been identified as multifunctional peptides with antibacterial, antiendotoxin, and anti-inflammatory properties. For further development of Os and Os-C as therapeutic peptides, it is essential to evaluate these effects in human mononuclear (MN) and polymorphonuclear (PMN) leukocytes. The cytotoxicity and the effects of both peptides on MN and PMN morphology were determined with the Alamar-Blue assay and scanning electron microscopy, respectively. The ability of Os and Os-C to induce reactive oxygen species (ROS) and to protect against 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidative damage in both cell populations was evaluated using 2',7'-dichlorofluorescin diacetate (DCFH-DA)...
February 10, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30734396/immunomodulatory-insulinotropic-and-cytotoxic-activities-of-phylloseptins-and-plasticin-tr-from-the-trinidanian-leaf-frog-phyllomedusa-trinitatis
#6
Jelena Pantic, Laure Guilhaudis, Vishal Musale, Samir Attoub, Miodrag L Lukic, Milena Mechkarska, J Michael Conlon
The aim of the study was to determine the in vitro immunomodulatory, cytotoxic, and insulin-releasing activities of seven phylloseptin-TR peptides and plasticin-TR, first isolated from the frog Phyllomedusa trinitatis. The most cationic peptides, phylloseptin-1.1TR and phylloseptin-3.1TR, showed greatest cytotoxic potency against A549, MDA-MB231, and HT-29 human tumor-derived cells and against mouse erythrocytes. Phylloseptin-4TR was the most hydrophobic and the most effective peptide at inhibiting production of the proinflammatory cytokines TNF-α and IL-1β by mouse peritoneal cells but was without effect on production of the antiinflammatory cytokine IL-10...
February 7, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30734395/design-synthesis-and-bioactivities-of-tasiamide-b-derivatives-as-cathepsin-d-inhibitors
#7
Zhi Li, Keting Bao, Hao Xu, Ping Wu, Wei Li, Jian Liu, Wei Zhang
Cathepsin D (Cath D) is overexpressed and hypersecreted by malignant tumors and involved in the progress of tumor invasion, proliferation, metastasis, and apoptosis. Cath D has been considered as a potential target to treat cancer. Our previous studies revealed that tasiamide B derivatives TB-9 and TB-11 exhibited high potent inhibition against Cath D and other aspartic proteases, but their molecular weights are still high, and the role of each residue is unknown yet. Based on this, two series of tasiamide B derivatives have been designed, synthesized, and evaluated for their inhibitory activity against Cath D/Cath E/BACE1...
February 7, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30723971/detection-of-oxytocin-atrial-natriuretic-peptide-and-brain-natriuretic-peptide-using-novel-imprinted-polymers-produced-with-amphiphilic-monomers
#8
Chung-Yin Lin, Sheng-Hung Tsai, Dar-Fu Tai
The cystine-bridged cyclic peptide hormones (CBCPHs) represent signature structural feature as well as unique biological activity. In this study, three CBCPHs have been identified and characterized, namely, oxytocin, atrial natriuretic peptides (ANPs), and brain natriuretic peptides (BNPs). Because research has shown that ANPs and BNPs are powerful diagnostic biomarkers for heart disease, a highly laudable endeavor would be to develop a novel sensor for detecting ANP or BNP levels. Therefore, an amphiphilic monomer Acr-His-NHNH-Fmoc was synthesized to form molecularly imprinted polymers (MIPs) for targeted CBCPH detection...
February 5, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30714272/mammalian-antimicrobial-peptide-protegrin-4-self-assembles-and-forms-amyloid-like-aggregates-assessment-of-its-functional-relevance
#9
Shalini Gour, Vijay Kumar, Ashutosh Singh, Kundlik Gadhave, Pankaj Goyal, Janmejay Pandey, Rajanish Giri, Jay Kant Yadav
Protegrin-4 (PG-4) is a member of the porcine leukocyte protegrins family of cysteine-rich antimicrobial peptides (AMPs) isolated from Sus scrofa. It consists of 18 amino acid residues and works as a part of innate immune system. In this study, we examined the intrinsic aggregation propensity of this AMP using multiple computational algorithms, namely, TANGO, AGGRESCAN, FOLDAMYLOID, AMYLPRED, and ZYGGREGATOR, and found that the peptide is predicted to have a high propensity for the β sheet formation that disposes this peptide to be amyloidogenic...
February 3, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30697868/synthesis-of-peptides-containing-oxo-amino-acids-and-their-crystallographic-analysis
#10
Mrinal Kalita, Archana Archana, Astha Dimri, Prema G Vasudev, Ramesh Ramapanicker
An isolated uncharged hydrogen bond acceptor such as the carbonyl functionality of an aldehyde or a keto group is absent in natural amino acids. Although glutamine and asparagine are known to hydrogen bond through the amide carbonyl group in their side chains, they also possess the amide NH2 group, which can act as a hydrogen bond donor. This makes the structural study of peptides containing an oxo residue, with an isolated carbonyl group in the side chain, interesting. Here, we report the synthesis of δ- and ε-oxo amino acids and their incorporation into oligopeptides as the N-terminal residue...
January 29, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30680847/adrenomedullin-disulfide-bond-mimetics-uncover-structural-requirements-for-am-1-receptor-activation
#11
Jan-Patrick Fischer, Ria Schönauer, Sylvia Els-Heindl, Donald Bierer, Johannes Koebberling, Bernd Riedl, Annette G Beck-Sickinger
Adrenomedullin (ADM) is a vasoactive peptide hormone of 52 amino acids and belongs to the calcitonin peptide superfamily. Its vasodilative effects are mediated by the interaction with the calcitonin receptor-like receptor (CLR), a class B G protein-coupled receptor (GPCR), associated with the receptor activity modifying protein 2 (RAMP2) and functionally described as AM-1 receptor (AM1 R). A disulfide-bonded ring structure consisting of six amino acids between Cys16 and Cys21 has been shown to be a key motif for receptor activation...
January 24, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30652389/short-plgf-derived-peptides-bind-vegfr-1-and-vegfr-2-in-vitro-and-on-the-surface-of-endothelial-cells
#12
Andrea Caporale, Aaron D Martin, Dominga Capasso, Giuseppina Focà, Annamaria Sandomenico, Luca Domenico D'Andrea, Paolo Grieco, Menotti Ruvo, Nuzianna Doti
The placental growth factor (PlGF), a member of VEGF family, plays a crucial role in pathological angiogenesis, especially ischemia, inflammation, and cancer. This activity is mediated by its selective binding to VEGF receptor 1 (VEGFR-1), which occurs predominantly through receptor domains 2 and 3. The PlGF β-hairpin region spanning residues Q87 to V100 is one of the key binding elements on the protein side. We have undertaken a study on the design, preparation, and functional characterization of the peptide reproducing this region and of a set of analogues where glycine 94, occurring at the corner of the hairpin in the native protein, is replaced by charged as well as hydrophobic residues...
January 16, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30588706/the-penetrating-properties-of-the-tumor-homing-peptide-lyp-1-in-model-lipid-membranes
#13
Corina Ciobanasu, Isabela Dragomir, Aurelia Apetrei
Cell-penetrating peptides (CPPs) have the property to cross the plasma membrane and enhance its permeability. CPPs were successfully used to deliver numerous cargoes such as drugs, proteins, nucleic acids, imaging and radiotherapeutic agents, gold and magnetic nanoparticles, or liposomes inside cells. Although CPPs were intensively investigated over the past 20 years, the exact molecular mechanisms of translocation across membranes are still controversial and vary from passive to active mechanisms. LyP-1 is a cyclic 9-amino-acids homing peptide that specifically binds to p32 receptors overexpressed in tumor cells...
December 27, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30588703/improved-mitochondrial-targeting-effect-of-hpma-copolymer-by-ss20-peptide-mediation-and-nonendocytosis-pathway
#14
Yanxi Liu, Qiuyi Li, Xiaofeng Xiong, Zhou Zhou
Mitochondrion plays an important role in executing cell programmed death pathway. Therefore, drugs designed to target mitochondria are supposed to make superior contributions to cancer therapy. However, the problem that drugs or drug delivery systems being sequestrated in endosomes/lysosomes needs to be solved for effective drug delivery. Here, mitochondrial targeting and nonendocytic cell entry peptide SS20 modified HPMA copolymer (P-FITC-SS20) was synthesized. With SS20 peptide modification, the uptake behavior of HPMA copolymers changed remarkably compared with unmodified ones...
December 27, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30575224/salicylic-acid-influences-the-protease-activity-and-posttranslation-modifications-of-the-secreted-peptides-in-the-moss-physcomitrella-patens
#15
Anna Filippova, Irina Lyapina, Ilya Kirov, Victor Zgoda, Alexey Belogurov, Anna Kudriaeva, Vadim Ivanov, Igor Fesenko
Plant secretome comprises dozens of secreted proteins. However, little is known about the composition of the whole secreted peptide pools and the proteases responsible for the generation of the peptide pools. The majority of studies focus on target detection and characterization of specific plant peptide hormones. In this study, we performed a comprehensive analysis of the whole extracellular peptidome, using moss Physcomitrella patens as a model. Hundreds of modified and unmodified endogenous peptides that originated from functional and nonfunctional protein precursors were identified...
December 21, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30575201/unexpected-dimerization-of-a-tripeptide-comprising-a-%C3%AE-%C3%AE-diamino-acid
#16
Yang Wan, Jean-Pierre Baltaze, Cyrille Kouklovsky, Emeric Miclet, Valérie Alezra
We have previously reported the synthesis of enantiopure β,γ-diamino acids and relevant short α/γ-peptide containing such building blocks. Complete nuclear magnetic resonance (NMR) studies, together with molecular modeling, highlighted the ability of a β,γ-diamino acid to induce various intramolecular turns. In this paper, we describe for the first time the formation of a dimeric structure constituted by α/γ/α-tripeptide and stabilized by intermolecular interactions. A structural model is proposed based on extensive NMR measurements...
December 21, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30488526/antifungal-activity-of-a-de-novo-synthetic-peptide-and-derivatives-against-fungal-food-contaminants
#17
Thibaut Thery, Laila N Shwaiki, Yvonne C O'Callaghan, Nora M O'Brien, Elke K Arendt
The development of novel solutions to fight microbial food contaminants rests upon two pillars, which are the development of resistant strains and consumers' desire for a reduced consumption of synthetic drugs. Natural antimicrobial peptides possess the qualities to overcome these issues. De novo synthesis of novel antifungal compounds is a major progress that has been facilitated by the identification of parameters involved in the antimicrobial activity. A 14-residue peptide named KK14, with the sequence KKFFRAWWAPRFLK-NH2 , was designed and inhibited conidial germination and fungal growth of food contaminants within the range 6...
November 28, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30479039/a-traceless-catch-and-release-method-for-rapid-peptide-purification
#18
Oliver Reimann, Oliver Seitz, Dominik Sarma, Robert Zitterbart
No abstract text is available yet for this article.
November 26, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30680876/improved-synthesis-on-solid-phase-of-dithiocarbamic-crgd-derivative-and-99m-tc-radiolabelling
#19
Andrea Caporale, Cristina Bolzati, Giuseppina Maria Incisivo, Nicola Salvarese, Paolo Grieco, Menotti Ruvo
In the field of angiogenesis, small cyclic pentapeptides containing the RGD motif are playing a relevant role for their high affinity and specificity for integrin receptors and for the possibility to act at both therapeutic and diagnostic level by inhibiting pathological angiogenesis and by serving as shuttles to deliver imaging-probe including SPECT/PET radionuclides to specific tissues. In the last decade, several new protocols were reported in literature for the direct synthesis of cyclic RDG either in solution or by SPPS...
February 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/30680875/modeling-interaction-between-gp120-hiv-protein-and-ccr5-receptor
#20
I Guryanov, F Real-Fernández, G Sabatino, N Prisco, V Korzhikov-Vlakh, B Biondi, A M Papini, E Korzhikova-Vlakh, P Rovero, T Tennikova
The study of the process of HIV entry into the host cell and the creation of biomimetic nanosystems that are able to selectively bind viral particles and proteins is a high priority research area for the development of novel diagnostic tools and treatment of HIV infection. Recently, we described multilayer nanoparticles (nanotraps) with heparin surface and cationic peptides comprising the N-terminal tail (Nt) and the second extracellular loop (ECL2) of CCR5 receptor, which could bind with high affinity some inflammatory chemokines, in particular, Rantes...
February 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
journal
journal
32233
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"