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Journals Journal of Thrombosis and Thro...

Journal of Thrombosis and Thrombolysis

https://read.qxmd.com/read/38393676/impact-of-hemodialysis-on-efficacies-of-the-antiplatelet-agents-in-coronary-artery-disease-patients-complicated-with-end-stage-renal-disease
#1
JOURNAL ARTICLE
Zekang Ye, Qin Wang, Inam Ullah, Qingxia Lin, Tianyu Wu, Mingwen Yang, Yuansheng Fan, Zhou Dong, Tong Wang, Jianzhen Teng, Rui Hua, Yingdan Tang, Yule Li, Xiaoxuan Gong, Liang Yuan, Zhengxian Tao, Chunjian Li
It is controversial whether hemodialysis affects the efficacy of the antiplatelet agents. We aimed to investigate the impact of hemodialysis on efficacies of the antiplatelet agents in coronary artery disease (CAD) patients complicated with end-stage renal disease (ESRD). 86 CAD patients complicated with ESRD requiring hemodialysis were consecutively enrolled. After 5-day treatment with aspirin and clopidogrel or ticagrelor, the platelet aggregations induced by arachidonic acid (PLAA ) or adenosine diphosphate (PLADP ), and the P2Y12 reaction unit (PRU) were measured before and after hemodialysis...
February 23, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38393675/a-ten-year-comparison-of-treatment-and-outcomes-of-cancer-associated-thrombosis-to-non-cancer-venous-thromboembolism-from-traditional-anticoagulants-to-direct-oral-anticoagulants
#2
JOURNAL ARTICLE
Benjamin Wee, Jeffrey Lai, Zille Khattak, Anna Kwok, Cynthia Donarelli, Prahlad Ho, Hui Yin Lim, Brandon Lui
DOACs have emerged as first-line treatment in most cancer-associated thrombosis (CAT), representing a paradigm shift in its management. However, CAT management remains challenging and requires careful risk-benefit considerations. A retrospective analysis of CAT presentations to a tertiary referral centre from January 2011 to December 2020. Outcomes in CAT patients were compared to VTE patients without malignancy. Subgroup analysis was also conducted for CAT according to anticoagulation type. 514 CAT cases from 491 patients were identified from 3230 total VTE cases...
February 23, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38393674/therapeutic-implication-of-microrna-320a-antagonist-in-attenuating-blood-clots-formed-during-venous-thrombosis
#3
JOURNAL ARTICLE
Swati Srivastava, Iti Garg, Nilanjana Ghosh, Rajeev Varshney
Venous thrombosis (VT) is a complex multi-factorial disease and a major health concern worldwide. Its clinical implications include deep vein thrombosis (DVT) and pulmonary embolism (PE). VT pathogenesis involves intricate interplay of various coagulants and anti-coagulants. Growing evidences from epidemiological studies have shown that many non-coding microRNAs play significant regulatory role in VT pathogenesis by modulating expressions of large number of gene involved in blood coagulation. Present study aimed to investigate the effect of human micro RNA (hsa-miR)-320a antagonist on thrombus formation in VT...
February 23, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38393673/effect-of-continuous-2%C3%A2-mhz-transcranial-ultrasound-as-an-adjunct-to-tenecteplase-thrombolysis-in-acute-anterior-circulation-ischemic-stroke-patients-an-open-labeled-non-randomized-clinical-trial
#4
JOURNAL ARTICLE
Semparuthi Arumugham, Sunil K Narayan, Rajeswari Aghoram
The treatment of acute ischemic stroke has improved in last few decades. While meta-analyses of several trials have established the safety and efficacy of Intravenous (IV) Tenecteplase thrombolysis, concomitant continuous transcranial doppler (TCD) ultrasound administration has not been assessed in any clinical trial. The aim of this study was to determine the effects of continuous 2 MHz TCD ultrasound during IV Tenecteplase thrombolysis for Middle cerebral artery (MCA) stroke. A total of 19 patients were included, 13 received TCD ultrasound and 6 sham TCD with IV Tenecteplase...
February 23, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38358568/enoxaparin-is-not-an-oral-factor-xa-inhibitor-response-to-sutton-et-al-real-world-clinical-outcomes-among-us-veterans-with-oral-factor-xa-inhibitor-related-major-bleeding-treated-with-andexanet-alfa-or-4-factor-prothrombin-complex-concentrate
#5
LETTER
https://read.qxmd.com/read/38347374/low-on-clopidogrel-adp-and-trap-6-induced-platelet-aggregation-in-patients-with-atrial-fibrillation-undergoing-percutaneous-coronary-intervention-an-observational-pilot-study
#6
JOURNAL ARTICLE
Diona Gjermeni, Viktoria Anfang, Hannah Vetter, Sofia Szabó, David Hesselbarth, Nadine Gauchel, Patrick M Siegel, Klaus Kaier, Alexander Kille, Kilian Franke, Stefan Leggewie, Dietmar Trenk, Daniel Duerschmied, Christoph Bode, Dirk Westermann, Christoph B Olivier
High on-clopidogrel platelet reactivity (HPR) associates with ischemic risk in patients after percutaneous intervention (PCI). This study aimed to evaluate the association of HPR as assessed by multiple electrode aggregometry (MEA) with ischemic, thromboembolic, and bleeding risk in patients with atrial fibrillation (AF) undergoing PCI. Patients with AF and an indication for oral anticoagulation (OAC) were included in this prospective cohort study on day 1-3 after PCI. Platelet aggregation [U] was analyzed by MEA...
February 12, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38347373/blood-group-ab-is-associated-with-reduced-blood-loss-but-also-elevated-cardiovascular-mortality-in-aortocoronary-bypass-surgery
#7
JOURNAL ARTICLE
Franz Masseli, Arlinda Veseli, Marvin Pfohl, Jochen Hoch, Hendrik Treede, Wolfgang Schiller
Patient blood group (BG) is predictive for von-Willebrand-factor (VWF) and Factor VIII variation. The clinical impact of this ABO-effect on blood loss, cardiovascular complications and outcome has been described for several patient cohorts. The aim of this study was to investigate the impact of patient BG on blood loss and outcome after coronary artery bypass surgery (CABG). Patient records, intraoperative data and perioperative transfusion records of 5713 patients receiving an on-pump CABG procedure between 05/2004 and 12/2018 were analyzed...
February 12, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38300500/remote-intensive-management-to-improve-antiplatelet-adherence-in-acute-myocardial-infarction-a-secondary-analysis-of-the-randomized-controlled-immaculate-trial
#8
JOURNAL ARTICLE
Hui Wen Sim, Karen W L Koh, Sock-Cheng Poh, Siew Pang Chan, Stephanie Marchesseau, Devinder Singh, Yiying Han, Faclin Ng, Eleanor Lim, Joseph F Prabath, Chi-Hang Lee, Ruth Chen, Leonardo Carvalho, Sock-Hwee Tan, Joshua P Y Loh, Jack W C Tan, Karishma Kuwelker, R M Amanullah, Chee-Tang Chin, James W L Yip, Choy-Yee Lee, Juvena Gan, Chew-Yong Lo, Hee-Hwa Ho, Derek J Hausenloy, Bee-Choo Tai, A Mark Richards, Mark Y Chan
This study aim to investigate if remote intensive coaching for the first 6 months post-AMI will improve adherence to the twice-a-day antiplatelet medication, ticagrelor. Between July 8, 2015, to March 29, 2019, AMI patients were randomly assigned to remote intensive management (RIM) or standard care (SC). RIM participants underwent 6 months of weekly then two-weekly consultations to review medication side effects and medication adherence coaching by a centralized nurse practitioner team, whereas SC participants received usual cardiologist face-to-face consultations...
February 1, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38296868/proteomics-associated-with-coronary-high-risk-plaques-by-optical-coherence-tomography
#9
JOURNAL ARTICLE
Takayuki Niida, Haruhito Yuki, Keishi Suzuki, Daisuke Kinoshita, Daichi Fujimoto, Akihiro Nakajima, Iris McNulty, Hang Lee, Kahraman Tanriverdi, Sunao Nakamura, Ik-Kyung Jang
Biomarkers are widely used for the diagnosis and monitoring of cardiovascular disease. However, markers for coronary high-risk plaques have not been identified. The aim of this study was to identify proteins specific to coronary high-risk plaques. Fifty-one patients (71.2 ± 11.1 years, male: 66.7%) who underwent intracoronary optical coherence tomography imaging and provided blood specimens for proteomic analysis were prospectively enrolled. A total of 1470 plasma proteins were analyzed per patient using the Olink® Explore 1536 Reagent Kit...
January 31, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38281232/anticoagulant-prescribing-patterns-in-patients-with-primary-central-nervous-system-malignancies-and-secondary-metastases
#10
JOURNAL ARTICLE
Emily Abdelmessih, Tania Ahuja, Stephanie Wo, Aaron Sango, John Papadopoulos, David Green, Elaine Xiang
To evaluate the safety of direct oral anticoagulants (DOACs) versus low-molecular weight heparin (LMWH) in patients with central nervous system (CNS) malignancies and secondary metastases. All adult patients with CNS malignancies and secondary metastases who were treated with a DOAC or LMWH for any indication from 2018 to 2022 were included. The primary outcome was the incidence of any intracranial hemorrhage (ICH) after anticoagulation initiation. Secondary outcomes included non-ICH bleeding events and thromboembolic events...
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38281231/direct-oral-anticoagulants-versus-vitamin-k-antagonists-in-patients-with-atrial-fibrillation-and-stage-5-chronic-kidney-disease-under-dialysis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
JOURNAL ARTICLE
Larissa A de Lucena, Marcos A A Freitas, Ana K C Souza, Caroliny H A Silva, Janine M F Watanabe, Felipe L Guedes, Jose B Almeida, Rodrigo A de Oliveira
BACKGROUND: In patients with atrial fibrillation (AF) and normal or slightly impaired renal function, the use of direct oral anticoagulants (DOACs) is preferable to vitamin K antagonists (VKAs). However, in patients undergoing hemodialysis, the efficacy, and safety of DOACs compared with VKAs are still unknown. PURPOSE: To review current evidence about the safety and efficacy of DOACs compared to VKAs, in patients with AF and chronic kidney disease under hemodialysis...
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38281230/prospective-analysis-of-pre-and-postoperative-laboratory-parameters-associated-with-thrombosis-in-patients-with-ovarian-cancer
#12
JOURNAL ARTICLE
Hyoeun Shim, Ji Hyun Kim, Dong-Eun Lee, Mi Hyang Kwak, Sang Yoon Park, Myong Cheol Lim, Sun-Young Kong
Patients with ovarian cancer have a high risk of developing thrombosis. We aimed to investigate pre and post operative biomarkers associated with thrombosis including deep vein thrombosis and pulmonary thromboembolism in patients treated for ovarian cancer. We collected pre and post operative blood samples from 133 patients undergoing surgery for ovarian cancer between December 2021 and August 2022. The measured parameters were white blood cell count, hemoglobin, platelets, monocytes, serum glucose, CA125, D-dimer, fibrinogen, prothrombin time, activated partial thromboplastin time, fibrinogen degradation products, antithrombin III, protein C, protein S, plasminogen, plasminogen activator inhibitor 1, homocysteine, N-terminal pro-brain natriuretic peptide, interleukin 6, thrombopoietin, soluble P-selectin and granulocyte stimulating factor...
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38281229/trends-of-pulmonary-embolism-related-sudden-cardiac-death-in-the-united-states-1999-2019
#13
JOURNAL ARTICLE
Marco Zuin, Thure Filskov Overvad, Ida Ehlers Albertsen, Claudio Bilato, Gregory Piazza
OBJECTIVES: Up-to-date population-based data on pulmonary embolism (PE)-related sudden cardiac death (SCD) mortality trends in the United States (US) are scant. We assess the current trends in PE-related SCD mortality in US over the past two decades and determine differences by sex, race, ethnicity, age, and census region. METHODS: We extracted PE-related SCD mortality rates from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2019, in patients aged ≥ 15 years old...
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38281228/treating-periprocedural-bleeding-in-patients-with-cirrhosis
#14
REVIEW
Antoni Sabate, Ecaterina Scarlatescu
Patients with cirrhosis are known to have an abnormal coagulation status, which is a particular concern when planning invasive procedures in which blood loss is possible or predictable. Careful consideration must be given to the bleeding risk for each individual patient and coagulation management strategies should be established in advance of procedural interventions, where possible. Perioperative clinical decision-making should utilize viscoelastic testing in addition to usual assessments, where possible, and focus on the well-established three pillars of patient blood management: optimization of erythropoiesis, minimization of bleeding and blood loss, and management of anemia...
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38281227/different-drugs-in-drug-eluting-stents-for-peripheral-artery-disease-a-systematic-evaluation-and-bayesian-meta-analysis
#15
REVIEW
Keqin Chen, Lei Xu, Xiehong Liu
Drug-eluting stents (DESs) have become the first-line treatment for symptomatic peripheral arterial disease (PAD). Currently, there are many types of DESs on the market. The same type of DESs has different concentrations, and various drugs in them show uneven efficacy. The selection of DESs remains controversial. This study was aimed at comparing the long-term real-world outcomes of different DESs in the treatment of peripheral arterial occlusive disease (PAOD). The databases including Cochrane Library, Embase, and PubMed were searched with a time frame until March 25, 2023...
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38281226/antiplatelet-therapy-in-elderly-patients-with-acs-moving-targets-need-more-tailored-treatments
#16
LETTER
Antonio Landi
No abstract text is available yet for this article.
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38280936/computed-tomography-based-radiomics-model-to-predict-adverse-clinical-outcomes-in-acute-pulmonary-embolism
#17
JOURNAL ARTICLE
Fei Yang, Rong Chen, Yue Yang, Zhixiang Yang, Yaying Su, Mengmeng Ji, Zhiying Pang, Dawei Wang
This preliminary study investigated the feasibility of a combined model constructed using radiomic features based on computed tomography (CT) and clinical features to predict adverse clinical outcomes in acute pulmonary embolism (APE). Currently, there is no widely recognized predictive model. Patients with confirmed APE who underwent CT pulmonary angiography were retrospectively categorized into good and poor prognosis groups. Seventy-four patients were randomized into a training (n = 51) or validation (n = 23) cohort...
January 28, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38265738/association-between-changed-self-rated-health-and-the-risk-of-venous-thromboembolism-in-malm%C3%A3-preventive-program-a-cohort-study
#18
JOURNAL ARTICLE
Peter Nymberg, Veronica Milos Nymberg, Susanna Calling, Gunnar Engström, Peter Svensson, Johan Elf, Bengt Zöller
Poor self-rated health (SRH) is associated with incident arterial cardiovascular disease in both sexes. Studies on the association between SRH and incident venous thromboembolism (VTE) show divergent results in women and no association in men. This study focuses on the association between change in SRH and incident VTE in a cohort of 11,558 men and 6682 women who underwent a baseline examination and assessment of SRH between 1974 and 1992 and a re-examination in 2002-2006. To investigate if changes in SRH over time affect the risk of incident VTE in men and women...
January 24, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38180591/effects-of-elevated-remnant-cholesterol-on-outcomes-of-acute-ischemic-stroke-patients-receiving-mechanical-thrombectomy
#19
JOURNAL ARTICLE
Mengmeng Li, Meng Wang, Yixin Zhao, Rui Zhong, Wanying Chen, Xiangyu Lei, Xiaoyu Wu, Jiaxin Han, Lei Lei, Qingfan Wang, Guogang Luo, Meng Wei
OBJECTIVE: Large cohort studies provided evidence that elevated remnant cholesterol (RC) was an important risk factor for ischemic stroke. However, the association between high RC and clinical outcomes in acute ischemic stroke (AIS) individuals was still undetermined. METHODS: This retrospective study enrolled 165 AIS patients undergoing mechanical thrombectomy in one tertiary stroke center. We divided patients into two groups based on the median of their RC levels (0...
January 5, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38180590/short-term-antiplatelet-versus-anticoagulant-therapy-after-left-atrial-appendage-closure-a-systematic-review-and-meta-analysis
#20
REVIEW
Qiang Zhou, Xiang Liu, Zhi-Chun Gu, Xian Yang, Xiao-Hui Huang, Yan-Zi Wu, Ying-Ying Tao, Meng Wei
This meta-analysis compared the efficacy and safety of different antithrombotic regimens after left atrial appendage closure (LAAC). PubMed, Embase, Medline, Cochrane Library databases were systematically searched from their inception to March 2023. Patients were divided into short-term oral anticoagulation (OAC) group and antiplatelet therapy (APT) group. The incidence of events were performed using RevMan 5.4. The events including device-related thrombus (DRT), ischemic stroke/systemic embolization (SE), major bleeding, any bleeding, any major adverse event and all-cause mortality...
January 5, 2024: Journal of Thrombosis and Thrombolysis
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