Joanna Trubicka, Maria Łastowska, Agnieszka Karkucińska-Więckowska, Magdalena Niemira, Maria Ejmont, Agnieszka Sowińska, Maciej Pronicki, Ewa Matyja, Wiesława Grajkowska
BCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and germinoma, to assess a potential involvement of BCOR in these tumours...
2023: Folia Neuropathologica