Journals Journal of Bone and Mineral Me...

Journal of Bone and Mineral Metabolism
Shuo Li, Wei Li, Lina Chang, Jieying Wan, Shanshan Chen, Xinxin Zhang, Qing He, Ming Liu
INTRODUCTION: This study is to investigate the relation between serum dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) levels and the risk of osteoporosis in patients with T2DM. MATERIALS AND METHODS: This cross-sectional study involved 938 hospitalized patients with T2DM. Linear regression models were used to explore the relationship between DHEA and DHEAS and the BMD at different skeletal sites. Multinominal logistic regression models and the restricted cubic spline (RCS) were used to evaluate the associations of DHEA and DHEAS with the risks of osteopenia and/or osteoporosis...
May 20, 2024: Journal of Bone and Mineral Metabolism
Hiroshi Hagino, Shiro Tanaka, Tatsuhiko Kuroda, Satoshi Mori, Satoshi Soen
INTRODUCTION: The purpose of this study was to evaluate whether bone mineral density (BMD) ≥ -2.5 SD could be used as the treat-to-target (T2T) goal when treating osteoporosis with teriparatide (TPTD) and alendronate (ALN), and to investigate the relationship with incident vertebral fracture by re-analyzing data from a randomized, controlled trial (JOINT-05) involving postmenopausal Japanese women at high fracture risk. MATERIALS AND METHODS: Participants received sequential therapy with once-weekly TPTD for 72 weeks, followed by ALN for 48 weeks (TPTD-ALN group) or ALN monotherapy for 120 weeks (ALN group)...
May 16, 2024: Journal of Bone and Mineral Metabolism
Guoju Hong, Lin Tang, Tianyu Zhou, Youhong Xie, Jiangyan Wang, Dongdong Ge, Qunwei Dong, Ping Sun
INTRODUCTION: Bone homeostasis depends on the regulation of β-catenin in osteoblasts. Glucocorticoids (GCs) are known to diminish β-catenin activity via Wnt pathway signaling, leading to osteoporosis. Conversely, activating β-catenin in osteoblasts through mitogen-activated protein kinase kinase kinase 2 (Mekk2) offers an innovative approach to combat GC-induced osteoporosis (GIOP). Fufang Zhenshu Tiaozhi (FTZ) capsules have shown effectiveness in treating GIOP, but the mechanisms behind this are still unclear...
May 16, 2024: Journal of Bone and Mineral Metabolism
Lilan Gao, Ruiqi Chen, Xianglong Lin, Jie Liu, Jin Liu, Yansong Tan, Chunqiu Zhang, Xizheng Zhang
INTRODUCTION: High + Gz loads, the gravitational forces experienced by the body in hypergravity environments, can lead to bone loss in pilots and astronauts, posing significant health risks. MATERIALS AND METHODS: To explore the effect of treadmill exercise on bone tissue recovery, a study was conducted on 72 male Wistar rats. These rats were subjected to four weeks of varying levels of periodic high + Gz loads (1G, 8G, 20G) experiments, and were subsequently divided into the treadmill group and the control group...
May 16, 2024: Journal of Bone and Mineral Metabolism
Henry Schwarcz, Chiara Micheletti, Kathryn Grandfield
PURPOSE: Transmission electron microscopy (TEM) is widely used to study the ultrastructure of bone. The mineral of bone occurs as polycrystalline mineral plates about 3 to 6 nm in thickness. A problem in using TEM to make quantitative analyses of bone is that the orientation of the plates with respect to the plane of the section being imaged is expected to affect their apparent thickness. The purpose of this study was to test if this was true, if the apparent thickness of plates changed substantially as a result of tilt of the section...
May 11, 2024: Journal of Bone and Mineral Metabolism
Kiyotaka Okada, Yuto Niwa, Kazusa Fukuhara, Takashi Ohira, Yuya Mizukami, Naoyuki Kawao, Osamu Matsuo, Hiroshi Kaji
INTRODUCTION: Glucocorticoids delay fracture healing and induce osteoporosis. Angiogenesis plays an important role in bone repair after bone injury. Plasminogen activator inhibitor-1 (PAI-1) is the principal inhibitor of plasminogen activators and an adipocytokine that regulates metabolism. However, the mechanisms by which glucocorticoids delay bone repair remain unclear. MATERIALS AND METHODS: Therefore, we herein investigated the roles of PAI-1 and angiogenesis in glucocorticoid-induced delays in bone repair after femoral bone injury using PAI-1-deficient female mice intraperitoneally administered dexamethasone (Dex)...
May 4, 2024: Journal of Bone and Mineral Metabolism
E M F Gama, L M C Mendonça, F P Paranhos-Neto, L Vieira Neto, M Madeira, M L F Farias
INTRODUCTION: Trabecular bone score (TBS) estimates bone microstructure, which is directly measured by high-resolution peripheral quantitative computed tomography (HRpQCT). We evaluated the correlation between these methods and TBS influence on fracture risk assessed by FRAX. MATERIALS AND METHODS: We evaluated 129 individuals (82 women, 43 postmenopausal) 20 to 82.3 years without prevalent clinical or non-clinical morphometric vertebral fractures, using DXA (spine and hip), HR-pQCT at distal radius (R) and tibia (T) and TBS which classifies bone microarchitecture as normal (TBS ≥ 1...
April 25, 2024: Journal of Bone and Mineral Metabolism
Tetsuya Kawahara, Yosuke Okada, Yoshiya Tanaka
It is well known that vitamin D has a profound effect on calcium and bone metabolism, but its influence on other organs (extraskeletal effect) has been proposed. Consistently, vitamin D deficiency is associated with an increased incidence of various diseases, including type 1 and type 2 diabetes, as reported by many observational studies. However, there has been no consensus on whether vitamin D deficiency is a causative factor in the incidence of diabetes mellitus. There have been no randomized controlled trials (RCTs) aimed at preventing the onset of type 1 diabetes with vitamin D intake...
April 25, 2024: Journal of Bone and Mineral Metabolism
Aoi Ikedo, Yuuki Imai
INTRODUCTION: Low energy availability due to excessive exercise lowers bone mass and impairs various physiological functions, including immunity and hematopoiesis. We focused on Cxcl12 abundant reticular (CAR) cells, which are bone marrow mesenchymal stem cells and are essential for the maintenance of hematopoietic and immune cells in bone marrow. We examine the functional changes in CAR cells resulting from dietary restriction combined with exercise. MATERIALS AND METHODS: Five-week-old wild-type female mice were divided into an ad libitum group (CON), a 60% dietary restriction group (DR), an ad libitum with exercise group (CON + ex), and a 60% dietary restriction with exercise group (DR + ex)...
April 1, 2024: Journal of Bone and Mineral Metabolism
Shun Yoshikoshi, Shohei Yamamoto, Yuta Suzuki, Keigo Imamura, Manae Harada, Kentaro Kamiya, Atsuhiko Matsunaga
INTRODUCTION: Osteosarcopenia is an age-related syndrome characterized by the coexistence of osteoporosis and sarcopenia. Little is known about the clinical implications of osteosarcopenia among patients undergoing hemodialysis. This study investigated the prevalence of osteosarcopenia and its association with all-cause mortality and fractures in this population. MATERIALS AND METHODS: This retrospective cohort study included outpatients undergoing hemodialysis in Japan...
March 28, 2024: Journal of Bone and Mineral Metabolism
Yoshiya Tanaka, Satoshi Soen, Shintaro Hirata, Yosuke Okada, Saeko Fujiwara, Ikuko Tanaka, Yuriko Kitajima, Takuo Kubota, Kosuke Ebina, Yuichi Takashi, Reiko Inoue, Mika Yamauchi, Naoaki Okubo, Masanobu Ueno, Yasuhisa Ohata, Nobuaki Ito, Keiichi Ozono, Hisanori Nakayama, Masakazu Terauchi, Sakae Tanaka, Seiji Fukumoto
INTRODUCTION: Although synthetic glucocorticoids (GCs) are commonly used to treat autoimmune and other diseases, GC induced osteoporosis (GIOP) which accounts for 25% of the adverse reactions, causes fractures in 30-50% of patients, and markedly decreases their quality of life. In 2014, the Japanese Society for Bone and Mineral Research (JSBMR) published the revised guidelines for the management and treatment of steroid-induced osteoporosis, providing the treatment criteria based on scores of risk factors, including previous fractures, age, GC doses, and bone mineral density, for patients aged ≥18 years who are receiving GC therapy or scheduled to receive GC therapy for ≥3 months...
March 28, 2024: Journal of Bone and Mineral Metabolism
Takuya Wakamatsu, Suguru Yamamoto, Koji Matsuo, Masatomo Taniguchi, Takayuki Hamano, Masafumi Fukagawa, Junichiro James Kazama
INTRODUCTION: This study aimed to assess the effectiveness of calcimimetics in reducing the risk of fractures in dialysis patients with secondary hyperparathyroidism (SHPT). MATERIAL AND METHODS: A comprehensive literature search was conducted using PubMed, Embase, and Cochrane Library for articles published through December 9, 2023. The quality of each trial was evaluated using the Cochrane Collaboration tool. Meta-analysis was performed using a random-effects model, and effect measures across studies were synthesized...
March 27, 2024: Journal of Bone and Mineral Metabolism
Kazuhiko Kato, Tatsuhiro Yaginuma, Arisa Kobayashi, Akio Nakashima, Ichiro Ohkido, Takashi Yokoo
INTRODUCTION: Denosumab, a fully human anti-RANKL monoclonal antibody, is a widely used osteoporosis treatment that is increasingly being used in patients undergoing dialysis; however, its long-term efficacy and safety in these patients remain unknown. MATERIALS AND METHODS: This observational study comprised individuals aged ≥ 20 years undergoing hemodialysis and receiving denosumab. After denosumab administration, we analyzed the long-term changes in bone mineral density (BMD) and levels of bone turnover markers (BTMs) and calcium...
March 21, 2024: Journal of Bone and Mineral Metabolism
Naoki Haruyama, Masaru Nakayama, Shunsuke Yamada, Shigeru Tanaka, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano
INTRODUCTION: In patients undergoing dialysis, major bone fracture is associated with a high risk of mortality, including death of cardiovascular (CV) origin. In the present study, we aimed to determine whether a history of fragility fracture is a predictor of CV death in patients undergoing hemodialysis with long-term follow-up. MATERIALS AND METHODS: In total, 3499 patients undergoing hemodialysis were analyzed for 10 years. We evaluated the history of fragility fracture in each patient at enrollment...
March 20, 2024: Journal of Bone and Mineral Metabolism
Zhubin Shen, Fengyi Zhang, Xiaoqing Guan, Zhiming Liu, Yuan Zong, Ding Zhang, Rui Wang, Qian Xue, Wenxuan Ma, Ruijian Zhuge, Li Guo, Fei Yin
INTRODUCTION: This study was to investigate the correlations between pyrethroid exposure and bone mineral density (BMD) and osteopenia. MATERIALS AND METHODS: This cross-sectional study included 1389 participants over 50 years of age drawn from the 2007-2010 and 2013-2014 National Health and Nutrition Examination Survey (NHANES). Three pyrethroid metabolites, 3-phenoxybenzoic acid (3-PBA), trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid (trans-DCCA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3PBA) were used as indicators of pyrethroid exposure...
March 18, 2024: Journal of Bone and Mineral Metabolism
Hisashi Matsushima, Tetsuya Taguchi, Sho Kodama, Naoki Okubo, Kengo Saito, Katarzyna Jabłońska, Seiji Fukumoto, Toshio Matsumoto
INTRODUCTION: Androgen deprivation therapy (ADT) is widely used for the treatment of prostate cancer. ADT is associated with reduced bone density leading to an increased risk of osteoporotic fracture. The objective of this retrospective cohort study was to quantify fracture risk in men treated with ADT for prostate cancer in real-world practice in Japan. MATERIALS AND METHODS: Data were extracted from the Japanese Medical Data Vision (MDV) database. Men initiating ADT for treatment of prostate cancer between April 2010 and March 2021 were identified and matched to a cohort of prostate cancer patients not taking ADT using a propensity score...
March 17, 2024: Journal of Bone and Mineral Metabolism
Mika Akahane, Kaoru Tada, Masashi Matsuta, Yuta Nakamura, Soichiro Honda, Akari Mori, Hiroyuki Tsuchiya
INTRODUCTION: The purpose of this study was to clarify the relationship between seasonal variation and distal radius fractures using diagnosis procedure combination data in Japan. MATERIALS AND METHODS: The participants were hospitalized patients who underwent surgical treatment for distal radius fracture as the primary injury at hospitals that introduced the diagnosis procedure combination system between April 2011 and March 2016. We obtained a summary table of the month of admission, region of residence, age at admission, and sex of the patients from the Ministry of Health, Labour and Welfare and evaluated it by month, region, age group, and sex...
February 28, 2024: Journal of Bone and Mineral Metabolism
Sayaka Ono, Naoki Tsuji, Tomoaki Sakamoto, Shuya Oguchi, Takashi Nakamura, Kazuto Hoshi, Atsuhiko Hikita
INTRODUCTION: Osteoporosis is a global health issue. Bisphosphonates that are commonly used to treat osteoporosis suppress both bone resorption and subsequent bone formation. Inhibition of cathepsin K, a cysteine proteinase secreted by osteoclasts, was reported to suppress bone resorption while preserving or increasing bone formation. Analyses of the different effects of antiresorptive reagents such as bisphosphonates and cysteine proteinase inhibitors will contribute to the understanding of the mechanisms underlying bone remodeling...
February 20, 2024: Journal of Bone and Mineral Metabolism
Junpei Hatakeyama, Shota Inoue, Changxin Li, Daisuke Takamura, Hanlin Jiang, Hiroshi Kuroki, Hideki Moriyama
INTRODUCTION: Exercise intensity determines the benefits of aerobic exercise. Our objectives were, in aerobic exercise at different intensities, to determine (1) changes in bone metabolism-related genes after acute exercise and (2) changes in bone mass, strength, remodeling, and bone formation-related proteins after long-term exercise. MATERIALS AND METHODS: Total 36 male C57BL/6J mice were divided into a control group and exercise groups at 3 different intensities: low, moderate, or high group...
February 13, 2024: Journal of Bone and Mineral Metabolism
Go Okumura, Noriaki Yamamoto, Hayato Suzuki, Hiroshi Ninomiya, Yuki Hirano, Yoshiaki Tei, Yasuyuki Tomiyama, Taketoshi Shimakura, Hideaki E Takahashi, Norio Imai, Hiroyuki Kawashima
INTRODUCTION: Vitamin D deficiency causes osteoporosis, bone mineralization disorders, and osteomalacia. Osteomalacia is diagnosed using blood biochemical tests, clinical symptoms, and imaging; however, accurate detection of mineralization disorders requires tissue observation. We investigated the prevalence of bone mineralization disorders and their relationship with serum 25-hydroxyvitamin D (25OHD) levels in patients with untreated osteoporosis with femoral neck fractures. MATERIALS AND METHODS: A non-demineralized specimen was prepared from the femoral head removed during surgery in 65 patients...
February 8, 2024: Journal of Bone and Mineral Metabolism
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