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Journal of Bone and Mineral Metabolism

Toshio Matsumoto
No abstract text is available yet for this article.
February 13, 2019: Journal of Bone and Mineral Metabolism
Juan M Guerra, Martha A Hanes, Cordelia Rasa, Nagarajan Loganathan, Wendy Innis-Whitehouse, Ednia Gutierrez, Saraswathy Nair, Jameela Banu
In women, age-related bone loss is associated with increased risk of bone fracture. Existing therapies are associated with severe side effects; thus, there is a need to find alternative medicines with less or optimal side effects. Cissus quadrangularis (CQ), an Ayurvedic medicine used to enhance fracture healing, was tested for its bone protective properties and studied to discern the mechanism by which it is beneficial to bone. Female Sprague Dawley rats were either sham operated or ovariectomized and were fed CQ for 3 months...
February 12, 2019: Journal of Bone and Mineral Metabolism
Akiko Kuwabara, Naoko Tsugawa, Kei Mizuno, Honami Ogasawara, Yasuyoshi Watanabe, Kiyoshi Tanaka
Vitamin D deficiency (VDD) is associated with an increased risk of various diseases. Serum 25-hydroxyvitamin D [25(OH)D] concentration is the best marker for vitamin D status and its concentration < 20 ng/mL indicates VDD. However, its measurement is not easily applicable for the evaluation of vitamin D status in the general population because of its cost. Therefore, we aimed to develop a simple questionnaire for easily identifying the risk of VDD. From the total sample (649 healthy subjects aged 19-70 years), 434 and 215 subjects were randomly assigned to the derivation and the validation cohort, respectively...
February 5, 2019: Journal of Bone and Mineral Metabolism
Frank Rauch, Ghalib Bardai, Cheryl Rockman-Greenberg
Tissue-nonspecific alkaline phosphatase (ALP), encoded by ALPL, is important for bone homeostasis and interacts with collagen type I. In the present study, we sequenced ALPL and a panel of collagen type I-related genes in 24 adults (age 22-80 years; 20 female) with persistently low serum ALP (< 40 U/L) and a range of rheumatologic symptoms. We found heterozygous pathogenic or likely pathogenic variants in ALPL in 14 (58%) of these individuals. In addition, 7 study participants had potentially damaging heterozygous variants of uncertain significance in genes related to collagen type I...
February 4, 2019: Journal of Bone and Mineral Metabolism
Akira Taguchi, Yukari Uemura, Takumi Imai, Shiro Tanaka, Hiroaki Ohta, Toshitaka Nakamura, Hajime Orimo, Toshitsugu Sugimoto, Satoshi Soen, Masataka Shiraki
Osteonecrosis of the jaw (ONJ) associated with bisphosphonate therapy is a rare but severe side effect in osteoporosis patients. Recently, the number of osteoporosis patients with ONJ has dramatically increased in Japan. This has contributed to an increase in the number of patients avoiding extractions. However, there has been no prospective study providing definitive incidence data for ONJ in Japanese patients. The purpose of this study was to elucidate the true as well as suspected incidence of ONJ. A total of 3229 subjects (1612 subjects in the minodronic acid group and 1617 subjects in the raloxifene group) in the Japanese Osteoporosis Intervention Trial protocol number 4 participated in this study...
February 4, 2019: Journal of Bone and Mineral Metabolism
Koichi Ishida, Naoki Ashizawa, Koji Matsumoto, Seiichi Kobashi, Naoki Kurita, Takashi Shigematsu, Takashi Iwanaga
In patients with chronic kidney disease (CKD) or those undergoing hemodialysis, pathological calcific deposition known as ectopic calcification occurs in soft tissue, resulting in a life-threatening disorder. A potent and effective inhibitor of ectopic calcification is eagerly expected. In the current study, the effects of FYB-931, a novel bisphosphonate compound synthesized for the prevention of ectopic calcification, were compared with those of etidronate using both in vitro and in vivo models. In vitro, FYB-931 inhibited calcification of human aortic smooth muscle cells induced by high phosphate medium in a concentration-dependent manner, and the effect was slightly more potent than that of etidronate...
February 2, 2019: Journal of Bone and Mineral Metabolism
Jianrong Zhao, Yingbin Li, Hao Zhang, Dongying Shi, Qingnan Li, Li Zuo, Yan Meng
This study evaluated the preventative effects of metformin (Met) on glucocorticoid (GC)-induced osteoporosis in a rat model, compared with alendronate (Aln). Twenty-eight 3-month-old female Sprague-Dawley rats were randomly assigned into four groups: normal control (Ctr), methylprednisolone (MP, 13 mg/kg/day, sc, 5 days per week), MP plus Aln orally (1 mg/kg/day), and MP plus Met orally (200 mg/kg/day). After 9 weeks, serum bone metabolic biochemistry, bone densitometry and histomorphometry were performed...
January 31, 2019: Journal of Bone and Mineral Metabolism
Masashi Shimamura, Ken Iwata, Tasuku Mashiba, Takanori Miki, Tetsuji Yamamoto
In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femoral heads were evaluated in 10 women who underwent total hip arthroplasty for OA and in nine cadaveric controls (CNT). Chondral thickness and subchondral bone plate thickness (SBP.Th) were measured in 5-mm-wide areas where cartilage was lost (area A) or preserved (area B) in OA and in corresponding areas in the load-bearing portion of the femoral head in the CNT...
January 30, 2019: Journal of Bone and Mineral Metabolism
Seong-Eun Byun, Sujin Kim, Kyu-Hwang Kim, Yong-Chan Ha
This study aimed to determine: (1) the association between psoas cross-sectional area (PCA) and mortality in hip fracture patients, and (2) the usefulness of PCA as a diagnostic tool for sarcopenia. A total of 373 female and 121 male hip fracture patients aged 50 years or more who had surgical repair of their hip fracture between 2011 and 2017 were analyzed. PCA was measured at L4-L5 disc level using CT. PCA of gender-specific 20th percentile determined from this study cohort was used as a cutoff value. The effect of decreased PCA on mortality was analyzed...
January 8, 2019: Journal of Bone and Mineral Metabolism
Chiaki Horii, Yoshiki Asai, Toshiko Iidaka, Shigeyuki Muraki, Hiroyuki Oka, Shunji Tsutsui, Hiroshi Hashizume, Hiroshi Yamada, Munehito Yoshida, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Sakae Tanaka, Noriko Yoshimura
Vertebral fracture (VF) is a common osteoporotic fracture, while its epidemiology varies according to regions and ethnicities, little is known about it in Japan. Using whole-spine radiographs from a population-based cohort study, the Research on Osteoarthritis/Osteoporosis Against Disability study 3rd survey performed in 2012-2013, we estimated the sex- and age-specific prevalence of VF in the Japanese. Genant's semiquantitative method (SQ) was used to define VF; SQ ≥ 1 as VF, SQ = 1 as mild VF, SQ≥ 2 as severe VF...
January 3, 2019: Journal of Bone and Mineral Metabolism
Feng Li, Jarrett D Cain, Joyce Tombran-Tink, Christopher Niyibizi
Mutations in Serpinf1 gene which encodes pigment epithelium-derived factor (PEDF) lead to osteogenesis imperfecta type VI whose hallmark is defective matrix mineralization. We reported previously that PEDF reduced expression and synthesis of Sost/Sclerostin as well as other osteocytes genes encoding proteins that regulate matrix mineralization [1]. To determine whether PEDF had an effect on osteocyte gene expression in bone, we used bone explant cultures. First, osteocytes were isolated from surgical waste of bone fragments obtained from patients undergoing elective foot surgeries under approved IRB protocol by Penn State College of Medicine IRB committee...
January 3, 2019: Journal of Bone and Mineral Metabolism
A Ram Hong, Jung Hee Kim, Ji Hyun Lee, Sang Wan Kim, Chan Soo Shin
The diagnosis of osteoporosis is determined based on the lowest bone mineral density (BMD) T-score at the lumbar spine (LS) and hip. However, there are occasional marked discordances between the T-score of LS and femur neck (FN). We aimed to examine the prevalence and characteristics of individuals with spine-femur BMD discordance using a nationwide survey. A total of 3233 men aged ≥ 50 years and 2915 postmenopausal women were included from the Korean National Health and Nutrition Examination Surveys (2008-2011)...
January 3, 2019: Journal of Bone and Mineral Metabolism
Chang Kyun Choi, Sun-Seog Kweon, Young-Hoon Lee, Hae-Sung Nam, Kyeong-Soo Park, So-Yeon Ryu, Seong-Woo Choi, Sun A Kim, Min-Ho Shin
Levels of vitamin D and parathyroid hormone (PTH) are closely associated with renal function. We evaluated the associations among 25-hydroxyvitamin D (25OHD) levels, PTH levels, and mortality, and whether these associations varied by renal function. We used data from the Dong-gu Study, a population-based cohort in Korean adults. We analyzed the associations among intact PTH, 25OHD levels and mortality in 8580 participants. Hazard ratios (HRs) for mortality were calculated using Cox proportional hazards regression after adjusting for age, sex, month of sampling, lifestyle, and comorbidities...
December 7, 2018: Journal of Bone and Mineral Metabolism
Toshitsugu Sugimoto, Daisuke Inoue, Masayuki Maehara, Ichiro Oikawa, Takashi Shigematsu, Yoshiki Nishizawa
Limited data are available on the safety and efficacy of anti-resorptive agents, particularly once-monthly bisphosphonates, for use in osteoporotic patients with chronic kidney disease (CKD). We conducted a post hoc analysis of data from a 12-month, randomized, double-blind, phase III study to evaluate the safety and efficacy of once-monthly risedronate (RIS-OM) 75 mg tablets in Japanese osteoporosis patients with mild-to-moderate CKD. Patients who received RIS-OM 75 mg were stratified by baseline estimated glomerular filtration rate (eGFR; ≥ 90, ≥ 60 to < 90, or ≥ 30 to < 60 mL/min/1...
December 6, 2018: Journal of Bone and Mineral Metabolism
Edgar Denova-Gutiérrez, Patricia Clark, Ricardo Francisco Capozza, Laura Marcela Nocciolino, Jose Luis Ferretti, Rafael Velázquez-Cruz, Berenice Rivera, Gustavo Roberto Cointry, Jorge Salmerón
The present study aims: (1) to explore the influence of lean mass (LM) on bone mineral content (BMC), (2) to investigate the pubertal influences on the BMC-LM relation, and (3) to perform Z-score charts of BMC-LM relation, stratified by gender and reproductive status categorized by age ranges. A cross-sectional analysis was conducted using 4001 healthy subjects between 7 and 90 years participating in the Health Workers Cohort Study. Of these, 720 participants were ≤ 19 years, 2417 were women ≥ 20 years, and 864 were men ≥ 20 years...
December 4, 2018: Journal of Bone and Mineral Metabolism
Qiong Yu, Dong Li, Dan Wang, Chun-Mei Hu, Yan Sun, Yan Tang, Guang Shi
Osteosarcoma (OS) is a prevalent cancer that plagues people worldwide. Identifying prognostic markers would be useful in treating human OS. In this study, we aimed to explore the functions of Ras-related protein Rab-31 (RAB31) in OS-cell proliferation, migration, and invasion as well as its roles in the Hedgehog signaling pathway for better understanding of the mechanism. To assess the detailed regulatory mechanism of RAB31 silencing on OS, both RT-qPCR and Western blot analysis were employed to evaluate the expressions of RAB31 as well as the Hedgehog signaling pathway-related genes...
November 23, 2018: Journal of Bone and Mineral Metabolism
Ruri Komiya, Takahiro Wada, Fumihiko Tsushima, Kei Sakamoto, Tohru Ikeda, Akira Yamaguchi, Hiroyuki Harada, Motohiro Uo
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive agents like bisphosphonates. Abnormal concentrations of various trace metallic elements contained in bone minerals have been associated with MRONJ. In this study, we focused on trace metallic elements contained in the MRONJ sequestrum; their content and distribution were compared to those in osteomyelitis and non-inflammatory bones using inductively coupled plasma atomic emission spectroscopy (ICP-AES) and synchrotron radiation X-ray fluorescence analysis (SR-XRF)...
November 22, 2018: Journal of Bone and Mineral Metabolism
Xinling Ma, Haiou Xia, Jinhua Wang, Xiaoxiao Zhu, Fangyan Huang, Liuxue Lu, Lanyan He
Re-fracture risk is higher following osteoporotic fracture. However, there is no accurately reported rate of re-fracture incidence in southwest China. The purpose of this study was to describe the osteoporotic vertebral fracture (OVF) survival for re-fracture state and analyze the risk of re-fracture. This historical cohort study was conducted in four hospitals in southwest China. Patients aged ≥ 50 years (n = 586) with OVF who were supposed to receive anti-osteoporosis drugs after the fracture were included (2012-2017)...
November 21, 2018: Journal of Bone and Mineral Metabolism
Nicola Oehler, Tim Rolvien, Tobias Schmidt, Sebastian Butscheidt, Ralf Oheim, Florian Barvencik, Haider Mussawy
In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this study was to assess trabecular and cortical bone microstructure in patients with CRPS of the distal tibiae. We retrospectively analysed 14 women diagnosed with unilateral CRPS type I of the lower limb whose affected and unaffected distal tibiae were examined by high-resolution peripheral quantitative computed tomography (HR-pQCT)...
November 21, 2018: Journal of Bone and Mineral Metabolism
Xiaoming Cao, Zhiqing Duan, Zheyi Yan, Yongping Li, Lu Li, Jian Sun, Pengfei Han, Pengcui Li, Lei Wei, Xiaochun Wei
The dysregulated expression of the osteoarthritis (OA)-related genes in cartilage, such as matrix metalloproteinase 13 (MMP-13) and type X collagen (Col X), facilitates the onset and progression of OA. Reduced parathyroid hormone-related protein (PTHrP) may also accelerate this progression. Furthermore, miRNAs, endogenous regulators of mRNAs, are thought to play key roles in the pathogenesis of OA. In this study, we found that miR-195 levels were significantly upregulated in OA tissue, while PTHrP mRNA/protein expression was substantially downregulated, and there was a negative correlation between miR-195 and PTHrP...
November 21, 2018: Journal of Bone and Mineral Metabolism
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