Bin Tong, Yaoqi Ba, Zhengyang Li, Caidi Yang, Kangtai Su, Haodong Qi, Deju Zhang, Xiao Liu, Yuting Wu, Yixuan Chen, Jitao Ling, Jing Zhang, Peng Yu, Xiaoping Yin
Alzheimer's and Parkinson's diseases are two of the most frequent neurological diseases. The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly manifests as motor dysfunction such as limb tremors, muscle rigidity abnormalities, and slow gait. Abnormalities in cholesterol, sphingolipid, and glycerophospholipid metabolism have been demonstrated to directly exacerbate the progression of AD by stimulating Aβ deposition and tau protein tangles. Indirectly, abnormal lipids can increase the burden on brain vasculature, induce insulin resistance, and affect the structure of neuronal cell membranes...
April 18, 2024: Neurobiology of Disease