journal
https://read.qxmd.com/read/37287289/polyphenolic-nano-formulations-a-new-avenue-against-bacterial-infection
#1
JOURNAL ARTICLE
Faegheh Farhadi, Samira Eghbali Friz, Sousan Torabi Parizi, Tannaz Jamialahmadi, Eric Gumpricht, Amirhossein Sahebkar
The gradual emergence of new bacterial strains impervious to one or more antibiotics necessitates discovering and applying natural alternatives. Among natural products, various polyphenols exhibit antibacterial activity. However, polyphenols with biocompatible and potent antibacterial characteristics are limited due to low aqueous solubility and bioavailability; therefore, recent studies are considering new polyphenol formulations. Nanoformulations of polyphenols, especially metal nanoparticles, are currently being investigated for their potential antibacterial activity...
June 7, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37287288/ginsenoside-rg1-suppresses-ferroptosis-of-renal-tubular-epithelial-cells-in-sepsis-induced-acute-kidney-injury-via-the-fsp1-coq10-nad-p-h-pathway
#2
JOURNAL ARTICLE
Jun Guo, Long Chen, Min Ma
INTRODUCTION: Sepsis-induced acute kidney injury is related to an increased mortality rate by modulating ferroptosis through ginsenoside Rg1. In this study, we explored the specific mechanism of it. METHODS: Human renal tubular epithelial cells (HK-2) were transfected with oe-ferroptosis suppressor protein 1 and treated with lipopolysaccharide for ferroptosis induction, and they were then treated with ginsenoside Rg1 and ferroptosis suppressor protein 1 inhibitor...
June 7, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37287287/effects-of-dietary-flavonoids-on-the-metabolism-of-vortioxetine-and-its-potential-mechanism
#3
JOURNAL ARTICLE
Yuxian Lin, Yu Wang, Zhize Ye, Nanyong Gao, Ren-Ai Xu, Lei Ye, Qinghua Weng, Xinhao Xu
INTRODUCTION: Quercetin and apigenin are two common dietary flavonoids widely found in foods and fruits. Quercetin and apigenin can act as the inhibitors of CYP450 enzymes, which may affect the pharmacokinetics of clinical drugs. Vortioxetine (VOR), approved for marketing by the Food and Drug Administration (FDA) in 2013, is a novel clinical drug for treating major depressive disorder (MDD). OBJECTIVE: This study aimed to evaluate the effects of quercetin and apigenin on the metabolism of VOR in in vivo and in vitro experiments...
June 7, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37287286/paste-blockade-of-the-lipid-phenotype-of-prostate-cancer-as-metabolic-therapy-a-theoretical-proposal
#4
JOURNAL ARTICLE
Adriana Romo-Perez, Guadalupe Domínguez-Gómez, Alma Chávez-Blanco, Aurora González-Fierro, José Correa-Basurto, Alfonso Dueñas-González
BACKGROUND: Prostate cancer is the most frequently diagnosed malignancy in 112 countries and is the leading cause of death in eighteen. In addition to continuing research on prevention and early diagnosis, improving treatments and making them more affordable is imperative. In this sense, the therapeutic repurposing of low-cost and widely available drugs could reduce global mortality from this disease. The malignant metabolic phenotype is becoming increasingly important due to its therapeutic implications...
June 7, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37287285/an-updated-review-on-the-significance-of-dna-and-protein-methyltransferases-and-de-methylases-in-human-diseases-from-molecular-mechanism-to-novel-therapeutic-approaches
#5
JOURNAL ARTICLE
Mohammad Ghanbari, Negin Sadi Khosroshahi, Maryam Alamdar, Adel Abdi, Aida Aghazadeh, Mohammad Pourfeizi, Mehdi Haghi
Epigenetic mechanisms are crucial in regulating gene expression. These mechanisms include DNA methylation and histone modifications, like methylation, acetylation, and phosphorylation. DNA methylation is associated with gene expression suppression; however, histone methylation can stimulate or repress gene expression depending on the methylation pattern of lysine or arginine residues on histones. These modifications are key factors in mediating the environmental effect on gene expression regulation. Therefore, their aberrant activity is associated with the development of various diseases...
June 7, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37282653/association-of-body-mass-index-and-abdominal-obesity-with-incidence-of-atrial-fibrillation-in-heart-failure-with-preserved-ejection-fraction
#6
JOURNAL ARTICLE
Xinyi Huang, Xiao Liu, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Zhiteng Chen, Runlu Sun, Peng Yu, Jianyong Ma, Wengen Zhu, Yangxin Chen, Guifu Wu, Yuling Zhang, Jingfeng Wang
INTRODUCTION: The association between obesity and atrial fibrillation (AF) incidence in heart failure with preserved ejection fraction (HFpEF) patients is currently unclear. Our analyses and results are based on the whole Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial (placebo and spironolactone). METHOD: A total of 2138 subjects without baseline AF were included in the trial. Kaplan-Meier (K-M) curves and Cox regression with hazard ratios (HRs) and confidence intervals (CIs) were used to assess the incidence of AF with obesity...
June 6, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37282570/identification-of-a-novel-diagnosis-model-based-on-5-hub-genes-for-chronic-thromboembolic-pulmonary-hypertension
#7
JOURNAL ARTICLE
Feng Zhang, Xiaoming Huang, Junqi Lin, Ruilin Yu, Shaoming Lin, Guanle Shen, Wenbiao Chen
BACKGROUND: As a type of precapillary pulmonary hypertension, chronic thromboembolic pulmonary hypertension (CTEPH) results from incomplete pulmonary embolism resolution. In this study, we aimed to determine biomarker genes for predicting the prognosis of CTEPH. METHOD: RNAseq of CTEPH was collected from the public database, namely Gene Expression Omnibus (GEO), including GSE84538 and GSE188938, which combined a dataset (GSE). Differentially expressed genes (DEG) or miRNA (DEM) were identified by limma package...
June 5, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37278037/the-effects-of-curcumin-on-brain-derived-neurotrophic-factor-expression-in-neurodegenerative-disorders
#8
JOURNAL ARTICLE
Shabnam Radbakhsh, Alexandra E Butler, Seyed Adel Moallem, Amirhossein Sahebkar
Brain-Derived Neurotrophic Factor (BDNF) is a crucial molecule implicated in plastic modifications related to learning and memory. The expression of BDNF is highly regulated, which can lead to significant variability in BDNF levels in healthy subjects. Changes in BDNF expression might be associated with neuropsychiatric diseases, particularly in structures important for memory processes, including the hippocampus and parahippocampal areas. Curcumin is a natural polyphenolic compound that has great potential for the prevention and treatment of age-related disorders by regulating and activating the expression of neural protective proteins such as BDNF...
June 2, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37272467/computational-protein-design-where-it-goes
#9
JOURNAL ARTICLE
Binbin Xu, Yingjun Chen, Weiwei Xue
Proteins have been playing a critical role in the regulation of diverse biological processes related to human life. With the increasing demand, functional proteins are sparse in this immense sequence space. Therefore, protein design has become an important task in various fields, including medicine, food, energy, materials, etc. Directed evolution has recently led to significant achievements. Molecular modification of proteins through directed evolution technology has significantly advanced the fields of enzyme engineering, metabolic engineering, medicine, and beyond...
June 2, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37259937/novel-pyrimidin-4-yl-3-amino-pyrrolo-3-4-c-pyrazoles-as-protein-kinase-c-inhibitors-for-treating-diseases
#10
JOURNAL ARTICLE
Surya K De
This patent describes the series of compounds and their pharmaceutically acceptable salts, such as compound K7 (as a representative potent compound). These protein kinase C selective inhibitors are useful for treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease, dermatological disease pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.
May 31, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37259936/role-of-circular-rnas-in-prostate-cancer
#11
JOURNAL ARTICLE
Feng Chen, Fa Zhang, Yong-Qiang Liu, Yu-Fang Leng
OBJECTIVES: This study aims to summarize the current literature to demonstrate the importance of circular RNAs (circRNAs) in multiple aspects of prostate cancer (PCa) occurrence, progression, and treatment resistance and explore the potential role in therapeutic strategies aimed at targeting this molecule in PCa. METHODS: The relevant literature from PubMed and Medline databases is reviewed in this article. RESULTS: Non-coding RNA has been proven to play a vital role in regulating tumor progression...
May 31, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37231753/setd1a-mediated-methylation-of-h3k4me3-inhibits-ferroptosis-in-non-small-cell-lung-cancer-by-regulating-the-wtapp1-wtap-axis
#12
JOURNAL ARTICLE
Dao Wang, Yukun Zu, Wei Sun, Xiaowu Fan
INTRODUCTION: SETD1A is upregulated in non-small cell lung cancer (NSCLC) tissues. This study investigated the molecular mechanism of the SETD1A/WTAPP1/WTAP axis in NSCLC. METHODS: Ferroptosis is a unique cell death mode driven by iron-reliant phospholipid peroxidation, which is regulated by multiple cellular metabolic pathways, including REDOX homeostasis, iron metabolism, mitochondrial activity and metabolism of amino acids, lipids and sugars. Thus, the levels of ferroptosis markers (MDA, SOD, GSH) were measured in vitro, and NSCLC cell behaviors were assessed...
May 25, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37231730/pyrazolo-4-3-h-quinazolines-as-cyclin-dependent-kinase-inhibitors-for-treating-cancer
#13
JOURNAL ARTICLE
Surya K De
The application describes the synthesis of 1H-pyrazolo[4,3-H]quinazoline compounds for treating cell proliferation dysfunction and is a broad-spectrum and strongly-active inhibitor for a cell cyclin-dependent kinase (CDK).
May 25, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37231729/drug-delivery-systems-based-in-microneedles-for-dermatological-diseases-and-aesthetic-enhancement
#14
JOURNAL ARTICLE
Mariane Massufero Vergilio, James Caradoc Birchall, Lonetá Lauro Lima, Rodrigo Alvarenga Rezende, Gislaine Ricci Leonardi
Microneedle (MN) devices comprise of micron-sized structures that circumvent biological barriers in a minimally invasive manner. MN research continues to grow and evolve; the technology was recently identified as one of the top ten overall emerging technologies of 2020. There is a growing interest in using such devices in cosmetology and dermatological conditions where the MNs mechanically disrupt the outer skin barrier layer, creating transient pathways that allow the passage of materials to underlying skin layers...
May 25, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37226795/berberine-decreases-thrombosis-potential-induced-by-a-high-choline-diet-by-inhibiting-cutc-enzyme
#15
JOURNAL ARTICLE
Hua Qu, Ying Zhang, Jun-He Shi, Yi-Han Zhao, Jie Gao, Zhu-Ye Gao, Da-Zhuo Shi
INTRODUCTION: Gut microbes influence thrombosis potential by generating trimethylamine N-oxide (TMAO). However, whether the antithrombotic effect of berberine is associated with TMAO generation remains unclear. OBJECTIVE: The present study was designed to explore whether berberine decreases the TMAO-induced thrombosis potential and the possible mechanism underneath it. METHODS: C57BL/6J female mice under a high-choline diet or standard diet were treated with/without berberine for 6 weeks...
May 24, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37226794/zingiber-pfficinale-roscoe-ginger-and-its-bioactive-compounds-in-diabetes-a-systematic-review-of-clinical-studies-and-insight-of-mechanism-of-action
#16
JOURNAL ARTICLE
Ashraf N Abdalla, Asaad Khalid, Alanood S Algarni, Bao Le Van, Gokhan Zengin, Muhammad Zakariyyah Aumeeruddy, Mohamad Fawzi Mahomoodally
Background Zingiber officinale Roscoe (Ginger) belongs to the Zingiberaceae family, which is renowned for its rich nutritional and phytochemical composition, and has been validated for its anti-diabetic and anti-inflammatory properties via in vitro, in vivo, and clinical studies. Nonetheless, a comprehensive review of these pharmacological studies, especially clinical studies, together with an analysis of the mechanism of action of the bioactive compounds is still lacking. This review provided a comprehensive and updated analysis of the anti-diabetic efficacy of Z...
May 24, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37226793/meta-analysis-of-the-impact-of-bariatric-surgery-on-circulating-tmao-levels-as-a-predictor-of-cardiovascular-disease-risk
#17
Tannaz Jamialahmadi, Luis E Simental-Mendia, Gokhan Zengin, Wael Almahmeed, Prashant Kesharwani, Amirhossein Sahebkar
INTRODUCTION: Trimethylamine N-oxide (TMAO) is a metabolite of the gut microbiota that is considered a cardiovascular risk factor. Because bariatric surgery (BS) produces changes in the composition of the gut microbiota, the production of TMAO can be compromised. Thus, the purpose of this meta-analysis was to determine the effect of BS on circulating TMAO levels. METHODS: A systematic search was carried on in Embase, PubMed, Web of Science, and Scopus databases...
May 23, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37226792/efficacy-of-the-novel-formulation-of-topical-liothyronine-and-liothyronine-insulin-in-mild-to-moderate-diabetic-foot-ulcer-a-randomized-triple-blind-clinical-trial
#18
JOURNAL ARTICLE
Fatemeh Saghafi, Saeed Hossein Khalilzadeh, Vahid Ramezani, Fatemeh Pasandeh, Hossein Fallahzadeh, Adeleh Sahebnasagh
BACKGROUND: Diabetic foot ulcer (DFU) is one of the challenging complications of chronic diabetes. OBJECTIVE: The study aimed to investigate whether liothyronine (T3) and liothyronine-insulin (T3/Ins) topical preparations could significantly reduce the healing time of DFU. METHODS: A prospective, randomized, placebo-controlled, patient-blinded clinical trial was conducted on patients with mild to moderate DFU, over a lesion area of no greater than 100 cm2...
May 23, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37226791/neuroprotective-properties-of-antiepileptics-what-are-the-implications-for-psychiatric-disorders
#19
JOURNAL ARTICLE
Liliana Dell'Osso, Benedetta Nardi, Leonardo Massoni, Davide Gravina, Francesca Benedetti, Ivan Mirko Cremone, Barbara Carpita
Since the discovery of the first antiepileptic compound, increasing attention has been paid to antiepileptic drugs (AEDs), and recently, with the understanding of the molecular mechanism underlying cells death, a new interest has revolved around a potential neuroprotective effect of AEDs. While many neurobiological studies in this field have focused on the protection of neurons, growing data are reporting how exposure to AEDs can also affect glial cells and the plastic response underlying recovery; however, demonstrating the neuroprotective abilities of AEDs remains a changeling task...
May 23, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37221682/linc00891-promotes-tumorigenesis-and-metastasis-of-thyroid-cancer-by-regulating-smad2-3-via-ezh2
#20
JOURNAL ARTICLE
Yuhao Si, Jialiang Wen, Chunlei Hu, Hao Chen, Lizhi Lin, Yiying Xu, Disuo Ren, Xinyu Meng, Yinghao Wang, Erjie Xia, Adheesh Bhandari, Ouchen Wang
BACKGROUND: Thyroid cancer (TC), the most common endocrine malignant tumor, is increasingly causing a huge threat to our health nowadays. METHODS: To explore the tumorigenesis mechanism of thyroid cancer, we identified that long intergenic non-coding RNA-00891 (LINC00891) was upregulated in TC using the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and local databases. LINC00891 expression correlated with histological type and lymph node metastasis (LNM)...
May 22, 2023: Current Medicinal Chemistry
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