Geir Bjørklund, Yuliya Semenova, Afaf El-Ansary, Laila Y Al-Ayadhi
Numerous studies demonstrated that the number of children with autism spectrum disorder (ASD) has increased remarkably in the past decade. A portion of ASD etiology, however, is attributed to environmental issues and genetic disorders. We highlighted a scoping review to principally evaluate the current information on mercury exposure in ASD children and to reveal knowledge gaps. Elevated porphyrins concentration in the urinary system related to mercury exposure, such as precoproporphyrin (prcP), coproporphyrin (cP), and pentacarboxyporphyrin (5cxP), was shown in comparison with controls...
November 29, 2023: Current Medicinal Chemistry
Annabelle Trojan, Yu Chun Lone, Ignacio Briceno, Jerzy Trojan
OBJECTIVE: Vaccines for the deadliest brain tumor - glioblastoma (GBM) - are generally based on targeting growth factors or their receptors, often using antibodies. The vaccines described in the review were prepared to suppress the principal cancer growth factor - IGF-I, using anti-gene approaches either of antisense (AS) or of triple helix (TH) type. Our objective was to increase the median survival of patients treated with AS and TH cell vaccines. METHODOLOGY: The cells were transfected in vitro by both constructed IGF-I AS and IGF-I TH expression episomal vectors; part of these cells was co-cultured with plant phytochemicals, modulating IGF-I expression...
November 28, 2023: Current Medicinal Chemistry
Mohammad A Khanfar, Mohammad I Saleh
BACKGROUND: The main protease (Mpro) is a crucial enzyme for the life cycle of SARS-CoV-2 and a validated target for the treatment of COVID-19 infection. Natural products have been a proper alternative for treating viral diseases by modulating different steps of the life cycle of many viruses. OBJECTIVE: This review article is designed to summarize the cumulative information of natural-derived Mpro inhibitors that are validated by experimental biological testing...
November 27, 2023: Current Medicinal Chemistry
Changxuan Deng, Nan Zhang, Hanlin Lin, Wangting Lu, Fei Ding, Yangguang Gao, Yongmin Zhang
α-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase inhibitors are mostly discovered from plants and microorganisms, the recent advance in natural αglucosidase inhibitors over the past five years has been reviewed in this article, and 139 distinct α-glucosidase inhibitors from the plants and microorganisms were classified into ten groups based on their chemical structures, including flavonoids (34), xanthones (6), alkaloids (8), benzopyrones / benzofuranones (8), terpenes (23), saponins (8), phenols / alcohols (25), esters (18), chalcone (5) and other compounds (4)...
November 27, 2023: Current Medicinal Chemistry
Rawan Mackieh, Nadia Al-Bakkar, Milena Kfoury, Nathalie Okdeh, Hervé Pietra, Rabih Roufayel, Christian Legros, Ziad Fajloun, Jean-Marc Sabatier
Fasting has gained significant attention in recent years for its potential health benefits in various body systems. This review aims to comprehensively examine the effects of fasting on human health, specifically focusing on its impact on different body's physiological systems. The cardiovascular system plays a vital role in maintaining overall health, and fasting has shown promising effects in improving cardiovascular health markers such as blood pressure, cholesterol levels, and triglyceride levels. Additionally, fasting has been suggested to enhance insulin sensitivity, promote weight loss, and improve metabolic health, thus offering potential benefits to individuals with diabetes and metabolic disorders...
November 24, 2023: Current Medicinal Chemistry
Guodong Liang, Yue Li, Ruijuan Li, Yuheng Ma, Heiya Na
SARS-CoV-2 has swept the world in recent years, triggering a global COVID-19 with a tremendous impact on human health and public safety. Similar to other coronaviruses, the six-helix bundle(6-HB) is not only a core structure driving the fusion of the SARS-CoV-2 envelope with the host cell membrane, but also the target of fusion inhibitors. The sequences from the HR1 or HR2 regions composing 6-HB are thus the original primary structures for the development of peptide-based fusion inhibitors. This review summarized the structure-activity relationship of the SARS-CoV-2 6- HB, analyzed the design methods and functional characteristics of peptide-based fusion inhibitors that contain different regions of HRs, and provided an outlook on the cutting- edge approaches for optimal modification of lead compounds (pan-coronavirization, chemical modification, superhelical construction, etc)...
November 24, 2023: Current Medicinal Chemistry
Zicheng Wang, Yanqing Liu, Zatollah Asemi
Cancer is known as a global problem for the health and economy. Following cancer onset, apoptosis is the primary mechanism countering the tumor cells' growth. Most anticancer agents initiate apoptosis to remove tumor cells. Phytochemicals have appeared as a beneficial treatment option according to their less adverse effects. In recent decades, quercetin has been highlighted due to its high pharmacological benefits, and various literature has suggested it as a potential anti-proliferative agent against different kinds of cancers...
November 24, 2023: Current Medicinal Chemistry
Xiaoyan Wang, Junqi Liu, Lakshmi Durga Yn, Narasimha M Beeraka, Runze Zhou, Pengwei Lu, Ruixia Song, Mikhail Sinelnikov, Kuo Chen, Ruitai Fan, Di Zhao
Conventional therapeutic modalities against the cancers such as surgery, chemotherapy (CT) and radiotherapy (RT) have limited efficacy due to drug resistance, and adverse effects. Recent developments in nanoscience emphasized novel approaches to overcome the aforementioned limitations and subsequently improve overall clinical outcomes in cancer patients. Photodynamic therapy (PDT), photothermal therapy (PTT), and radiodynamic therapy (RDT) can be used as cancer treatments due to their high selectivity, low drug resistance, and low toxicity...
November 24, 2023: Current Medicinal Chemistry
Yufei Zheng, Junqi Liu, Narasimha M Beeraka, Prasath Manogaran, Hemanth Vikram P R, Lakshmi Durga Yn, Shaik Mohammed Suhail, Bhupalam Pradeepkumar, Mikhail Y Sinelnikov, M V Greeshma, Mahesh P A, Namratha Mp, Gurupadayya Bannimath, Jie Zhao, Ruitai Fan
BACKGROUND: Chemoresistance by stemness in HPV-induced cervical carcinogenesis has significant implications for the overall disease-specific survival of the patients. To date, there are no reports related to the implications of significant aspects of inflammation and microbiome-- mediated epigenetics in cervical cancers. OBJECTIVE: The current systematic review delineates the significant aspects of the inflammation-related pathophysiology, cervical cancer diagnosis based on the HPV-indued stemness, and microbiome- mediated epigenetic markers to develop personalized therapies to target the stemness-acquired indefinitely dividing cancer stem cells...
November 24, 2023: Current Medicinal Chemistry
Emmanuel Androulakis, Syed Ahsan, Nikolaos Papageorgiou
No abstract text is available yet for this article.
November 24, 2023: Current Medicinal Chemistry
Mirjana Macvanin, Zoran Gluvic, Aleksandra Klisic, Mia Manojlovic, Jasjit Suri, Manfredi Rizzo, Esma Isenovic
Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden macrophages (foam cells) that secrete compounds involved in plaque formation...
November 16, 2023: Current Medicinal Chemistry
Xianguo Li, Junping Lei, Yongping Shi, Zuojie Peng, Minmin Gong, Xiaogang Shu
AIM: We screened key angiogenesis-related lncRNAs based on colon adenocarcinoma (COAD) to construct a RiskS-core model for predicting COAD prognosis and help reveal the pathogenesis of the COAD as well as optimize clinical treatment. BACKGROUND: Regulatory roles of lncRNAs in tumor progression and prognosis have been confirmed, but few studies have probed into the role of angiogenesis-related lncRNAs in COAD. OBJECTIVE: To identify key angiogenesis-related lncRNAs and build a RiskS-core model to predict the survival probability of COAD patients and help optimize clinical treatment...
November 13, 2023: Current Medicinal Chemistry
Trisha Bhatia, Shweta Sharma
Drug development is a complex and expensive process that involves extensive research and testing before a new drug can be approved for use. This has led to a limited availability of potential therapeutics for many diseases. Despite significant advances in biomedical science, the process of drug development remains a bottleneck, as all hypotheses must be tested through experiments and observations, which can be time-- consuming and costly. To address this challenge, drug repurposing has emerged as an innovative strategy for finding new uses for existing medications that go beyond their original intended use...
November 8, 2023: Current Medicinal Chemistry
Xianghe Li, Nuojin Li, Pingping Zhao, Dongyan Ren, Bin Luo, Tian Zhou
Perineuronal nets (PNN) is condensed extracellular matrix (ECM) in the central nervous system (CNS), which surrounds cell soma, axon initial segments, and synapses. In the brain, most neurons surrounded by PNN are interneurons, especially the parvalbumin-expressing interneurons (PVI). The formation of PNN is involved in the PVI maturation as well as the onset and closure of critical periods for developmental plasticity end. Dysfunction of PVI can lead to some neurological disorders, such as schizophrenia, bipolar depression, and Alzheimer's disease...
November 8, 2023: Current Medicinal Chemistry
Geir Bjørklund, Olha Storchylo, Massimiliano Peana, Tony Hangan, Roman Lysiuk, Larysa Lenchyk, Oleh Koshovyi, Halyna Antonyak, Nataliia Hudz, Salvatore Chirumbolo
BACKGROUND: Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti-inflammatory properties and potential therapeutic applications. OBJECTIVES: This narrative review explores the potential utility of CAPE in cancer treatment. METHODS: We comprehensively reviewed relevant studies from scientific databases (PubMed and Web of Science) from 2000 to 2022. Our search focused on keywords such as cancer, natural drugs, caffeic acid phenethyl ester, CAPE, cancer cell lines, antitumor effects, and propolis...
November 6, 2023: Current Medicinal Chemistry
Zai-Qun Liu
Nucleosides are sensitive sites towards oxidations caused by endogenous and exogenous oxidative resources, and a large number of the produced DNA lesions behave as pathogenesis event1ually. We herein analyze oxidative modes of nucleosides and structure-activity relationships of some clinical nucleoside drugs. Together with our previous findings on the inhibitory effects of nucleoside derivatives against DNA oxidation, all these results imply a possibility for nucleoside to be a new member in the family of antioxidants...
November 6, 2023: Current Medicinal Chemistry
Xiao Zheng, Cong Xu, Kumar Ganesan, Haiyong Chen, Yuen Shan Cheung, Jianping Chen
BACKGROUND: Breast cancer (BC) is one of the most common cancers in the world. Studies show that left-sided BC in pre and post-menopausal women leads to double the risk of worse morbidity and mortality and the reasons are uncertain. Finding the relationship between BC laterality and other possible risk factors can be advantageous for the prognosis of BC. OBJECTIVE: This present study aimed to analyze the relationship between BC laterality and possible risk factors...
November 6, 2023: Current Medicinal Chemistry
Cong Xu, Chen Zhang, Kumar Ganesan, Qiu Chen, Hailin Tang, Fei Gao, Qingqing Liu, Jianming Wu, Yue Sui, Peng Li, Jinming Zhang, Jianping Chen
INTRODUCTION: Triple-negative breast cancer (TNBC), an aggressive type of breast cancer, remains difficult to treat. Isoliquiritigenin (ISL) is a bioactive compound that is insoluble in water and exhibits significant anti-TNBC activity. METHOD: We previously prepared oral aqueous ISL@ZLH NPs; however, they were less stable in a freezing environment. Hence, the present study aimed to improve the stability of ISL@ZLH NPs using cryoprotectants that can withstand long storage times and are effective in TNBC treatment by creating an efficient oral drug delivery system...
November 3, 2023: Current Medicinal Chemistry
Na Li, Chen-Fu Liu, Wen Zhang, Guo-Wu Rao
K-Ras is a frequently mutated oncogene in human malignancies, and the development of inhibitors targeting various oncogenic K-Ras mutant proteins is a major challenge in targeted cancer therapy, especially K-Ras(G12C) is the most common mutant, which occurs in pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other highly prevalent malignancies. In recent years, significant progress has been made in developing small molecule covalent inhibitors targeting K-Ras(G12C), thanks to the production of nucleophilic cysteine by the G12C mutant, breaking the "spell" that K-Ras protein cannot be used as a drug target...
November 2, 2023: Current Medicinal Chemistry
Yingying Zhu, Bi Peng, Xiaoxiao Luo, Wei Sun, Dongbo Liu, Na Li, Ping Qiu, Guoxian Long
BACKGROUND: Head and neck squamous cell carcinoma (HNSC) is the seventh most common cancer worldwide. Although there are several options for the treatment of HNSC, there is still a lack of better biomarkers to accurately predict the response to treatment and thus be more able to correctly treat the therapeutic modality. METHODS: First, we typed cases from the TCGA-HNSC cohort into subtypes by a Bayesian non-negative matrix factorization (BayesNMF)-based consensus clustering approach...
November 2, 2023: Current Medicinal Chemistry
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.