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Journal of the International Neuropsychological Society : JINS

https://read.qxmd.com/read/38525671/determinants-of-confrontation-naming-deficits-on-the-boston-naming-test-associated-with-transactive-response-dna-binding-protein-43-pathology
#1
JOURNAL ARTICLE
Carling G Robinson, Austin W Goodrich, Stephen D Weigand, Nha Trang Thu Pham, Arenn F Carlos, Marina Buciuc, Melissa E Murray, Aivi T Nguyen, R Ross Reichard, David S Knopman, Ronald C Petersen, Dennis W Dickson, Rene L Utianski, Jennifer L Whitwell, Keith A Josephs, Mary M Machulda
OBJECTIVE: To determine whether poorer performance on the Boston Naming Test (BNT) in individuals with transactive response DNA-binding protein 43 pathology (TDP-43+) is due to greater loss of word knowledge compared to retrieval-based deficits. METHODS: Retrospective clinical-pathologic study of 282 participants with Alzheimer's disease neuropathologic changes (ADNC) and known TDP-43 status. We evaluated item-level performance on the 60-item BNT for first and last available assessment...
March 25, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38515367/impact-of-age-and-apolipoprotein-e-%C3%AE%C2%B54-status-on-regional-white-matter-hyperintensity-volume-and-cognition-in-healthy-aging
#2
JOURNAL ARTICLE
Emily J Van Etten, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Georg A Hishaw, Matthew J Huentelman, Theodore P Trouard, Gene E Alexander
OBJECTIVE: White matter hyperintensity (WMH) volume is a neuroimaging marker of lesion load related to small vessel disease that has been associated with cognitive aging and Alzheimer's disease (AD) risk. METHOD: The present study sought to examine whether regional WMH volume mediates the relationship between APOE ε4 status, a strong genetic risk factor for AD, and cognition and if this association is moderated by age group differences within a sample of 187 healthy older adults (APOE ε4 status [carrier/non-carrier] = 56/131)...
March 22, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38465734/six-elements-test-vs-d-kefs-what-does-ecological-validity-tell-us
#3
JOURNAL ARTICLE
Yana Suchy, Michelle Gereau Mora, Stacey Lipio Brothers, Libby A DesRuisseaux
OBJECTIVE: Extensive research shows that tests of executive functioning (EF) predict instrumental activities of daily living (IADLs) but are nevertheless often criticized for having poor ecological validity. The Modified Six Elements Test (MSET) is a pencil-and-paper test that was developed to mimic the demands of daily life, with the assumption that this would result in a more ecologically valid test. Although the MSET has been extensively validated in its ability to capture cognitive deficits in various populations, support for its ability to predict functioning in daily life is mixed...
March 11, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38465668/neurocognitive-outcome-and-associated-factors-in-long-term-adult-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-without-cranial-radiation-therapy
#4
JOURNAL ARTICLE
Kaja Solland Egset, Jan Stubberud, Ellen Ruud, Magnus Aassved Hjort, Mary-Elizabeth Bradley Eilertsen, Anne Mari Sund, Odin Hjemdal, Siri Weider, Trude Reinfjell
OBJECTIVE: There is limited research on neurocognitive outcome and associated risk factors in long-term, adult survivors of childhood acute lymphoblastic leukemia (ALL), without treatment of cranial radiation therapy. Moreover, the impact of fatigue severity and pain interference on neurocognition has received little attention. In this cross-sectional study, we examined neurocognitive outcome and associated factors in this population. METHOD: Intellectual abilities, verbal learning/memory, processing speed, attention, and executive functions were compared to normative means/medians with one sample t tests or Wilcoxon signed-rank tests...
March 11, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38456286/facilitating-clinical-use-of-the-amsterdam-instrumental-activities-of-daily-living-questionnaire-normative-data-and-a-diagnostic-cutoff-value
#5
JOURNAL ARTICLE
Merel C Postema, Mark A Dubbelman, Jürgen Claesen, Craig Ritchie, Merike Verrijp, Leonie Visser, Pieter-Jelle Visser, Marissa D Zwan, Wiesje M van der Flier, Sietske A M Sikkes
OBJECTIVE: The Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) is well validated and commonly used to assess difficulties in everyday functioning regarding dementia. To facilitate interpretation and clinical implementation across different European countries, we aim to provide normative data and a diagnostic cutoff for dementia. METHODS: Cross-sectional data from Dutch Brain Research Registry ( N = 1,064; mean ( M ) age = 62 ± 11 year; 69...
March 8, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38425303/robust-reference-group-normative-data-for-neuropsychological-tests-accounting-for-primary-language-use-in-asian-american-older-adults
#6
JOURNAL ARTICLE
Arunima Kapoor, Jean K Ho, Jung Yun Jang, Daniel A Nation
OBJECTIVE: The present study aimed to develop neuropsychological norms for older Asian Americans with English as a primary or secondary language, using data from the National Alzheimer's Coordinating Center (NACC). METHOD: A normative sample of Asian American participants was derived from the NACC database using robust criteria: participants were cognitively unimpaired at baseline (i.e., no MCI or dementia) and remained cognitively unimpaired at 1-year follow-up...
March 1, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38389489/visual-associative-learning-to-detect-early-episodic-memory-deficits-and-distinguish-alzheimer-s-disease-from-other-types-of-dementia
#7
JOURNAL ARTICLE
Mark A Dubbelman, Jori Tomassen, Sophie M van der Landen, Els Bakker, Suzie Kamps, Annemartijn A J M van Unnik, Marie-Christine A B J van de Glind, Annelies E van der Vlies, Ted Koene, Anna E Leeuwis, Frederik Barkhof, Argonde C van Harten, Charlotte Teunissen, Elsmarieke van de Giessen, Afina W Lemstra, Yolande A L Pijnenburg, Rudolf W H Ponds, Sietske A M Sikkes
OBJECTIVE: We investigated how well a visual associative learning task discriminates Alzheimer's disease (AD) dementia from other types of dementia and how it relates to AD pathology. METHODS: 3,599 patients (63.9 ± 8.9 years old, 41% female) from the Amsterdam Dementia Cohort completed two sets of the Visual Association Test (VAT) in a single test session and underwent magnetic resonance imaging. We performed receiver operating curve analysis to investigate the VAT's discriminatory ability between AD dementia and other diagnoses and compared it to that of other episodic memory tests...
February 23, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38369517/new-insights-on-what-leads-bilinguals-to-be-able-to-name-some-pictures-only-in-their-nondominant-language-immersion-dominance-reversal-and-balanced-bilingualism
#8
JOURNAL ARTICLE
Anne Neveu, Tamar H Gollan
OBJECTIVE: The present study asked if bilinguals who are immersed in their nondominant language are more likely to know some words only in their nondominant language. METHOD: The either-language scoring benefit (ELSB) reflects how many more points bilinguals get when credited for pictures named regardless of which language is used. We asked if the ELSB varies with self-rated proficiency level of the nondominant language in young English-dominant ( n = 68) compared to Spanish-dominant ( n = 33) bilinguals, and in older English-dominant ( n = 36) compared to Spanish-dominant ( n = 32) bilinguals...
February 19, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38361424/exploring-symptom-clusters-in-mild-cognitive-impairment-and-dementia-with-the-nih-toolbox
#9
JOURNAL ARTICLE
Callie E Tyner, Aaron J Boulton, Jerry Slotkin, Matthew L Cohen, Sandra Weintraub, Richard C Gershon, David S Tulsky
OBJECTIVE: Symptom clustering research provides a unique opportunity for understanding complex medical conditions. The objective of this study was to apply a variable-centered analytic approach to understand how symptoms may cluster together, within and across domains of functioning in mild cognitive impairment (MCI) and dementia, to better understand these conditions and potential etiological, prevention, and intervention considerations. METHOD: Cognitive, motor, sensory, emotional, and social measures from the NIH Toolbox were analyzed using exploratory factor analysis (EFA) from a dataset of 165 individuals with a research diagnosis of either amnestic MCI or dementia of the Alzheimer's type...
February 16, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38282413/naturalistic-assessment-of-reaction-time-variability-in-older-adults-at-risk-for-alzheimer-s-disease
#10
JOURNAL ARTICLE
Matthew S Welhaf, Hannah Wilks, Andrew J Aschenbrenner, David A Balota, Suzanne E Schindler, Tammie L S Benzinger, Brian A Gordon, Carlos Cruchaga, Chengjie Xiong, John C Morris, Jason Hassenstab
OBJECTIVE: Maintaining attention underlies many aspects of cognition and becomes compromised early in neurodegenerative diseases like Alzheimer's disease (AD). The consistency of maintaining attention can be measured with reaction time (RT) variability. Previous work has focused on measuring such fluctuations during in-clinic testing, but recent developments in remote, smartphone-based cognitive assessments can allow one to test if these fluctuations in attention are evident in naturalistic settings and if they are sensitive to traditional clinical and cognitive markers of AD...
January 29, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38282390/premorbid-personality-traits-as-predictors-for-incident-predementia-syndromes-a-multistate-model-approach
#11
JOURNAL ARTICLE
Morgan J Schaeffer, Stuart W S MacDonald, Theone S E Paterson
OBJECTIVE: Associations have been found between five-factor model (FFM) personality traits and risk of developing specific predementia syndromes such as subjective cognitive decline (SCD) and mild cognitive impairment (MCI). The aims of this study were to: 1) Compare baseline FFM traits between participants who transitioned from healthy cognition or SCD to amnestic MCI (aMCI) versus non-amnestic MCI (naMCI); and 2) Determine the relationship between FFM traits and risk of transition between predementia cognitive states...
January 29, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38282389/development-of-robust-normative-data-for-the-neuropsychological-assessment-of-greek-older-adults
#12
JOURNAL ARTICLE
Xanthi Arampatzi, Eleni S Margioti, Lambros Messinis, Mary Yannakoulia, Georgios Hadjigeorgiou, Efthimios Dardiotis, Paraskevi Sakka, Nikolaos Scarmeas, Mary H Kosmidis
OBJECTIVE: Normative data for older adults may be tainted by inadvertent inclusion of undiagnosed individuals at the very early stage of a neurodegenerative process. To avoid this pitfall, we developed norms for a cohort of older adults without MCI/dementia at 3-year follow-up. METHODS: A randomly selected sample of 1041 community-dwelling individuals (age ≥ 65) received a full neurological and neuropsychological examination on two occasions [mean interval = 3...
January 29, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38273645/the-association-between-symptom-burden-and-processing-speed-and-executive-functioning-at-4-and-12-weeks-following-pediatric-concussion
#13
JOURNAL ARTICLE
Veronik Sicard, Andrée-Anne Ledoux, Ken Tang, Keith Owen Yeates, Brian L Brooks, Peter Anderson, Michelle Keightley, Naddley Desire, Miriam H Beauchamp, Roger Zemek
OBJECTIVES: Symptoms and cognition are both utilized as indicators of recovery following pediatric concussion, yet their interrelationship is not well understood. This study aimed to investigate: 1) the association of post-concussion symptom burden and cognitive outcomes (processing speed and executive functioning [EF]) at 4 and 12 weeks after pediatric concussion, and 2) the moderating effect of sex on this association. METHODS: This prospective, multicenter cohort study included participants aged 5...
January 26, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38263747/discrepancies-between-self-and-informant-ratings-of-functional-abilities-and-objective-cognition-predictors-of-bias-in-mild-cognitive-impairment
#14
JOURNAL ARTICLE
Liselotte De Wit, Felicia C Goldstein, Jessica L Saurman, Amy D Rodriguez, Kayci L Vickers
OBJECTIVE: Self- and informant-ratings of functional abilities are used to diagnose mild cognitive impairment (MCI) and are commonly measured in clinical trials. Ratings are assumed to be accurate, yet they are subject to biases. Biases in self-ratings have been found in individuals with dementia who are older and more depressed and in caregivers with higher distress, burden, and education. This study aimed to extend prior findings using an objective approach to identify determinants of bias in ratings...
January 24, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38263745/comparing-neuropsychological-typical-and-adni-criteria-for-the-diagnosis-of-mild-cognitive-impairment-in-vietnam-era-veterans
#15
JOURNAL ARTICLE
Monica T Ly, Jennifer Adler, Adan F Ton Loy, Emily C Edmonds, Mark W Bondi, Lisa Delano-Wood
OBJECTIVE: Neuropsychological criteria for mild cognitive impairment (MCI) more accurately predict progression to Alzheimer's disease (AD) and are more strongly associated with AD biomarkers and neuroimaging profiles than ADNI criteria. However, research to date has been conducted in relatively healthy samples with few comorbidities. Given that history of traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are risk factors for AD and common in Veterans, we compared neuropsychological, typical (Petersen/Winblad), and ADNI criteria for MCI in Vietnam-era Veterans with histories of TBI or PTSD...
January 24, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38263740/psychometric-reliability-validity-and-generalizability-of-3mse-scores-among-american-indian-adults-the-strong-heart-study
#16
JOURNAL ARTICLE
Astrid M Suchy-Dicey, Thao T Vo, Kyra Oziel, Dedra S Buchwald, Lonnie A Nelson, Steven P Verney, Brian F French
OBJECTIVE: Modified Mini-Mental State Examination (3MSE) is often used to screen for dementia, but little is known about psychometric validity in American Indians. METHODS: We recruited 818 American Indians aged 65-95 for 3MSE examinations in 2010-2013; 403 returned for a repeat examination in 2017-2019. Analyses included standard psychometrics inferences for interpretation, generalizability, and extrapolation: factor analysis; internal consistency-reliability; test-retest score stability; multiple indicator multiple cause structural equation models...
January 24, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38251679/conceptualization-of-the-term-ecological-validity-in-neuropsychological-research-on-executive-function-assessment-a-systematic-review-and-call-to-action
#17
REVIEW
Yana Suchy, Libby A DesRuisseaux, Michelle Gereau Mora, Stacey Lipio Brothers, Madison A Niermeyer
OBJECTIVE: "Ecological validity" (EV) is classically defined as test's ability to predict real-world functioning, either alone or together with test's similarity to real-world tasks. In neuropsychological literature on assessment of executive functions (EF), EV is conceptualized inconsistently, leading to misconceptions about the utility of tests. The goal of this systematic review was to examine how EV is conceptualized in studies of EF tests described as ecologically valid. METHOD: MEDLINE and PsychINFO Databases were searched...
January 22, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38223955/moving-on-with-social-cognition-in-idiopathic-cervical-dystonia
#18
JOURNAL ARTICLE
Maraike A Coenen, Jacoba M Spikman, Marenka Smit, Jesper Klooster, Marina A J Tijssen, Marleen J J Gerritsen
OBJECTIVE: Cervical dystonia (CD) is a movement disorder characterized by involuntary muscle contractions causing sustained twisting movements and abnormal postures of the neck and head. Assumed affected neuronal regions are the cortico-striatal-thalamo-cortical circuits, which are also involved in cognitive functioning. Indeed, impairments in different cognitive domains have been found in CD patients. However, to date studies have only investigated a limited range of cognitive functions within the same sample...
January 15, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38221867/metamemory-and-executive-function-mediate-the-age-related-decline-in-memory
#19
JOURNAL ARTICLE
Michael K Yeung
OBJECTIVE: Although the effect of aging on episodic memory is relatively well studied, little is known about how aging influences metamemory. In addition, while executive function (EF) is known to mediate the age-related decline in episodic memory, the role of metamemory in aging-related memory differences beyond EF remains unknown. This study aimed to elucidate the effect of aging on metamemory and to clarify the role of metamemory in the age-related decline in memory. METHOD: One hundred and four adults aged 18-79 years (50 M, 54 F) performed several EF tasks, as well as a face-scene paired-associate learning task that required them to make judgments of learning, feeling-of-knowing judgments, and retrospective confidence judgments...
January 15, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38221864/the-effect-of-age-on-executive-functions-in-adults-is-not-sex-specific
#20
JOURNAL ARTICLE
Marilou Lemire, Isabelle Soulières, Dave Saint-Amour
OBJECTIVE: Numerous studies have shown a decrease in executive functions (EF) associated with aging. However, few investigations examined whether this decrease is similar between sexes throughout adulthood. The present study investigated if age-related decline in EF differs between men and women from early to late adulthood. METHODS: A total of 302 participants (181 women) aged between 18 and 78 years old completed four computer-based cognitive tasks at home: an arrow-based Flanker task, a letter-based Visual search task, the Trail Making Test, and the Corsi task...
January 15, 2024: Journal of the International Neuropsychological Society: JINS
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