journal
https://read.qxmd.com/read/38174688/lmtk2-inhibits-a%C3%AE-25-35-elicited-ferroptosis-oxidative-stress-and-apoptotic-damage-in-pc12-cells-through-activating-nrf2-are-signalling-pathway
#1
JOURNAL ARTICLE
Lili Zhang, Fei Shu
Alzheimer's disease (AD), the most common contributor to dementia, is a growing global health problem. This study aimed to investigate the role of lemur tyrosine kinase 2 (LMTK2) in AD as well as its relevant mechanism. To establish an in vitro cell model, PC12 cells were challenged with 20 µmol/l Ab 25-35 for 24 h. RT-qPCR and western blot examined LMTK2 mRNA and protein expressions. With the application of CCK-8, TUNEL, iron colorimetric assay kit and DCFH-DA, the viability, apoptosis, Fe 2+ and ROS content in PC12 cells were assessed...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174687/triptolide-promotes-nerve-repair-after-cerebral-ischemia-reperfusion-injury-by-regulating-the-nogoa-ngr-rock-pathway
#2
JOURNAL ARTICLE
Huiyu Zhang, Minfang Guo, Peijun Zhang, Bingtao Mu, Zhenjun Bai, Liang Li, Jingwen Yu
Activation of the NogoA/NgR/ROCK pathway limits nerve repair after brain ischemia-reperfusion (I/R) injury. Triptolide displays anti-inflammatory, anti-oxidant, and immunosuppressive effects and is derived from the traditional Chinese medicine Tripterygium wilfordii Hook F. This agent can also penetrate the blood-brain barrier, where it has a neuroprotective effect and ameliorates cerebral I/R injury via an as yet unknown mechanism(s). Here, an animal model of middle cerebral artery occlusion and reperfusion (MCAO/R) was employed to assess triptolide's therapeutic impact on brain I/R injury and the possible mechanism of action...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174686/targeting-the-nrf2-dependent-mechanism-of-b-ecdysterone-in-attenuating-the-motor-dysfunction-in-the-mptp-pro-induced-parkinson-s-disease-mice-model
#3
JOURNAL ARTICLE
Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wang
Oxidative stress is a pivotal stimulating factor in neurocyte apoptosis and has been involved in the pathogenesis of Parkinson's disease (PD). In this study, we have demonstrated that the improvement in the motor disorder of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/Pro-induced mice caused by b-Ecdysterone (b-Ecd) treatment is due to its antioxidant properties. Using open field, rotarod, and pole climbing tests, we have found that b-Ecd alleviates motor disorder in MPTP/Pro-induced mice and ultimately reduces the impairment of tyrosine hydroxylase (TH)-positive dopaminergic neurons in the substantia nigra (SN)...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174685/the-neutrophil-extracellular-traps-related-gene-signature-predicts-the-prognosis-of-glioblastoma-multiforme
#4
JOURNAL ARTICLE
Guanghui Sun, Wei Liu
INTRODUCTION: This research hoped to explore the molecular mechanism of neutrophil extracellular traps (NETs) on glioblastoma multiforme (GBM) progression, and develop a promising prognostic signature for GBM based on NETs-related genes (NETGs). MATERIAL AND METHODS: Gene expression data and clinical data of GBM tumour samples were downloaded from TCGA and CGGA databases. NETs-related molecular subtypes were explored by using ConsensusClusterPlus. The NETGs with a prognostic value were identified, and then a prognostic model was constructed using LASSO Cox regression...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174684/relationship-between-astrocyte-damage-and-different-levels-of-cerebrospinal-fluid-markers-and-prognosis-in-patients-with-subarachnoid-hemorrhage
#5
JOURNAL ARTICLE
Tao Wu, Xiao He, Li Su, Xiaofeng Zhang
INTRODUCTION: The aim of the study was to explore the relationship between astrocyte damage and different levels of cerebrospinal fluid markers and prognosis in patients with subarachnoid hemorrhage (SAH). MATERIAL AND METHODS: A total of 168 SAH patients diagnosed and treated in the emergency department of our hospital during the period October 2019 to February 2022 were randomly selected as the study subjects. The severity of these patients' condition was evaluated by Hunt-Hess grading and these subjects were graded as the low-level group (78 patients) and high-level group (90 patients) according to the evaluation results...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174683/exercise-attenuates-mitochondrial-autophagy-and-neuronal-degeneration-in-mptp-induced-parkinson-s-disease-by-regulating-inflammatory-pathway
#6
JOURNAL ARTICLE
Zhiwei Li, Hua Lv, Xiaoli Cui, Wei Di, Xiansong Cheng, Jun Liu, Alok Tripathi
Parkinson's disease (PD) is a chronic neuronal loss of dopamine and drugs used for its management has several limitations. The present report determines the effect of exercise on mitochondrial autophagy against PD. Parkinson's disease was induced by 15 doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, i.p.) for 3 weeks, on five consecutive days in a week. Exposure of exercise was provided for 40 min for a period of 2 weeks after PD confirmation. Assessment of behaviour was performed to evaluate the effect of exercise on motor function and cognitive function in PD rats...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174682/working-memory-deficit-in-schizophrenia-a-systematic-review-and-meta-analysis-of-fmri-studies-examining-frontal-and-parietal-brain-activity
#7
JOURNAL ARTICLE
Xueying Ding, Hongyang Fu, Liyuan Luo, Jun Wu
INTRODUCTION: The role of functional magnetic resonance imaging (fMRI) findings in investigation of working memory (WM) deficit in schizophrenia patients is still debatable. The aim of the study was to investigate the role of fMRI findings of the frontal and parietal brain activity in investigation of WM deficit in schizophrenia patients. MATERIAL AND METHODS: We used Medline, Embase, and the Cochrane Database to conduct a comprehensive search up to January 2023...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174679/large-haemorrhage-within-glioblastoma-mimicking-haemorrhagic-stroke-and-consistence-of-meningioma-a-case-of-collision-tumours
#8
Michał Sobstyl, Ewa Nagańska, Piotr Glinka, Teresa Wierzba-Bobrowicz, Albert Acewicz, Aleksandra Kuls-Oszmaniec
Intracranial collision tumours are rare pathologies in which two distinct neoplasms are found in the same location. We present an unusual case of an intracranial collision tumour composed of meningothelial meningioma (CNS WHO G1) and glioblastoma (IDH-wildtype, CNS WHO G4). This collision tumour was found in a 64-year-old man. This patient was hospitalized urgently due to left-sided hemiparesis. The computed tomography (CT) revealed large multilobar intracranial haemorrhage located in the right hemisphere. The history of hypertension and obesity pointed to the misdiagnosis of a typical haemorrhagic stroke...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174678/dexmedetomidine-promotes-the-functional-recovery-of-mice-after-acute-ischemic-stroke-via-activation-of-the-%C3%AE-2-adrenoceptor
#9
JOURNAL ARTICLE
Yuhao Peng, Xiaoling Hu, Haifeng He, Xinting Zhou, Zhonghui Luo
Ischemic stroke (IS) is a well-known acute cerebrovascular disease characterized by high disability, morbidity, and recurrence rates with no effective treatments. Dexmedetomidine (DEX), a selective a2-adrenoceptor agonist used in anaesthesiology and pain management, has been found to exhibit neuroprotective effects in various diseases. However, its role in IS and the underlying mechanisms remains to be determined. Hence, the aim of the present study was to investigate the neuroprotective role of DEX in the recovery of mice following middle cerebral artery occlusion (MCAO)...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174677/effect-of-ultra-early-intervention-of-ndt-therapy-on-nerve-and-motor-development-in-infants-at-high-risk-of-cerebral-palsy
#10
JOURNAL ARTICLE
Meihua Li, Lihua Wang, Shujie Yu, Xuesong Guo, Bingbing Xun, Yu Zhang
INTRODUCTION: The aim of the study was to investigate the effect of ultra-early intervention of nerve and motor development in infants at high risk of cerebral palsy. MATERIAL AND METHODS: One hundred and twenty cases of infants born in The Affiliated Hospital of Harbin Medical University from January 2017 to January 2019 and diagnosed with high risk of cerebral palsy were included in the observation group. In addition, 120 cases of infants at high risk of cerebral palsy (three to five months old) who were admitted to this hospital during the same period were included in the control group, and 120 healthy infants born in the same hospital were included in the healthy group...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174676/cerebral-echinococcus-that-can-be-confused-with-brain-tumour-a%C3%A2-case-report
#11
Şule Göktürk, Yasin Göktürk
Echinococcus is a parasitic disease known as echinococcal zoonosis and is often caused by Echinococcus granulosus. Cerebral echinococcus is extremely rare and has been reported to be less than 1% in the literature and it is more common in the childhood age group. In the case we are going to present, the patient is an 83-year-old male who was admitted to our clinic with complaints of headache and forgetfulness. The patient, who was initially thought to have a brain tumour, was pathologically diagnosed as echinococcus after surgery...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174675/vanillin-attenuates-oxidative-stress-and-neurochemical-balance-in-mptp-induced-parkinson-s-disease-mice-by-regulating-the-tlr-4-inflammatory-pathway
#12
JOURNAL ARTICLE
Yuan Gao, Jiang Liu, Xiaoyan Wang, Qiang Meng
This study investigated the protective effect of vanillin against Parkinson's disease (PD). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg) was administered s.c. for 6 consecutive days to induce PD and mice were treated with vanillin (100 and 200 mg/kg, p.o.) for 15 days. Cognitive, motor and non-motor functions were assessed to evaluate the effect of vanillin in PD mice. Levels of dopamine and glutamate and activity of monoamine oxidaseB (MAO-B) were estimated in vanillin-treated PD mice. The effect of vanillin on the level of lipid peroxidation and superoxide dismutase in brain tissue of PD mice was estimated...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174674/long-term-survival-of-stage-ib-lung-adenocarcinoma-with-postoperative-brain-oligometastasis-a%C3%A2-case-report-and-literature-review
#13
Kai Xu, Xing Feng, Limin Wang, Quan Du, Er Jin
Lung adenocarcinoma remains one of the most frequent and deadly tumour entities. Early-stage lung adenocarcinoma is extremely difficult to detect and is also easy to recur or metastasize after treatment. Since the new adenocarcinoma classification was presented in 2011, several studies have shown that patients with solid and/or micropapillary (S/MP) predominant patterns showed a worse prognosis. Here we report the case of a 54-year-old woman who was diagnosed with stage Ib lung adenocarcinoma with S/MP components and developed an isolated brain oligometastasis after resection and adjuvant therapy...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174673/pf4-induces-inflammatory-response-through-nf-kb-signal-pathway-in-rats-with-intracerebral-haemorrhage
#14
JOURNAL ARTICLE
Na Hu, Ran An, Kun Yu, Yanzhong Chang, Weijuan Gao
Intracerebral haemorrhage (ICH) is a lethal cerebrovascular disorder with a high mortality and morbidity. Although it is a major public health problem, there is no effective treatment for ICH. After ICH, the primary and secondary mechanisms are mentioned when discussing brain injury. The transcription factor, nuclear factor-kappa B (NF-kB), is an important regulator of inflammatory responses. The role of platelet factor 4 (PF4) in ICH is unclear. To study the effect of PF4 on inflammatory response of rats in ICH, a rat model of striatum ICH was established by injecting autologous blood from the autogenous femoral artery into the right striatum of rats...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174672/study-on-the-intervention-effect-of-smg-health-management-in-patients-with-ischemic-stroke
#15
JOURNAL ARTICLE
Bu Xu, Tao Wang, Lei Zhu, Xiu-Qun Gong, Yan Gan, Chuan-Qing Yu, Xiang-Xia Rong
INTRODUCTION: The aim of the study was to explore the clinical effect of brain and heart health managers combined with the "SMG" health management mode on nursing intervention in ischemic stroke patients. MATERIAL AND METHODS: A total of 187 ischemic stroke patients divided into 96 patients in the observation group and 91 patients in the control group with the random number table method. The control group conducted the routine care intervention, and the observation group used the brain and heart health managers combined with the "SMG" health management model for the nursing intervention...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174671/clinical-characteristics-in-patients-with-oculomotor-paralysis-caused-by-isolated-midbrain-infarction
#16
JOURNAL ARTICLE
Eryi Zhao, Daimei Wang, Zhongyan Zhao, Shijun Hu, Xiangying He, Peijian Huang
INTRODUCTION: The aim of the study was to investigate the clinical characteristics of isolated oculomotor paralysis (OP) cases caused by pure midbrain infarction (MI) with pupil sparing. MATERIAL AND METHODS: Patients with pure MI and pontine infarction (PI) at our hospital were included in this study. We compared the blood pressure and lipid levels between the two groups. And the clinical data and imaging features were summarized. RESULTS: In total, 33 and 35 patients were included in the MI and PI groups, respectively...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174670/attitudes-of-caregivers-towards-prolonging-and-shortening-life-in-advanced-stages-of-amyotrophic-lateral-sclerosis
#17
JOURNAL ARTICLE
Anna Maksymowicz-Śliwińska, Dorothée Lulé, Krzysztof Nieporęcki, Katarzyna Ciećwierska, Albert C Ludolph, Magdalena Kuźma-Kozakiewicz
INTRODUCTION: Inevitable disease progression in amyotrophic lateral sclerosis (ALS) forces patients and their caregivers (CGs) to reflect on end-of-life treatment. The CGs are often heavily burdened with their role of surrogate decision-makers. The aim of the study was to analyze attitudes of CGs and presumable attitudes of ALS patients from the CGs' perspective towards palliative care in advanced disease stages. MATERIAL AND METHODS: One hundred and sixty four CGs from Germany and Poland were interviewed regarding their own preferences and patients' ideational attitudes towards life-prolonging (invasive and non-invasive ventilation, tube feeding) and life-shortening methods (termination of measures, active measures if permitted by law)...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38174669/botulinum-neurotoxin-a%C3%A2-in-a%C3%A2-patient-with-post-stroke-spasticity-a%C3%A2-neurophysiological-study
#18
JOURNAL ARTICLE
Safa Muntadher Fawzi, Farqad Bader Hamdan, Israa F Jaafar, Gheyath Abd Ali Shallal Al Gawwam
INTRODUCTION: Post-stroke spasticity (PSS) is a disorder of the sensory-motor control, leading to upper motor neuron lesions manifesting either as intermittent or sustained involuntary activation of muscles. Botulinum neurotoxin-A (BoNT-A) is mostly utilized in a variety of therapeutic indications, and it is effective and safe in the management of focal PSS in the rehabilitation scenario. The study aimed to evaluate the effect of BoNT-A administration on H-reflex of upper and lower limbs following PSS...
January 4, 2024: Folia Neuropathologica
https://read.qxmd.com/read/38741437/extranodal-marginal-zone-lymphoma-of-mucosa-associated-lymphoid-tissue-of-the-dura-mimicking-meningioma-a-case-report-and-literature-review
#19
REVIEW
Piotr Glinka, Michał Sobstyl, Grzegorz Rymkiewicz, Teresa Wierzba-Bobrowicz, Ewa Paszkiewicz-Kozik, Wiesława Grajkowska
MALT lymphoma of the dura is a very rare type of low-grade B-cell lymphoma. Little more than 100 cases have been reported in the literature to date. We report a 43-year-old woman who was referred to hospital because of a series of three tonic-clonic seizures on the day of admission. Neurological examination revealed confusion and aphasia. Magnetic resonance imaging (MRI) showed a contrast-enhanced, broad-based lesion along the dura in the left parieto-occipital area. The suspicion of an en plaque meningioma was raised...
2024: Folia Neuropathologica
https://read.qxmd.com/read/38741436/transformation-of-idh-wildtype-glioblastoma-to-gliosarcoma-with-features-of-osteosarcoma
#20
JOURNAL ARTICLE
Paweł Sobczyk, Michał Sobstyl, Albert Acewicz, Joanna Rosa, Marta Grabiec, Wiesława Grajkowska
Gliosarcoma (GS) is a rare variant of IDH-wildtype glioblastoma. It is classified as grade 4 in the latest WHO CNS classification of both glial and mesenchymal components. Gliosarcoma may arise de novo or secondary from glioblastoma. It occurs in up to 2% of patients diagnosed with glioblastoma. We present a case report of a 51-year-old patient who was initially diagnosed with glioblastoma multiforme, which transformed into secondary gliosarcoma with an osteosarcoma component 16 months after the initial diagnosis...
2024: Folia Neuropathologica
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