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Folia Neuropathologica | Page 2

Sumit Das, Abdullah Ishaque
Argyrophilic grain disease (AGD) is a sporadic tauopathy and actually the second most frequent cause of dementia after Alzheimer's disease. Patients can present with slowly progressive cognitive decline as well as psychiatric manifestations such as depression. Definite diagnosis of AGD can only be made by post-mortem examination of the brain. Neuropathological features include argyrophilic grains in limbic areas along with oligodendroglial coiled bodies in hippocampal and amygdaloid white matter, and ballooned neurons in the amygdala...
2018: Folia Neuropathologica
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2018: Folia Neuropathologica
Eros Bruzzone, Ilaria Melloni, Salvina Barra, Giulio Fraternali Orcioni, Leonardo Cocito
We describe a rare case of intracranial malignant triton tumor (MTT) arising in the middle cranial fossa in a 74-year-old female patient who had previously been exposed to radiation in the Chernobyl disaster. The patient underwent a surgical subtotal removal of the mass and radiation therapy, but the progression-free survival was only 2.5 months and death occurred four months after the onset of symptoms. MTTs are rare aggressive tumors arising from the nerve sheath showing rhabdomyosarcomatous differentiation and associated with a poor prognosis...
2018: Folia Neuropathologica
Ali Sayyahi, Mehrdad Jahanshahi, Hossein Amini, Hamid Sepehri
M1 muscarinic receptor plays a fundamental role in memory and is closely associated with Alzheimer's disease (AD); it has long been assumed as a therapeutic goal. By activating of the cholinergic receptor vitamin E helps with memory retention. But effects of vitamin E on density of M1 muscarinic receptor-immunoreactive (ir) neurons remain poorly understood. The present research aimed to examine the chronic administration effect of vitamin E against scopolamine-induced memory loss and the number of M1 muscarinic receptor-ir neurons of the hippocampus in male rats...
2018: Folia Neuropathologica
Prathibha Maria D Almeida, Shobha Ullas Kamath, Pooja R Shenoy, Liegelin Kavitha Bernhardt, Anoop Kishore, Kiranmai Sesappa Rai
INTRODUCTION: Perinatal maternal separation stress (PMSS) induces brain lipid peroxidation and reduction in endogenous antioxidants. The present study was designed to assess the brain oxidative stress (MDA) and protein thiol levels through various stages of aging in PMSS rat pups supplemented with choline with docosahexaenoic acid (DHA) or Clitoria ternatea (Linn) aqueous root extract (CTR). MATERIAL AND METHODS: Study groups, control, PMSS, PMSS + choline with DHA, PMSS + CTR (n = 6/group) were included in the study...
2018: Folia Neuropathologica
Kinga Czubowicz, Sylwia Wójtowicz, Przemysław Leonard Wencel, Robert Piotr Strosznajder
Alzheimer's disease (AD) is characterized by alterations of amyloid precursor protein (APP) metabolism, accumulation of amyloid  peptides (A), hyperphosphorylation of Tau proteins and also by sphingolipids disturbances. These changes lead to oxidative stress, mitochondria dysfunction, synaptic loss and neuro-inflammation. It is known that A may promote ceramides formation and reversely, ceramides could stimulate A peptides release. However, the effect of ceramide and sphingosine-1-phosphate (S1P) on APP metabolism has not been fully elucidated...
2018: Folia Neuropathologica
Mariusz Kobek, Zbigniew Jankowski, Janusz Szala, Zbigniew Gąszczyk-Ożarowski, Artur Pałasz, Rafał Skowronek
In our previous work, we have discussed the importance of neurofilaments in determination of the age of brain contusions. The purpose of this paper is to examine a possibility of angiogenesis-related assessment of the age of brain contusions by means of morphometric analysis of the CD34 expression in the contused sites. The researched material comprised 90 cases divided into nine groups according to the time of death: immediately on the spot, 12 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, 6 days, and 7 days after the head trauma...
2018: Folia Neuropathologica
Jinyu Xu, Jun Shi, Jiaming Zhang, Yun Zhang
The present investigation evaluates the protective effect of vorinostat on neuronal cells in the traumatic brain injury (TBI) and also postulates the possible mechanism of its action. Marmarou's weight-drop model was used to induce the TBI. Further, animals were treated with vorinostat 100 mg/kg intraperitoneally 30 min before the TBI induction. Neurological score and brain water content were determined in all the groups and thereafter oxidative stress parameters and adenosine triphosphate (ATP) content were determined in the neuronal tissues of TBI mice...
2018: Folia Neuropathologica
Paweł P Liberski, Agata Gajos, Beata Sikorska
We re-examined the database of some 20,000 electron micrographs from the Echigo-1, the 263K-strain or the 22C-H of scrapie-infected hamsters to look for the cytoplasmic clearance. We reevaluated the largest database in the world of photographed dystrophic neurites for the presence of cytoplasmic clearance as shown in transgenic fruit flies transfected with A-42. In several neurites, we found electron-lucent areas not bound by any membranes or only partially bound; thus, they were not autophagic vacuoles as the latter are membrane-bound and contain cargo...
2018: Folia Neuropathologica
Bozena Kuzniewska, Krzysztof Sadowski, Katarzyna Urbanska, Malgorzata Urbanska, Katarzyna Kotulska, Ewa Liszewska, Wieslawa Grajkowska, Sergiusz Jóźwiak, Magdalena Dziembowska
Tuberous sclerosis complex (TSC) represents a genetic condition, in which the clinical manifestations are caused by the disinhibition of the mammalian target of rapamycin (mTOR) pathway due to mutations in the TSC1 (hamartin) or TSC2 (tuberin) genes. The deregulated mTOR activity leads to multi-site tumors, including subependymal giant cell astrocytoma (SEGA). SEGA is a brain tumor that affects around 15% of TSC patients. The aim of the study was to evaluate miR-21 expression in the serum of two groups of TSC patients: with or without SEGA tumors...
2018: Folia Neuropathologica
Meili Yang, Yafang Chen, Zhengang Wu, Yaping Zhang, Ruowei Cai, Lichao Ye, Yinhui Huang, Lingxing Wang, Huiling He
The aim of this study was to investigate the effect and mechanism of chronic intermittent hypoxia (CIH) on cerebral injury using the ischemia-reperfusion rat model. In total, 36 SD rats were divided into three groups: pseudo-surgery group (sham group), ischemia-reperfusion (IR) group (CIR group), and CIH intervention group (CIH group). The IR model was established using the suture-occluded method. CIH intervention was performed starting at 12 weeks prior to the establishment of the IR model for rats in the CIH group...
2018: Folia Neuropathologica
Hongxiang Wang, Liangzhe Wang, Yicheng Lu, Chengyin Lu, Tao Xu, Yong Yan, Juxiang Chen
Haemangiopericytomas (HPCs) in the spinal canal are extremely rare and have only been infrequently reported. Severe and sustained spinal cord compression resulting from these intraspinal tumours may cause potentially irreversible neurological impairment. We described a rare case of primary intradural extramedullary HPC recovered from serious compression of thoracic spinal cord in a 65-year-old man suffered from a rapidly progressive disease with complete paralysis of the lower limbs. Magnetic resonance imaging (MRI) and spinal angiography exhibited an unusual hypervascular mass, which was confirmed as HPC by pathological examination, in the dorsal aspects of T7 to T8 spine...
2018: Folia Neuropathologica
Gozal Bahlakeh, Mehrdad Jahanshahi, Mohsen Saeidi
INTRODUCTION: The pharmacological suppression of luteinising hormone or human chorionic gonadotropin (hCG) can reduce Aβ plaques in the brains of rats and mice, but the effects of hCG on the phosphorylated tau protein level in the hippocampus have not been studied. Therefore, we investigated the effects of hCG on the phosphorylated tau protein level and its effect on hCG receptor-immunoreactive neuron density in the hippocampus of Alzheimer's disease (AD) model rats (streptozotocin [STZ] injected intracerebroventricularly)...
2018: Folia Neuropathologica
Bing Han, Lijie Wang, Fenghua Fu, Zhenhua Wang, Leiming Zhang, Grace Jia Qi, Tian Wang
Autophagy is an intracellular degradation process that is involved in α-synuclein (α-syn) homeostasis and Parkinson's disease (PD). The purpose of this study was to investigate whether hydroxysafflor yellow A (HSYA) could promote α-syn clearance via regulating autophagy in PD mice. Male C57BL/6 mice were intraperitoneally treated with HSYA. Thirty minutes later, they were intragastrically administered with rotenone at a dose of 30 mg/kg. The hanging wire test was performed at 14 and 28 days. Then, autophagosomes and ultrastructural changes were examined by transmission electron microscopy...
2018: Folia Neuropathologica
Monika Barczewska, Katarzyna Jezierska-Wozniak, Aleksandra Habich, Seweryn Lipinski, Piotr Holak, Wojciech Maksymowicz, Joanna Wojtkiewicz
INTRODUCTION: The pathophysiology of degenerative disc disease (DDD) is complex and not fully understood. While surgical treatment and appropriate rehabilitation offer relief of acute symptoms, there is a need to find tissue engineering strategies for intervertebral disc repair to restore healthy higher and histological structure. The purpose of this study was to estimate the survival rate of transplanted cells and their post-delivery integration level at the damage site. MATERIAL AND METHODS: We used an <i>in vivo</i> porcine model to investigate autogenic bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation for intervertebral disc repair...
2018: Folia Neuropathologica
Wei Hu, Jian Jiang, Feng Yang, Jun Liu
INTRODUCTION: The impact of bone marrow-derived mesenchymal stem cells (BM-MSCs) on neovascularisation in rats with craniocerebral injury (CI) was investigated. MATERIAL AND METHODS: The rate CI model was established by the free-fall method, and then rats were randomly divided into a transplanted group (EG) and a control group (CG). Rats in the transplanted group were injected with BM-MSCs in the lateral ventricle, while those in the control group were injected with normal saline...
2018: Folia Neuropathologica
Xinkai Niu, Chaochun Yu, Guanfu Jiang, Jun Wu, Xiaohui Tan, Weijia Zhang, Lijun Hou
INTRODUCTION: Brain injury caused by ischaemic stroke is a major cause of disability and death throughout the world. The present study evaluates the neuroprotective effect of pseudopterosin A (PtA) against ischaemia-induced brain injury. MATERIAL AND METHODS: Ischaemia was induced by pMCAO model, and rats were separated in to three groups. A control group; an ischemic group receiving saline solution; and a PtA group receiving PtA (5 mg/kg, i.p.) for the period of three days, i...
2018: Folia Neuropathologica
Mieszko Olczak, Magdalena Kwiatkowska, Justyna Niderla-Bielińska, Dominik Chutorański, Sylwia Tarka, Teresa Wierzba-Bobrowicz
The release of brain-originated peptides such as tau protein (MAPT), S-100β, neurofilament light chain (NFL), and glial fibrillary acidic protein (GFAP) into the cerebrospinal fluid (CSF) has been positively correlated with head injuries in clinical and basic research. In this study, we wanted to examine if selected CSF biomarkers (GFAP, NFL, and myelin basic protein - MBP) of head injury may be useful in post-mortem examination and diagnosis of forensic cases. The study was carried out using cases of head injury and cases of sudden death (cardiopulmonary failure, no injuries of the head as control group) provided by forensic pathologists at the Department of Forensic Medicine, Medical University of Warsaw...
2018: Folia Neuropathologica
Anna Filipek-Gliszczyńska, Anna Barczak, Magdalena Budziszewska, Monika Mandecka, Tomasz Gabryelewicz, Maria Barcikowska
The evaluation of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) (β-amyloid, t-tau, p-tau) can be used to estimate the risk of developing dementia in patients at the pre-clinical stages of AD, i.e. subjective cognitive decline (SCD) and mild cognitive impairment (MCI). Erlangen Score Algorithm allows interpretation of CSF biomarker concentrations and is cut-off value independent. The aim of this study was to establish if this algorithm can be applied for routine diagnostic testing in clinical and preclinical subjects and has prognostic value...
2018: Folia Neuropathologica
Jacques De Reuck, Claude-Alain Maurage, Vincent Deramecourt, Florence Pasquier, Charlotte Cordonnier, Didier Leys, Regis Bordet
INTRODUCTION: The prevalence of dementia is increasing in our aging population. Because of the complexity of disease pathology, dementia classifications remain controversial. The present post-mortem study investigates whether there are age differences between dementia brains with a single pure neurodegenerative or cerebrovascular disease and those with mixed pathological features. Also, the impact of these vascular lesions is compared. MATERIAL AND METHODS: A total of 132 dementia brains with a pure neurodegenerative or cerebrovascular disease and 84 with mixed features were examined...
2018: Folia Neuropathologica
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