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Journals Journal of Molecular Medicine ...

Journal of Molecular Medicine : Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"

https://read.qxmd.com/read/38850298/exploring-the-role-of-trna-derived-small-rnas-tsrnas-in-disease-implications-for-hif-1-pathway-modulation
#1
REVIEW
Qurui Wang, Xiaowei Ying, Qinyuan Huang, Zehua Wang, Shiwei Duan
The tRNA-derived small RNAs (tsRNAs) can be categorized into two main groups: tRNA-derived fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs). Each group possesses specific molecular sizes, nucleotide compositions, and distinct physiological functions. Notably, hypoxia-inducible factor-1 (HIF-1), a transcriptional activator dependent on oxygen, comprises one HIF-1β subunit and one HIF-α subunit (HIF-1α/HIF-2α/HIF-3α). The activation of HIF-1 plays a crucial role in gene transcription, influencing key aspects of cancer biology such as angiogenesis, cell survival, glucose metabolism, and invasion...
June 8, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38829423/removal-of-git-lesions-and-the-role-of-impedance-of-the-injection-solution-an-innovative-approach-to-known-methods
#2
JOURNAL ARTICLE
Martina Lösle, K E Grund, B Duckworth-Mothes
In this work, for the first time, the specific impedances of various injection solutions as well as the surface and tissue impedance after injection of these solutions were analyzed and compared regarding the radio-frequency surgical cutting process. The impedances of 0.9% NaCl, 4% gelatine, 6% hydroxyethyl starch, 10% glycerol/5% fructose, 10% glucose, 5% and 20% albumin, blood, and blood plasma as well as aqua destillata have been tested in vitro. Even if EMR and ESD are routinely used in clinical practice, there is so far no easy, fast, and safe method to remove larger lesions en bloc...
June 3, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38814362/tumor-derived-extracellular-vesicle-proteins-as-new-biomarkers-and-targets-in-precision-oncology
#3
REVIEW
Haiyan Liao, Cheng Zhang, Fen Wang, Feng Jin, Qiqi Zhao, Xinying Wang, Shubin Wang, Jing Gao
Extracellular vesicles (EVs) are important carriers of signaling molecules, such as nucleic acids, proteins, and lipids, and have become a focus of increasing interest due to their numerous physiological and pathological functions. For a long time, most studies on EV components focused on noncoding RNAs; however, in recent years, extracellular vesicle proteins (EVPs) have been found to play important roles in diagnosis, treatment, and drug resistance and thus have been considered favorable biomarkers and therapeutic targets for various tumors...
May 30, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38802517/research-progress-and-application-of-liver-organoids-for-disease-modeling-and-regenerative-therapy
#4
REVIEW
Yang Hu, Qiao Geng, Lu Wang, Yi Wang, Chuyue Huang, Zhimin Fan, Desong Kong
The liver is a major metabolic organ of the human body and has a high incidence of diseases. In recent years, the annual incidence of liver disease has increased, seriously endangering human life and health. The study of the occurrence and development mechanism of liver diseases, discovery of new therapeutic targets, and establishment of new methods of medical treatment are major issues related to the national economy and people's livelihood. The development of stable and effective research models is expected to provide new insights into the pathogenesis of liver diseases and the search for more effective treatment options...
May 28, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38780771/sphingosine-is-involved-in-paptp-induced-death-of-pancreas-cancer-cells-by-interfering-with-mitochondrial-functions
#5
JOURNAL ARTICLE
Sameer H Patel, Gregory C Wilson, Yuqing Wu, Simone Keitsch, Barbara Wilker, Andrea Mattarei, Syed A Ahmad, Ildiko Szabo, Erich Gulbins
Pancreas ductal adenocarcinoma belongs to the most common cancers, but also to the tumors with the poorest prognosis. Here, we pharmacologically targeted a mitochondrial potassium channel, namely mitochondrial Kv1.3, and investigated the role of sphingolipids and mutated Kirsten Rat Sarcoma Virus (KRAS) in Kv1.3-mediated cell death. We demonstrate that inhibition of Kv1.3 using the Kv1.3-inhibitor PAPTP results in an increase of sphingosine and superoxide in membranes and/or membranes associated with mitochondria, which is enhanced by KRAS mutation...
May 23, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38758435/mitochondria-targeted-esculetin-administration-improves-insulin-resistance-and-hyperglycemia-induced-atherosclerosis-in-db-db-mice
#6
JOURNAL ARTICLE
Gajalakshmi Singuru, Sriravali Pulipaka, Altab Shaikh, Shashikanta Sahoo, Aruna Jangam, Rajamannar Thennati, Srigiridhar Kotamraju
The development and progression of hyperglycemia (HG) and HG-associated atherosclerosis are exacerbated by mitochondrial dysfunction due to dysregulated mitochondria-derived ROS generation. We recently synthesized a novel mitochondria-targeted esculetin (Mito-Esc) and tested its dose-response therapeutic efficacy in mitigating HG-induced atherosclerosis in db/db mice. In comparison to simvastatin and pioglitazone, Mito-Esc administration resulted in a considerable reduction in body weights and improved glucose homeostasis, possibly by reducing hepatic gluconeogenesis, as indicated by a reduction in glycogen content, non-esterified free fatty acids (NEFA) levels, and fructose 1,6-bisphosphatase (FBPase) activity...
May 17, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38753041/non-invasive-biomarkers-prognostic-of-decompensation-events-in-nash-cirrhosis-a-systematic-literature-review
#7
REVIEW
Mattia Amoroso, Salvador Augustin, Sven Moosmang, Isabella Gashaw
Liver cirrhosis due to nonalcoholic steatohepatitis (NASH) is a life-threatening condition with increasing incidence world-wide. Although its symptoms are unspecific, it can lead to decompensation events such as ascites, hepatic encephalopathy, variceal hemorrhage, and hepatocellular carcinoma (HCC). In addition, an increased risk for cardiovascular events has been demonstrated in patients with NASH. Pharmacological treatments for NASH cirrhosis are not yet available, one of the reasons being the lack in surrogate endpoints available in clinical trials of NASH cirrhosis...
May 16, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38753040/loss-of-function-mutation-in-ddx53-associated-with-hereditary-spastic-paraplegia-like-disorder
#8
JOURNAL ARTICLE
Xiangshu Yuan, Ya Wang, Xiyuan Li, Sheng Zhong, Danyi Zhou, Xianlong Lin, Hezhi Fang, Yanling Yang, Maofeng Wang
DEAD-box helicase 53 (DDX53) is a member of the DEAD-box protein family of RNA helicases. Unlike other family members that are responsible for RNA metabolism, the biological function of DDX53 and its impact on the human condition are unclear. Herein, we found a full-length DDX53 deletion mutation in a hereditary spastic paraplegia-like (HSP-like) patient with lower extremity spasticity, walking disorder, visual impairment, and lateral ventricular white matter lesions. Bioinformatic analysis revealed that DDX53 was mainly expressed in the cerebellar cortex and may function as a tissue-specific RNA helicase...
May 16, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38740600/role-and-molecular-mechanism-of-nod2-in-chronic-non-communicable-diseases
#9
REVIEW
Lingjun Kong, Yanhua Cao, Yanan He, Yahui Zhang
Nucleotide-binding oligomerization domain containing 2 (NOD2), located in the cell cytoplasm, is a pattern recognition receptor belonging to the innate immune receptor family. It mediates the innate immune response by identifying conserved sequences in bacterial peptide glycans and plays an essential role in maintaining immune system homeostasis. Gene mutations of NOD2 lead to the development of autoimmune diseases such as Crohn's disease and Blau syndrome. Recently, NOD2 has been shown to be associated with the pathogenesis of diabetes, cardiac-cerebral diseases, and cancers...
May 14, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38739269/pcdh11x-mutation-as-a-potential-biomarker-for-immune-checkpoint-therapies-in-lung-adenocarcinoma
#10
JOURNAL ARTICLE
Manjiao Liu, Meijia Yang, Bei Zhang, Sijian Xia, Jie Zhao, Linlin Yan, Yong Ren, Hao Guo, Jie Zhao
Immune checkpoint inhibitors (ICIs) have achieved impressive success in lung adenocarcinoma (LUAD). However, the response to ICIs varies among patients, and predictive biomarkers are urgently needed. PCDH11X is frequently mutated in LUAD, while its role in ICI treatment is unclear. In this study, we curated genomic and clinical data of 151 LUAD patients receiving ICIs from three independent cohorts. Relations between PCDH11X and treatment outcomes of ICIs were examined. A melanoma cohort collected from five published studies, a pan-cancer cohort, and non-ICI-treated TCGA-LUAD cohort were also examined to investigate whether PCDH11X mutation is a specific predictive biomarker for LUAD ICI treatment...
May 13, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38733386/blocking-h-1-r-signal-aggravates-atherosclerosis-by-promoting-inflammation-and-foam-cell-formation
#11
JOURNAL ARTICLE
Baoling Zhu, Yi Yang, Xiangfei Wang, Dili Sun, Xiyang Yang, Xiaowei Zhu, Suling Ding, Chun Xiao, Yunzeng Zou, Xiangdong Yang
Atherosclerosis (AS) is a chronic inflammatory arterial disease, in which abnormal lipid metabolism and foam cell formation play key roles. Histamine is a vital biogenic amine catalyzed by histidine decarboxylase (HDC) from L-histidine. Histamine H1 receptor (H1 R) antagonist is a commonly encountered anti-allergic agent in the clinic. However, the role and mechanism of H1 R in atherosclerosis have not been fully elucidated. Here, we explored the effect of H1 R on atherosclerosis using Apolipoprotein E-knockout (ApoE-/- ) mice with astemizole (AST, a long-acting H1 R antagonist) treatment...
May 11, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38727748/mechanism-of-efferocytosis-in-atherosclerosis
#12
REVIEW
Li-Xia Shu, Liu-Li Cao, Xin Guo, Zong-Bao Wang, Shu-Zhi Wang
Atherosclerosis (AS) is a chronic inflammatory vascular disease that occurs in the intima of large and medium-sized arteries with the immune system's involvement. It is a common pathological basis for high morbidity and mortality of cardiovascular diseases. Abnormal proliferation of apoptotic cells and necrotic cells leads to AS plaque expansion, necrotic core formation, and rupture. In the early stage of AS, macrophages exert an efferocytosis effect to engulf and degrade apoptotic, dead, damaged, or senescent cells by efferocytosis, thus enabling the regulation of the organism...
May 10, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38695882/myeloid-derived-growth-factor-ameliorates-dextran-sodium-sulfate-induced-colitis-by-regulating-macrophage-polarization
#13
JOURNAL ARTICLE
Yang Yang, Conghui Zhao, Zi Yang, Conglin Du, Zhichao Chang, Xin Wen, Xiujuan Zhang, Yi Liu, Liang Hu, Zhenhua Gao
Inflammatory bowel disease (IBD) is characterized by inflammatory conditions in the gastrointestinal tract. According to reports, IBD prevalence is increasing globally, with heavy economic and physical burdens. Current IBD clinical treatment is limited to pharmacological methods; therefore, new strategies are needed. Myeloid-derived growth factor (MYDGF) secreted by bone marrow-derived mononuclear macrophages has beneficial effects in multiple inflammatory diseases. To this end, the present study aimed to establish an experimental IBD mouse model using dextran sulfate sodium in drinking water...
May 2, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38668786/mechanistic-complement-of-autosomal-dominant-polycystic-kidney-disease-the-role-of-aquaporins
#14
REVIEW
Qiumei Lan, Jie Li, Hanqing Zhang, Zijun Zhou, Yaxuan Fang, Bo Yang
Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. Its course is characterized by the formation of progressively enlarged cysts in the renal tubules bilaterally. The basic genetic explanation for autosomal dominant polycystic kidney disease is the double-hit theory, and many of its mechanistic issues can be explained by the cilia doctrine. However, the precise molecular mechanisms underpinning this condition's occurrence are still not completely understood...
April 26, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38653825/analysis-of-the-action-mechanisms-and-targets-of-herbal-anticonvulsants-highlights-opportunities-for-therapeutic-engagement-with-refractory-epilepsy
#15
REVIEW
Sobia Tabassum, Susan Shorter, Saak V Ovsepian
Epilepsy is a neurological disorder characterized by spontaneous and recurring seizures. It poses significant therapeutic challenges due to diverse etiology, pathobiology, and pharmacotherapy-resistant variants. The anticonvulsive effects of herbal leads with biocompatibility and toxicity considerations have attracted much interest, inspiring mechanistic analysis with the view of their use for engagement of new targets and combination with antiseizure pharmacotherapies. This article presents a comprehensive overview of the key molecular players and putative action mechanisms of the most common antiepileptic herbals demonstrated in tissue culture and preclinical models...
April 24, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38639785/the-role-of-annexins-in-central-nervous-system-development-and-disease
#16
REVIEW
Zachary B White, Sindhu Nair, Markus Bredel
Annexins, a group of Ca2+ -dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal central nervous system (CNS) functioning, neurological disorders, and CNS tumors. This paper reviews the roles of individual annexins (A1-A13) in these contexts. Annexins possess unique structural and functional features, such as Ca2+ -dependent binding to phospholipids, participating in membrane organization, and modulating cell signaling. They are implicated in various CNS processes, including endocytosis, exocytosis, and stabilization of plasma membranes...
April 19, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38600305/the-role-of-the-immunosuppressive-pd-1-pd-l1-checkpoint-pathway-in-the-aging-process-and-age-related-diseases
#17
REVIEW
Antero Salminen
The accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly present in many age-related diseases and in the cancer microenvironment. The escape of abnormal cells from immune surveillance indicates that there is some defect in the function of cytotoxic immune cells, e.g., CD8+ T cells and natural killer (NK) cells. Recent studies have revealed that the expression of programmed death-ligand 1 (PD-L1) protein is abundantly increased in senescent cells...
April 11, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38568327/metabolomic-profiling-of-maternal-plasma-identifies-inverse-associations-of-acetate-and-urea-with-anti-sars-cov-2-antibody-titers-following-covid-19-vaccination-during-pregnancy
#18
JOURNAL ARTICLE
An-Shine Chao, Chiao-Yun Lin, Meng-Han Chiang, Kuan-Ying Lu, Cheng-Kun Tsai, Kuan-Ju Chen, Chih-Wei Chien, Ting-Shu Wu, Yao-Lung Chang, Angel Chao, Gigin Lin, Chih-Yung Chiu
We conducted a comprehensive metabolomic analysis of plasma samples obtained from pregnant women who displayed varying post-vaccination antibody titers after receiving mRNA-1273-SARS-CoV-2 vaccines. The study involved 62 pregnant women, all of whom had been vaccinated after reaching 24 weeks of gestation. To quantify post-vaccination plasma antibody titers, we employed binding antibody units (BAU) in accordance with the World Health Organization International Standard. Subsequently, we classified the study participants into three distinct BAU/mL categories: those with high titers (above 2000), medium titers (ranging from 1000 to 2000), and low titers (below 1000)...
April 3, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38565749/abnormal-protein-sumoylation-in-liver-disease-novel-target-for-therapy
#19
REVIEW
Yanfang Yang, Fuxun Yu
SUMOylation is an important protein post-translational modification (PTM) process, in which the small ubiquitin-like modifier (SUMO) protein covalently binds to the target protein and regulates stability, subcellular localization, and protein-protein interaction of the target protein. Protein SUMOylation exerts crucial regulatory function in the liver, and its abnormalities are associated with various liver-related disease processes. This review focuses on the biological functions of protein SUMOylation in liver-related diseases in recent years, summarizes the molecular mechanisms of SUMOylation in the replication of hepatitis viruses and the occurrence of hepatocellular carcinoma, and discusses the significance of SUMOylation in liver-related disorders, which is essential for understanding liver biological processes and formulating therapeutic strategies...
April 3, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38554151/pathogenic-effects-of-leu200pro-and-arg387his-vrk1-protein-variants-on-phosphorylation-targets-and-h4k16-acetylation-in-distal-hereditary-motor-neuropathy
#20
JOURNAL ARTICLE
Aurora Campos-Díaz, Patricia Morejón-García, Eva Monte-Serrano, David Ros-Pardo, Iñigo Marcos-Alcalde, Paulino Gómez-Puertas, Pedro A Lazo
Rare recessive variants in the human VRK1 gene are associated with several motor neuron diseases (MND), such as amyotrophic lateral sclerosis, spinal muscular atrophy, or distal hereditary motor neuropathies (dHMN). A case with dHMN carrying two novel VRK1 gene variants, expressing Leu200Pro (L200P) and Arg387His (R387H) variant proteins, identified that these protein variants are functionally different. The Leu200Pro variant shares with several variants in the catalytic domain the loss of the kinase activity on different substrates, such as histones, p53, or coilin...
March 30, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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