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Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists

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https://read.qxmd.com/read/30509062/quiz-what-is-your-diagnosis
#1
I-Wei Chang, Mpendulo Felix Gule
No abstract text is available yet for this article.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509061/intramural-florid-cystic-endosalpingiosis-of-the-uterus-after-menopause
#2
Yui Hattori, Kazuhiro Sentani, Naoki Matsuoka, Hirofumi Nakayama, Takuya Hattori, Yoshiki Kudo, Wataru Yasui
Endosalpingiosis is a benign condition characterized by the presence of tubal epithelium outside the fallopian tube and the absence of endometrial stroma. Florid cystic endosalpingiosis is a very rare form of endosalpingiosis that presents as a tumor-like lesion. We report the case of a 67-year-old woman who presented with a cystic lesion of the uterus. Macroscopically, a cut section revealed a multicystic, whitish mass in the myometrium of the fundus. Histologically, the lesion consisted of numerous variably sized glands that were lined with a single or stratified layer of ciliated columnar cells similar to tubal epithelium...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509060/the-health-outcome-and-the-costs-of-primary-hpv-testing-with-dual-stain-cytology-triage-in-cervical-cancer-screening
#3
Wiebren A A Tjalma
No abstract text is available yet for this article.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509059/fatal-systemic-angiomatosis-with-widespread-sclerotic-skeletal-changes-diagnosed-with-the-aid-of-a-bone-marrow-biopsy-the-lymphatics-enter-the-bone-marrow
#4
Zbigniew Rudzki, Richard Lovell, Ben Miller, Vidhya Murthy, Shankara Paneesha, Guy Pratt, Neil Smith
A 56-year-old female presented with popliteal venous thrombosis, splenomegaly, and sclerotic bone lesions. Bone marrow biopsy showed fibrosis, proliferation of abnormal blood vessels and lymphatics, bone remodelling, and no significant changes in haematopoietic elements. Following a relatively indolent initial clinical course, one year later she rapidly deteriorated and died of respiratory failure associated with widespread disease. Ingrowth of podoplanin+ lymphatics mixed with CD34+/podoplanin- blood vessels into the bone marrow is a new finding and may be a unique feature of this disease...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509058/er-pr-subset-of-invasive-breast-carcinoma-ibc-a-distinct-phenotype-with-good-prognosis
#5
Simona Stolnicu, Orsolya Bauer, Adrian Naznean, Cristian Podoleanu, Rareş Georgescu
The expression of the estrogen (ER) and progesterone (PR) receptors in IBC patients represents a well-know prognostic and predictive factor. The existence of ER-/PR+ as a distinct phenotype, however, is controversial as well as is its prognostic significance. The aim of the study was to assess the incidence and prognosis in patients with ER-/PR+ IBC. One hundred and twelve patients with IBC were analyzed regarding ER/PR profile and survival. GraphPad prism 6 for Windows and Kaplan Mayer curve were used to determine overall survival (OS) and disease-free survival (DFS), with p < 0...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509057/peritoneal-fluid-stimulates-neoplastic-transformation-of-normal-hek-293-cells-by-high-expression-of-pluripotent-genes
#6
Ilona Szabłowska-Gadomska, Magdalena Ducher, Magdalena Orzechowska, Joanna Bogusławska-Duch, Magdalena Kowalska, Helena Poławska, Maciej Małecki
Gynecological cancers constitute a serious problem in the world. Their advanced stages are often characterized by the accumulation of ascites, which leads to spreading of cancer cells outside their primary focus. Despite progress in the treatment, prognoses are still not satisfactory. The main causes of these failures are chemoresistance, metastases and recurrences of the disease, which is influenced by, among others, the microenvironment of cancer cells. This study investigated the effect of the microenvironment, which create ascites derived from patients with ovarian and endometrial cancer to non-gynecological HEK 293 cells...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509056/histopathological-liver-findings-in-patients-with-hepatocerebral-mitochondrial-depletion-syndrome-with-defined-molecular-basis
#7
Maciej Pronicki, Dorota Piekutowska-Abramczuk, Dariusz Rokicki, Katarzyna Iwanicka-Pronicka, Wiesława Grajkowska
Mitochondrial DNA depletion consisting of the systemic reduction of mtDNA copy number in cells may have a heterogenous genetic basis, resulting from a pathogenic change in the nuclear genes involved in mtDNA synthesis. The mode of inheritance is autosomal recessive. Severe hepatocerebral disease represents one of many different clinical forms of so-called mitochondrial depletion syndrome (MDS). We present the liver histopathology of 13 children who eventually died in the course of hepatocerebral MDS confirmed molecularly, harbouring mutations of <i>DGUOK</i>, <i>MPV17</i>, and <i>POLG </i>genes...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509055/molecular-prognostic-factors-in-early-stage-cervical-adenocarcinoma
#8
Maciej Bodzek, Paweł Blecharz, Janusz Ryś, Wiktor Szatkowski, Marek Jasiówka, Paweł Majchrzak, Krzysztof Halaszka, Anna Kruczak, Bożena Lackowska
Within the past years the proportion of cervical adenocarcinomas has increased, however, there is a shortage of data regarding immunohistochemical and molecular features and their prognostic relevance in early-stage cervical adenocarcinoma (esCAC). Aim of the present study was to evaluate molecular prognostic factors in esCAC patients treated with primary surgery. Analyses of surgical specimens in 59 patients with esCAC were performed on fixed paraffin-embedded sections of tumour tissue. Tumour tissue sections were routinely stained with hematoxylin and eosin followed by microscopic examination...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509054/assessment-of-diagnostic-value-of-cytological-examination-in-lung-carcinoma-in-own-material-obtained-by-ebus-and-eus-methods
#9
Piotr Wiśniewski, Maciej Głogowski, Włodzimierz Olszewski
The aim of the study was the evaluation of the efficiency of cytological examination of the material obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound bronchoscope-guided fine needle aspiration (EUSB-FNA) methods in the diagnosis of lung carcinoma. The usefulness was also assessed of the material obtained in that way for immunocytochemical and molecular tests in the diagnosis of non-small cell lung carcinoma. The material included cytological preparations obtained by EBUS and EUS methods...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509053/effect-of-sinapic-acid-on-memory-deficits-and-neuronal-degeneration-induced-by-intracerebroventricular-administration-of-streptozotocin-in-rats
#10
Pouneh Shahmohamady, Akram Eidi, Pejman Mortazavi, Negar Panahi, Dariush Minai-Tehrani
The present study aimed to elucidate the neuroprotective effect of sinapic acid on intracerebroventricular streptozotocin (ICV-STZ) induced neuronal loss and memory impairment. To test this hypothesis, male Wistar rats were randomly divided into 11 groups: normal control, sham-operated control, sinapic acid (2.5, 5, 10, and 20 mg/kg bw intragastrically, daily) alone, Alzheimer control rats (ICV-STZ, 3 mg/kg bw), sinapic acid (2.5, 5, 10, and 20 mg/kg bw intragastrically, daily) together with STZ, and the treatment was performed accordingly...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509052/increased-angiogenesis-seems-to-correlate-with-inferior-overall-survival-in-myeloid-sarcoma-patients
#11
Pier P Piccaluga, Stefania Paolini, Mohsen Navari, Maryam Etebari, Giuseppe Visani, Stefano Ascani
Myeloid sarcomas (MS) are tumors composed by myeloid elements and developing outside bone marrow. The prognosis is overall poor, only stem cell transplantation being consistently reposted as a potentially curative approach. In this study we explored whether microvessel density, a biomarker of angiogenesis, might be relevant in MS. We studied 60 MS, 24 acute myeloid leukemia, 5 normal bone marrow samples and 2 cases of extramedullary hemopoiesis in patients without evidence of hematological malignancy. We used immunohistochemistry (anti-CD34) to identify and quantify micro-vessel density (MVD) and micro-vessel grading (MVG)...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509051/primary-ameloblastic-carcinoma-literature-review-with-case-series
#12
Sarah Ahmed Mohamed Mahmoud, Hatem Wael Amer, Sally Ibrahim Mohamed
Ameloblastic carcinoma (AC) is an extremely rare malignant odontogenic tumour arising from odontogenic epithelium. It was classified into primary type and secondary type. A previous study revealed that primary ameloblastic carcinoma cases were associated with more favourable prognosis than secondary cases. The aim of the present work was: to report the clinical, histopathological, immunohistochemical, and ploidy status, and therapeutic details of four cases of primary AC, and to review the literature with regard to clinical, follow-up, prognosis, histopathological, and immunohistochemical information of primary AC...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509050/the-prognostic-significance-of-androgen-receptor-and-%C3%AE-catenin-immunohistochemical-expression-in-urothelial-carcinoma-with-and-without-detrusor-muscle-invasion-from-an-egyptian-institution
#13
Shaimaa Elzamy, Abd Allah Ms, Wael Kandeel
Androgen receptor (AR) activation plays an important role in the promotion and progression of urothelial tumorigenesis. Also, dysregulation of the Wnt/β-catenin signaling pathway has also been linked to bladder cancer growth. However, cross talk between the two pathways in remains unclear in bladder cancer. This study investigated the prognostic significance of AR and β-catenin expression and their relationship to different clinic-pathological parameters, recurrence free and progression free survival. 106 urothelial carcinoma cases were used to study the immunohistochemical expression of AR and β-catenin...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509049/clinicopathological-characteristics-of-breast-sebaceous-adenocarcinoma
#14
Chen Heng, Tan Wei, Tu Yingbing, Liu Hanzhong
Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. The differences between the two cases are as follows: First, the mass in the first case had a mixed echo pattern on ultrasound, whereas that in the second case had a hypoechoic pattern...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509048/low-grade-fibromyxoid-sarcoma-of-the-extremities-a-clinicopathologic-study-of-24-cases-and-review-of-the-literature
#15
Andrea Sambri, Alberto Righi, Gianmarco Tuzzato, Davide Donati, Giuseppe Bianchi
Low-grade fibromyxoid sarcoma (LGFMS) and hybrid sclerosing epithelioid fibrosarcoma (SEF)/LGFMS have a low potential for recurrence (10%) and metastasis (5%) but they are notorious for late occurring metastases. The aim of this study was to evaluate the outcome of LGFMS and review similar cases reported in the literature. We retrospectively evaluated 24 LGFMS operated at a single Institution. All cases were histologically revised. Mean age was 34 years (range, 8 to 74). Two cases presented areas of SEF (hybrid tumours)...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509047/membranous-glomerulonephritis-a-common-unspecific-pattern-of-glomerular-injury
#16
Aleksandra Starzyńska-Kubicka, Agnieszka Perkowska-Ptasińska, Barbara Górnicka
Membranous nephropathy (MN) is a chronic form of glomerulonephritis, associated with the presence of immune complexes beneath the podocytes on the subepithelial region of glomerular capillaries. MN is not a disease entity but one of relatively common patterns of glomerular injury that may be a manifestation of primary renal autoimmunological reaction or may evolve as a phenomenon secondary to wide spectrum of systemic processes.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30509046/in-memoriam-professor-olga-mioduszewska
#17
Anna Porwit, Bogna Ziarkiewicz-Wróblewska, Jan Walewski
No abstract text is available yet for this article.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30351870/quiz-what-is-your-diagnosis
#18
Yui Hattori, Kazuhiro Sentani, Naoki Matsuoka, Hirofumi Nakayama, Takuya Hattori, Yoshiki Kudo, Wataru Yasui
No abstract text is available yet for this article.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30351869/intraoral-manifestation-of-systemic-al-amyloidosis-with-unique-microscopic-presentation-of-intracellular-amyloid-deposition-in-striated-muscles
#19
Zuzanna Oruba, Tomasz Kaczmarzyk, Katarzyna Urbańczyk, Artur Jurczyszyn, Szymon Fornagiel, Krystyna Gałązka, Anna Bednarczyk, Maria Chomyszyn-Gajewska
We report the history of a 59-year old patient with systemic AL amyloidosis of intraoral manifestation. The patient first presented with complaints about dysphagia and remarkable enlargement of the tongue with highly reduced mobility, as well as bilateral submucosal thickenings on the cheeks. Histopathological examination of the incisional biopsy of the buccal mucosa and underlying tissues revealed AL amyloidosis. The microscopic presentation was, however, unique, as the amyloid deposits were present intracellularly in the striated muscles...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30351868/dedifferentiated-endometrial-carcinoma-an-ongoing-diagnostic-dilemma
#20
Ameer Hamza, Sidrah Khawar, Warda Ibrar, Ramen Sakhi, Lamia Fathallah
Tumours of uterine corpus are the most common gynaecological malignancies. The clinicopathological features of most of these tumours are well understood; however, dedifferentiated endometrial carcinoma still requires a lot of research to establish adequate management guidelines. The entity was first described in 2006 and is an aggressive tumour with poor prognosis. We present two cases of this tumour with a literature review, emphasising morphologic and immunohistochemical features that may help in the differential diagnosis...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
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