QJM : Monthly Journal of the Association of Physicians

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BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is increasingly recognized as a chronic, progressive, and fatal lung disease with an unknown etiology. Current studies focus on revealing the genetic factors in the risk of IPF, making the integrative analysis of genetic variations and transcriptomic alterations of substantial value. AIM: This study aimed to improve the understanding of the molecular basis of IPF through an integrative analysis of whole-exome sequencing (WES), bulk RNA sequencing (RNA-seq), and single-cell RNA sequencing (scRNA-seq) data...

Posterior reversible encephalopathy syndrome(PRES) is an acute onset neurological disorder characterized by a variety of neurologic symptoms. Here we reported a case of lupus nephritis with posterior reversible encephalopathy syndrome as the first manifestation.

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Two brief patients' histories are presented to increase clinicians' awareness of the possible presentation of staphylococcus aureus bacteraemia as a metastatic infection of the sternal joints, without endocarditis and possibly without fever or a potential portal of entry. Referred shoulder pain often mimics a benign, chronic shoulder condition, with dangerous diagnostic delays. However, common point-tenderness over the sternoclavicular joint, and increased WBC and C-reactive protein will suggest the correct diagnosis to the practitioner, confirmed by CT imaging, even before results of blood cultures are received...

BACKGROUND: Purtscher-like retinopathy (PLR) is a rare ocular manifestation in systemic lupus erythematosus (SLE) with poor prognosis, but its clear risk factors and treatment consensus are still lacking. AIM: To investigate the clinical features, risk factors and prognosis of PLR in SLE patients. DESIGN AND METHODS: A retrospective analysis was conducted on SLE patients with PLR admitted at Peking Union Medical College Hospital from 2013 to 2022...

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A 38-year-old patient presented with decreased vision and was found to have right sided facial port-wine stain, telangiectasia of episcleral vessels, and posterior subcapsular cataract. Both eyes showed bone-spicule pigmentation throughout the fundus with arteriolar attenuation. He had a history of seizures and computed tomography (CT) scan of the brain revealed occipital lobe calcifications. This case describes an uncommon occurrence of rod cone dystrophy in a patient with Sturge Weber syndrome.

BACKGROUND: From November 2022 to February 2023, the Chinese mainland experienced a surge in COVID-19 infection and hospitalization, and the hospital-based healthcare workers (HCWs) might suffer serious psychological crisis during this period. This study aims to assess the depressive and anxiety symptoms among HCWs during the surge of COVID-19 pandemic, to provide possible reference on protecting mental health of HCWs in future infectious disease outbreaks. METHODS: A multicenter cross-sectional study was carried out among hospital-based HCWs in the Chinese mainland from January 5 to February 9, 2023...

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BACKGROUND: Short term in-hospital mortality following acute medical admission has been widely investigated. Longer term mortality, particularly out of hospital mortality, has been less well studied. AIM: To evaluate short and long-term mortality, and predictors of such, following acute medical admission. DESIGN: Retrospective database study. METHODS: We evaluated all acute medical admissions to our institution over 10 years (2002 -2011) with a minimum of a further 10 years follow-up to 2021 using the Irish National Death Register...

Facial trauma is a common occurrence; however, the first-line imaging tool, plain radiographs, has a low sensitivity in detecting facial bone fractures, leading to frequent misdiagnosis. We described the case of an old man who presented with right periorbital region pain and swelling noted after a fall. Through plain facial radiography, we identified a "black eyebrow sign," which is a pathological air collected in the superior aspect of the orbit, leading to the diagnosis of an occult orbital wall fracture...