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Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"

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https://read.qxmd.com/read/30741319/correction-to-trichostatin-a-a-histone-deacetylase-inhibitor-induces-synergistic-cytotoxicity-with-chemotherapy-via-suppression-of-raf-mek-erk-pathway-in-urothelial-carcinoma
#1
Wei-Chou Lin, Fu-Shun Hsu, Kuan-Lin Kuo, Shing-Hwa Liu, Chia-Tung Shun, Chung-Sheng Shi, Hong-Chiang Chang, Yu-Chieh Tsai, Ming-Chieh Lin, June-Tai Wu, Yu Kuo, Po-Ming Chow, Shih-Ming Liao, Shao-Ping Yang, Jo-Yu Hong, Kuo-How Huang
In Fig. 1b, upper part, the cell viability counts after treatment with cisplatin and TSA in T24 cells was by mistake a duplication of the image for NTUB1 on the left. In the corrected version of Fig. 1, the image was replaced appropriately.
February 11, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30739141/efficacy-of-novel-selective-nlrp3-inhibitors-in-human-and-murine-retinal-pigment-epithelial-cells
#2
Luping Wang, Sarah Schmidt, Petra P Larsen, Johanna H Meyer, William R Roush, Eicke Latz, Frank G Holz, Tim U Krohne
NLRP3 inflammasome activation in the retinal pigment epithelium (RPE) is observed in atrophic age-related macular degeneration (AMD), and pharmacological NLRP3 inhibition may provide a therapeutic strategy to halt disease progression. We tested selective NLRP3 inhibitors (IFM-514, IFM-632, and CRID3) for their efficacy in human and murine RPE cells. Inflammasome activation was induced in primary human RPE cells and ARPE-19 cells following priming with IL-1α by different stimuli, including lysosomal membrane permeabilization by leucyl-leucine methyl ester (Leu-Leu-OMe), oxidative damage induced by hydrogen peroxide, lipofuscin-mediated photooxidative damage induced by incubation with 4-hydroxynonenal-modified photoreceptor outer segments and subsequent blue light irradiation, and P2X7 receptor activation by benzoylbenzoyl-ATP...
February 10, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30729280/exploring-the-roles-of-mscs-in-infections-focus-on-bacterial-diseases
#3
REVIEW
Pasquale Marrazzo, Annunziata Nancy Crupi, Francesco Alviano, Laura Teodori, Laura Bonsi
Despite human healthcare advances, some microorganisms continuously react evolving new survival strategies, choosing between a commensal fitness and a pathogenic attitude. Many opportunistic microbes are becoming an increasing cause of clinically evident infections while several renowned infectious diseases sustain a considerable number of deaths. Besides the primary and extensively investigated role of immune cells, other cell types are involved in the microbe-host interaction during infection. Interestingly, mesenchymal stem cells (MSCs), the current leading players in cell therapy approaches, have been suggested to contribute to tackling pathogens and modulating the host immune response...
February 7, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30729279/foxm1-plays-a-role-in-autophagy-by-transcriptionally-regulating-beclin-1-and-lc3-genes-in-human-triple-negative-breast-cancer-cells
#4
Zuhal Hamurcu, Nesrin Delibaşı, Ufuk Nalbantoglu, Elif Funda Sener, Nursultan Nurdinov, Bayram Tascı, Serpil Taheri, Yusuf Özkul, Hamiyet Donmez-Altuntas, Halit Canatan, Bulent Ozpolat
Triple-negative breast cancer (TNBC) is associated with poor prognosis owing to its aggressive and heterogeneous nature, and the lack of therapeutic targets. Although Forkhead Box M1 (FOXM1) is one of the most important oncogenes contributing to tumorigenesis, progression, and drug resistance in TNBC, the underlying molecular mechanisms are not well understood. Emerging evidence indicates that autophagy plays a critical role in cell survival and protective mechanism in TNBC. However, signaling pathways that are involved in the regulation of autophagy remain to be elucidated...
February 7, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30729278/microrna-145-targets-smad1-in-endometrial-stromal-cells-and-regulates-decidualization-in-rat
#5
Vijay K Sirohi, Kanchan Gupta, Radhika Kapoor, Anila Dwivedi
Decidualization of endometrial stromal cells is the pre-requisite for the embryo implantation and establishment of pregnancy. Although known to be regulated by several factors, the process of regulation of decidualization by miRNAs is largely unknown. Previous reports suggest that the upregulated expression of miR-145 is associated with repeated implantation failure. The current study was aimed to identify and validate the role of miR-145 in regulating stromal cell decidualization and the mechanism involved therein...
February 7, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30725119/mots-c-peptide-regulates-adipose-homeostasis-to-prevent-ovariectomy-induced-metabolic-dysfunction
#6
Huanyu Lu, Ming Wei, Yue Zhai, Qingyang Li, Zichen Ye, Li Wang, Wenjing Luo, Jingyuan Chen, Zifan Lu
The postmenopausal state is associated with an increased risk of metabolic disorder including reduced energy expenditure and weight gain, leading to higher cardiovascular and cancer risks among other diseases. Mitochondrial-derived peptide (MOTS-c) is a 16-amino acid peptide encoded by mitochondrial DNA. Here, we showed that MOTS-c treatment in mice prevented ovariectomy-induced obesity and insulin resistance. After ovariectomy, low levels of estrogens increased fat mass overload and disturbed normal adipose function, forcing the development of insulin resistance...
February 6, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30721324/ampk-agonist-aicar-ameliorates-portal-hypertension-and-liver-cirrhosis-via-no-pathway-in-the-bdl-rat-model
#7
Liangshuo Hu, Lin Su, Zhixia Dong, Yunhua Wu, Yi Lv, Jacob George, Jianhua Wang
Recent studies have indicated that the Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway is closely involved in liver fibrosis and other fibrotic diseases. However, whether targeting the AMPK pathway can rescue liver fibrosis and its complications, such as portal hypertension, is unknown. This study aimed to explore the therapeutic value of AICAR (5-aminoimidazole-4-carboxyamide ribonucleoside), an agonist of the AMPK pathway, on liver fibrosis and portal hypertension in bile duct ligation (BDL) rats...
February 5, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30715622/mir-449a-5p-mediates-mitochondrial-dysfunction-and-phenotypic-transition-by-targeting-myc-in-pulmonary-arterial-smooth-muscle-cells
#8
Chen Zhang, Cui Ma, Lixin Zhang, Linlin Zhang, Fengying Zhang, Mingfei Ma, Xiaodong Zheng, Min Mao, Tingting Shen, Daling Zhu
MicroRNAs have been considered to participate in pulmonary arterial hypertension (PAH) and regulate numerous disease pathways in pulmonary vasculature. However, the molecular role in the pathologies has not yet been fully uncovered, particularly in the view of energy metabolism and vascular smooth muscle cell phenotypic regulation. Here, several altered miRNAs are founded in genome-wide miRNA sequencing analysis, in which miR-449a-5p was identified as a probable candidate in hypoxic PAH and verified such a decreasing trend...
February 4, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30707256/role-of-sirtuin-1-in-diabetic-nephropathy
#9
REVIEW
Wanning Wang, Weixia Sun, Yanli Cheng, Zhonggao Xu, Lu Cai
Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms have been shown to be involved in its pathogenesis and many useful drugs have been developed, the management of DN remains challenging. Increasing amounts of evidence show that silent information regulator 2 homolog 1 (sirtuin-1), a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase, plays a crucial role in the pathogenesis and development of DN...
February 1, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30675649/are-glutamate-transporters-neuroprotective-or-neurodegenerative-during-cerebral-ischemia
#10
REVIEW
Li-Nan Zhang, Liang Hao, Yu-Song Guo, Hai-Yan Wang, Lin-Lin Li, Li-Zhe Liu, Wen-Bin Li
The accumulation of glutamate (Glu) in the synaptic cleft during cerebral ischemia triggers the death of neurons, causing mental or physical handicap. However, the mechanisms of the alteration in Glu homeostasis and the imbalance between the release and clearance of Glu in ischemia are not yet completely understood. Additionally, the role of Glu transporters in regulating Glu concentration in the synaptic cleft is controversial. This review aims to provide readers with an in-depth understanding of Glu transporters in the early or later stages of ischemic events, or in mild or severe cerebral ischemia via alteration of Glu transporter expression, reversal of Glu transporters function, and trafficking between membrane and cytoplasm, to further clarify whether the Glu transporters are neuroprotective or neurodegenerative during cerebral ischemia...
January 23, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30666346/follicular-helper-t-cell-and-memory-b-cell-immunity-in-chc-patients
#11
Yong Liu, Huifan Ji, Pingwei Zhao, Hongqing Yan, Yanjun Cai, Lei Yu, Xiaoli Hu, Xiguang Sun, Yanfang Jiang
Chronic hepatitis C (CHC) is associated with biological activity of T follicular helper (Tfh) cells and memory B cells (MBCs). However, the nature of Tfh cell subsets that are responsible for MBCs in CHC patients has not been evaluated. This study aimed to investigate Tfh and MBC immunity before and after direct-acting antiviral (DAA) therapy in patients with CHC. A total of 31 CHC patients and 15 healthy controls (HCs) were recruited. Individual patients were treated with sofosbuvir/ribavirin (SOF/RBV) or in combination with pegylated interferon alpha-2a (PEG-IFN-α-2a) for 12 weeks...
January 21, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30661088/idh-1-deficiency-induces-growth-defects-and-metabolic-alterations-in-gspd-1-deficient-caenorhabditis-elegans
#12
Hung-Chi Yang, Hsiang Yu, You-Cheng Liu, Tzu-Ling Chen, Arnold Stern, Szecheng J Lo, Daniel Tsun-Yee Chiu
NADPH is a reducing equivalent that maintains redox homeostasis and supports reductive biosynthesis. Lack of major NADPH-producing enzymes predisposes cells to growth retardation and demise. It was hypothesized that double deficiency of the NADPH-generating enzymes, GSPD-1 (Glucose-6-phosphate 1-dehydrogenase), a functional homolog of human glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and IDH-1 (isocitrate dehydrogenase-1) affect growth and development in the nematode, Caenorhabditis elegans (C...
January 19, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30637441/suppression-of-syk-activation-by-resveratrol-inhibits-msu-crystal-induced-inflammation-in-human-monocytes
#13
Yeon-Ho Chung, Hee Young Kim, Bo Ruem Yoon, Yeon Jun Kang, Won-Woo Lee
Monosodium urate (MSU) crystals are an endogenous sterile particulate that has been identified as a potent damage-associated molecular pattern (DAMP). In humans, the induction of IL-1β production through MSU-induced NLRP3 inflammasome activation in monocytes/macrophages is responsible for pathogenesis of gouty arthritis. It was recently reported that in a murine model of this disease, resveratrol decreases MSU-induced recurrent attacks of gouty arthritis. Despite its demonstrated anti-inflammatory effects, the mechanisms underlying resveratrol-mediated repression of IL-1β production in MSU-activated monocytes remain poorly understood...
January 12, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30617930/nlrp7-is-increased-in-human-idiopathic-fetal-growth-restriction-and-plays-a-critical-role-in-trophoblast-differentiation
#14
R Abi Nahed, D Reynaud, A J Borg, W Traboulsi, A Wetzel, V Sapin, S Brouillet, M N Dieudonné, M Dakouane-Giudicelli, M Benharouga, P Murthi, Nadia Alfaidy
Fetal growth restriction (FGR) the leading cause of perinatal mortality and morbidity is highly related to abnormal placental development, and placentas from FGR pregnancies are often characterized by increased inflammation. However, the mechanisms of FGR-associated inflammation are far from being understood. NLRP7, a member of a family of receptors involved in the innate immune responses, has been shown to be associated with gestational trophoblastic diseases. Here, we characterized the expression and the functional role of NLRP7 in the placenta and investigated its involvement in the pathogenesis of FGR...
January 8, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30617854/pathological-role-of-apoptosis-signal-regulating-kinase-1-in-human-diseases-and-its-potential-as-a-therapeutic-target-for-cognitive-disorders
#15
REVIEW
So Yeong Cheon, Kyoung Joo Cho
Cognitive disorders are among the leading causes of health and social issues, as well as socioeconomic burden. Cognitive dysfunction associated with diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, diabetes, and stroke can lead to dementia. Despite extensive efforts, strategies for the prevention and treatment of cognitive dysfunction are scarce. Apoptosis signal-regulating kinase 1 (ASK1) participates in diverse biological pathological processes, such as cell death, survival, and differentiation, and it has been suggested as a therapeutic target in various diseases...
January 7, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30617853/soluble-and-membrane-bound-adenylate-kinase-and-nucleotidases-augment-atp-mediated-inflammation-in-diabetic-retinopathy-eyes-with-vitreous-hemorrhage
#16
Julian Zeiner, Sirpa Loukovaara, Karolina Losenkova, Mariachiara Zuccarini, Ani M Korhonen, Kaisa Lehti, Anu Kauppinen, Kai Kaarniranta, Christa E Müller, Sirpa Jalkanen, Gennady G Yegutkin
ATP and adenosine are important signaling molecules involved in vascular remodeling, retinal function, and neurovascular coupling in the eye. Current knowledge on enzymatic pathways governing the duration and magnitude of ocular purinergic signaling is incompletely understood. By employing sensitive analytical assays, this study dissected ocular purine homeostasis as a complex and coordinated network. Along with previously characterized ecto-5'-nucleotidase/CD73 and adenylate kinase activities, other enzymes have been identified in vitreous fluids, including nucleoside triphosphate diphosphohydrolase (NTPDase), adenosine deaminase, and alkaline phosphatase...
January 7, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30612140/calreticulin-regulates-mycn-expression-to-control-neuronal-differentiation-and-stemness-of-neuroblastoma
#17
Andy Chi-Lung Lee, Yu-Yin Shih, Fanfan Zhou, Tsi-Chian Chao, Hsinyu Lee, Yung-Feng Liao, Wen-Ming Hsu, Ji-Hong Hong
Oncogenic N-MYC (MYCN) is widely used as a biomarker in clinics for neuroblastoma (NB) patients; nevertheless, mechanism that underlines MYCN regulation remains elusive. In the present study, we identified calreticulin (CRT) as a novel MYCN suppressor that downregulated MYCN promoter activity and protein expression to modulate neuronal differentiation and stemness. Our data showed that CRT-mediated MYCN suppression led to increased neurite length and commensurate elevation in differentiation marker GAP-43. We examined effect of radiotherapy and discovered that ionizing radiation (IR) was able to augment CRT expression dose-dependently in NB...
January 5, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30610257/an-endothelial-cell-line-infected-by-kaposi-s-sarcoma-associated-herpes-virus-kshv-allows-the-investigation-of-kaposi-s-sarcoma-and-the-validation-of-novel-viral-inhibitors-in-vitro-and-in-vivo
#18
Tatyana Dubich, Anna Lieske, Susann Santag, Guillaume Beauclair, Jessica Rückert, Jennifer Herrmann, Jan Gorges, Guntram Büsche, Uli Kazmaier, Hansjörg Hauser, Marc Stadler, Thomas F Schulz, Dagmar Wirth
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), a tumor of endothelial origin predominantly affecting immunosuppressed individuals. Up to date, vaccines and targeted therapies are not available. Screening and identification of anti-viral compounds are compromised by the lack of scalable cell culture systems reflecting properties of virus-transformed cells in patients. Further, the strict specificity of the virus for humans limits the development of in vivo models...
January 4, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30607440/nuclear-localization-of-ldl-receptor-related-protein-1b-in-mammary-gland-carcinogenesis
#19
Yoshimi Asano, Tamotsu Takeuchi, Hiroshi Okubo, Chiemi Saigo, Yusuke Kito, Yoshinori Iwata, Manabu Futamura, Kazuhiro Yoshida
LRP1B intracellular domain is released and transported to the nucleus; however, pathological consequences of this nuclear transport are largely unclear. We aimed to unravel the pathobiological significance of nuclear localization of LRP1B intracellular domain in mammary gland carcinogenesis. Immunohistochemical staining using antibodies for LRP1B intracellular domain was performed to determine LRP1B expression in 92 invasive ductal breast carcinomas. LRP1B immunoreactivity was detected in the surface membrane and cytoplasm of 60 of 92 invasive ductal carcinomas and in the nucleus of 15 of 92 carcinomas...
January 3, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/30604168/overexpression-of-branched-chain-amino-acid-aminotransferases-rescues-the-growth-defects-of-cells-lacking-the-barth-syndrome-related-gene-taz1
#20
Diana Antunes, Arpita Chowdhury, Abhishek Aich, Sreedivya Saladi, Nofar Harpaz, Mark Stahl, Maya Schuldiner, Johannes M Herrmann, Peter Rehling, Doron Rapaport
The yeast protein Taz1 is the orthologue of human Tafazzin, a phospholipid acyltransferase involved in cardiolipin (CL) remodeling via a monolyso CL (MLCL) intermediate. Mutations in Tafazzin lead to Barth syndrome (BTHS), a metabolic and neuromuscular disorder that primarily affects the heart, muscles, and immune system. Similar to observations in fibroblasts and platelets from patients with BTHS or from animal models, abolishing yeast Taz1 results in decreased total CL amounts, increased levels of MLCL, and mitochondrial dysfunction...
January 3, 2019: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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