journal
https://read.qxmd.com/read/38785501/molecular-markers-in-melanoma-progression-a-study-on-the-expression-of-mirna-gene-subtypes-in-tumoral-vs-benign-nevi
#1
JOURNAL ARTICLE
Mihaela Prodan, Sergiu Costescu, Ahmed Elagez, Sorina Maria Denisa Laitin, Vlad Bloanca, Zorin Crainiceanu, Edward Seclaman, Ana-Olivia Toma, Roxana Manuela Fericean, George Puenea, Gabriel Veniamin Cozma
This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi in individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor stage and progression. Conducted between 2019 and 2022, this descriptive, quantitative observational research analyzed 90 formalin-fixed paraffin-embedded (FFPE) samples from the Pius Brinzeu County Emergency Clinical Hospital, Timisoara, including 45 samples of advanced-stage melanoma and 45 samples of pigmented nevi...
May 17, 2024: Current Oncology
https://read.qxmd.com/read/38785500/establishing-the-top-10-research-priorities-for-adolescent-and-young-adult-aya-cancer-in-canada-a-protocol-for-a-james-lind-alliance-priority-setting-partnership
#2
JOURNAL ARTICLE
Perri R Tutelman, Chantale Thurston, Tamara Rader, Brianna Henry, Tristyn Ranger, Mohamed Abdelaal, Michelle Blue, Timothy W Buckland, Stefanie Del Gobbo, Lexy Dobson, Emily Gallant, Cheryl Heykoop, Mackenzie Jansen, Lorna Larsen, Nicole Maseja, Sapna Oberoi, Vinesha Ramasamy, Marlie Smith, Evan Taylor, Nadia Wendowsky, Sara Beattie, Jacqueline Bender, Kathryn A Birnie, Sheila N Garland, Lindsay Jibb, Melanie Noel, Fiona S M Schulte
Adolescents and young adults (AYAs; 15-39 years) diagnosed with cancer have unique medical and psychosocial needs. These needs could be better addressed through research that is focused on the topics that matter most to them. However, there is currently no patient-oriented research agenda for AYA cancer in Canada. This manuscript describes the early development and project protocol for a priority-setting partnership (PSP) for establishing the top 10 research priorities for AYA cancer in Canada. This project follows the PSP methodology outlined by the James Lind Alliance (JLA) to engage patients, caregivers, and clinicians in research prioritization...
May 17, 2024: Current Oncology
https://read.qxmd.com/read/38785499/pharmacy-workload-in-clinical-trial-management-a-preliminary-complexity-assessment-tool-for-sponsored-oncology-and-haematology-trials
#3
JOURNAL ARTICLE
Lorenzo Gasperoni, Carla Masini, Giada Toscano, Alessandro Cafaro, Chiara Zani, Cristina Andrianò, Paolo Silimbani, Caterina Donati, Giorgia Bortolin, Sara Cecco
Investigational drug services need to be organised in a structured approach, especially for sites with a large number of ongoing clinical trials. The aim of this study was to develop a tool to assess the complexity of pharmacy involvement in a sponsored oncology clinical trial. Categorisation into ordinal complexity categories was used to assess the complexity of the clinical trials for consistent pharmacy grant applications. The 15 items of the tool were divided into three sections, and individual item scores were agreed upon among four pharmacists with experience in the conduct of clinical trials at two different centres...
May 16, 2024: Current Oncology
https://read.qxmd.com/read/38785498/multidisciplinary-and-tailored-treatment-of-locally-advanced-breast-cancer-in-progression-during-neoadjuvant-chemotherapy-case-report
#4
JOURNAL ARTICLE
Letizia Cuniolo, Marco Gipponi, Federica Murelli, Francesca Depaoli, Chiara Cornacchia, Simonetta Franchelli, Marianna Pesce, Elena Ronda, Stefano Picardi, Raquel Diaz, Francesca Poggio, Daniele Friedman, Franco De Cian, Piero Fregatti
Locally advanced breast cancer (LABC) is a complex disease that requires a multidisciplinary approach. Neoadjuvant chemotherapy (NAC) is usually performed in order to achieve loco-regional radical resection; although its importance in the multidisciplinary approach to LABC is well recognized, a small number of patients show Progressive Disease (PD). No standard salvage treatment (ST) has been defined and different strategies can be adopted, such as second-line systemic therapies, radiation therapy, and surgery...
May 16, 2024: Current Oncology
https://read.qxmd.com/read/38785497/discrepancy-in-the-location-of-prostate-cancer-indicated-on-biparametric-magnetic-resonance-imaging-and-pathologically-diagnosed-using-surgical-specimens
#5
JOURNAL ARTICLE
Masayuki Tomioka, Keita Nakane, Makoto Kawase, Koji Iinuma, Daiki Kato, Kota Kawase, Tomoki Taniguchi, Yuki Tobisawa, Fumiya Sugino, Tetsuro Kaga, Hiroki Kato, Masayuki Matsuo, Yusuke Kito, Chiemi Saigo, Natsuko Suzui, Takayasu Ito, Tatsuhiko Miyazaki, Tamotsu Takeuchi, Takuya Koie
Accurate diagnosis of the localization of prostate cancer (PCa) on magnetic resonance imaging (MRI) remains a challenge. We aimed to assess discrepancy between the location of PCa pathologically diagnosed using surgical specimens and lesions indicated as possible PCa by the Prostate Imaging Reporting and Data System on MRI. The primary endpoint was the concordance rate between the site of probable clinically significant PCa (csPCa) identified using biparametric MRI (bpMRI) and location of PCa in the surgical specimen obtained using robot-assisted total prostatectomy...
May 16, 2024: Current Oncology
https://read.qxmd.com/read/38785496/trends-in-early-stage-cervical-cancer-management-in-the-us-a-national-cancer-database-analysis
#6
JOURNAL ARTICLE
Jennifer Wolf, Yiyuan Wu, Judy Hayek, Qi Zhang, Ioannis Alagkiozidis
The Laparoscopic Approach to Cervical Cancer (LACC) trial was published in 2018 and demonstrated that minimally invasive surgery (MIS) yields inferior survival outcomes in early-stage cervical cancer compared to open surgery. This study investigates how the results of the LACC trial have impacted the selection of the primary treatment modality and adjuvant radiation utilization in early-stage cervical cancer. Using the National Cancer Database (NCDB), we compared patients with stage IA2-IB1 cervical cancer before (1/2016-12/2017) and after (1/2019-12/2020) the LACC trial...
May 16, 2024: Current Oncology
https://read.qxmd.com/read/38785495/evaluation-of-a-conference-on-cancer-related-financial-and-legal-issues-a-potential-resource-to-counter-financial-toxicity
#7
JOURNAL ARTICLE
Lauren V Ghazal, Joanna Doran, Monica Bryant, Brad Zebrack, Margaret I Liang
This study describes the conception, development, and growth of the Triage Cancer Conference hosted by Triage Cancer, a national nonprofit organization providing free legal and financial education to the cancer community. We conducted a retrospective analysis of post-conference participant surveys. Descriptive statistics were calculated for participant demographics, and acceptability, feasibility, and appropriateness were evaluated. From 2016-2021, 1239 participants attended the conference and completed post-conference surveys...
May 15, 2024: Current Oncology
https://read.qxmd.com/read/38785494/a-two-step-approach-to-the-surgical-treatment-of-soft-tissue-sarcomas
#8
JOURNAL ARTICLE
Camillo Fulchignoni, Luigi Cianni, Maria Rosaria Matrangolo, Mariagrazia Cerrone, Francesco Cavola, Elisabetta Pataia, Raffaele Vitiello, Giulio Maccauro, Pasquale Farsetti, Giuseppe Rovere
Background: Nowadays, limb-sparing procedures are the gold standard in the treatment of soft-tissue sarcomas of the limbs. Wide tumor resection with appropriate oncological margins, reconstruction, and stabilization of the involved bone and joint and restoration of the soft tissue lost are essential in order to obtain good clinical and functional outcomes. Tumor excision and soft-tissue reconstruction performed in one-step surgery is chosen by many centers as the preferred approach; however, according to our experience in some selected patients, two-step surgery performed using a dermal regeneration template first and then a margin revision, taking into account the definitive results of the anatomopathological exam conducted over the surgical specimen from the previous surgery, associated with definitive reconstruction surgery over a healthy bed of granulated tissue, showed many potential benefits...
May 15, 2024: Current Oncology
https://read.qxmd.com/read/38785493/the-consistency-and-quality-of-chatgpt-responses-compared-to-clinical-guidelines-for-ovarian-cancer-a-delphi-approach
#9
JOURNAL ARTICLE
Dario Piazza, Federica Martorana, Annabella Curaba, Daniela Sambataro, Maria Rosaria Valerio, Alberto Firenze, Basilio Pecorino, Paolo Scollo, Vito Chiantera, Giuseppe Scibilia, Paolo Vigneri, Vittorio Gebbia, Giuseppa Scandurra
INTRODUCTION: In recent years, generative Artificial Intelligence models, such as ChatGPT, have increasingly been utilized in healthcare. Despite acknowledging the high potential of AI models in terms of quick access to sources and formulating responses to a clinical question, the results obtained using these models still require validation through comparison with established clinical guidelines. This study compares the responses of the AI model to eight clinical questions with the Italian Association of Medical Oncology (AIOM) guidelines for ovarian cancer...
May 14, 2024: Current Oncology
https://read.qxmd.com/read/38785492/epstein-barr-virus-monitoring-after-an-allogeneic-hematopoietic-stem-cell-transplant-review-of-the-recent-data-and-current-practices-in-canada
#10
REVIEW
Claire Ratiu, Simon F Dufresne, Stéphanie Thiant, Jean Roy
Epstein-Barr virus-related post-transplantation lymphoproliferative disorder (EBV-PTLD) is a serious complication following hematopoietic stem cell transplantation (HSCT). A pre-emptive strategy using rituximab, which aims to manage patients early at the time of EBV reactivation to avoid PTLD, has been recommended by the most recent ECIL-6 guidelines in 2016. However, there is still a great heterogeneity of viral-load monitoring protocols, targeted patient populations, and pre-emptive treatment characteristics between centers, making precise EBV monitoring recommendations difficult...
May 14, 2024: Current Oncology
https://read.qxmd.com/read/38785491/misp-is-overexpressed-in-intestinal-metaplasia-and-gastric-cancer
#11
JOURNAL ARTICLE
Tomás Vilarinho, Diana Pádua, Bruno Pereira, Patrícia Mesquita, Raquel Almeida
Gastric cancer is the fifth most common cancer and the fourth cause of global cancer mortality. The identification of new biomarkers and drug targets is crucial to allow the better prognosis and treatment of patients. The mitotic spindle positioning (MISP) protein has the function of correcting mitotic spindle positioning and centrosome clustering and has been implicated in the cytokinesis and migration of cancer cells. The goal of this work was to evaluate the expression and clinical relevance of MISP in gastric cancer...
May 14, 2024: Current Oncology
https://read.qxmd.com/read/38785490/impact-of-robotic-assisted-partial-nephrectomy-with-single-layer-versus-double-layer-renorrhaphy-on-postoperative-renal-function
#12
MULTICENTER STUDY
Hiroyuki Ito, Keita Nakane, Noriyasu Hagiwara, Makoto Kawase, Daiki Kato, Koji Iinuma, Kenichiro Ishida, Torai Enomoto, Minori Nezasa, Yuki Tobisawa, Takayasu Ito, Takuya Koie
We aimed to investigate the differences in renal function between patients who underwent single inner-layer renorrhaphy (SILR) or double-layer renorrhaphy (DLR) among those with renal tumors who underwent robot-assisted partial nephrectomy (RAPN). This retrospective multicenter cohort study was conducted between November 2018 and October 2023 at two institutions and included patients who underwent RAPN. In total, 93 eligible patients who underwent RAPN were analyzed. Preoperative renal function and prevalence of chronic kidney disease were not significantly different between the two groups...
May 13, 2024: Current Oncology
https://read.qxmd.com/read/38785489/parenteral-nutrition-in-palliative-cancer-care-detrimental-futile-or-beneficial
#13
JOURNAL ARTICLE
Erik Torbjørn Løhre, Tora Skeidsvoll Solheim, Gunnhild Jakobsen, Ola Magne Vagnildhaug, Terese Louise Schmidberger Karlsen, Ragnhild Hansdatter Habberstad, Trude Rakel Balstad, Morten Thronæs
Palliative cancer care patients may live for a long time, but malnutrition worsens the prognosis. Parenteral nutrition (PN) is suitable for replenishing a calorie deficit, but its advantages and tolerance late in the cancer trajectory are debated. We examined symptom development in hospitalized patients with and without PN. A total of 21 palliative cancer care patients receiving PN and 155 palliative cancer care patients not receiving PN during hospitalization in a specialized unit were retrospectively compared...
May 11, 2024: Current Oncology
https://read.qxmd.com/read/38785488/application-of-machine-learning-in-predicting-perioperative-outcomes-in-patients-with-cancer-a-narrative-review-for-clinicians
#14
REVIEW
Garry Brydges, Abhineet Uppal, Vijaya Gottumukkala
This narrative review explores the utilization of machine learning (ML) and artificial intelligence (AI) models to enhance perioperative cancer care. ML and AI models offer significant potential to improve perioperative cancer care by predicting outcomes and supporting clinical decision-making. Tailored for perioperative professionals including anesthesiologists, surgeons, critical care physicians, nurse anesthetists, and perioperative nurses, this review provides a comprehensive framework for the integration of ML and AI models to enhance patient care delivery throughout the perioperative continuum...
May 11, 2024: Current Oncology
https://read.qxmd.com/read/38785487/patient-and-family-financial-burden-in-cancer-a-focus-on-differences-across-four-provinces-and-reduced-spending-including-decisions-to-forego-care-in-canada
#15
JOURNAL ARTICLE
Christopher J Longo, Tuhin Maity, Margaret I Fitch, Jesse T Young
GOAL: This study aimed to examine provincial differences in patient spending for cancer care and reductions in household spending including decisions to forego care in Canada. METHODS: Nine-hundred and one patients with cancer, from twenty cancer centers across Canada, completed a self-administered questionnaire (P-SAFE version 7.2.4) (344 breast, 183 colorectal, 158 lung, and 216 prostate) measuring direct and indirect costs and spending changes. RESULTS: Provincial variations showed a high mean out-of-pocket cost (OOPC) of CAD 938 (Alberta) and a low of CAD 280 (Manitoba)...
May 11, 2024: Current Oncology
https://read.qxmd.com/read/38785486/real-world-evidence-study-of-patients-with-kras-mutated-nsclc-in-finland
#16
JOURNAL ARTICLE
Anna Anttalainen, Paavo Pietarinen, Samuli Tuominen, Riikka Mattila, Aino Mutka, Aija Knuuttila
While KRAS is the most frequently mutated oncogene in non-small cell lung cancer (NSCLC), KRAS -mutant tumors have long been considered difficult to treat and thus, an unmet need still remains. Partly due to the lack of targeted treatments, comprehensive real-world description of NSCLC patients with KRAS mutation is still largely missing in Finland. In this study, all adult patients diagnosed with locally advanced and unresectable or metastatic NSCLC from 1 January 2018 to 31 August 2020 at the Hospital District of Helsinki and Uusimaa were first identified in this retrospective registry-based real-world study...
May 11, 2024: Current Oncology
https://read.qxmd.com/read/38785485/epidemiology-of-pediatric-tumors-in-quebec-a-17-year-report-of-cancer-in-young-people-in-the-canada-registry
#17
JOURNAL ARTICLE
Caroline Bellavance, Benoit Lalonde, David Simonyan, Nada Jabado, Sebastien Perreault, Valérie Larouche
BACKGROUND: Cancer is the leading cause of disease-related death among children of more than 1 year of age. However, childhood cancer risk factors and etiology are yet to be fully understood. The goal of this study is to identify geographic variation among children and adolescents diagnosed with pediatric tumors between 2001 and 2018 in the province of Quebec. METHODS: We analyzed pediatric patients less than 15 years of age from the Cancer in Young People in Canada (CYP-C) surveillance system who were diagnosed between 2001 and 2018 with cancer in the province of Quebec...
May 9, 2024: Current Oncology
https://read.qxmd.com/read/38785484/online-adaptive-mr-guided-ultrahypofractionated-radiotherapy-of-prostate-cancer-on-a-1-5-t-mr-linac-clinical-experience-and-prospective-evaluation
#18
JOURNAL ARTICLE
Vlatko Potkrajcic, Cihan Gani, Stefan Georg Fischer, Simon Boeke, Maximilian Niyazi, Daniela Thorwarth, Otilia Voigt, Moritz Schneider, David Mönnich, Sarah Kübler, Jessica Boldt, Elgin Hoffmann, Frank Paulsen, Arndt-Christian Mueller, Daniel Wegener
The use of hypofractionated radiotherapy in prostate cancer has been increasingly evaluated, whereas accumulated evidence demonstrates comparable oncologic outcomes and toxicity rates compared to normofractionated radiotherapy. In this prospective study, we evaluate all patients with intermediate-risk prostate cancer treated with ultrahypofractionated (UHF) MRI-guided radiotherapy on a 1.5 T MR-Linac within our department and report on workflow and feasibility, as well as physician-recorded and patient-reported longitudinal toxicity...
May 9, 2024: Current Oncology
https://read.qxmd.com/read/38785483/progressive-multifocal-leukoencephalopathy-unmasked-by-teclistamab-in-a-refractory-multiple-myeloma-patient
#19
JOURNAL ARTICLE
Panos Arvanitis, Dimitrios Farmakiotis, Ari Pelcovits
This case report describes the development of Progressive Multifocal Leukoencephalopathy (PML) in a 72-year-old male with relapsed/refractory multiple myeloma (RRMM), following a single dose of teclistamab amidst a COVID-19 infection. Shortly after starting teclistamab treatment, the patient developed symptoms, including fever, altered mental status, and right-sided paresis. A diagnosis of PML was confirmed through the detection of JC virus PCR in the cerebrospinal fluid. Our report emphasizes the occurrence of PML after only one dose of teclistamab and highlights teclistamab's potential for severe infectious complications, despite its promise in treating RRMM...
May 9, 2024: Current Oncology
https://read.qxmd.com/read/38785482/minimally-invasive-conversion-surgery-for-unresectable-gastric-cancer-with-splenic-metastasis-and-splenic-vein-tumor-thrombus-a-case-report
#20
JOURNAL ARTICLE
Nobuhisa Tanioka, Michio Kuwahara, Takashi Sakai, Yuzuko Nokubo, Shigeto Shimizu, Makoto Hiroi, Toyokazu Akimori
While the importance of conversion surgery has increased with the development of systemic chemotherapy for gastric cancer (GC), reports of conversion surgery for patients with GC with distant metastasis and tumor thrombus are extremely scarce, and a definitive surgical strategy has yet to be established. Herein, we report a 67-year-old man with left abdominal pain referred to our hospital following a diagnosis of unresectable GC. Esophagogastroduodenoscopy and contrast-enhanced abdominal computed tomography (CT) revealed advanced GC with splenic metastasis...
May 8, 2024: Current Oncology
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