journal
https://read.qxmd.com/read/38643713/taohe-chengqi-decoction-ameliorates-sepsis-induced-cardiac-dysfunction-through-anti-ferroptosis-via-the-nrf2-pathway
#1
JOURNAL ARTICLE
Si-Min Lu, Bo Yang, Zhang-Bin Tan, Hui-Juan Wang, Jun-di Xie, Meng-Ting Xie, Wei-Hao Jiang, Jin-Zhou Huang, Jun Li, Lei Zhang, Yong-Zhen Tan, Jing-Zhi Zhang, Bin Liu, Wei-Wei Wu, Shuang-Wei Zhang
BACKGROUND: Sepsis-induced cardiac dysfunction (SICD) is a serious complication of sepsis that is associated with increased mortality. Ferroptosis has been reported in the SICD. TaoHe ChengQi decoction (THCQD), a classical traditional Chinese medicinal formula, has multiple beneficial pharmacological effects. The potential effects of THCQD on the SICD remain unknown. PURPOSE: To investigate the effect of THCQD on SICD and explore whether this effect is related to the regulation of myocardial ferroptosis through nuclear factor erythroid 2-related factor 2 (Nrf2) activation...
April 20, 2024: Phytomedicine
https://read.qxmd.com/read/38643715/artificial-aging-conditions-for-artemisia-argyi-leaves-based-on-quality-inflammation-quality-marker-transformation
#2
JOURNAL ARTICLE
Xiuli Guo, DongPeng Wang, Yangxin Xiao, Huangliang Cao, Ding Yao, Gaoyuan Chen, Shuiqing Li, Guangzhong Wang, Jiyuan Tu, Yanju Liu
BACKGROUND: Appropriate conditions for storage of Artemisia argyi leaves reduce irritation during treatment and increase the active ingredient content. Naturally aged A. argyi leaves (≥1 year) are optimal for moxibustion; however, this process is time-consuming and costly. A comprehensive understanding of the conditions for artificial aging of A. argyi leaves and the mechanism of quality-marker conversion are required to guarantee A. argyi quality and moxibustion efficacy. OBJECTIVE: To identify the optimal conditions for artificial aging of A...
April 16, 2024: Phytomedicine
https://read.qxmd.com/read/38640861/lycium-barbarum-glycopeptide-ameliorates-motor-and-visual-deficits-in-autoimmune-inflammatory-diseases
#3
JOURNAL ARTICLE
Li Xu, Lu Yang, Huiming Xu, Yuhan Li, Fuhua Peng, Wei Qiu, Changyong Tang
BACKGROUND: Lycium barbarum glycopeptide (LbGp), extracted from the traditional Chinese medicine (TCM) of Lycium barbarum (LB), provides a neuroprotective effect against neurodegenerative and neuroimmune disorders contributing to its immunomodulatory and anti-inflammatory roles. Neuromyelitis optica spectrum disorders (NMOSD) is an autoimmune-mediated central nervous system (CNS) demyelinating disease, clinically manifested as transverse myelitis (TM) and optic neuritis. However, no drug has been demonstrated to be effective in relieving limb weakness and visual impairment of NMOSD patients...
April 16, 2024: Phytomedicine
https://read.qxmd.com/read/38643714/integrated-pharmacokinetic-properties-and-tissue-distribution-of-multiple-active-constituents-in-qing-yi-recipe-a-comparison-between-granules-and-decoction
#4
JOURNAL ARTICLE
Shurong Ma, Tianfu Wei, Biao Zhang, Yunshu Zhang, Jinwen Lai, Jialin Qu, Jianjun Liu, Peiyuan Yin, Dong Shang
BACKGROUND: Qing-Yi Recipe, a classic traditional Chinese medicine (TCM), is widely used for treating acute diseases of the abdomen, especially pancreatitis, the efficacy of which has been demonstrated in more than thirty clinical trials. However, the in-vivo pharmacodynamic material basis for this formula remains unclear. METHODS: A sensitive and accurate method for quantifying twenty-two potential bioactive constituents of Qing-Yi Recipe in biological samples was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and this method was fully validated...
April 15, 2024: Phytomedicine
https://read.qxmd.com/read/38640860/sijunzi-decoction-a-classical-chinese-herbal-formula-improves-fatigue-symptoms-with-changes-in-gut-microbiota-in-chronic-fatigue-syndrome-a-randomized-double-blind-placebo-controlled-multi-center-clinical-trial
#5
JOURNAL ARTICLE
Liang Dai, Zhidong Liu, Wenjuan Zhou, Li Zhang, Minjie Miao, Lei Wang, Haibing Hua, Bing Wang, Guang Ji
BACKGROUD: Chronic fatigue syndrome (CFS) severely impact patients' quality of life and lacks well-acknowledged drug therapy. Sijunzi decoction (SJZD), a classical Chinese herbal formula, has been widely used for spleen deficiency syndrome like fatigue in China. However, there is a lack of evidence on the efficacy of SJZD in treating CFS. PURPOSE: To evaluate the efficacy and safety of SJZD for CFS. STUDY DESIGN: A multi-center, double-blinded, randomized controlled trial...
April 13, 2024: Phytomedicine
https://read.qxmd.com/read/38640859/hydroethanolic-extract-of-cirsium-setidens-ameliorates-doxorubicin-induced-cardiotoxicity-by-ampk-pgc-1%C3%AE-sod-mediated-mitochondrial-protection
#6
JOURNAL ARTICLE
Ji-Hye Song, Min-Sun Kim, Seung-Hyun Lee, Jin-Taek Hwang, Soo-Hyun Park, Sahng Wook Park, Sae-Bom Jeon, Ru-Ri Lee, Jangho Lee, Hyo-Kyoung Choi
BACKGROUND: Doxorubicin (DOX) is an effective anticancer agent. However, the clinical outcomes of DOX-based therapies are severely hampered by their significant cardiotoxicity. PURPOSE: We investigated the beneficial effects of an ethanol extract of Cirsium setidens (CSE) on DOX-induced cardiomyotoxicity (DICT). METHODS: UPLC-TQ/MS analysis was used to identify CSE metabolite profiles. H9c2 rat cardiomyocytes and MDA-MB-231 human breast cancer cells were used to evaluate the effects of CSE on DICT-induced cell death...
April 12, 2024: Phytomedicine
https://read.qxmd.com/read/38640858/ginsenoside-rg5-inhibits-glioblastoma-by-activating-ferroptosis-via-nr3c1-hspb1-ncoa4
#7
JOURNAL ARTICLE
Guoqing Zhang, Jinpeng Hu, Ao Li, Haiying Zhang, Zhengting Guo, Xinqiao Li, Zinan You, Yongfeng Wang, Zhitao Jing
BACKGROUND: The utilization of Chinese medicine as an adjunctive therapy for cancer has recently gained significant attention. Ferroptosis, a newly regulated cell death process depending on the ferrous ions, has been proved to be participated in glioma stem cells inactivation. PURPOSE: We aim to study whether ginsenoside Rg5 exerted inhibitory effects on crucial aspects of glioma stem cells, including cell viability, tumor initiation, invasion, self-renewal ability, neurosphere formation, and stemness...
April 12, 2024: Phytomedicine
https://read.qxmd.com/read/38615493/gentisic-acid-prevents-colorectal-cancer-metastasis-via-blocking-gpr81-mediated-depdc5-degradation
#8
JOURNAL ARTICLE
Guize Feng, Lijie Zhang, Weilian Bao, Jiahui Ni, Yirui Wang, Yuran Huang, Jiaren Lyv, Xinyue Cao, Tongqing Chen, Keyuan You, Haroon Khan, Xiaoyan Shen
BACKGROUND: Metastasis driven by epithelial-mesenchymal transition (EMT) remains a significant contributor to the poor prognosis of colorectal cancer (CRC), and requires more effective interventions. GPR81 signaling has been linked to tumor metastasis, while lacks an efficient specific inhibitor. PURPOSE: Our study aimed to investigate the effect and mechanism of Gentisic acid on colorectal cancer (CRC) metastasis. STUDY DESIGN: A lung metastasis mouse model induced by tail vein injection and a subcutaneous graft tumor model were used...
April 10, 2024: Phytomedicine
https://read.qxmd.com/read/38614041/geniposide-ameliorates-atherosclerosis-by-restoring-lipophagy-via-suppressing-parp1-pi3k-akt-signaling-pathway
#9
JOURNAL ARTICLE
Jinhai Lin, Xiaolong Wang, Mingyang Gu, Yuanyuan Chen, Jiongbo Xu, Nhi Van Chau, Junlong Li, Xiaodong Ji, Qingmin Chu, Lijin Qing, Wei Wu
BACKGROUND: Atherosclerosis (AS) is the leading cause of global death, which manifests as arterial lipid stack and plaque formation. Geniposide is an iridoid glycoside extract from Gardenia jasminoides J.Ellis that ameliorates AS by mediating autophagy. However, how Geniposide regulates autophagy and treats AS remains unclear. PURPOSE: To evaluate the efficacy and mechanism of Geniposide in treating AS. STUDY DESIGN AND METHODS: Geniposide was administered to high-fat diet-fed ApoE-/- mice and oxidized low-density lipoprotein-incubated primary vascular smooth muscle cells (VSMCs)...
April 10, 2024: Phytomedicine
https://read.qxmd.com/read/38642413/targeting-cd8-t-cells-with-natural-products-for-tumor-therapy-revealing-insights-into-the-mechanisms
#10
REVIEW
Yuke Wang, Yan Zeng, Wenyong Yang, Xiuxuan Wang, Jingwen Jiang
BACKGROUND: Despite significant advances in cancer immunotherapy over the past decades, such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune checkpoint blockade (ICB), therapeutic failure resulting from various factors remains prevalent. Therefore, developing combinational immunotherapeutic strategies is of great significance for improving the clinical outcome of cancer immunotherapy. Natural products are substances that naturally exist in various living organisms with multiple pharmacological or biological activities, and some of them have been found to have anti-tumor potential...
April 8, 2024: Phytomedicine
https://read.qxmd.com/read/38614042/research-progress-of-the-mechanisms-and-applications-of-ginsenosides-in-promoting-bone-formation
#11
REVIEW
Ze Li, Yanan Li, Chaoran Liu, Yuqing Gu, Guanghong Han
BACKGROUND: Bone deficiency-related diseases caused by various factors have disrupted the normal function of the skeleton and imposed a heavy burden globally, urgently requiring potential new treatments. The multi-faceted role of compounds like ginsenosides and their interaction with the bone microenvironment, particularly osteoblasts can promote bone formation and exhibit anti-inflammatory, vascular remodeling, and antibacterial properties, holding potential value in the treatment of bone deficiency-related diseases and bone tissue engineering...
April 8, 2024: Phytomedicine
https://read.qxmd.com/read/38626646/genipin-ameliorates-diabetic-retinopathy-via-the-hif-1%C3%AE-and-ages-rage-pathways
#12
JOURNAL ARTICLE
Kexin Sun, Yanyi Chen, Shijie Zheng, Wenjuan Wan, Ke Hu
BACKGROUND: Traditional Chinese medicine (TCM) is useful in disease treatment and prevention. Genipin is an active TCM compound used to treat diabetic retinopathy (DR). In this study, a network pharmacology (NP)-based approach was employed to investigate the therapeutic mechanisms underlying genipin administration in DR. METHODS: The potential targets of DR were identified using the gene expression omnibus (GEO) database. TCM database screening and NP were used to predict the potential active targets and pathways of genipin in DR...
April 7, 2024: Phytomedicine
https://read.qxmd.com/read/38621328/aloe-emodin-alleviates-cerebral-ischemia-reperfusion-injury-by-regulating-microglial-polarization-and-pyroptosis-through-inhibition-of-nlrp3-inflammasome-activation
#13
JOURNAL ARTICLE
Xun Li, Minghe Yao, Lingling Li, Huifen Ma, Yiran Sun, Xiangpeng Lu, Weipeng Jing, Shanshan Nie
BACKGROUND: Microglial activation plays a crucial role in injury and repair after cerebral ischemia, and microglial pyroptosis exacerbates ischemic injury. NOD-like receptor protein 3 (NLRP3) inflammasome activation has an important role in microglial polarization and pyroptosis. Aloe-emodin (AE) is a natural anthraquinone compound originated from rhubarb and aloe. It exerts antioxidative and anti-apoptotic effects during cerebral ischemia/reperfusion (I/R) injury. However, whether AE affects microglial polarization, pyroptosis, and NLRP3 inflammasome activation remains unknown...
April 7, 2024: Phytomedicine
https://read.qxmd.com/read/38614043/natural-products-and-derivatives-for-breast-cancer-treatment-from-drug-discovery-to-molecular-mechanism
#14
REVIEW
Jing Zhang, Yongya Wu, Yanhong Li, Shutong Li, Jiaxi Liu, Xiao Yang, Guiyang Xia, Guan Wang
BACKGROUND: Breast cancer stands as the most common malignancy among women globally and a leading cause of cancer-related mortality. Conventional treatments, such as surgery, hormone therapy, radiotherapy, chemotherapy, and small-molecule targeted therapy, often fall short of addressing the complexity and heterogeneity of certain breast cancer subtypes, leading to drug resistance and metastatic progression. Thus, the search for novel therapeutic targets and agents is imperative. Given their low toxicity and abundant variety, natural products and their derivatives are increasingly considered valuable sources for small-molecule anticancer drugs...
April 7, 2024: Phytomedicine
https://read.qxmd.com/read/38614040/huangqin-decoction-attenuates-spared-nerve-injury-sni-induced-neuropathic-pain-by-modulating-microglial-m1-m2-polarization-partially-mediated-by-intestinal-nicotinamide-metabolism
#15
JOURNAL ARTICLE
Li Gao, Ai-Ping Zhang, Lei Fu, Qian-Wen Li, Xue-Mei Qin, Jing Zhao
BACKGROUND: The incidence of neuropathic pain is progressively increasing over time. The activation of M1-type microglia plays a crucial role in the initiation and progression of neuropathic pain. Huangqin Decoction (HQD) is traditionally used to alleviate dysentery and abdominal pain. However, it remains unclear whether HQD can effectively mitigate neuropathic pain and the underlying mechanisms. PURPOSE: The present study aims to investigate the impact of HQD on neuropathic pain induced by spared nerve injury (SNI) in mice, and to elucidate whether the analgesic effect of HQD is associated with microglia polarization...
April 7, 2024: Phytomedicine
https://read.qxmd.com/read/38621329/cartilage-protective-and-anti-edema-effects-of-jtf-in-osteoarthritis-via-inhibiting-ncoa4-hmgb1-driven-ferroptosis-and-aquaporin-dysregulation
#16
JOURNAL ARTICLE
Yudong Liu, Tengteng Xu, Zhaochen Ma, Chu Zhang, Mingzhu Xu, Qun Li, Weiheng Chen, Yanqiong Zhang, Chunfang Liu, Na Lin
BACKGROUND: Preventing joint edema is crucial in halting osteoarthritis (OA) progression. Growing clinical evidence indicate that Jianpi-Tongluo Formula (JTF) may have a promising anti-edema effect. However, the therapeutic properties of JTF and the underlying mechanisms remains unclear. MATERIALS AND METHODS: An OA rat model was established and employed to evaluate pharmacological effects of JTF in vivo based on dynamic histopathologic assessments and micro-CT observations...
April 6, 2024: Phytomedicine
https://read.qxmd.com/read/38608598/pectolinarigenin-ameliorates-osteoporosis-via-enhancing-wnt-signaling-cascade-in-ppar%C3%AE-dependent-manner
#17
JOURNAL ARTICLE
Jun Qian, Qian Li, Yangjie Song, Xuyan Gong, Kaili Hu, Guangbo Ge, Yao Sun
BACKGROUND: Osteoporosis is a prevalent metabolic bone disease in older adults. Peroxisome proliferator-activated receptor β (PPARβ), the most abundant PPAR isotype expressed in bone tissues, plays a critical role in regulating the energy metabolism of osteoblasts. However, the botanical compounds targeting PPARβ for the treatment of osteoporosis remain largely unexplored. PURPOSE: To discover a potent PPARβ agonist from botanical compounds, as well as to investigate the anti-osteoporosis effects and to elucidate the underlying mechanisms of the newly identified PPARβ agonist...
April 6, 2024: Phytomedicine
https://read.qxmd.com/read/38608597/bergenin-alleviates-proliferative-arterial-diseases-by-modulating-glucose-metabolism-in-vascular-smooth-muscle-cells
#18
JOURNAL ARTICLE
Yujie Song, Meng Deng, Yufeng Qiu, Yang Cui, Bing Zhang, Jialin Xin, Lele Feng, Xingdou Mu, Jun Cui, Hong Li, Yang Sun, Wei Yi
BACKGROUND: Vascular smooth muscle cell (VSMC) proliferation and phenotypic switching are key mechanisms in the development of proliferative arterial diseases. Notably, reprogramming of the glucose metabolism pattern in VSMCs plays an important role in this process. PURPOSE: The aim of this study is to investigate the therapeutic potential and the mechanism underlying the effect of bergenin, an active compound found in Bergenia, in proliferative arterial diseases...
April 6, 2024: Phytomedicine
https://read.qxmd.com/read/38608596/effects-of-natural-extract-interventions-in-prostate-cancer-a-systematic-review-and-network-meta-analysis
#19
JOURNAL ARTICLE
Haotian Huang, Jiao Qin, Zhi Wen, Yang Liu, Caixia Chen, Chongjian Wang, Hongyuan Li, Xuesong Yang
BACKGROUND: Over years, there has been a widespread quest for effective dietary patterns and natural extracts to mitigate prostate cancer risk. However, despite numerous experimental studies conducted on various natural extracts, the evidence substantiating their efficacy remains largely insufficient. This dearth of compelling evidence presents a significant challenge in advocating for their widespread use as preventive measures against prostate cancer. OBJECTIVE: Our study endeavors to undertake a network meta-analysis to evaluate the influence of natural extracts on prostate cancer...
April 6, 2024: Phytomedicine
https://read.qxmd.com/read/38636179/antidiabetic-action-of-the-chinese-formula-shouhuitongbian-and-the-underlying-mechanism-associated-with-alteration-of-gut-microbiota
#20
JOURNAL ARTICLE
Tao Wang, Huan Liao, Jinghan Lin, Mingkai Zhang, Baosong Chen, Ruopeng Yin, Jingzu Sun, Huanqin Dai, Hongwei Liu
BACKGROUND: The prevalence and incidence of type 2 diabetes mellitus (T2DM) have dramatically increased. The intestinal flora and its derived metabolites are demonstrated to play vital roles in the etiology and onset of T2DM. Shouhuitongbian (SHTB) is a traditional Chinese formula to treat constipation. SHTB is composed of seven herbs and components of Colla corii asini (CCA) that are obtained from the hide of Equus asinus L.. Some of herbs in SHTB such as Aloe vera (L.) Burm.f., Cassia obtusifolia L...
April 4, 2024: Phytomedicine
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