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Journal of Atherosclerosis and Thrombosis

Yu Du, Yingxin Zhao, Yong Zhu, Chenping Hu, Jianwei Zhang, Qingwei Ji, Wei Liu, Hongya Han, Lixia Yang, Dai Zhang, Shan Tong, Zhijian Wang, Yonghe Guo, Xiaoli Liu, Yujie Zhou
AIM: Several members of secreted frizzled-related protein (SFRP) are involved in the process of myocardial ischemia-reperfusion injury. However, little is known about the role of SFRP5 in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: In this cross-sectional study, 85 patients with first-time anterior STEMI who underwent timely primary percutaneous coronary intervention (PCI) and 35 patients without coronary artery disease (CAD) were enrolled...
February 15, 2019: Journal of Atherosclerosis and Thrombosis
Masato Furuhashi
Fatty acid-binding proteins (FABPs), a family of lipid chaperones, contribute to systemic metabolic regulation via several lipid signaling pathways. Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays important roles in the development of insulin resistance and atherosclerosis in relation to metabolically driven low-grade and chronic inflammation, referred to as 'metaflammation'. FABP4 is secreted from adipocytes in a non-classical pathway associated with lipolysis and acts as an adipokine for the development of insulin resistance and atherosclerosis...
February 7, 2019: Journal of Atherosclerosis and Thrombosis
Hung Hsu, Powen Hsu, Ming-Hui Cheng, Yasuki Ito, Eiichiro Kanda, Ernst J Schaefer, Masumi Ai
AIMS: Prediabetes and diabetes are associated with increased insulin resistance and decreased insulin production, dyslipidemia, and increased cardiovascular disease (CVD) risk. Our goals were to assess lipoprotein subfractions using novel assays in such subjects. METHODS: Fasting normal, prediabetic, and diabetic Taiwanese men and women (n=2,049) had their serum glucose, glycosylated hemoglobin, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), HDL3-C, apolipoprotein E-HDL-C, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-TG, and remnant lipoprotein cholesterol (RLP-C) levels measured using novel assays...
February 7, 2019: Journal of Atherosclerosis and Thrombosis
Miki Sakamoto, Naoki Edo, Satoshi Takahashi, Erina Okamura, Kenji Uno, Koji Morita, Toshio Ishikawa, Koichi Asahi, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Shouichi Fujimoto, Ichiei Narita, Tsuneo Konta, Masahide Kondo, Kenjiro Kimura, Yasuo Ohashi, Tsuyoshi Watanabe, Kazuhisa Tsukamoto
AIMS: The proper management of atherosclerotic risk factors (ARFs) and attainment of target levels (TLs) for ARFs are crucial in preventing atherosclerotic cardiovascular disease (ASCVD). In this study, utilizing data from the "Specific Health Check and Guidance in Japan," which was conducted from 2008 to 2011, we examined TL attainment status of low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) and prescription status of dyslipidemia and hypertension in patients with diabetes undergoing medical treatment, and analyzed the factors that affected prescription status...
February 6, 2019: Journal of Atherosclerosis and Thrombosis
Qi Kong, Xin Ma, Chen Wang, Wuwei Feng, Bruce Ovbiagele, Yuren Zhang, Xiangying Du
AIM: Coronary artery stenosis (CAS) ≥ 50% frequently coexists in patients with acute ischemic cerebrovascular disease (AICVD), which portends unfavorable outcomes. We sought to examine whether patients with AICVD with CAS had more severe and more diffused cervicocephalic atherosclerosis (CA). METHODS: Patients with AICVD were consecutively enrolled and underwent simultaneous computed tomography angiography (CTA) of the coronary and cervicocephalic arteries. A total of 140 patients were divided into "AICVD+CAS" and "AICVD only" groups according to whether CTA showed stenosis of ≥ 50% in at least one coronary arterial segment...
February 6, 2019: Journal of Atherosclerosis and Thrombosis
Yoko Nishida, Yasuhiko Kubota, Hiroyasu Iso, Akiko Tamakoshi
AIM: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. METHODS: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often)...
January 31, 2019: Journal of Atherosclerosis and Thrombosis
Ran Lee, Hye-Ran Ahn, Min-Ho Shin, Hee-Nam Kim, Young-Hoon Lee, Seong-Woo Choi, Sun-Seog Kweon
AIM: To elucidate the role of pentraxin-3 (PTX3) in atherosclerosis, we evaluated lipid and cardiovascular risk profiles according to the plasma PTX3 levels in subjects from the general population. METHODS: A sub-cohort of 2,000 subjects was randomly sampled from a Korean community-based cohort study. After excluding those with a medication history for dyslipidemia, 1,747 subjects (902 men and 845 women) were included in the final analyses. Linear and logistic regressions with adjustment for appropriate variables were performed...
January 23, 2019: Journal of Atherosclerosis and Thrombosis
Rodrigo Alonso, Ada Cuevas, Alberto Cafferata
Statins are the main treatment for hypercholesterolemia and the cornerstone of atherosclerotic cardiovascular disease prevention. Many patients taking statins report muscle-related symptoms, one of the most important causes of statin treatment discontinuation, which is associated with an increased risk of cardiovascular events. Therefore, it is important to identify patients who are truly statin intolerant to avoid unnecessary discontinuation of this beneficial treatment. Some studies indicate that not all muscle complaints are caused by statins, and most patients can tolerate a statin upon re-challenge, down-titration of dose, or switching to another statin...
January 19, 2019: Journal of Atherosclerosis and Thrombosis
Xian Fu, Xianliang Li, Li Xiong, Xuelong Li, Ruxun Huang, Qingchun Gao
AIM: Carotid-cerebral pulse wave velocity (ccPWV) reflects the segment (C-M segment) stiffness between the common carotid artery and ipsilateral middle cerebral artery. C-M segment atherosclerosis (CMSA) is regarded the most frequent cause of anterior circulation ischemic stroke. We aimed to evaluate the association of ccPWV with early stage CMSA in this study. METHODS: Eighty-one acute ischemic stroke (AIS) patients with 154 C-M segments who were successfully evaluated with digital subtraction angiography, ccPWV, carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity were enrolled into this study...
January 19, 2019: Journal of Atherosclerosis and Thrombosis
Xiaolan Yu, Jianping Lu, Jingjing Li, Wen Guan, Shaorong Deng, Qing Deng, Hao Ye, Wei Han, Yan Yu, Ruiyan Zhang
AIM: Endothelial lipase (EL), hepatic lipase (HL), and lipoprotein lipase (LPL) are all triglyceride lipases and are associated with coronary artery disease (CAD). However, whether they can be simultaneous independent risk factors for CAD is unknown. In the present study, we investigated whether the three lipases can be independent risk factors simultaneously for CAD and whether combining these lipases could provide greater predictive power than high-density lipoprotein cholesterol (HDL-c) for the development of CAD...
January 17, 2019: Journal of Atherosclerosis and Thrombosis
Hao Wang, Dongyuan Liu, Hongbing Zhang
AIM: The study aimed to identify the underlying differentially expressed genes (DEGs) and mechanism of macrophage-enriched rupture atherosclerotic plaque using bioinformatics methods. METHODS: GSE41571, which includes six stable samples and five ruptured atherosclerotic samples, was downloaded from the GEO database. After preprocessing, DEGs between ruptured and stable atherosclerotic samples were identified using LIMMA. Gene Ontology biological process (GO_BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of DEGs were performed using the Database for Annotation, Visualization, and Integration Discovery (DAVID) online tool...
January 15, 2019: Journal of Atherosclerosis and Thrombosis
Mingming Lu, Yuanyuan Cui, Peng Peng, Huiyu Qiao, Jianming Cai, Xihai Zhao
AIM: The present study aimed to investigate the association between shape and location of atherosclerotic plaques and intraplaque hemorrhage (IPH) in carotid arteries using magnetic resonance (MR) imaging. METHODS: Overall, 114 symptomatic patients (mean age: 64.9±10.9 years; 81 males) who underwent MR imaging and had advanced carotid plaques were included in analysis. IPH presence and carotid plaque shape and location (below and above bifurcation) were evaluated...
January 9, 2019: Journal of Atherosclerosis and Thrombosis
Naofumi Yoshida, Kengo Sasaki, Daisuke Sasaki, Tomoya Yamashita, Hajime Fukuda, Tomohiro Hayashi, Tokiko Tabata, Ro Osawa, Ken-Ichi Hirata, Akihiko Kondo
AIM: Bacteroides vulgatus and B. dorei have a protective effect against atherosclerosis, suggesting that expansion of these species in the gut microbiota could help patients with coronary artery disease (CAD). This study aimed to investigate the effect of resistant starch (RS) on the gut microbiota and its metabolites in fecal sample cultures from patients with CAD and individuals without CAD, using a single-batch fermentation system. METHODS: Fecal samples from 11 patients with CAD and 10 individuals without CAD were fermented for 30 h with or without RS in the Kobe University Human Intestinal Microbiota Model (KUHIMM)...
December 27, 2018: Journal of Atherosclerosis and Thrombosis
Sandy Huey-Jen Hsu, Men-Hwang Jang, Pao-Ling Torng, Ta-Chen Su
AIMS: Recent studies suggest elevated levels of small dense low-density lipoprotein cholesterol (sdLDL-C) can predict the risk of incident coronary heart disease (CHD), even in individuals considered to be at low risk for cardiovascular disease(CVD) based on their LDL-C levels. This study aims to prospectively investigate the association between sdLDL-C concentration and traditional and nontraditional CHD risk markers to explore the underlying roles of sdLDL-C in atherogenic processes...
December 26, 2018: Journal of Atherosclerosis and Thrombosis
Ruka Yoshida, Hideki Ishii, Itsuro Morishima, Akihito Tanaka, Yasuhiro Morita, Kensuke Takagi, Naoki Yoshioka, Kenshi Hirayama, Naoki Iwakawa, Hiroshi Tashiro, Hiroki Kojima, Takayuki Mitsuda, Yusuke Hitora, Kenji Furusawa, Hideyuki Tsuboi, Toyoaki Murohara
AIM: Patients undergoing percutaneous coronary intervention (PCI) who require both oral anticoagulant (OAC) and antiplatelet therapy (APT) are exposed to a serious risk of bleeding. The aim of this study was to clarify the relationship among nutritional and inflammation status and long-term bleeding in patients requiring both OACs and APT after PCI. METHODS: We performed PCI in 3,718 consecutive patients between April 2011 and March 2017, 302 of whom were treated with both OACs and APT...
December 22, 2018: Journal of Atherosclerosis and Thrombosis
Takashi Yamaguchi, Kohji Shirai, Daiji Nagayama, Shoko Nakamura, Rena Oka, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Yuta Sato, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Naomi Shimizu, Ichiro Tatsuno
AIM: Cardio-ankle vascular index (CAVI) reflects arterial stiffness and has been established as a useful surrogate marker of atherosclerosis. Contrary to the abundant data indicating slower progression of atherosclerosis with statins, studies on fibrates remain scarce. The aim of this study was thus to clarify the effect of bezafibrate on CAVI as well as on oxidative stress. METHODS: A randomized, open-label, controlled study was performed. 66 hypertriglyceridemic patients with type 2 diabetes were assigned to two groups: bezafibrate (400 mg/day) group and eicosapentaenoic acid (EPA 1...
December 22, 2018: Journal of Atherosclerosis and Thrombosis
Yoshiki Yagita
No abstract text is available yet for this article.
December 20, 2018: Journal of Atherosclerosis and Thrombosis
Tsuyoshi Nozue, Takeshi Takamura, Kazuki Fukui, Kiyoshi Hibi, Satoru Kishi, Ichiro Michishita
AIM: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT ) accurately diagnoses ischemic lesions of intermediate stenosis severity. However, significant determinants of FFRCT have not been fully evaluated. METHODS: This was a sub-analysis of the Treatment of Alogliptin on Coronary Atherosclerosis Evaluated by Computed Tomography-Based Fractional Flow Reserve trial. Thirty-nine diabetic patients (117 vessels) with intermediate coronary artery stenosis [percent diameter stenosis (%DS) <70%] in whom FFRCT was measured were included in this study...
December 20, 2018: Journal of Atherosclerosis and Thrombosis
Yasushi Ishigaki, Naoki Kawagishi, Yutaka Hasegawa, Shojiro Sawada, Hideki Katagiri, Susumu Satomi, Shinichi Oikawa
Pharmacological treatments to decrease low-density lipoprotein (LDL) cholesterol (LDL-C) have limited effects on patients with homozygous familial hypercholesterolemia (HoFH). Since LDL receptors are located mainly in the liver, liver transplantation is considered to be the only way to correct the hepatic cholesterol metabolism abnormalities in HoFH. Liver transplantations, including those combined with heart transplantation, for HoFH have been increasing since 1984, making this a globally established therapeutic option for HoFH...
December 15, 2018: Journal of Atherosclerosis and Thrombosis
Xuesen Cheng, Aimin Dang, Naqiang Lv, Tong Zhao
AIM: This study was designed to analyze microparticles (MPs) from endothelial cells (EMPs) and immune cells from healthy individuals and paitents with Takayasu arteritis (TA), and any possible relationships between MPs and TA acitivity. METHODS: MPs derived from the plasma of 51 subjects were analyzed, including 32 patients with TA and 19 healthy individuals. Flow cytometry was performed with Annexin (Anx)-V and antibodies against surface markers of endothelial cells (CD144), T cells (CD3), B cells (CD19), and monocytes (CD14)...
December 15, 2018: Journal of Atherosclerosis and Thrombosis
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