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Journals Journal of Molecular Medicine ...

Journal of Molecular Medicine : Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"

https://read.qxmd.com/read/36951969/identification-of-the-regulatory-mechanism-of-ace2-in-covid-19-induced-kidney-damage-with-systems-genetics-approach
#1
JOURNAL ARTICLE
Xueling Yang, Chunhua Lin, Jian Liu, Ya Zhang, Tingzhi Deng, Mengna Wei, Shuijing Pan, Lu Lu, Xuri Li, Geng Tian, Jia Mi, Fuyi Xu, Chunhua Yang
Studies showed that SARS-CoV-2 can directly target the kidney and induce renal damage. As the cell surface receptor for SARS-CoV-2 infection, the angiotensin-converting enzyme 2 (ACE2) plays a pivotal role for renal physiology and function. Thus, it is important to understand ACE2 through which pathway influences the pathogenesis of renal damage induced by COVID-19. In this study, we first performed an eQTL mapping for Ace2 in kidney tissues in 53 BXD mice strains. Results demonstrated that Ace2 is highly expressed and strongly controlled by a genetic locus on chromosome 16 in the kidney, with six genes (Dnase1, Vasn, Usp7, Abat, Mgrn1, and Rbfox1) dominated as the upstream modulator, as they are highly correlated with Ace2 expression...
March 23, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36905436/recent-advances-in-the-molecular-mechanisms-of-low-intensity-pulsed-ultrasound-against-inflammation
#2
REVIEW
Xueke Li, Yi Zhong, Li Zhang, Mingxing Xie
Low-intensity pulsed ultrasound (LIPUS), as a safe and potent physical therapy, has been widely used. It has been demonstrated that LIPUS could induce multiple biological effects, such as relieving pain, accelerating tissue repair/regeneration, and alleviating inflammation. A number of in vitro studies have indicated that LIPUS could significantly reduce the expression of proinflammatory cytokines. This anti-inflammatory effect has also been verified in many in vivo researches. However, the molecular mechanisms underlying LIPUS against inflammation are far from fully elucidated and may differ among different tissues and cells...
March 11, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36872315/the-regulatory-role-of-lncrna-hcg18-in-various-cancers
#3
REVIEW
Zhuoying Du, Bei Wang, Fangshun Tan, Yinxin Wu, Jinlan Chen, Fangnan Zhao, Mengpan Liu, Gang Zhou, Chengfu Yuan
As a member of long non-coding RNAs (lncRNAs), LncRNA HLA complex group 18 (HCG18) has recently become the focus of cancer research. As outlined in this review, LncRNA HCG18 has been reported to be dysregulated in various cancers development and appears to be activated in a variety of tumors, including clear cell renal cell carcinoma (ccRCC), colorectal cancer (CRC), gastric cancer (GC), hepatocellular carcinoma (HCC), laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC), lung adenocarcinoma (LUAD), nasopharyngeal cancer (NPC), osteosarcoma (OS), and prostate cancer (PCa)...
March 6, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36869893/novel-extracellular-role-of-reic-dkk-3-protein-in-pd-l1-regulation-in-cancer-cells
#4
JOURNAL ARTICLE
Yuma Gohara, Nahoko Tomonobu, Rie Kinoshita, Junichiro Futami, Léna Audebert, Youyi Chen, Ni Luh Gede Yoni Komalasari, Fan Jiang, Chikako Yoshizawa, Hitoshi Murata, Ken-Ichi Yamamoto, Masami Watanabe, Hiromi Kumon, Masakiyo Sakaguchi
The adenovirus-REIC/Dkk-3 expression vector (Ad-REIC) has been the focus of numerous clinical studies due to its potential for the quenching of cancers. The cancer-suppressing mechanisms of the REIC/DKK-3 gene depend on multiple pathways that exert both direct and indirect effects on cancers. The direct effect is triggered by REIC/Dkk-3-mediated ER stress that causes cancer-selective apoptosis, and the indirect effect can be classified in two ways: (i) induction, by Ad-REIC-mis-infected cancer-associated fibroblasts, of the production of IL-7, an important activator of T cells and NK cells, and (ii) promotion, by the secretory REIC/Dkk-3 protein, of dendritic cell polarization from monocytes...
March 4, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36867206/never-in-mitosis-gene-a-related-kinase-6-deficiency-deteriorates-diabetic-cardiomyopathy-via-regulating-heat-shock-protein-72
#5
JOURNAL ARTICLE
Shuangyin Shao, Lili Xiao, Meng Jia, Chuyang Zhang, Guojun Zhao, Rui Yao, Xiaofang Wang, Lu Gao
NIMA (never in mitosis, gene A)-related kinase-6 (NEK6), a cell cycle regulatory gene, was found to regulate cardiac hypertrophy. However, its role in diabetes-induced cardiomyopathy has not been fully elucidated. This research was designed to illustrate the effect of NEK6 involved in diabetic cardiomyopathy. Here we used a streptozotocin (STZ)-induced mice diabetic cardiomyopathy model and NEK6 knockout mice to explore the role and mechanism of NEK6 in diabetic-induced cardiomyopathy. NEK6 knockout mice and wild-type littermates were subjected to STZ injection (50 mg/kg/day for 5 days) to induce a diabetic cardiomyopathy model...
March 3, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36856811/identification-of-a-novel-eighteen-gene-signature-of-recurrent-metastasis-neuroblastoma
#6
JOURNAL ARTICLE
Shufan Zhang, Rong Jiang, Manqiu Yang, Tao Wang, Hui Chen, Yifan Shi, Wei Liu, Moli Huang
Neuroblastoma is the most common malignant tumor in childhood, and metastases occur in more than 30% patients. Recurrent metastasis is the main cause of poor prognosis and high mortality in neuroblastoma. In this regard, there is still a lack of sufficient biomarkers and effective therapies. Therefore, we performed a multi-omics analysis of neuroblastoma patients from Therapeutically Applicable Research To Generate Effective Treatments (TARGET). With clinical relapse site information, tumor samples derived from the primary site were divided into recurrent metastasis and primary tumor groups...
March 1, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36843036/potential-role-for-protein-kinase-d-inhibitors-in-prostate-cancer
#7
REVIEW
Victor Chalfant, Carlos Riveros, Pankaj Singh, Sanjeev Shukla, Nandita Balaji, K C Balaji
Protein kinase D (PrKD), a novel serine-threonine kinase, belongs to a family of calcium calmodulin kinases that consists of three isoforms: PrKD1, PrKD2, and PrKD3. The PrKD isoforms play a major role in pathologic processes such as cardiac hypertrophy and cancer progression. The charter member of the family, PrKD1, is the most extensively studied isoform. PrKD play a dual role as both a proto-oncogene and a tumor suppressor depending on the cellular context. The duplicity of PrKD can be highlighted in advanced prostate cancer (PCa) where expression of PrKD1 is suppressed whereas the expressions of PrKD2 and PrKD3 are upregulated to aid in cancer progression...
February 27, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36811655/histone-h3k9-methyltransferase-setdb1-overexpression-correlates-with-pediatric-high-grade-gliomas-progression-and-prognosis
#8
JOURNAL ARTICLE
Alexia Klonou, Penelope Korkolopoulou, Angeliki-Ioanna Giannopoulou, Dimitrios S Kanakoglou, Andromachi Pampalou, Antonios N Gargalionis, Panagiotis Sarantis, Andreas Mitsios, Spyros Sgouros, Athanasios G Papavassiliou, Christina Piperi
Pediatric high-grade gliomas (pHGGs) are heterogeneous, diffuse, and highly infiltrative tumors with dismal prognosis. Aberrant post-translational histone modifications with elevated histone 3 lysine trimethylation (H3K9me3) have been recently implicated in pHGGs' pathology, conferring to tumor heterogeneity. The present study investigates the potential involvement of H3K9me3 methyltransferase SETDB1 in the cellular function, progression, and clinical significance of pHGG. The bioinformatic analysis detected SETDB1 enrichment in pediatric gliomas compared to the normal brain, as well as positive and negative correlations with a proneural and mesenchymal signature, respectively...
February 22, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36808265/novel-read-through-agent-zkn-0013-demonstrates-efficacy-in-apc-min-model-of-familial-adenomatous-polyposis
#9
JOURNAL ARTICLE
Martin R Graf, Shruti Apte, Esteban Terzo, Simran Padhye, Shuhao Shi, Megan K Cox, Roger B Clark, Vijay Modur, Vasudeo Badarinarayana
Familial adenomatous polyposis (FAP) is a precancerous, colorectal disease characterized by hundreds to thousands of adenomatous polyps caused by mutations in the tumor suppressor gene adenomatous polyposis coli (APC). Approximately 30% of these mutations are premature termination codons (PTC), resulting in the production of a truncated, dysfunctional APC protein. Consequently, the β-catenin degradation complex fails to form in the cytoplasm, leading to elevated nuclear levels of β-catenin and unregulated β-catenin/wnt-pathway signaling...
February 20, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36808555/nicotinamide-riboside-kinase-2-regulates-metabolic-adaptation-in-the-ischemic-heart
#10
JOURNAL ARTICLE
Hezlin Marzook, Anamika Gupta, Dhanendra Tomar, Mohamed A Saleh, Kiran Patil, Mohammad H Semreen, Rifat Hamoudi, Nelson C Soares, Rizwan Qaisar, Firdos Ahmad
Ischemia-induced metabolic remodeling plays a critical role in the pathogenesis of adverse cardiac remodeling and heart failure however, the underlying molecular mechanism is largely unknown. Here, we assess the potential roles of nicotinamide riboside kinase-2 (NRK-2), a muscle-specific protein, in ischemia-induced metabolic switch and heart failure through employing transcriptomic and metabolomic approaches in ischemic NRK-2 knockout mice. The investigations revealed NRK-2 as a novel regulator of several metabolic processes in the ischemic heart...
February 19, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36792729/recent-updates-on-targeting-the-molecular-mediators-of-nafld
#11
REVIEW
Jia Wang, Lei Wang, Xiao-Jing Zhang, Peng Zhang, Jingjing Cai, Zhi-Gang She, Hongliang Li
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common disease worldwide in an era of rapid economic growth. NAFLD is a multifactorial disease, involving multiple genetic, metabolic, and environmental factors, and is closely associated with metabolic syndrome, obesity, and cardiovascular disease. NAFLD can be classified into nonalcoholic fatty liver disease (NAFL) and nonalcoholic steatohepatitis (NASH), which can both progress to cirrhosis and even hepatocellular carcinoma (HCC). Due to the enormous burden of NAFLD and its complications, no FDA-approved drugs for the treatment of NAFLD are on the market, and therapeutic targets and drug therapies are being actively investigated...
February 16, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36790534/endotoxin-tolerance-and-low-activation-of-tlr-4-nf-%C3%AE%C2%BAb-axis-in-monocytes-of-covid-19-patients
#12
JOURNAL ARTICLE
Gilson P Dorneles, Paula C Teixeira, Alessandra Peres, Luiz Carlos Rodrigues Júnior, Simone Gonçalves da Fonseca, Marta Chagas Monteiro, Sarah Eller, Tiago F Oliveira, Eliana M Wendland, Pedro R T Romão
Higher endotoxin in the circulation may indicate a compromised state of host immune response against coinfections in severe COVID-19 patients. We evaluated the inflammatory response of monocytes from COVID-19 patients after lipopolysaccharide (LPS) challenge. Whole blood samples of healthy controls, patients with mild COVID-19, and patients with severe COVID-19 were incubated with LPS for 2 h. Severe COVID-19 patients presented higher LPS and sCD14 levels in the plasma than healthy controls and mild COVID-19 patients...
February 15, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36790533/the-per3-rs772027021-snp-induces-pigmentation-phenotypes-of-dyschromatosis-universalis-hereditaria
#13
JOURNAL ARTICLE
Hongyu Chen, Pingping Yang, Dan Yang, Dongsheng Wang, Mao Lu, Yadong Li, Zhiqiang Zhong, Jing Zhang, Zhen Zeng, Zhi Liu, Xiaohua Zeng, Xu Jia, Qinghe Xing, Ding'an Zhou
Dyschromatosis universalis hereditaria (DUH) is a pigmentary genodermatosis characterized by a mixture of hyperpigmented and hypopigmented macules distributed randomly over the body. Although Sterile Alpha motif- and SH3 domain-containing protein 1 (SASH1) and ATP-binding cassette subfamily B, member 6 (ABCB6) have been identified as causative genes for this disorder, some cases involve unknown pathogenic genes. In this study, whole-exome sequencing, data analysis, and Sanger sequencing were utilized for a four-generation extended Chinese family with DUH...
February 15, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36790532/simultaneous-targeting-of-mitochondrial-kv1-3-and-lysosomal-acid-sphingomyelinase-amplifies-killing-of-pancreatic-ductal-adenocarcinoma-cells-in-vitro-and-in-vivo
#14
JOURNAL ARTICLE
Sameer H Patel, Magdalena Bachmann, Stephanie Kadow, Gregory C Wilson, Mostafa M L Abdel-Salam, Kui Xu, Simone Keitsch, Matthias Soddemann, Barbara Wilker, Katrin Anne Becker, Alexander Carpinteiro, Syed A Ahmad, Ildiko Szabo, Erich Gulbins
Pancreas ductal adenocarcinoma (PDAC) remains a malignant tumor with very poor prognosis and low 5-year overall survival. Here, we aimed to simultaneously target mitochondria and lysosomes as a new treatment paradigm of malignant pancreas cancer in vitro and in vivo. We demonstrate that the clinically used sphingosine analog FTY-720 together with PAPTP, an inhibitor of mitochondrial Kv1.3, induce death of pancreas cancer cells in vitro and in vivo. The combination of both drugs results in a marked inhibition of the acid sphingomyelinase and accumulation of cellular sphingomyelin in vitro and in vivo in orthotopic and flank pancreas cancers...
February 15, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36759357/ectodomain-shedding-of-proteins-important-for-sars-cov-2-pathogenesis-in-plasma-of-tobacco-cigarette-smokers-compared-to-electronic-cigarette-vapers-a-cross-sectional-study
#15
JOURNAL ARTICLE
Theodoros Kelesidis, Madhav Sharma, Sandro Satta, Elizabeth Tran, Rajat Gupta, Jesus A Araujo, Holly R Middlekauff
The impact of tobacco cigarette (TCIG) smoking and electronic cigarette (ECIG) vaping on the risk of development of severe COVID-19 is controversial. The present study investigated levels of proteins important for SARS-CoV-2 pathogenesis present in plasma because of ectodomain shedding in smokers, ECIG vapers, and non-smokers (NSs). Protein levels of soluble angiotensin-converting enzyme 2 (ACE2), angiotensin (Ang) II (the ligand of ACE2), Ang 1-7 (the main peptide generated from Ang II by ACE2 activity), furin (a protease that increases the affinity of the SARS-CoV-2 spike protein for ACE2), and products of ADAM17 shedding activity that predict morbidity in COVID-19 (IL-6/IL-6R alpha (IL-6/IL-6Rα) complex, soluble CD163 (sCD163), L-selectin) were determined in plasma from 45 NSs, 30 ECIG vapers, and 29 TCIG smokers using ELISA...
February 10, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36757399/activation-of-aryl-hydrocarbon-receptor-ahr-in-alzheimer-s-disease-role-of-tryptophan-metabolites-generated-by-gut-host-microbiota
#16
REVIEW
Antero Salminen
Gut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric conditions and Alzheimer's disease (AD). L-tryptophan metabolites and short-chained fatty acids (SCFA) are major messengers in the microbiota-brain axis. Aryl hydrocarbon receptors (AhR) are main targets of tryptophan metabolites in brain microvessels which possess an enriched expression of AhR protein. The Ah receptor is an evolutionarily conserved, ligand-activated transcription factor which is not only a sensor of xenobiotic toxins but also a pleiotropic regulator of both developmental processes and age-related tissue degeneration...
February 9, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36746800/correction-to-prmt4-drives-post-ischemic-angiogenesis-via-yb1-vegf-signaling
#17
Shu Yan, Ji Hu, Jia Li, Pengchao Wang, Yilong Wang, Zhaohui Wang
No abstract text is available yet for this article.
February 7, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36688961/antiangiogenic-activity-of-the-penicillin-derivative-tap7f-in-melanoma
#18
JOURNAL ARTICLE
Elizabeth Barrionuevo, Patricia G Cornier, Carina M L Delpiccolo, Ernesto G Mata, Leonor P Roguin, Viviana C Blank
Previously , we demonstrated that the non-antibiotic penicillin derivative TAP7f inhibited melanoma metastasis in vitro and in vivo through the downregulation of β-catenin and integrin αVβ3. As angiogenesis is required for tumor growth and metastasis, we decided to explore the possible antiangiogenic effect of TAP7f. We found that TAP7f inhibited proliferation, migration, tube formation, and actin cytoskeleton organization of human endothelial cells. In a gel plug assay, an in vivo model for angiogenesis, TAP7f also blocked vascular formation induced by fibroblast growth factor 2...
January 23, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36688960/inhibition-of-erk-creb-signaling-contributes-to-postoperative-learning-and-memory-dysfunction-in-neonatal-rats
#19
JOURNAL ARTICLE
Hui Wang, Gang Ma, Jia Min, Jun Li, Weiran Shan, Zhiyi Zuo
Exposure to surgery with anesthesia early in life may lead to abnormal behavior, learning, and memory in humans. Pre-clinical studies have suggested a critical role of glial cell-derived neurotrophic factor (GDNF) in these effects. We hypothesize that the inhibition of extracellular signal-regulated kinase (ERK)-cAMP response element-binding protein (CREB) pathway contributes to GDNF decrease and the dysfunction of learning and memory. To address this hypothesis, 7-day-old Sprague-Dawley male and female rats were subjected to right carotid artery exposure (surgery) under sevoflurane anesthesia...
January 23, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/36688959/the-crl4-dcaf6-e3-ligase-ubiquitinates-ctbp1-2-to-induce-apoptotic-signalling-and-promote-intervertebral-disc-degeneration
#20
JOURNAL ARTICLE
Changchun Tseng, Yingchao Han, Zhendong Lv, Qingxin Song, Kun Wang, Hongxing Shen, Zhi Chen
Inflammation and apoptosis are two important pathological causes of intervertebral disc degeneration (IDD). The crosstalk between these two biological processes during IDD pathogenesis remains elusive. Herein, we discovered that chronic inflammation induced apoptosis through a cullin-RING E3 ligase (CRL)-dependent mechanism. Two cullin proteins, CUL4A and 4B, recruited DNA damage-binding protein 1 (DDB1), RING-box protein 1 (RBX1) and DDB1- and CUL4-associated factor 6 (DCAF6) to assemble a CRL4DCAF6 E3 ligase in intervertebral discs (IVDs) derived from IDD patients...
January 23, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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