journal
https://read.qxmd.com/read/38879763/predictive-analysis-of-yi-gai-san-s-multifaceted-mechanisms-for-tremor-dominant-parkinson-s-disease-via-network-pharmacology-and-molecular-docking-validation
#1
JOURNAL ARTICLE
Chih-Ting Lin, Lung-Yuan Wu, Fan-Shiu Tsai
INTRODUCTION: Based on comprehensive network-pharmacology and molecular docking analysis, this study was intended to unveil the multiple mechanisms of Yi-- Gai-San (YGS) in treating the tremor-dominant subtype of Parkinson's disease (PDDT). The compounds of YGS were meticulously analyzed, selected, and standardized with references to their pharmacological attributes. Its components included Gouteng (Uncaria rhynchophylla), Chaihu (Radix Bupleuri), Chuanxiong (Chuanxiong Rhizoma), Danggui (Angelicae Sinensis Radix), Fuling (Wolfiporia extensa), Baizhu (Atractylodis macrocephalae rhizoma), and Gancao (Licorice, Glycyrrhizae radix)...
June 14, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38879762/relationship-between-cellular-oxygen-consumption-and-atherosclerosis-associated-mitochondrial-mutations-variants-of-the-mitochondrial-genome
#2
JOURNAL ARTICLE
Alexander N Orekhov, Vasily V Sinyov, Mikhail Y Vyssokikh, Ludmila Manukhova, Maria V Marey, Plamena R Angelova, Andrey V Omelchenko, Andrey Y Vinokurov, Zukhra B Khasanova, Igor A Sobenin
BACKGROUND: Mitochondria are the main sites of cellular aerobic energy production through conjugation of respiration and oxidative phosphorylation. We have recently discovered mutations (genome variants) of mitochondrial DNA (mtDNA) associated with atherosclerosis. We have then investigated the possible mechanisms underlying such association and the role of mitochondrial mutations in atherogenesis. Mitochondrial dysfunction is a known component of the pathogenesis of chronic human diseases, including atherosclerosis...
June 14, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38877863/determination-of-inhibitory-effect-of-pkm2-enzyme-and-antitumoral-activity-of-novel-coumarin-naphthoquinone-hybrids
#3
JOURNAL ARTICLE
Amanda de A Borges, Gabriel Ouverney, Afonso T S Arruda, Amanda V Ribeiro, Ruan C B Ribeiro, Acácio S Souza, Anna Carolina C da Fonseca, Lucas N Nicolau de Queiroz, Elan C P de Almeida, Bruno Pontes, Vitor W Rabelo, Vitor F Ferreira, Paula A Abreu, Fernando de C da Silva, Luana da S M Forezi, Bruno K Robbs
BACKGROUND: Oral squamous cell carcinoma (OSCC) represents the primary form of oral cancer, posing a significant global health threat. The existing chemotherapy options are accompanied by notable side effects impacting patient treatment adherence. Consequently, the exploration and development of novel substances with enhanced anticancer effects and fewer side effects have become pivotal in the realms of biological and chemical science. OBJECTIVE: This work presents the pioneering examples of naphthoquinone-coumarin hybrids as a new category of highly effective cytotoxic substances targeting oral squamous cell carcinoma (OSCC)...
June 14, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38874036/computational-discovery-of-angiomirs-and-evaluating-the-synergistic-effects-of-target-mirna-with-tranexamic-acid-in-colorectal-cancer
#4
JOURNAL ARTICLE
Ali Ahmadizad Firouzjaei, Kazem Sharifee, Majid Khazaei, Samira Mohammadi-Yeganeh, Seyed Hamid Aghaee-Bakhtiari
INTRODUCTION: microRNA (miRNA) levels are dysregulated in many cancers, suggesting that miRNA-based therapy may be effective. The molecular pathways of colorectal cancer (CRC) development are unknown. METHOD: Understanding miRNAs implicated in CRC formation may reveal new diagnostic and therapeutic targets. Angiogenesis is a key mechanism in tumor growth. CRC treatment may involve inhibiting angiogenesis, but existing drugs can cause negative effects. Tranexamic acid, an FDA-approved medication, may reduce the adverse effects of angiogenesis inhibitors...
June 13, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38874035/multitargeted-docking-dft-based-optimisation-pharmacokinetics-and-md-simulation-reveal-6-oxidopamine-hbr-as-a-multitargeted-inhibitor-of-cervical-cancer-proteins
#5
JOURNAL ARTICLE
Yossef Saeed Alghamdi, Mutaib M Mashraqi, Ohud Alsalmi, Afaf Awwadh Alharthi, Amal F Gharib
BACKGROUND: Cervical cancer originates in the cervix, the lower part of the uterus, and results from the uncontrolled growth of abnormal cervical cells, forming malignant tumours. It poses a major global health challenge, calling for innovative drug design strategies to enhance treatment outcomes. METHOD: In this study, we have screened the FDA-approved drug library against four proteins, MCM10, MCM6, DNA polymerase epsilon subunit-2, and TBK1, which are essential for DNA replication, DNA repair, and cellular signalling pathways, which are dysregulated in cervical cancer cells, leading to uncontrolled growth...
June 13, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38867528/current-evidence-on-molecular-mechanisms-of-andrographolide-in-cancer
#6
JOURNAL ARTICLE
Dharam Chand Attri, Praveen Dhyani, Vijay Laxmi Trivedi, Eshita Sharma, Manshuk Ibrayeva, Arvind Jantwal, Priyanka Sati, Daniela Calina, Javad Sharifi-Rad
Cancer, a diverse group of diseases characterized by abnormal cell growth and the potential to spread throughout the body, accounts for approximately 10 million deaths globally each year. Current cancer therapies, including chemotherapy, radiation, and various pharmacological treatments, present several challenges and potential side effects. It is important to differentiate these conventional methods, which often involve synthetic drugs, from adjuvant therapies that might be used in conjunction. As a result, there is an increasing interest in alternative therapies, particularly in agents derived from natural sources for cancer treatment...
June 11, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38860910/biosensors-for-detection-of-hepatitis-b-virus-review
#7
JOURNAL ARTICLE
Amir Hossein Esfandiari, Hadis Hajipir Farkhani, Zahra Hashemi Javan, Arastoo Vojdani, Mahla Velayati, Hanie Mahaki, Zahra Meshkat, Hamed Manoochehri, Amir Avan, Hamid Tanzadehpanah
Hepatitis B is still one of the most important infectious diseases among humans, which is considered a serious threat to their lives. Early diagnosis of this disease can be an effective measure in stopping the chain of transmission and treatment of the disease. In this review study, an attempt has been made to explain the use of biosensors as a fast, high-efficiency, and low-cost method in diagnosis. The biosensors prepared for hepatitis detection included DNA-based, aptamers-based, protein-based, enzyme-based, antibody-based, and polymers-based biosensors, each of which had different advantages...
June 11, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38860908/medicinal-chemistry-of-antisense-oligonucleotides-for-therapeutic-use-in-sars-cov-2-design-strategies-and-challenges-for-targeted-delivery
#8
JOURNAL ARTICLE
Reza Nedaeinia, Maryam Ranjbar, Mohammad Goli, Mahmoud Etebari, Saied Safabakhsh, Hasan Bayram, Gordon A Ferns, Helena Moradiyan Tehrani, Rasoul Salehi
BACKGROUND: The evolution of novel Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) strains with greater degrees of infectivity, resistance to vaccine-induced acquired immunity, and more severe morbidity have contributed to the recent spread of COVID-19. In light of this, novel therapeutic alternatives with improved effectiveness and fewer side effects have become a necessity. Despite many new or repurposed antiviral agents recommended for Coronavirus disease (COVID-19) therapy, this objective remains unfulfilled...
June 11, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38860909/advances-in-small-molecule-dual-inhibitors-targeting-egfr-and-her2-receptors-as-anti-cancer-agents
#9
JOURNAL ARTICLE
Jia-Xiong Kang, Chao Li, Yi-Mei Cheng, Mou-Xin Huang, Guang-Kuan Zhao, Zhi-Liang Jin, Xiao-Wei Qi, Jing Gu, Qin Ouyang
As members of the protein tyrosine kinase family, the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor 2 (HER2) play essential roles in cellular signal transduction pathways. Overexpression or abnormal activation of EGFR and HER2 can lead to the development of various solid tumors. Therefore, they have been confirmed as biological targets for the development of anticancer drugs. Due to the fact that many cancers are highly susceptible to developing resistance to single-target EGFR inhibitors in clinical practice, dual inhibitors that target both EGFR and HER2 have been developed to increase efficacy, reduce drug resistance and interactions, and improve patient compliance...
June 10, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38860907/smart-cancer-nanomedicine-for-synergetic-therapy
#10
JOURNAL ARTICLE
Anwesha Kanungo, Chandana Mohanty, Sarbari Acharya
Cancer is the second leading cause of death. Notwithstanding endeavors to comprehend tumor causes and therapeutic modalities, no noteworthy advancements in cancer therapy have been identified. Nanomedicine has drawn interest for its diagnostic potential because of its ability to deliver therapeutic agents specifically to tumors with little adverse effects. Nanomedicines have become prevalent in the treatment of cancer. Here, we present four strategic suggestions for improvement in the functionality and use of nanomedicine...
June 10, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38847255/precise-molecular-subtyping-reveals-heterogeneity-of-lung-adenocarcinoma-based-on-dna-methylation
#11
JOURNAL ARTICLE
Jiaxin Shi, Mengyan Zhang, Mu Su, Bo Peng, Ran Xu, Chenghao Wang, Xiang Zhou, Yan Zhang, Linyou Zhang
BACKGROUND: Due to the high heterogeneity of lung adenocarcinoma (LUAD), which restricts the effectiveness of therapy, precise molecular subgrouping of LUAD is of great significance. Clinical research has demonstrated the significant potential of DNA methylation as a classification indicator for human malignancies. METHODS: WGML framework (which was developed based on weighted gene correlation network analysis (WGCNA), Gene Ontology (GO), and machine learning) was developed to precisely subgroup molecular subtypes of LUAD...
June 5, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38847254/synthesis-and-anti-gastric-cancer-activity-by-targeting-fgfr1-pathway-of-novel-asymmetric-bis-chalcone-compounds
#12
JOURNAL ARTICLE
Chunhui Nian, Xin Gan, Qunpeng Liu, Yuna Wu, Miaomiao Kong, Peiqin Zhang, Mingming Jin, Zhaojun Dong, Wulan Li, Ledan Wang, Wenfei He, Xiaokun Li, Jianzhang Wu
BACKGROUP: Bis-chalcone compounds with symmetrical structures, either isolated from natural products or chemically synthesized, have multiple pharmacological activities. Asymmetric Bis-chalcone compounds have not been reported before, which might be attributed to the synthetic challenges involved, and it remains unknown whether these compounds possess any potential pharmacological activities. AIMS: The aim of this study is to investigate the synthesis route of asymmetric bis-chalcone compounds and identify potential candidates with efficient anti-tumor activity...
June 5, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38847253/smart-physicochemical-triggered-chitosan-based-nanogels-for-sirna-delivery-and-gene-therapy-a-focus-on-emerging-strategies-and-paradigms-for-cancer-therapy
#13
JOURNAL ARTICLE
Seyed Morteza Naghib, Bahar Ahmadi, M R Mozafari
Cancer therapy has seen significant advancements in recent years, with the emergence of RNA interference (RNAi) as a promising strategy for targeted gene silencing. However, the successful delivery of small interfering RNA (siRNA) to cancer cells remains a challenge. Chitosan nanoparticles (CSNPs) can be derived from the natural polysaccharide chitin sources. CSNPs have gained considerable attention as a potential solution to encapsulate siRNA due to their biocompatibility, and biodegradability. This article explores the application of CSNPs for siRNA delivery in cancer therapy...
June 5, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38840391/early-onset-or-premature-coronary-artery-disease
#14
JOURNAL ARTICLE
Antonis A Manolis, Theodora A Manolis, Antonis S Manolis
The aim of this review was to examine the literature regarding younger individuals without classical risk factors for atherosclerosis who develop coronary artery disease (CAD) prematurely at an early age. An extensive literature review was undertaken in Pubmed, Scopus, and Google Scholar regarding early-onset or premature atherosclerosis, CAD, its diagnosis, management, and prophylaxis. There are individuals of both genders, particularly in the younger age group of 20-40 years of age, who lack the traditional/ classical risk factors and still develop CAD and other manifestations of atherosclerosis...
June 4, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38835129/circrna_0008668-sponges-mir-1301-3p-to-promote-the-inflammatory-response-in-allergic-rhinitis-by-upregulating-gata6-expression
#15
JOURNAL ARTICLE
Xiyan Xiao, Feng Zhai, Yue Yang, Jie Chen
AIMS: We aim to explore GATA6 modulation in allergic rhinitis (AR). BACKGROUND: Circular RNAs (circRNAs) and microRNAs (miRNAs) are involved in inflammatory responses; GATA6 is also known to regulate multiple inflammatory pathways. However, the mechanism of regulation of AR between them is unclear. OBJECTIVE: We expect that this study will provide new treatment options for AR from a GATA6 perspective. METHODS: In vitro, AR models were employed to examine the efficacy of our study, where we utilized monoclonal anti-2,4,6-dinitrophenyl immunoglobulin (Ig) E/human serum albumin (DNP-IgE/HSA) to induce rat basophilic leukemia cells (RBL-2H3 cells)...
June 3, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38831578/mouse-model-of-low-density-lipoprotein-desialylation-in-vivo
#16
JOURNAL ARTICLE
Dmitry Kashirskikh, Nelya Chicherina, Victor Glanz, Alexander Orekhov, Igor Sobenin
BACKGROUND: Atherosclerosis is a chronic disease characterized by the increased infiltration and retention of LDL particles in arterial walls. There are several mechanisms underlying atherogenesis, with the pro-atherogenic modifications of LDL playing a significant role. One such modification of native LDL is desialylation, which is characterized by the removal of terminal sialic acid from ApoB-100 glycans that induces critical changes in the overall functionality of the LDL particle...
May 31, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38818917/role-of-mmp-9-and-nf-%C3%AE%C2%BAb-in-diabetic-retinopathy-progression-and-potential-role-of-bioflavonoids-in-the-mitigation-of-diabetic-retinopathy
#17
JOURNAL ARTICLE
Ritu, Ramesh K Goyal, Sonia Narwal, Alok Bhatt, Renu Sehrawat, Pooja Devi, Monica Gulati, Rajeev K Singla
"Diabetes mellitus" is a chronic metabolic disorder manifested by elevated blood glucose levels, primarily due to insufficient insulin production or resistance to insulin. Long-term diabetes results in persistent complications like retinopathy, cardiomyopathy, nephropathy, and neuropathy, causing significant health risks. The most alarming microvascular consequence allied with diabetes is "diabetic retinopathy," distinguished by the proliferation of anomalous blood vessels in the eye, mainly in the retina, resulting in visual impairment, diabetic macular edema, and retinal detachment if left untreated...
May 30, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38818916/antimalarial-drug-discovery-from-natural-and-synthetic-sources
#18
JOURNAL ARTICLE
Nik Nur Solehah Fitri Nik Mohd Azam, Shatrah Othman, Yeun-Mun Choo
Malaria remains a significant global health threat despite extensive efforts aimed at its eradication. Numerous challenges persist in eliminating the disease, chief among them being the parasite's ability to mutate, resulting in drug resistance. The discovery of antimalarial drugs has relied on both phenotypic and target-based approaches. While phenotypic screening has identified promising candidates, target-based methods offer a more precise approach by leveraging chemically validated targets and computational tools...
May 30, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38818915/pioglitazone-alleviates-%C3%AE-1-adrenergic-receptor-antibody-induced-atrial-fibrillation-susceptivity-via-mitigation-of-ppar-%C3%AE-mediated-metabolic-inflexibility
#19
JOURNAL ARTICLE
Linqiang Xi, Huaxin Sun, Na Yang, Qianhui Wang, Ling Zhang, Jie Song, Dilare Taiwaikuli, Luxiang Shang, Xian Hui Zhou
BACKGROUND: Beta-1-adrenergic receptor antibodies (β1-AAbs) function as arrhythmogenic molecules in autoimmune-related atrial fibrillation (AF). This study examined the potential impact of pioglitazone, an agonist for peroxisome proliferator-activated receptor-γ (PPAR-γ), on atrial remodeling induced by β1-AAbs. METHODS: An in vivo study was performed to confirm the protective effects of pioglitazone on β1- AAbs-induced atrial remodeling...
May 30, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38808714/feline-leishmaniasis-evidence-based-treatments-and-challenges-to-be-solved
#20
JOURNAL ARTICLE
Caroline de Jesus Sousa, Joilson Ferreira Batista, Amanda Karoliny Figueredo Brito, Nathália Castelo Branco Barros, Simone Santiago Carvalho de Oliveira, Marta Helena Branquinha, Maria do Socorro Pires E Cruz, Ivete Lopes de Mendonça, André Luis Souza Dos Santos
Leishmaniasis is a neglected tropical disease caused by protozoa parasites from the Leishmania genus. Vertebrate hosts acquire the infection through the bite of a female sandfly, initiating a complex parasite development cycle. Contrary to previous beliefs regarding cats' resistance, these animals have recently been identified as potential reservoirs for leishmaniasis. Clinical symptoms in cats can manifest in diverse forms, including cutaneous, mucocutaneous, and visceral manifestations. The diagnosis of feline leishmaniasis is complicated by nonspecific symptoms and the relatively lower specificity of serological tests...
May 28, 2024: Current Medicinal Chemistry
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