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Cancer Control: Journal of the Moffitt Cancer Center

Revital Azulay, Liora Valinsky, Fabienne Hershkowitz, Racheli Magnezi
BACKGROUND: Fecal occult blood tests are recommended for colorectal cancer screening, but are only effective if colonoscopy follows positive results. Patients with positive results often do not complete follow-up. This study examined the association between patient comprehension and adherence to colonoscopy after positive FIT (Fecal Immunochemical Test). METHODS: Five hundred twenty-two patients completed a telephone questionnaire regarding the FIT and its implications 120 days after a positive result...
January 2019: Cancer Control: Journal of the Moffitt Cancer Center
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January 2018: Cancer Control: Journal of the Moffitt Cancer Center
A E Zubidat, B Fares, F Fares, A Haim
Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Marjon Khairy, Duy K Duong, Salma Shariff-Marco, Iona Cheng, Jennifer Jain, Anupama Balakrishnan, Lynn Liu, Aarti Gupta, Ranjani Chandramouli, Ann Hsing, Ann Leung, Baldeep Singh, Viswam S Nair
Despite guidelines recommending annual low-dose computed tomography (LDCT) screening for lung cancer, uptake remains low due to the perceived complexity of initiating and maintaining a clinical program-problems that likely magnify in underserved populations. We conducted a survey of community providers at Federally Qualified Health Centers (FQHCs) in Santa Clara County, California, to evaluate provider-related factors that affect adherence. We then compared these findings to academic providers' (APs) LDCT screening knowledge, behaviors, and attitudes at an academic referral center in the same county...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Yanhua Wang, Tianyou Luo
Cervical cancer is the fourth most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Few single-nucleotide polymorphisms associated with risk of cervical cancer have been identified, yet genetic predisposition contributes significantly to this malignancy. Long noncoding RNA LINC00673 has been widely explored for its role in the development and prognosis of many tumors, and 2 genome-wide association studies identified that LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Yingying Du, Jin Wu, Le Luo
Small-cell lung cancer (SCLC) represents the progressive form of lung cancer. Patients with SCLC have poor prognosis, partially due to drug resistance. Therefore, understanding the underlying mechanism for drug resistance in SCLC is needed to improve clinical outcomes. The concentrations of heat shock protein 90α (HSP90α) in medium were detected by enzyme-linked immunosorbent assay. The protein levels were detected by Western blot. Cell apoptosis was detected by propidium iodide staining in cell lines or terminal deoxynucleotidyl transferase dUTP nick end labeling staining in tumor sections...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Niko Lietzén, Janne Pitkäniemi, Sirpa Heinävaara, Pauliina Ilmonen
Finding new etiological components is of great interest in disease epidemiology. We consider time series version of invariant coordinate selection (tICS) as an exploratory tool in the search of hidden structures in the analysis of population-based registry data. Increasing cancer burden inspired us to consider a case study of age-stratified cervical cancer incidence in Finland between the years 1953 and 2014. The latent components, which we uncover using tICS, show that the etiology of cervical cancer is age dependent...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Anna M Bielecka-Wajdman, Tomasz Ludyga, Grzegorz Machnik, Miłosz Gołyszny, Ewa Obuchowicz
A common feature of solid tumors, including glioblastoma multiforme (GBM), is mitochondrial dysfunction. However, it is reported that the current standard of anti-GBM therapies may potentiate mitochondrial damage and, in effect, support the aggressive character of cancer. As mitochondria are implicated in the modulation of cellular drug sensitivity and chemoresistance mechanisms, activation-stressed mitochondria in GBM cells may represent a new target for anti-GBM therapy that is nontoxic for normal cells. METHODS: As mitochondria are possible targets for antidepressant drugs used as adjuvant therapy in patients with GBM, we examined their influence on mitochondrial volume and activity, reactive oxygen species level, extracellular lactate concentration, and p65 NF-κB gene expression in GBM cells...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Li Yuanyue, Zulqarnain Baloch, Li Shanshan, Nafeesa Yasmeen, Wu Xiaomei, Jamal Muhammad Khan, Xia Xueshan
Cervical cancer (CC) has a high incidence and mortality and is accompanied by lack of organized CC screening programs, lack of health-care facilities, and a lack of human papillomavirus (HPV) vaccination among female population in the world, particularly China. We recruited 487 females who visited the outpatient department of the First People's Hospital of Yunnan Province from November 2015 to January 2016 to complete a standardized-designed questionnaire. We found that only 39.6% of the females knew about the role of HPVs in the development of cervical cancer...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Akinori Minato, Hirotsugu Noguchi, Ikko Tomisaki, Atsushi Fukuda, Tatsuhiko Kubo, Toshiyuki Nakayama, Naohiro Fujimoto
The prognostic value of squamous differentiation (SD) in urothelial carcinoma (UC) of the bladder is unclear. The aim of this study was to identify the clinical significance of SD in UC in terms of oncological outcomes in patients undergoing radical cystectomy (RC). We evaluated consecutive patients with muscle-invasive bladder cancer (MIBC; clinical T2-4aN0M0) treated with RC at our institution from March 2003 to March 2017. We enrolled 20 and 81 patients with UC with SD (UCSD) and pure UC, respectively. Postoperative survival outcomes were compared between the patients with UCSD and pure UC using the Kaplan-Meier method...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Nancy Rihana, Sowmya Nanjappa, Cara Sullivan, Ana Paula Velez, Narach Tienchai, John N Greene
The introduction of antiretroviral therapy (ART) in 1995 had a dramatic impact on the morbidity and mortality of the HIV population, and subsequently, the natural history of cancer has changed. The purpose of our study was to review the prevalence of AIDS-defining malignancies and non-AIDS defining cancers (NADC), taking into consideration racial and gender variations. After the institutional review board approval, the study was conducted as a retrospective chart review of 279 HIV-infected patients who were treated at the Moffitt Cancer Center between January 1, 2000 and December 31, 2010...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Erdem Sahin, Yusuf Madendag, Mefkure Eraslan Sahin, Ilknur Col Madendag, Gokhan Acmaz, Cıgdem Karakukcu, Hatice Karaman, Iptisam Ipek Muderris
PURPOSE: To evaluate cervical mucus secretory leukocyte protease inhibitor (SLPI) concentrations in patients with high-risk human papillomavirus (hrHPV) 16 or 18 positive and low-grade squamous intraepithelial lesions (LGSIL) or high-grade squamous intraepithelial lesions (HGSIL). METHOD: Patients with HPV 16 or 18 positive from 30 to 45 years of age whose cervical cancer screening results reported cytologically LGSIL or HGSIL were included in the study. In the control group, we included participants in the same age with cytology negative and HPV-negative healthy women...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Johanna H Yun, Roberto Diaz, Amber G Orman
PURPOSE: The optimal approach to the integration of postmastectomy reconstruction and radiation therapy is not well-established. This review will summarize current literature pertaining to the most common types of reconstruction in the setting of postmastectomy radiation therapy (PMRT). DATA SOURCES: Literature from PubMed was reviewed from 2000 to 2016. STUDY SELECTION: Studies were selected with relevance to "postmastectomy breast reconstruction," "breast reconstruction," and "breast reconstructive methods and PMRT...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Hsiu-Yin Chiang, Tung-Han Wu, Chiann-Yi Hsu, Wen-Cheng Chao
The number of patients with cancer being admitted to intensive care units (ICUs) is increasing worldwide, and these patients are vulnerable to infection. This study aimed to address the long-term impact of positive cultures during admission on 1-year mortality among patients with cancer who received perioperative intensive care. This retrospective cohort study enrolled adult patients with cancer who were admitted to ICUs and received surgery during 2011 to 2016 at a tertiary hospital in central Taiwan. Cancer-related data were retrieved from the cancer registry, and data during ICU admissions were obtained from the electronic medical records...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Monika Zajkowska, Monika Zbucka-Krętowska, Iwona Sidorkiewicz, Emilia Lubowicka, Grażyna Ewa Będkowska, Ewa Gacuta, Maciej Szmitkowski, Sławomir Ławicki
Cervical cancer (CC) remains a major diagnostic problem. The introduction of human papillomavirus vaccination significantly reduced the number of new cases; however, the search for new methods that would earlier indicate the development of cancerous changes is vital. The aim of this study was to investigate the diagnostic power of those parameters in comparison to Cancer Antigen 125 (CA 125) and Squamous Cell Carcinoma Antigen (SCC-Ag) in patients with CC and in relation to the control group. The study included 100 patients with CC and 50 healthy women...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Koichi Suyama, Hirotaka Iwase
Lenvatinib is a small-molecule tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet-derived growth factor receptor α (PDGFRα), stem cell factor receptor (KIT), and rearranged during transfection (RET). These receptors are important for tumor angiogenesis, and lenvatinib inhibits tumor angiogenesis by inhibiting function of these receptors. Phase I trials of lenvatinib were conducted at the same time in Japan, Europe, and the United States, and tumor shrinkage effects were observed in thyroid cancer, endometrial cancer, melanoma, renal cell carcinoma, sarcoma, and colon cancer...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Najla A Lakkis, Salim M Adib, Ghassan N Hamadeh, Rana T El-Jarrah, Mona H Osman
Lebanon has one of the highest estimated age-standardized incidence rate (ASR(w)) of bladder cancer (BC) worldwide. The aim of this study is to analyze the incidence rates for BC in Lebanon over a period of 7 years and to compare them to the rates in other countries. Data were obtained from the Lebanese National Cancer Registry for the currently available years 2005 to 2011. The calculated ASR(w) and age-specific rates were expressed as per 100 000 population. From 2005 to 2011, BC has been ranked as the third most common cancer in Lebanon...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Parul Agarwal, Erin Moshier, Meng Ru, Nisha Ohri, Ronald Ennis, Kenneth Rosenzweig, Madhu Mazumdar
The objectives of this study are to illustrate the effects of immortal time bias (ITB) using an oncology outcomes database and quantify through simulations the magnitude and direction of ITB when different analytical techniques are used. A cohort of 11 626 women who received neoadjuvant chemotherapy and underwent mastectomy with pathologically positive lymph nodes were accrued from the National Cancer Database (2004-2008). Standard Cox regression, time-dependent (TD), and landmark models were used to compare overall survival in patients who did or did not receive postmastectomy radiation therapy (PMRT)...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Alexis M Koskan, Madeline Fernandez-Pineda
This study explores understanding of primary and secondary prevention of anal cancer among human immunodeficiency virus (HIV)-infected foreign-born Latino gay and bisexual men (GBM). Between August 2015 and December 2016, researchers conducted 33 in-depth, semi-structured interviews with HIV-infected foreign-born Latino GBM. Interview questions sought to determine participants' knowledge and perceived barriers and facilitators to primary and secondary prevention of anal cancer. Researchers analyzed interview transcripts using a qualitative content analysis approach...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Huiyun Zhu, Si Chen, Pei Xie, Geliang Yang, Zhenqiang Zhong, Huiqing Zhang, Yiqi Du
Randomized controlled trials (RCTs) are important for evidence-based medicine; however, their quality of reporting remains to be evaluated. The aim of this study was to assess the quality of the report concerning solid tumor medication. Articles were searched in PubMed to identify all oncology phase III RCTs published from 2011 to 2015, and the results were classified manually through Endnote X7.0 software. Registration rate, primary end point (PEP) consistency, positive result rate, enrollment time point, outcome feedback in the registry, and publish time zone were extracted and assessed...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
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