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Journals Journal of Molecular Medicine ...

Journal of Molecular Medicine : Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"

https://read.qxmd.com/read/37737908/the-role-of-loxl2-induced-by-glucose-metabolism-activated-nf-%C3%AE%C2%BAb-in-maintaining-drug-resistance-through-emt-and-cancer-stemness-in-gemcitabine-resistant-pdac
#1
JOURNAL ARTICLE
Yun Sun Lee, Hyung Sun Kim, Hyo Jung Kim, Hyeon Woong Kang, Da Eun Lee, Myeong Jin Kim, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Joon Seong Park
Gemcitabine is considered a standard treatment for pancreatic cancer, but developing drug resistance greatly limits the effectiveness of chemotherapy and increases the rate of recurrence. Lysyl oxide-like 2 (LOXL2) is highly expressed in pancreatic cancer and is involved in carcinogenesis and EMT regulation. However, studies on the role of LOXL2 in drug resistance are limited. Here, we investigated the mechanism of LOXL2 induction and the effect of LOXL2 on EMT and CSC in gemcitabine-resistant pancreatic cancer...
September 22, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37728644/peroxiredoxins-in-erythrocytes-far-beyond-the-antioxidant-role
#2
REVIEW
Carla Peres de Paula, João Pedro Maia de Oliveira da Silva, Karen Simone Romanello, Victoria Simões Bernardo, Flaviene Felix Torres, Danilo Grünig Humberto da Silva, Anderson Ferreira da Cunha
The red blood cells (RBCs) are essential to transport oxygen (O2 ) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, the enzyme peroxiredoxin (Prx) has the higher decomposition power of hydrogen peroxide, especially in RBCs, standing out because of its abundance...
September 20, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37725101/large-extracellular-vesicles-derived-from-human-regulatory-macrophages-l-ev-mreg-attenuate-cd3-cd28-induced-t-cell-activation-in-vitro
#3
JOURNAL ARTICLE
Martin Albrecht, Lars Hummitzsch, Rene Rusch, Christine Eimer, Melanie Rusch, Katharina Heß, Markus Steinfath, Jochen Cremer, Fred Fändrich, Rouven Berndt, Karina Zitta
Macrophages belong to the innate immune system, and we have recently shown that in vitro differentiated human regulatory macrophages (Mreg) release large extracellular vesicles (L-EVMreg ) with an average size of 7.5 μm which regulate wound healing and angiogenesis in vitro. The aim of this study was to investigate whether L-EVMreg also affect the CD3/CD28-mediated activation of T-cells. Mreg were differentiated using blood monocytes and L-EVMreg were isolated from culture supernatants by differential centrifugation...
September 19, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37712965/integration-of-clinical-characteristics-and-molecular-signatures-of-the-tumor-microenvironment-to-predict-the-prognosis-of-neuroblastoma
#4
JOURNAL ARTICLE
Haiyan Cheng, Li Zhang, Shen Yang, Qinghua Ren, Saishuo Chang, Yaqiong Jin, Wenjun Mou, Hong Qin, Wei Yang, Xianwei Zhang, Wancun Zhang, Huanmin Wang
This study aimed to analyze the clinical characteristics, cell types, and molecular characteristics of the tumor microenvironment to better predict the prognosis of neuroblastoma (NB). The gene expression data and corresponding clinical information of 498 NB patients were obtained from the Gene Expression Omnibus (GEO: GSE62564) and ArrayExpress (accession: E-MTAB-8248). The relative cell abundances were estimated using single-sample gene set enrichment analysis (ssGSEA) with the R gene set variation analysis (GSVA) package...
September 15, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37707557/gsk-3%C3%AE-aggravates-inflammation-metabolic-derangement-and-cardiac-injury-post-ischemia-reperfusion
#5
JOURNAL ARTICLE
Firdos Ahmad, Hezlin Marzook, Anamika Gupta, Aseel Aref, Kiran Patil, Amir Ali Khan, Mohamed A Saleh, Walter J Koch, James R Woodgett, Rizwan Qaisar
Reperfusion after acute myocardial infarction further exaggerates cardiac injury and adverse remodeling. Irrespective of cardiac cell types, loss of specifically the α isoform of the protein kinase GSK-3 is protective in chronic cardiac diseases. However, the role of GSK-3α in clinically relevant ischemia/reperfusion (I/R)-induced cardiac injury is unknown. Here, we challenged cardiomyocyte-specific conditional GSK-3α knockout (cKO) and littermate control mice with I/R injury and investigated the underlying molecular mechanism using an in vitro GSK-3α gain-of-function model in AC16 cardiomyocytes post-hypoxia/reoxygenation (H/R)...
September 14, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37707556/insufficient-sirt1-in-macrophages-promotes-oxidative-stress-and-inflammation-during-scarring
#6
JOURNAL ARTICLE
Ting He, Xiaozhi Bai, Yan Li, Dongliang Zhang, Zhigang Xu, Xuekang Yang, Dahai Hu, Juntao Han
Macrophage is a critical regulator in wound healing and scar formation, and SIRT1 is related to macrophage activation and polarization, while the specific mechanism is still unclear. To explore the specific effects of SIRT1 in scarring, we established a skin incision mouse model and LPS-induced inflammation cell model. The expression of SIRT1 in tissue and macrophage was detected, and the level of SIRT1 was changed to observe the downstream effects. LPS-induced macrophages with or without SIRT1 deficiency were used for TMT-based quantitative proteomic analysis...
September 14, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37704856/microrna-signature-from-extracellular-vesicles-of-hcv-hiv-co-infected-individuals-differs-from-hcv-mono-infected
#7
JOURNAL ARTICLE
Victoria Cairoli, Daniel Valle-Millares, María C Terrón-Orellano, Daniel Luque, Pablo Ryan, Lourdes Dominguez, Luz Martín-Carbonero, Ignacio De Los Santos, Elena De Matteo, Beatriz Ameigeiras, Verónica Briz, Paola Casciato, María Victoria Preciado, Pamela Valva, Amanda Fernández-Rodríguez
Hepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), as essential components of EVs cargo, are key regulators of normal cellular processes and also promote viral replication, viral pathogenesis, and disease progression. We aimed to characterize the plasma-derived EVs miRNA signature of chronic HCV infected and HIV coinfected patients to unravel the molecular mechanisms of coinfection...
September 14, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37698712/spp1-osteopontin-a-driver-of-fibrosis-and-inflammation-in-degenerative-ascending-aortic-aneurysm
#8
JOURNAL ARTICLE
David Freiholtz, Otto Bergman, Sailendra Pradhananga, Karin Lång, Flore-Anne Poujade, Carl Granath, Christian Olsson, Anders Franco-Cereceda, Pelin Sahlén, Per Eriksson, Hanna M Björck
Degenerative ascending aortic aneurysm (AscAA) is a silent and potentially fatal disease characterized by excessive vascular inflammation and fibrosis. We aimed to characterize the cellular and molecular signature for the fibrotic type of endothelial mesenchymal transition (EndMT) that has previously been described in degenerative AscAA. Patients undergoing elective open-heart surgery for AscAA and/or aortic valve repair were recruited. Gene expression in the intima-media of the ascending aorta was measured in 22 patients with non-dilated and 24 with dilated aortas, and candidate genes were identified...
September 12, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37691076/the-mechanisms-of-exosomes-in-diabetic-foot-ulcers-healing-a-detailed-review
#9
REVIEW
Lei Yu, Jianxin Qin, Jiajun Xing, Zihao Dai, Tingting Zhang, Feng Wang, Jin Zhou, Xiaobai Zhang, Xia Chen, Yunjuan Gu
As time goes by, the morbidity of diabetes mellitus continues to rise, and the economic burden of diabetic foot ulcers as a common and serious complication of diabetes is increasing. However, currently there is no unified clinical treatment strategy for this complication, and the therapeutic efficacy is unsatisfactory. Recent studies have revealed that biological effects of exosomes involved in multiple stages of the process of wound closure are similar to source cells. Compared with source cells, exosomes possess lowly immunogenicity, highly stability and easily stored, etc...
September 11, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37672078/an-atlas-of-genome-wide-gene-expression-and-metabolite-associations-and-possible-mediation-effects-towards-body-mass-index
#10
JOURNAL ARTICLE
Carl Beuchel, Julia Dittrich, Susen Becker, Holger Kirsten, Anke Tönjes, Peter Kovacs, Michael Stumvoll, Markus Loeffler, Andrej Teren, Joachim Thiery, Berend Isermann, Uta Ceglarek, Markus Scholz
Investigating the cross talk of different omics layers is crucial to understand molecular pathomechanisms of metabolic diseases like obesity. Here, we present a large-scale association meta-analysis of genome-wide whole blood and peripheral blood mononuclear cell (PBMC) gene expressions profiled with Illumina HT12v4 microarrays and metabolite measurements from dried blood spots (DBS) characterized by targeted liquid chromatography tandem mass spectrometry (LC-MS/MS) in three large German cohort studies with up to 7706 samples...
September 6, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37656227/the-plasma-exosomes-from-patients-with-primary-sj%C3%A3-gren-s-syndrome-contain-epithelial-cell-derived-proteins-involved-in-ferroptosis
#11
JOURNAL ARTICLE
Xin Peng, Lei Hou, Xue Wu, Zhengqi Liu, Yun Wang, Ping Zeng, Ying Yang, Wukai Ma, Peng Yang
Primary Sjögren's syndrome (pSS) is an autoimmune disease represented by exocrine gland epithelial cell lesions. However, the mechanism underlying these lesions remains unclear. This study analyzed the plasma exosomes of pSS patients using proteomics and revealed the presence of 24 differentially expressed proteins (DEPs) involved in the primary biological processes and signaling pathways related to ferroptosis. The DEPs enriched in the ferroptosis-related items were represented by downregulated ceruloplasmin (CP) and transferrin (TF)...
September 1, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37653150/evaluation-of-drug-sensitivity-immunological-characteristics-and-prognosis-in-melanoma-patients-using-an-endoplasmic-reticulum-stress-associated-signature-based-on-bioinformatics-and-pan-cancer-analysis
#12
JOURNAL ARTICLE
Alphonse Houssou Hounye, Bingqian Hu, Zheng Wang, Jiaoju Wang, Cong Cao, Jianglin Zhang, Muzhou Hou, Min Qi
We aimed to develop endoplasmic reticulum (ER) stress-related risk signature to predict the prognosis of melanoma and elucidate the immune characteristics and benefit of immunotherapy in ER-related risk score-defined subgroups of melanoma based on a machine learning algorithm. Based on The Cancer Genome Atlas (TCGA) melanoma dataset (n = 471) and GTEx database (n = 813), 365 differentially expressed ER-associated genes were selected using the univariate Cox model and LASSO penalty Cox model...
August 31, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37624387/role-of-the-pioneer-transcription-factor-gata2-in-health-and-disease
#13
REVIEW
Amena Aktar, Bryan Heit
The transcription factor GATA2 is involved in human diseases ranging from hematopoietic disorders, to cancer, to infectious diseases. GATA2 is one of six GATA-family transcription factors that act as pioneering transcription factors which facilitate the opening of heterochromatin and the subsequent binding of other transcription factors to induce gene expression from previously inaccessible regions of the genome. Although GATA2 is essential for hematopoiesis and lymphangiogenesis, it is also expressed in other tissues such as the lung, prostate gland, gastrointestinal tract, central nervous system, placenta, fetal liver, and fetal heart...
August 25, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37615686/a-novel-rbbp8-p-e281-germline-mutation-is-a-predisposing-mutation-in-familial-hereditary-cancer-syndrome
#14
JOURNAL ARTICLE
Jinhua Yan, Jinzheng Wu, Yang Wang, Xiaotang Di, Hao Jiang, Doudou Wen, Duo Li, Shubing Zhang
Screening tumor susceptibility genes helps in identifying powerful biomarkers for hereditary cancer monitoring, prevention, and diagnosis, providing opportunities for understanding potential molecular mechanisms and biomarkers for the precise treatment of hereditary cancer syndromes. Whole-exome sequencing of blood and bioinformatics analysis uncovered a novel RBBP8(p.E281*) germline mutation in a family with hereditary cancer syndrome, which was verified by Sanger sequencing. Cell proliferation, colony formation, cell migration, and in vivo tumorigenesis were investigated by CCK8, colony formation, Transwell, and in vivo xenograft assays...
August 24, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37606688/the-role-of-immunosuppressive-myofibroblasts-in-the-aging-process-and-age-related-diseases
#15
REVIEW
Antero Salminen
Tissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to adapt to the changes in the microenvironment and thus maintain tissue homeostasis. Several stresses, also those associated with the aging process, convert quiescent fibroblasts into myofibroblasts which not only display fibrogenic properties but also act as immune regulators cooperating both with tissue-resident immune cells and those immune cells recruited into affected tissues...
August 22, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37603049/distinctive-metabolic-remodeling-in-tymp-deficiency-beyond-mitochondrial-dysfunction
#16
JOURNAL ARTICLE
Jixiang Du, Chao Zhang, Fuchen Liu, Xihan Liu, Dongdong Wang, Dandan Zhao, Guanghou Shui, Yuying Zhao, Chuanzhu Yan
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in the TYMP gene, which encodes thymidine phosphorylase (TP). As a cytosolic metabolic enzyme, TP defects affect biological processes that are thought to not be limited to the abnormal replication of mitochondrial DNA. This study aimed to elucidate the characteristic metabolic alterations and associated homeostatic regulation caused by TYMP deficiency. The pathogenicity of novel TYMP variants was evaluated in terms of clinical features, genetic analysis, and structural instability...
August 21, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37594540/targeting-acc1-in-t-cells-ameliorates-psoriatic-skin-inflammation
#17
JOURNAL ARTICLE
Yu-San Kao, Panagiota Mamareli, Ayesha Dhillon-LaBrooy, Philipp Stüve, Gloria Janet Godoy, Lis Noelia Velasquez, Verena Katharina Raker, Beate Weidenthaler-Barth, Fatima Boukhallouk, Francesca Rampoldi, Luciana Berod, Tim Sparwasser
Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including T helper (Th) and cytotoxic T (Tc) cells, and is associated with dysfunctional regulatory T cells (Tregs). Acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme of fatty acid synthesis (FAS), directs cell fate decisions between Th17 and Tregs and thus could be a promising therapeutic target for psoriasis treatment. Here, we demonstrate that targeting ACC1 in T cells by genetic ablation ameliorates skin inflammation in an experimental model of psoriasis by limiting Th17, Tc17, Th1, and Tc1 cells in skin lesions and increasing the frequency of effector Tregs in skin-draining lymph nodes (LNs)...
August 18, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37584739/the-ever-wider-clinical-spectrum-of-rmnd1-related-disorders-and-limitedness-of-phenotype-based-classifications
#18
JOURNAL ARTICLE
Alexis V Rioux, Nicolas Ad Bergeron, Julie Riopel, Nicolas Marcoux, Catherine Thériault, Peter V Gould, Alexandre P Garneau, Paul Isenring
RMND1 has been identified as a mitochondriopathy-associated gene less than 12 years ago. The most common phenotype related to this gene is an early onset, severe form of encephalomyopathy that leads to death in a medium time of three years after birth. However, milder and later onset presentations have been reported in some individuals, including two in whom the mitochondriopathy was identified at ~ 40 years of age, and the early onset presentations have been the object of no reports in those who survived beyond age 10...
August 16, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37584738/pkhd1-cyli-cyli-mice-have-altered-renal-pkhd1-mrna-processing-and-hormonally-sensitive-liver-disease
#19
JOURNAL ARTICLE
Chaozhe Yang, Naoe Harafuji, Ljubica Caldovic, Weiying Yu, Ravindra Boddu, Surajit Bhattacharya, Hayk Barseghyan, Heather Gordish-Dressman, Oded Foreman, Zsuzsa Bebok, Eva M Eicher, Lisa M Guay-Woodford
Autosomal-recessive polycystic kidney disease (ARPKD; MIM #263200) is a severe, hereditary, hepato-renal fibrocystic disorder that causes early childhood morbidity and mortality. Mutations in the polycystic kidney and hepatic disease 1 (PKHD1) gene, which encodes the protein fibrocystin/polyductin complex (FPC), cause all typical forms of ARPKD. Several mouse lines carrying diverse, genetically engineered disruptions in the orthologous Pkhd1 gene have been generated, but none expresses the classic ARPKD renal phenotype...
August 16, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37558754/retraction-note-antioxidative-effects-of-polypyrimidine-tract-binding-protein-associated-splicing-factor-against-pathological-retinal-angiogenesis-through-promotion-of-mitochondrial-function
#20
Lijie Dong, Tingting Lin, Wenbo Li, Yaru Hong, Xinjun Ren, YiFeng Ke, Xiaomin Zhang, Xiaorong Li
No abstract text is available yet for this article.
August 10, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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